Modulation of MAD1-like 1 expression

ABSTRACT

Compounds, compositions and methods are provided for modulating the expression of MAD 1 -like  1 . The compositions comprise oligonucleotides, targeted to nucleic acid encoding MAD 1 -like  1 . Methods of using these compounds for modulation of MAD 1 -like  1  expression and for diagnosis and treatment of disease associated with expression of MAD 1 -like  1  are provided.

FIELD OF THE INVENTION

[0001] The present invention provides compositions and methods for modulating the expression of MAD1-like 1. In particular, this invention relates to compounds, particularly oligonucleotide compounds, which, in preferred embodiments, hybridize with nucleic acid molecules encoding MAD1-like 1. Such compounds are shown herein to modulate the expression of MAD1-like 1.

BACKGROUND OF THE INVENTION

[0002] The progression of eukaryotic cells through the cell division cycle is driven by a biochemical clock or oscillator. Cellular surveillance mechanisms known as checkpoints regulate the timing of the clock by monitoring the successful completion of prerequisite events and ensuring the readiness of a cell to enter the next stage of the cell cycle before the subsequent event occurs. Checkpoints can also delay cell cycle progression if a prerequisite step is not completed correctly. Malfunctions due to DNA damage, errant DNA replication or improper chromosome attachment to mitotic spindle microtubules activate checkpoint delays. In the case of severe and irreparable DNA damage, apoptotic programs may also be triggered. Two major mitotic checkpoints control passage through the G2/M transition and M-phase progression/spindle assembly stages of the cell cycle. In the budding yeast, Saccharomyces cerevisiae, the MAD (mitotic arrest deficient) and BUB (budding uninhibited by benzimidazole) genes were first identified as genes encoding proteins necessary for mitotic arrest in response to spindle damage. At least seven distinct yeast genes (BUB1, 2, and 3 and MAD1, 2, and 3 as well as a gene encoding the kinase, MPS1, which phosphorylates MAD1) are important in regulating the spindle assembly checkpoint and maintaining genomic integrity. The MAD and BUB genes appear to be highly conserved through evolution, as homologues are found in higher eukaryotic organisms as well (Gorbsky, BioEssays, 1997, 19, 193-197).

[0003] During mitosis in higher eukaryotes, chromosomes condense and the kinetochore protein assemblies at the centromeric regions of the chromosomes attach to spindle microtubules. In its role as a mitotic spindle assembly checkpoint protein, the MAD1-like1 (also known as mitotic arrest-deficient 1, S. cerevisiae, homolog; mitotic arrest deficient-like 1; MAD1L1; MAD1; mad1; HsMAD1; Tax-binding protein 181; and TXBP181) gene product is enriched at kinetochores, and is a component of the mitotic spindle-assembly checkpoint that prevents onset of anaphase until all chromosomes are properly aligned at the metaphase plate (Shah and Cleveland, Cell, 2000, 103, 997-1000).

[0004] In a search for cellular targets of the human T cell leukemia virus type 1 (HTLV-I) oncoprotein Tax, the Mad1-like1 gene product was identified. The Mad1-like1 protein homodimerizes and shares several characteristics with its budding yeast homolog, MAD1: it is hyperphosphorylated during late S through M phases of the cell cycle and upon treatment of cells with nocodazole, and it interacts with HsMAD2 (the human homolog of the budding yeast MAD2 protein). Over the course of mitosis, the localization of the Mad1-like1 protein was observed to move from a diffusely nuclear distribution to the centrosome, to the spindle midzone and finally to the midbody connecting the daughter cells during cytokinesis. The viral Tax protein is believed to target MAD1-like1 as a means of defeating the mitotic checkpoint, leading to cell cycle dysregulation (Jin et al., Cell, 1998, 93, 81-91). The human Mad1-like1 gene has been mapped to chromosomal region 7p22, near two other genes involved in cell cycle control, and the murine Mad1-like1 gene has been mapped to mouse chromosome 5 (Jin et al., Genomics, 1999, 55, 363-364).

[0005] The BUB1 and BUB3 gene products (known as Bub1p and Bub3p in yeast) interact, and Bub3p appears to be required for kinetochore localization of Bub1p. The budding yeast MAD1 gene product (Mad1p) was shown to have a regulated association with Bub1p and Bub3p during a normal cell cycle, and this complex is found at significantly higher levels upon activation of the spindle checkpoint. Mutation of a motif within Mad1p essential for the formation of the Mad1p-Bub1p-Bub3p complex abolishes checkpoint function (Brady and Hardwick, Curr. Biol., 2000, 10, 675-678). Two leucine zippers in the Mad1-like1 protein are required for binding the HsMAD2 protein as well as for localization of the HsMAD2 protein to the kinetochore region. Notably, in several cancer cell lines, a single nucleotide polymorphism at codon 558 results in an arginine to histidine amino acid change within the second leucine zipper, and this was reported to represent the first example of loss-of-heterozygosity for a spindle checkpoint gene in human breast cancer (Iwanaga et al., J. Biol. Chem., 2002, 277, 31005-31013).

[0006] Antibodies to the HsMAD1-like1 protein have been used to immunolocalize the protein to kinetochores during mitosis; brightest labeling was found at prometaphase and disappeared from chromosomes aligned at the metaphase plate and during anaphase. Interestingly, unlike other known mitotic checkpoint proteins, MAD1-like1 and HsMAD2 proteins were found to co-localize at nuclear pores with proteins of the nuclear pore complex throughout interphase. It has been proposed that the MAD1-like1 protein might serve as a docking partner for interphase centromeres often observed to be associated with the nuclear envelope, or it might be involved in regulating the nuclear transport of proteins required for entry into mitosis (Campbell et al., J. Cell Sci., 2001, 114, 953-963).

[0007] In addition to its role in the cell cycle checkpoint, the MAD1-like1 protein is believed to be involved in tumorigenesis. Chromosomal instability is a common feature of many malignant human neoplasms. In subsets of colorectal, gastric, and endometrial cancers, this instability is sometimes manifest as microsatellite instability; however, in most other neoplasms, such as brain tumors, genetic instability occurs at the chromosomal level and may involve gain or loss of whole chromosomes, leading to aneuploidy (abnormal chromosome number). One mechanism leading to genomic instability is the disruption of the mitotic checkpoint, presumably due to the loss of a factor required to ensure accurate chromosome segregation. The critical role MAD1-like1 plays in surveillance of kinetochore-spindle attachment and promoting the faithful segregation of chromosomes during cell division predicts that aberrant MAD1-like1 function would result in a compromised mitotic checkpoint, favoring aneuploidy, with lethal consequences during development as well as the uncontrolled cell growth and proliferation characteristic of cancer (Shah and Cleveland, Cell, 2000, 103, 997-1000).

[0008] Dysfunction of MAD1-like1 is associated with chromosomal instability. Rare mutations of the MAD1-like1 gene have been reported in colon and lung cancers, and in a search for alterations in the MAD1-like1 mRNA transcript in 44 cell lines and 133 fresh cancer cells, eight mutations (missense, nonsense, frameshift and nucleotide polymorphisms) were found, suggesting a pathogenic role for MAD1-like1 mutations in various types of human cancer (Tsukasaki et al., Oncogene, 2001, 20, 3301-3305). In a panel of 19 aneuploid tumor cell lines, the MAD1-like1 gene was found to be expressed, and six single nucleotide polymorphisms were noted (Cahill et al., Genomics, 1999, 58, 181-187).

[0009] A promoter has been identified within the human genomic sequence upstream of the 5′-most coding exon of the MAD1-like1 gene, and was found to be activated by mitogenic stimuli as well as topoisomerase inhibitors. Intracellular levels of the MAD1-like1 protein correlated with cellular proliferative status. Furthermore, a gain-of-function p53 mutant causes increased expression of MAD1-like1 mRNA. Thus, activity of the MAD1-like1 gene may link p53 function to the generation of cellular aneuploidy observed in many cancers, and increased activation of the MAD1-like1 gene in gain-of-function p53 mutants could contribute to a poorer prognosis in certain types of cancer (Iwanaga and Jeang, Cancer Res., 2002, 62, 2618-2624).

[0010] HTLV-I is the etiological agent for adult T cell leukemia (ATL). ATL develops in a small percentage (5% or less) usually more than 20 years after initial exposure to the virus. The viral oncoprotein Tax binds to the MAD1-like1 protein via the same domain the MAD1-like1 protein uses to homodimerize as well as bind to HsMAD2. Thus, the interaction between the Tax and MAD1-like1 proteins and subsequent mitotic checkpoint inactivation is believed to contribute to HTLV-I tumorigenesis and to provide a molecular explanation for the karyotypic abnormalities of ATL cells (Jin et al., Cell, 1998, 93, 81-91). HTLV-I transformed cells fail to arrest in mitosis in response to the microtubule inhibitor, nocodazole. In HTLV-I Tax-expressing cells, the MAD1-like1 and HsMAD2 proteins were mislocated from the nucleus to the cytoplasm, correlating with loss of mitotic checkpoint function and chemoresistance to microtubule inhibitors (Kasai et al., J. Biol. Chem., 2002, 277, 5187-5193).

[0011] Currently, there are no known therapeutic agents which effectively inhibit the synthesis of MAD1-like1 and to date, investigative strategies aimed at modulating MAD1-like1 function have involved using RNA-mediated interference (Luo et al., Mol. Cell, 2002, 9, 59-71).

[0012] One means by which the mitotic checkpoint system prevents cells with misaligned chromosomes from prematurely exiting mitosis is to inhibit the activity of the mammalian anaphase-promoting complex (APC). The APC is involved in ubiquitination of proteins, a process which marks them for degradation, and APC activation is required for the degradation of proteins that inhibit anaphase initiation and mitotic exit. Transfection of a 21-base pair double-stranded RNA corresponding to nucleotides 391-413 of the MAD1-like1 coding region was demonstrated to cause a 3-fold reduction in the protein levels of MAD1-like1 in HeLa cells. The MAD1-like1 protein was found to be required for proper signaling of the mitotic checkpoint and for recruitment of the HsMAD2 protein to unattached kinetochores upon checkpoint activation. The MAD1-like1 protein was also proposed to promote the binding of HsMAD2 to the Cdc20 protein (an activator of the APC), thereby assisting in the inhibition of APC activation (Luo et al., Mol. Cell, 2002, 9, 59-71).

[0013] Disclosed and claimed in U.S. Pat. No. 5,972,640 is a method for identifying an antimitotic agent comprising the steps of contacting in culture cells with an agent not previously known to be associated with mitotic arrest and detecting a phenotypic change in the cells, and wherein one group of said cells have a functionally disrupted mitotic checkpoint resulting from a genetic mutation in at least one of a Mad, Bub, MPS1 or Cdc20 gene (Drubin and Barnes, 1999).

[0014] Disclosed and claimed in PCT Publication WO 01/21794 is an isolated nucleic acid molecule which hybridizes to a molecule that codes for a polypeptide which binds SMad6, a nucleic acid-molecule that differs from said nucleic acid molecules in codon sequence due to the degeneracy of the genetic code, and complements thereof; an expression vector; a host cell; a method for producing a polypeptide; a transgenic non-human animal; an isolated polypeptide encoded by said isolated nucleic acid molecule; an isolated complex of polypeptides; a method for modulating TGF-alpha superfamily signal transduction in a mammalian cell, comprising contacting the mammalian cell with an amount of an agent which increases the amount of a SMad associating protein selected from the group consisting of SAP1/AMSH, SAP2, SAP3, Hsp40 homolog, Uba80, Tax-1 binding protein (MAD1-like1), rabaptin-5, and 26S proteinase S5a or a fragment thereof in the cell effective to reduce TGF-□ superfamily signal transduction in the mammalian cell; said method wherein the agent is a nucleic acid molecule; a method for regulating the cell cycle in a mammalian cell; and a method for identifying lead compounds for a pharmacological agent. Antisense is generally disclosed (Itoh et al., 2001).

[0015] Disclosed and claimed in PCT Publication WO 02/06315 is an isolated nucleic acid sequence selected from a group of nucleic acid sequences wherein a member of said group is MAD1-like1; a sequence having at least 70% identity with said sequence where the nucleic acid sequence is obtained by alternative splicing; a fragment of said sequences of at least 20 base pairs, provided that said fragment contains a sequence which is not present, as a continuous stretch of nucleotides, in the original nucleic acid sequence from which the sequence has been varied by alternative splicing or to which it features homology; an isolated nucleic acid sequence complementary to said nucleic acid sequence; an amino acid sequence encoded by a member selected from said group of nucleic acid sequences, variants or homologues; a purified antibody; and expression vector; a host cell; a pharmaceutical composition; a probe; a method for detecting or determining the level of a nucleic acid sequence in a biological sample; and a method for detecting any one of the amino acid sequences in a biological sample. Antisense is generally disclosed (Mintz et al., 2002).

[0016] Consequently, there remains a long felt need for agents capable of effectively inhibiting MAD1-like1 function.

[0017] Antisense technology is emerging as an effective means for reducing the expression of specific gene products and may therefore prove to be uniquely useful in a number of therapeutic, diagnostic, and research applications for the modulation of MAD1-like1 expression.

[0018] The present invention provides compositions and methods for modulating MAD1-like1 expression.

SUMMARY OF THE INVENTION

[0019] The present invention is directed to compounds, especially nucleic acid and nucleic acid-like oligomers, which are targeted to a nucleic acid encoding MAD1-like 1, and which modulate the expression of MAD1-like 1. Pharmaceutical and other compositions comprising the compounds of the invention are also provided. Further provided are methods of screening for modulators of MAD1-like 1 and methods of modulating the expression of MAD1-like 1 in cells, tissues or animals comprising contacting said cells, tissues or animals with one or more of the compounds or compositions of the invention. Methods of treating an animal, particularly a human, suspected of having or being prone to a disease or condition associated with expression of MAD1-like 1 are also set forth herein. Such methods comprise administering a therapeutically or prophylactically effective amount of one or more of the compounds or compositions of the invention to the person in need of treatment.

DETAILED DESCRIPTION OF THE INVENTION

[0020] A. Overview of the Invention

[0021] The present invention employs compounds, preferably oligonucleotides and similar species for use in modulating the function or effect of nucleic acid molecules encoding MAD1-like 1. This is accomplished by providing oligonucleotides which specifically hybridize with one or more nucleic acid molecules encoding MAD1-like 1. As used herein, the terms “target nucleic acid” and “nucleic acid molecule encoding MAD1-like 1” have been used for convenience to encompass DNA encoding MAD1-like 1, RNA (including pre-mRNA and mRNA or portions thereof) transcribed from such DNA, and also cDNA derived from such RNA. The hybridization of a compound of this invention with its target nucleic acid is generally referred to as “antisense”. Consequently, the preferred mechanism believed to be included in the practice of some preferred embodiments of the invention is referred to herein as “antisense inhibition.” Such antisense inhibition is typically based upon hydrogen bonding-based hybridization of oligonucleotide strands or segments such that at least one strand or segment is cleaved, degraded, or otherwise rendered inoperable. In this regard, it is presently preferred to target specific nucleic acid molecules and their functions for such antisense inhibition.

[0022] The functions of DNA to be interfered with can include replication and transcription. Replication and transcription, for example, can be from an endogenous cellular template, a vector, a plasmid construct or otherwise. The functions of RNA to be interfered with can include functions such as translocation of the RNA to a site of protein translation, translocation of the RNA to sites within the cell which are distant from the site of RNA synthesis, translation of protein from the RNA, splicing of the RNA to yield one or more RNA species, and catalytic activity or complex formation involving the RNA which may be engaged in or facilitated by the RNA. One preferred result of such interference with target nucleic acid function is modulation of the expression of MAD1-like 1. In the context of the present invention, “modulation” and “modulation of expression” mean either an increase (stimulation) or a decrease (inhibition) in the amount or levels of a nucleic acid molecule encoding the gene, e.g., DNA or RNA. Inhibition is often the preferred form of modulation of expression and mRNA is often a preferred target nucleic acid.

[0023] In the context of this invention, “hybridization” means the pairing of complementary strands of oligomeric compounds. In the present invention, the preferred mechanism of pairing involves hydrogen bonding, which may be Watson-Crick, Hoogsteen or reversed Hoogsteen hydrogen bonding, between complementary nucleoside or nucleotide bases (nucleobases) of the strands of oligomeric compounds. For example, adenine and thymine are complementary nucleobases which pair through the formation of hydrogen bonds. Hybridization can occur under varying circumstances.

[0024] An antisense compound is specifically hybridizable when binding of the compound to the target nucleic acid interferes with the normal function of the target nucleic acid to cause a loss of activity, and there is a sufficient degree of complementarity to avoid non-specific binding of the antisense compound to non-target nucleic acid sequences under conditions in which specific binding is desired, i.e., under physiological conditions in the case of in vivo assays or therapeutic treatment, and under conditions in which assays are performed in the case of in vitro assays.

[0025] In the present invention the phrase “stringent hybridization conditions” or “stringent conditions” refers to conditions under which a compound of the invention will hybridize to its target sequence, but to a minimal number of other sequences. Stringent conditions are sequence-dependent and will be different in different circumstances and in the context of this invention, “stringent conditions” under which oligomeric compounds hybridize to a target sequence are determined by the nature and composition of the oligomeric compounds and the assays in which they are being investigated.

[0026] “Complementary,” as used herein, refers to the capacity for precise pairing between two nucleobases of an oligomeric compound. For example, if a nucleobase at a certain position of an oligonucleotide (an oligomeric compound), is capable of hydrogen bonding with a nucleobase at a certain position of a target nucleic acid, said target nucleic acid being a DNA, RNA, or oligonucleotide molecule, then the position of hydrogen bonding between the oligonucleotide and the target nucleic acid is considered to be a complementary position. The oligonucleotide and the further DNA, RNA, or oligonucleotide molecule are complementary to each other when a sufficient number of complementary positions in each molecule are occupied by nucleobases which can hydrogen bond with each other. Thus, “specifically hybridizable” and “complementary” are terms which are used to indicate a sufficient degree of precise pairing or complementarity over a sufficient number of nucleobases such that stable and specific binding occurs between the oligonucleotide and a target nucleic acid.

[0027] It is understood in the art that the sequence of an antisense compound need not be 100% complementary to that of its target nucleic acid to be specifically hybridizable. Moreover, an oligonucleotide may hybridize over one or more segments such that intervening or adjacent segments are not involved in the hybridization event (e.g., a loop structure or hairpin structure). It is preferred that the antisense compounds of the present invention comprise at least 70% sequence complementarity to a target region within the target nucleic acid, more preferably that they comprise 90% sequence complementarity and even more preferably comprise 95% sequence complementarity to the target region within the target nucleic acid sequence to which they are targeted. For example, an antisense compound in which 18 of 20 nucleobases of the antisense compound are complementary to a target region, and would therefore specifically hybridize, would represent 90 percent complementarity. In this example, the remaining noncomplementary nucleobases may be clustered or interspersed with complementary nucleobases and need not be contiguous to each other or to complementary nucleobases. As such, an antisense compound which is 18 nucleobases in length having 4 (four) noncomplementary nucleobases which are flanked by two regions of complete complementarity with the target nucleic acid would have 77.8% overall complementarity with the target nucleic acid and would thus fall within the scope of the present invention. Percent complementarity of an antisense compound with a region of a target nucleic acid can be determined routinely using BLAST programs (basic local alignment search tools) and PowerBLAST programs known in the art (Altschul et al., J. Mol. Biol., 1990, 215, 403-410; Zhang and Madden, Genome Res., 1997, 7, 649-656).

[0028] B. Compounds of the Invention

[0029] According to the present invention, compounds include antisense oligomeric compounds, antisense oligonucleotides, ribozymes, external guide sequence (EGS) oligonucleotides, alternate splicers, primers, probes, and other oligomeric compounds which hybridize to at least a portion of the target nucleic acid. As such, these compounds may be introduced in the form of single-stranded, double-stranded, circular or hairpin oligomeric compounds and may contain structural elements such as internal or terminal bulges or loops. Once introduced to a system, the compounds of the invention may elicit the action of one or more enzymes or structural proteins to effect modification of the target nucleic acid. One non-limiting example of such an enzyme is RNAse H, a cellular endonuclease which cleaves the RNA strand of an RNA:DNA duplex. It is known in the art that single-stranded antisense compounds which are “DNA-like” elicit RNAse H. Activation of RNase H, therefore, results in cleavage of the RNA target, thereby greatly enhancing the efficiency of oligonucleotide-mediated inhibition of gene expression. Similar roles have been postulated for other ribonucleases such as those in the RNase III and ribonuclease L family of enzymes.

[0030] While the preferred form of antisense compound is a single-stranded antisense oligonucleotide, in many species the introduction of double-stranded structures, such as double-stranded RNA (dsRNA) molecules, has been shown to induce potent and specific antisense-mediated reduction of the function of a gene or its associated gene products. This phenomenon occurs in both plants and animals and is believed to have an evolutionary connection to viral defense and transposon silencing.

[0031] The first evidence that dsRNA could lead to gene silencing in animals came in 1995 from work in the nematode, Caenorhabditis elegans (Guo and Kempheus, Cell, 1995, 81, 611-620). Montgomery et al. have shown that the primary interference effects of dsRNA are posttranscriptional (Montgomery et al., Proc. Natl. Acad. Sci. USA, 1998, 95, 15502-15507). The posttranscriptional antisense mechanism defined in Caenorhabditis elegans resulting from exposure to double-stranded RNA (dsRNA) has since been designated RNA interference (RNAi). This term has been generalized to mean antisense-mediated gene silencing involving the introduction of dsRNA leading to the sequence-specific reduction of endogenous targeted mRNA levels (Fire et al., Nature, 1998, 391, 806-811). Recently, it has been shown that it is, in fact, the single-stranded RNA oligomers of antisense polarity of the dsRNAs which are the potent inducers of RNAi (Tijsterman et al., Science, 2002, 295, 694-697).

[0032] In the context of this invention, the term “oligomeric compound” refers to a polymer or oligomer comprising a plurality of monomeric units. In the context of this invention, the term “oligonucleotide” refers to an oligomer or polymer of ribonucleic acid (RNA) or deoxyribonucleic acid (DNA) or mimetics, chimeras, analogs and homologs thereof. This term includes oligonucleotides composed of naturally occurring nucleobases, sugars and covalent internucleoside (backbone) linkages as well as oligonucleotides having non-naturally occurring portions which function similarly. Such modified or substituted oligonucleotides are often preferred over native forms because of desirable properties such as, for example, enhanced cellular uptake, enhanced affinity for a target nucleic acid and increased stability in the presence of nucleases.

[0033] While oligonucleotides are a preferred form of the compounds of this invention, the present invention comprehends other families of compounds as well, including but not limited to oligonucleotide analogs and mimetics such as those described herein.

[0034] The compounds in accordance with this invention preferably comprise from about 8 to about 80 nucleobases (i.e. from about 8 to about 80 linked nucleosides). One of ordinary skill in the art will appreciate that the invention embodies compounds of 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73, 74, 75, 76, 77, 78, 79, or 80 nucleobases in length.

[0035] In one preferred embodiment, the compounds of the invention are 12 to 50 nucleobases in length. One having ordinary skill in the art will appreciate that this embodies compounds of 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, or 50 nucleobases in length.

[0036] In another preferred embodiment, the compounds of the invention are 15 to 30 nucleobases in length. One having ordinary skill in the art will appreciate that this embodies compounds of 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, or 30 nucleobases in length.

[0037] Particularly preferred compounds are oligonucleotides from about 12 to about 50 nucleobases, even more preferably those comprising from about 15 to about 30 nucleobases.

[0038] Antisense compounds 8-80 nucleobases in length comprising a stretch of at least eight (8) consecutive nucleobases selected from within the illustrative antisense compounds are considered to be suitable antisense compounds as well.

[0039] Exemplary preferred antisense compounds include oligonucleotide sequences that comprise at least the 8 consecutive nucleobases from the 5′-terminus of one of the illustrative preferred antisense compounds (the remaining nucleobases being a consecutive stretch of the same oligonucleotide beginning immediately upstream of the 5′-terminus of the antisense compound which is specifically hybridizable to the target nucleic acid and continuing until the oligonucleotide contains about 8 to about 80 nucleobases). Similarly preferred antisense compounds are represented by oligonucleotide sequences that comprise at least the 8 consecutive nucleobases from the 3′-terminus of one of the illustrative preferred antisense compounds (the remaining nucleobases being a consecutive stretch of the same oligonucleotide beginning immediately downstream of the 3′-terminus of the antisense compound which is specifically hybridizable to the target nucleic acid and continuing until the oligonucleotide contains about 8 to about 80 nucleobases). One having skill in the art armed with the preferred antisense compounds illustrated herein will be able, without undue experimentation, to identify further preferred antisense compounds.

[0040] C. Targets of the Invention

[0041] “Targeting” an antisense compound to a particular nucleic acid molecule, in the context of this invention, can be a multistep process. The process usually begins with the identification of a target nucleic acid whose function is to be modulated. This target nucleic acid may be, for example, a cellular gene (or mRNA transcribed from the gene) whose expression is associated with a particular disorder or disease state, or a nucleic acid molecule from an infectious agent. In the present invention, the target nucleic acid encodes MAD1-like 1.

[0042] The targeting process usually also includes determination of at least one target region, segment, or site within the target nucleic acid for the antisense interaction to occur such that the desired effect, e.g., modulation of expression, will result. Within the context of the present invention, the term “region” is defined as a portion of the target nucleic acid having at least one identifiable structure, function, or characteristic. Within regions of target nucleic acids are segments. “Segments” are defined as smaller or sub-portions of regions within a target nucleic acid. “Sites,” as used in the present invention, are defined as positions within a target nucleic acid.

[0043] Since, as is known in the art, the translation initiation codon is typically 5′-AUG (in transcribed mRNA molecules; 5′-ATG in the corresponding DNA molecule), the translation initiation codon is also referred to as the “AUG codon,” the “start codon” or the “AUG start codon”. A minority of genes have a translation initiation codon having the RNA sequence 5′-GUG, 5′-UUG or 5′-CUG, and 5′-AUA, 5′-ACG and 5′-CUG have been shown to function in vivo. Thus, the terms “translation initiation codon” and “start codon” can encompass many codon sequences, even though the initiator amino acid in each instance is typically methionine (in eukaryotes) or formylmethionine (in prokaryotes). It is also known in the art that eukaryotic and prokaryotic genes may have two or more alternative start codons, any one of which may be preferentially utilized for translation initiation in a particular cell type or tissue, or under a particular set of conditions. In the context of the invention, “start codon” and “translation initiation codon” refer to the codon or codons that are used in vivo to initiate translation of an mRNA transcribed from a gene encoding MAD1-like 1, regardless of the sequence(s) of such codons. It is also known in the art that a translation termination codon (or “stop codon”) of a gene may have one of three sequences, i.e., 5′-UAA, 5′-UAG and 5′-UGA (the corresponding DNA sequences are 5′-TAA, 5′-TAG and 5′-TGA, respectively).

[0044] The terms “start codon region” and “translation initiation codon region” refer to a portion of such an mRNA or gene that encompasses from about 25 to about 50 contiguous nucleotides in either direction (i.e., 540 or 3′) from a translation initiation codon. Similarly, the terms “stop codon region” and “translation termination codon region” refer to a portion of such an mRNA or gene that encompasses from about 25 to about 50 contiguous nucleotides in either direction (i.e., 5′ or 3′) from a translation termination codon. Consequently, the “start codon region” (or “translation initiation codon region”) and the “stop codon region” (or “translation termination codon region”) are all regions which may be targeted effectively with the antisense compounds of the present invention.

[0045] The open reading frame (ORF) or “coding region,” which is known in the art to refer to the. region between the translation initiation codon and the translation termination codon, is also a region which may be targeted effectively. Within the context of the present invention, a preferred region is the intragenic region encompassing the translation initiation or termination codon of the open reading frame (ORF) of a gene.

[0046] Other target regions include the 5′ untranslated region (5′UTR), known in the art to refer to the portion of an mRNA in the 5′ direction from the translation initiation codon, and thus including nucleotides between the 5′ cap site and the translation initiation codon of an mRNA (or corresponding nucleotides on the gene), and the 3′ untranslated region (3′UTR), known in the art to refer to the portion of an mRNA in the 3′ direction from the translation termination codon, and thus including nucleotides between the translation termination codon and 3′ end of an mRNA (or corresponding nucleotides on the gene). The 5′ cap site of an mRNA comprises an N7-methylated guanosine residue joined to the 5′-most residue of the mRNA via a 5′-5′ triphosphate linkage. The 5′ cap region of an mRNA is considered to include the 5′ cap structure itself as well as the first 50 nucleotides adjacent to the cap site. It is also preferred to target the 5′ cap region.

[0047] Although some eukaryotic mRNA transcripts are directly translated, many contain one or more regions, known as “introns,” which are excised from a transcript before it is translated. The remaining (and therefore translated) regions are known as “exons” and are spliced together to form a continuous mRNA sequence. Targeting splice sites, i.e., intron-exon junctions or exon-intron junctions, may also be particularly useful in situations where aberrant splicing is implicated in disease, or where an overproduction of a particular splice product is implicated in disease. Aberrant fusion junctions due to rearrangements or deletions are also preferred target sites. mRNA transcripts produced via the process of splicing of two (or more) mRNAs from different gene sources are known as “fusion transcripts”. It is also known that introns can be effectively targeted using antisense compounds targeted to, for example, DNA or pre-mRNA.

[0048] It is also known in the art that alternative RNA transcripts can be produced from the same genomic region of DNA. These alternative transcripts are generally known as “variants”. More specifically, “pre-mRNA variants” are transcripts produced from the same genomic DNA that differ from other transcripts produced from the same genomic DNA in either their start or stop position and contain both intronic and exonic sequence.

[0049] Upon excision of one or more exon or intron regions, or portions thereof during splicing, pre-mRNA variants produce smaller “mRNA variants”. Consequently, mRNA variants are processed pre-mRNA variants and each unique pre-mRNA variant must always produce a unique mRNA variant as a result of splicing. These mRNA variants are also known as “alternative splice variants”. If no splicing of the pre-mRNA variant occurs then the pre-mRNA variant is identical to the mRNA variant.

[0050] It is also known in the art that variants can be produced through the use of alternative signals to start or stop transcription and that pre-mRNAs and mRNAs can possess more that one start codon or stop codon. Variants that originate from a pre-mRNA or mRNA that use alternative start codons are known as “alternative start variants” of that pre-mRNA or mRNA. Those transcripts that use an alternative stop codon are known as “alternative stop variants” of that pre-mRNA or mRNA. One specific type of alternative stop variant is the “polyA variant” in which the multiple transcripts produced result from the alternative selection of one of the “polyA stop signals” by the transcription machinery, thereby producing transcripts that terminate at unique polyA sites. Within the context of the invention, the types of variants described herein are also preferred target nucleic acids.

[0051] The locations on the target nucleic acid to which the preferred antisense compounds hybridize are hereinbelow referred to as “preferred target segments.” As used herein the term “preferred target segment” is defined as at least an 8-nucleobase portion of a target region to which an active antisense compound is targeted. While not wishing to be bound by theory, it is presently believed that these target segments represent portions of the target nucleic acid which are accessible for hybridization.

[0052] While the specific sequences of certain preferred target segments are set forth herein, one of skill in the art will recognize that these serve to illustrate and describe particular embodiments within the scope of the present invention. Additional preferred target segments may be identified by one having ordinary skill.

[0053] Target segments 8-80 nucleobases in length comprising a stretch of at least eight (8) consecutive nucleobases selected from within the illustrative preferred target segments are considered to be suitable for targeting as well.

[0054] Target segments can include DNA or RNA sequences that comprise at least the 8 consecutive nucleobases from the 5′-terminus of one of the illustrative preferred target segments (the remaining nucleobases being a consecutive stretch of the same DNA or RNA beginning immediately upstream of the 5′-terminus of the target segment and continuing until the DNA or RNA contains about 8 to about 80 nucleobases). Similarly preferred target segments are represented by DNA or RNA sequences that comprise at least the 8 consecutive nucleobases from the 3′-terminus of one of the illustrative preferred target segments (the remaining nucleobases being a consecutive stretch of the same DNA or RNA beginning immediately downstream of the 3′-terminus of the target segment and continuing until the DNA or RNA contains about 8 to about 80 nucleobases). One having skill in the art armed with the preferred target segments illustrated herein will be able, without undue experimentation, to identify further preferred target segments.

[0055] Once one or more target regions, segments or sites have been identified, antisense compounds are chosen which are sufficiently complementary to the target, i.e., hybridize sufficiently well and with sufficient specificity, to give the desired effect.

[0056] D. Screening and Target Validation

[0057] In a further embodiment, the “preferred target segments” identified herein may be employed in a screen for additional compounds that modulate the expression of MAD1-like 1. “Modulators” are those compounds that decrease or increase the expression of a nucleic acid molecule encoding MAD1-like 1 and which comprise at least an 8-nucleobase portion which is complementary to a preferred target segment. The screening method comprises the steps of contacting a preferred target segment of a nucleic acid molecule encoding MAD1-like 1 with one or more candidate modulators, and selecting for one or more candidate modulators which decrease or increase the expression of a nucleic acid molecule encoding MAD1-like 1. Once it is shown that the candidate modulator or modulators are capable of modulating (e.g. either decreasing or increasing) the expression of a nucleic acid molecule encoding MAD1-like 1, the modulator may then be employed in further investigative studies of the function of MAD1-like 1, or for use as a research, diagnostic, or therapeutic agent in accordance with the present invention.

[0058] The preferred target segments of the present invention may be also be combined with their respective complementary antisense compounds of the present invention to form stabilized double-stranded (duplexed) oligonucleotides.

[0059] Such double stranded oligonucleotide moieties have been shown in the art to modulate target expression and regulate translation as well as RNA processsing via an antisense mechanism. Moreover, the double-stranded moieties may be subject to chemical modifications (Fire et al., Nature, 1998, 391, 806-811; Timmons and Fire, Nature 1998, 395, 854; Timmons et al., Gene, 2001, 263, 103-112; Tabara et al., Science, 1998, 282, 430-431; Montgomery et al., Proc. Natl. Acad. Sci. USA, 1998, 95, 15502-15507; Tuschl et al., Genes Dev., 1999, 13, 3191-3197; Elbashir et al., Nature, 2001, 411, 494-498; Elbashir et al., Genes Dev. 2001, 15, 188-200). For example, such double-stranded moieties have been shown to inhibit the target by the classical hybridization of antisense strand of the duplex to the target, thereby triggering enzymatic degradation of the target (Tijsterman et al., Science, 2002, 295, 694-697).

[0060] The compounds of the present invention can also be applied in the areas of drug discovery and target validation. The present invention comprehends the use of the compounds and preferred target segments identified herein in drug discovery efforts to elucidate relationships that exist between MAD1-like 1 and a disease state, phenotype, or condition. These methods include detecting or modulating MAD1-like 1 comprising contacting a sample, tissue, cell, or organism with the compounds of the present invention, measuring the nucleic acid or protein level of MAD1-like 1 and/or a related phenotypic or chemical endpoint at some time after treatment, and optionally comparing the measured value to a non-treated sample or sample treated with a further compound of the invention. These methods can also be performed in parallel or in combination with other experiments to determine the function of unknown genes for the process of target validation or to determine the validity of a particular gene product as a target for treatment or prevention of a particular disease, condition, or phenotype.

[0061] E. Kits, Research Reagents, Diagnostics, and Therapeutics

[0062] The compounds of the present invention can be utilized for diagnostics, therapeutics, prophylaxis and as research reagents and kits. Furthermore, antisense oligonucleotides, which are able to inhibit gene expression with exquisite specificity, are often used by those of ordinary skill to elucidate the function of particular genes or to distinguish between functions of various members of a biological pathway.

[0063] For use in kits and diagnostics, the compounds of the present invention, either alone or in combination with other compounds or therapeutics, can be used as tools in differential and/or combinatorial analyses to elucidate expression patterns of a portion or the entire complement of genes expressed within cells and tissues.

[0064] As one nonlimiting example, expression patterns within cells or tissues treated with one or more antisense compounds are compared to control cells or tissues not treated with antisense compounds and the patterns produced are analyzed for differential levels of gene expression as they pertain, for example, to disease association, signaling pathway, cellular localization, expression level, size, structure or function of the genes examined. These analyses can be performed on stimulated or unstimulated cells and in the presence or absence of other compounds which affect expression patterns.

[0065] Examples of methods of gene expression analysis known in the art include DNA arrays or microarrays (Brazma and Vilo, FEBS Lett., 2000, 480, 17-24; Celis, et al., FEBS Lett., 2000, 480, 2-16), SAGE (serial analysis of gene expression)(Madden, et al., Drug Discov. Today, 2000, 5, 415-425), READS (restriction enzyme amplification of digested cDNAs) (Prashar and Weissman, Methods Enzymol., 1999, 303, 258-72), TOGA (total gene expression analysis) (Sutcliffe, et al., Proc. Natl. Acad. Sci. U. S. A., 2000, 97, 1976-81), protein arrays and proteomics (Celis, et al., FEBS Lett., 2000, 480, 2-16; Jungblut, et al., Electrophoresis, 1999, 20, 2100-10), expressed sequence tag (EST) sequencing (Celis, et al., FEBS Lett., 2000, 480, 2-16; Larsson, et al., J. Biotechnol., 2000, 80, 143-57), subtractive RNA fingerprinting (SuRF) (Fuchs, et al., Anal. Biochem., 2000, 286, 91-98; Larson, et al., Cytometry, 2000, 41, 203-208), subtractive cloning, differential display (DD) (Jurecic and Belmont, Curr. Opin. Microbiol., 2000, 3, 316-21), comparative genomic hybridization (Carulli, et al., J. Cell Biochem. Suppl., 1998, 31, 286-96), FISH (fluorescent in situ hybridization) techniques (Going and Gusterson, Eur. J. Cancer, 1999, 35, 1895-904) and mass spectrometry methods (To, Comb. Chem. High Throughput Screen, 2000, 3, 235-41).

[0066] The compounds of the invention are useful for research and diagnostics, because these compounds hybridize to nucleic acids encoding MAD1-like 1. For example, oligonucleotides that are shown to hybridize with such efficiency and under such conditions as disclosed herein as to be effective MAD1-like 1 inhibitors will also be effective primers or probes under conditions favoring gene amplification or detection, respectively. These primers and probes are useful in methods requiring the specific detection of nucleic acid molecules encoding MAD1-like 1 and in the amplification of said nucleic acid molecules for detection or for use in further studies of MAD1-like 1. Hybridization of the antisense oligonucleotides, particularly the primers and probes, of the invention with a nucleic acid encoding MAD1-like 1 can be detected by means known in the art. Such means may include conjugation of an enzyme to the oligonucleotide, radiolabelling of the oligonucleotide or any other suitable detection means. Kits using such detection means for detecting the level of MAD1-like 1 in a sample may also be prepared.

[0067] The specificity and sensitivity of antisense is also harnessed by those of skill in the art for therapeutic uses. Antisense compounds have been employed as therapeutic moieties in the treatment of disease states in animals, including humans. Antisense oligonucleotide drugs, including ribozymes, have been safely and effectively administered to humans and numerous clinical trials are presently underway. It is thus established that antisense compounds can be useful therapeutic modalities that can be configured to be useful in treatment regimes for the treatment of cells, tissues and animals, especially humans.

[0068] For therapeutics, an animal, preferably a human, suspected of having a disease or disorder which can be treated by modulating the expression of MAD1-like 1 is treated by administering antisense compounds in accordance with this invention. For example, in one non-limiting embodiment, the methods comprise the step of administering to the animal in need of treatment, a therapeutically effective amount of a MAD1-like 1 inhibitor. The MAD1-like 1 inhibitors of the present invention effectively inhibit the activity of the MAD1-like 1 protein or inhibit the expression of the MAD1-like 1 protein. In one embodiment, the activity or expression of MAD1-like 1 in an animal is inhibited by about 10%. Preferably, the activity or expression of MAD1-like 1 in an animal is inhibited by about 30%. More preferably, the activity or expression of MAD1-like 1 in an animal is inhibited by 50% or more.

[0069] For example, the reduction of the expression of MAD1-like 1 may be measured in serum, adipose tissue, liver or any other body fluid, tissue or organ of the animal. Preferably, the cells contained within said fluids, tissues or organs being analyzed contain a nucleic acid molecule encoding MAD1-like 1 protein and/or the MAD1-like 1 protein itself.

[0070] The compounds of the invention can be utilized in pharmaceutical compositions by adding an effective amount of a compound to a suitable pharmaceutically acceptable diluent or carrier. Use of the compounds and methods of the invention may also be useful prophylactically.

[0071] F. Modifications

[0072] As is known in the art, a nucleoside is a base-sugar combination. The base portion of the nucleoside is normally a heterocyclic base. The two most common classes of such heterocyclic bases are the purines and the pyrimidines. Nucleotides are nucleosides that further include a phosphate group covalently linked to the sugar portion of the nucleoside. For those nucleosides that include a pentofuranosyl sugar, the phosphate group can be linked to either the 2′, 3′ or 5′ hydroxyl moiety of the sugar. In forming oligonucleotides, the phosphate groups covalently link adjacent nucleosides to one another to form a linear polymeric compound. In turn, the respective ends of this linear polymeric compound can be further joined to form a circular compound, however, linear compounds are generally preferred. In addition, linear compounds may have internal nucleobase complementarity and may therefore fold in a manner as to produce a fully or partially double-stranded compound. Within oligonucleotides, the phosphate groups are commonly referred to as forming the internucleoside backbone of the oligonucleotide. The normal linkage or backbone of RNA and DNA is a 3′ to 5′ phosphodiester linkage.

[0073] Modified Internucleoside Linkages (Backbones)

[0074] Specific examples of preferred antisense compounds useful in this invention include oligonucleotides containing modified backbones or non-natural internucleoside linkages. As defined in this specification, oligonucleotides having modified backbones include those that retain a phosphorus atom in the backbone and those that do not have a phosphorus atom in the backbone. For the purposes of this specification, and as sometimes referenced in the art, modified oligonucleotides that do not have a phosphorus atom in their internucleoside backbone can also be considered to be oligonucleosides.

[0075] Preferred modified oligonucleotide backbones containing a phosphorus atom therein include, for example, phosphorothioates, chiral phosphorothioates, phosphorodithioates, phosphotriesters, aminoalkylphosphotriesters, methyl and other alkyl phosphonates including 3′-alkylene phosphonates, 5′-alkylene phosphonates and chiral phosphonates, phosphinates, phosphoramidates including 3′-amino phosphoramidate and aminoalkylphosphoramidates, thionophosphoramidates, thionoalkylphosphonates, thionoalkylphosphotriesters, selenophosphates and borano-phosphates having normal 3′-5′ linkages, 2′-5′ linked analogs of these, and those having inverted polarity wherein one or more internucleotide linkages is a 3′ to 3′, 5′ to 5′ or 2′ to 2′ linkage. Preferred oligonucleotides having inverted polarity comprise a single 3′ to 3′ linkage at the 3′-most internucleotide linkage i.e. a single inverted nucleoside residue which may be abasic (the nucleobase is missing or has a hydroxyl group in place thereof). Various salts, mixed salts and free acid forms are also included.

[0076] Representative United States patents that teach the preparation of the above phosphorus-containing linkages include, but are not limited to, U.S. Pat. Nos.: 3,687,808; 4,469,863; 4,476,301; 5,023,243; 5,177,196; 5,188,897; 5,264,423; 5,276,019; 5,278,302; 5,286,717; 5,321,131; 5,399,676; 5,405,939; 5,453,496; 5,455,233; 5,466,677; 5,476,925; 5,519,126; 5,536,821; 5,541,306; 5,550,111; 5,563,253; 5,571,799; 5,587,361; 5,194,599; 5,565,555; 5,527,899; 5,721,218; 5,672,697 and 5,625,050, certain of which are commonly owned with this application, and each of which is herein incorporated by reference.

[0077] Preferred modified oligonucleotide backbones that do not include a phosphorus atom therein have backbones that are formed by short chain alkyl or cycloalkyl internucleoside linkages, mixed heteroatom and alkyl or cycloalkyl internucleoside linkages, or one or more short chain heteroatomic or heterocyclic internucleoside linkages. These include those having morpholino linkages (formed in part from the sugar portion of a nucleoside); siloxane backbones; sulfide, sulfoxide and sulfone backbones; formacetyl and thioformacetyl backbones; methylene formacetyl and thioformacetyl backbones; riboacetyl backbones; alkene containing backbones; sulfamate backbones; methyleneimino and methylenehydrazino backbones; sulfonate and sulfonamide backbones; amide backbones; and others having mixed N, O, S and CH₂ component parts.

[0078] Representative United States patents that teach the preparation of the above oligonucleosides include, but are not limited to, U.S. Pat. Nos.: 5,034,506; 5,166,315; 5,185,444; 5,214,134; 5,216,141; 5,235,033; 5,264,562; 5,264,564; 5,405,938; 5,434,257; 5,466,677; 5,470,967; 5,489,677; 5,541,307; 5,561,225; 5,596,086; 5,602,240; 5,610,289; 5,602,240; 5,608,046; 5,610,289; 5,618,704; 5,623,070; 5,663,312; 5,633,360; 5,677,437; 5,792,608; 5,646,269 and 5,677,439, certain of which are commonly owned with this application, and each of which is herein incorporated by reference.

[0079] Modified Sugar and Internucleoside linkages-Mimetics

[0080] In other preferred oligonucleotide mimetics, both the sugar and the internucleoside linkage (i.e. the backbone), of the nucleotide units are replaced with novel groups. The nucleobase units are maintained for hybridization with an appropriate target nucleic acid. One such compound, an oligonucleotide mimetic that has been shown to have excellent hybridization properties, is referred to as a peptide nucleic acid (PNA). In PNA compounds, the sugar-backbone of an oligonucleotide is replaced with an amide containing backbone, in particular an aminoethylglycine backbone. The nucleobases are retained and are bound directly or indirectly to aza nitrogen atoms of the amide portion of the backbone. Representative United States patents that teach the preparation of PNA compounds include, but are not limited to, U.S. Pat. Nos.: 5,539,082; 5,714,331; and 5,719,262, each of which is herein incorporated by reference. Further teaching of PNA compounds can be found in Nielsen et al., Science, 1991, 254, 1497-1500.

[0081] Preferred embodiments of the invention are oligonucleotides with phosphorothioate backbones and oligonucleosides with heteroatom backbones, and in particular —CH₂—NH—O—CH₂—, —CH₂—N(CH₃)—O—CH₂—[known as a methylene (methylimino) or MMI backbone], —CH₂—O—N(CH₃)—CH₂—, —CH₂—N(CH₃)—N(CH₃)—CH₂—and —O—N(CH₃)—CH₂—CH₂—[wherein the native phosphodiester backbone is represented as —O—P—O—CH₂—] of the above referenced U.S. Pat. No. 5,489,677, and the amide backbones of the above referenced U.S. Pat. No. 5,602,240. Also preferred are oligonucleotides having morpholino backbone structures of the above-referenced U.S. Pat. No. 5,034,506.

[0082] Modified Sugars

[0083] Modified oligonucleotides may also contain one or more substituted sugar moieties. Preferred oligonucleotides comprise one of the following at the 2′ position: OH; F; O—, S—, or N-alkyl; O—, S—, or N-alkenyl; O—, S—or N-alkynyl; or O-alkyl-O-alkyl, wherein the alkyl, alkenyl and alkynyl may be substituted or unsubstituted C₁ to C₁₀ alkyl or C₂ to C₁₀ alkenyl and alkynyl. Particularly preferred are O[(CH₂)_(n)O]_(m)CH₃, O(CH₂)_(n)OCH₃, O(CH₂)_(n)NH₂, O(CH₂)_(n)CH₃, O(CH₂)_(n)ONH₂, and O(CH₂)_(n)ON[(CH₂)_(n)CH₃]₂, where n and m are from 1 to about 10. Other preferred oligonucleotides comprise one of the following at the 2′ position: C₁ to C₁₀ lower alkyl, substituted lower alkyl, alkenyl, alkynyl, alkaryl, aralkyl, O-alkaryl or O-aralkyl, SH, SCH₃, OCN, Cl, Br, CN, CF₃, OCF₃, SOCH₃, SO₂CH₃, ONO₂, NO₂, N₃, NH₂, heterocycloalkyl, heterocycloalkaryl, aminoalkylamino, polyalkylamino, substituted silyl, an RNA cleaving group, a reporter group, an intercalator, a group for improving the pharmacokinetic properties of an oligonucleotide, or a group for improving the pharmacodynamic properties of an oligonucleotide, and other substituents having similar properties. A preferred modification includes 2′-methoxyethoxy (2′-O—CH₂CH₂OCH₃, also known as 2′-O—(2-methoxyethyl) or 2′-MOE) (Martin et al., Helv. Chim. Acta, 1995, 78, 486-504) i.e., an alkoxyalkoxy group. A further preferred modification includes 2′-dimethylaminooxyethoxy, i.e., a O(CH₂)₂ON(CH₃)₂ group, also known as 2′-DMAOE, as described in examples hereinbelow, and 2′-dimethylaminoethoxyethoxy (also known in the art as 2′-O—dimethyl-amino-ethoxy-ethyl or 2′-DMAEOE), i.e., 2′-O—CH₂—O—CH₂—N(CH₃)₂, also described in examples hereinbelow.

[0084] Other preferred modifications include 2′-methoxy (2′-O—CH₃), 2′-aminopropoxy (2′-OCH₂CH₂CH₂NH₂), 2′-allyl (2′-CH₂-CH═CH₂), 2′-O-allyl (2′-O—CH₂—CH═CH₂) and 2′-fluoro (2′-F). The 2′-modification may be in the arabino (up) position or ribo (down) position. A preferred 2′-arabino modification is 2′-F. Similar modifications may also be made at other positions on the oligonucleotide, particularly the 3′ position of the sugar on the 3′ terminal nucleotide or in 2′-5′ linked oligonucleotides and the 5′ position of 5′ terminal nucleotide. Oligonucleotides may also have sugar mimetics such as cyclobutyl moieties in place of the pentofuranosyl sugar. Representative United States patents that teach the preparation of such modified sugar structures include, but are not limited to, U.S. Pat. Nos.: 4,981,957; 5,118,800; 5,319,080; 5,359,044; 5,393,878; 5,446,137; 5,466,786; 5,514,785; 5,519,134; 5,567,811; 5,576,427; 5,591,722; 5,597,909; 5,610,300; 5,627,053; 5,639,873; 5,646,265; 5,658,873; 5,670,633; 5,792,747; and 5,700,920, certain of which are commonly owned with the instant application, and each of which is herein incorporated by reference in its entirety.

[0085] A further preferred modification of the sugar includes Locked Nucleic Acids (LNAs) in which the 2′-hydroxyl group is linked to the 3′ or 4′ carbon atom of the sugar ring, thereby forming a bicyclic sugar moiety. The linkage is preferably a methylene (—CH₂—)_(n) group bridging the 2′ oxygen atom and the 4′ carbon atom wherein n is 1 or 2. LNAs and preparation thereof are described in WO 98/39352 and WO 99/14226.

[0086] Natural and Modified Nucleobases

[0087] Oligonucleotides may also include nucleobase (often referred to in the art simply as “base”) modifications or substitutions. As used herein, “unmodified” or “natural” nucleobases include the purine bases adenine (A) and guanine (G), and the pyrimidine bases thymine (T), cytosine (C) and uracil (U). Modified nucleobases include other synthetic and natural nucleobases such as 5-methylcytosine (5-me-C), 5-hydroxymethyl cytosine, xanthine, hypoxanthine, 2-aminoadenine, 6-methyl and other alkyl derivatives of adenine and guanine, 2-propyl and other alkyl derivatives of adenine and guanine, 2-thiouracil, 2-thiothymine and 2-thiocytosine, 5-halouracil and cytosine, 5-propynyl (—C≡C—CH₃) uracil and cytosine and other alkynyl derivatives of pyrimidine bases, 6-azo uracil, cytosine and thymine, 5-uracil (pseudouracil), 4-thiouracil, 8-halo, 8-amino, 8-thiol, 8-thioalkyl, 8-hydroxyl and other 8-substituted adenines and guanines, 5-halo particularly 5-bromo, 5-trifluoromethyl and other 5-substituted uracils and cytosines, 7-methylguanine and 7-methyladenine, 2-F-adenine, 2-amino-adenine, 8-azaguanine and 8-azaadenine, 7-deazaguanine and 7-deazaadenine and 3-deazaguanine and 3-deazaadenine. Further modified nucleobases include tricyclic pyrimidines such as phenoxazine cytidine(1H-pyrimido[5,4-b][1,4]benzoxazin-2(3H)-one), phenothiazine cytidine (1H-pyrimido[5,4-b][1,4]benzothiazin-2(3H)-one), G-clamps such as a substituted phenoxazine cytidine (e.g. 9-(2-aminoethoxy)-H-pyrimido[5,4-b][1,4]benzoxazin-2(3H)-one), carbazole cytidine (2H-pyrimido[4,5-b]indol-2-one), pyridoindole cytidine (H-pyrido[3′,2′:4,5]pyrrolo[2,3-d]pyrimidin-2-one). Modified nucleobases may also include those in which the purine or pyrimidine base is replaced with other heterocycles, for example 7-deaza-adenine, 7-deazaguanosine, 2-aminopyridine and 2-pyridone. Further nucleobases include those disclosed in U.S. Pat. No. 3,687,808, those disclosed in The Concise Encyclopedia Of Polymer Science And Engineering, pages 858-859, Kroschwitz, J. I., ed. John Wiley & Sons, 1990, those disclosed by Englisch et al., Angewandte Chemie, International Edition, 1991, 30, 613, and those disclosed by Sanghvi, Y. S., Chapter 15, Antisense Research and Applications, pages 289-302, Crooke, S. T. and Lebleu, B. ed., CRC Press, 1993. Certain of these nucleobases are particularly useful for increasing the binding affinity of the compounds of the invention. These include 5-substituted pyrimidines, 6-azapyrimidines and N-2, N-6 and O-6 substituted purines, including 2-aminopropyladenine, 5-propynyluracil and 5-propynylcytosine. 5-methylcytosine substitutions have been shown to increase nucleic acid duplex stability by 0.6-1.2° C. and are presently preferred base substitutions, even more particularly when combined with 2′-O-methoxyethyl sugar modifications.

[0088] Representative United States patents that teach the preparation of certain of the above noted modified nucleobases as well as other modified nucleobases include, but are not limited to, the above noted U.S. Pat. No. 3,687,808, as well as U.S. Pat. Nos.: 4,845,205; 5,130,302; 5,134,066; 5,175,273; 5,367,066; 5,432,272; 5,457,187; 5,459,255; 5,484,908; 5,502,177; 5,525,711; 5,552,540; 5,587,469; 5,594,121, 5,596,091; 5,614,617; 5,645,985; 5,830,653; 5,763,588; 6,005,096; and 5,681,941, certain of which are commonly owned with the instant application, and each of which is herein incorporated by reference, and U.S. Pat. No. 5,750,692, which is commonly owned with the instant application and also herein incorporated by reference.

[0089] Conjugates

[0090] Another modification of the oligonucleotides of the invention involves chemically linking to the oligonucleotide one or more moieties or conjugates which enhance the activity, cellular distribution or cellular uptake of the oligonucleotide. These moieties or conjugates can include conjugate groups covalently bound to functional groups such as primary or secondary hydroxyl groups. Conjugate groups of the invention include intercalators, reporter molecules, polyamines, polyamides, polyethylene glycols, polyethers, groups that enhance the pharmacodynamic properties of oligomers, and groups that enhance the pharmacokinetic properties of oligomers. Typical conjugate groups include cholesterols, lipids, phospholipids, biotin, phenazine, folate, phenanthridine, anthraquinone, acridine, fluoresceins, rhodamines, coumarins, and dyes. Groups that enhance the pharmacodynamic properties, in the context of this invention, include groups that improve uptake, enhance resistance to degradation, and/or strengthen sequence-specific hybridization with the target nucleic acid. Groups that enhance the pharmacokinetic properties, in the context of this invention, include groups that improve uptake, distribution, metabolism or excretion of the compounds of the present invention. Representative conjugate groups are disclosed in International Patent Application PCT/US92/09196, filed Oct. 23, 1992, and U.S. Pat. No. 6,287,860, the entire disclosure of which are incorporated herein by reference. Conjugate moieties include but are not limited to lipid moieties such as a cholesterol moiety, cholic acid, a thioether, e.g., hexyl-S-tritylthiol, a thiocholesterol, an aliphatic chain, e.g., dodecandiol or undecyl residues, a phospholipid, e.g., di-hexadecyl-rac-glycerol or triethyl-ammonium 1,2-di-O-hexadecyl-rac-glycero-3-H-phosphonate, a polyamine or a polyethylene glycol chain, or adamantane acetic acid, a palmityl moiety, or an octadecylamine or hexylamino-carbonyl-oxycholesterol moiety. Oligonucleotides of the invention may also be conjugated to active drug substances, for example, aspirin, warfarin, phenylbutazone, ibuprofen, suprofen, fenbufen, ketoprofen, (S)-(+)-pranoprofen, carprofen, dansylsarcosine, 2,3,5-triiodobenzoic acid, flufenamic acid, folinic acid, a benzothiadiazide, chlorothiazide, a diazepine, indomethicin, a barbiturate, a cephalosporin, a sulfa drug, an antidiabetic, an antibacterial or an antibiotic. Oligonucleotide-drug conjugates and their preparation are described in U.S. patent application Ser. No. 09/334,130 (filed Jun. 15, 1999) which is incorporated herein by reference in its entirety.

[0091] Representative United States patents that teach the preparation of such oligonucleotide conjugates include, but are not limited to, U.S. Pat. Nos.: 4,828,979; 4,948,882; 5,218,105; 5,525,465; 5,541,313; 5,545,730; 5,552,538; 5,578,717, 5,580,731; 5,580,731; 5,591,584; 5,109,124; 5,118,802; 5,138,045; 5,414,077; 5,486,603; 5,512,439; 5,578,718; 5,608,046; 4,587,044; 4,605,735; 4,667,025; 4,762,779; 4,789,737; 4,824,941; 4,835,263; 4,876,335; 4,904,582; 4,958,013; 5,082,830; 5,112,963; 5,214,136; 5,082,830; 5,112,963; 5,214,136; 5,245,022; 5,254,469; 5,258,506; 5,262,536; 5,272,250; 5,292,873; 5,317,098; 5,371,241, 5,391,723; 5,416,203, 5,451,463; 5,510,475; 5,512,667; 5,514,785; 5,565,552; 5,567,810; 5,574,142; 5,585,481; 5,587,371; 5,595,726; 5,597,696; 5,599,923; 5,599,928 and 5,688,941, certain of which are commonly owned with the instant application, and each of which is herein incorporated by reference.

[0092] Chimeric Compounds

[0093] It is not necessary for all positions in a given compound to be uniformly modified, and in fact more than one of the aforementioned modifications may be incorporated in a single compound or even at a single nucleoside within an oligonucleotide.

[0094] The present invention also includes antisense compounds which are chimeric compounds. “Chimeric” antisense compounds or “chimeras, ” in the context of this invention, are antisense compounds, particularly oligonucleotides, which contain two or more chemically distinct regions, each made up of at least one monomer unit, i.e., a nucleotide in the case of an oligonucleotide compound. These oligonucleotides typically contain at least one region wherein the oligonucleotide is modified so as to confer upon the oligonucleotide increased resistance to nuclease degradation, increased cellular uptake, increased stability and/or increased binding affinity for the target nucleic acid. An additional region of the oligonucleotide may serve as a substrate for enzymes capable of cleaving RNA:DNA or RNA:RNA hybrids. By way of example, RNAse H is a cellular endonuclease which cleaves the RNA strand of an RNA:DNA duplex. Activation of RNase H, therefore, results in cleavage of the RNA target, thereby greatly enhancing the efficiency of oligonucleotide-mediated inhibition of gene expression. The cleavage of RNA:RNA hybrids can, in like fashion, be accomplished through the actions of endoribonucleases, such as RNAseL which cleaves both cellular and viral RNA. Cleavage of the RNA target can be routinely detected by gel electrophoresis and, if necessary, associated nucleic acid hybridization techniques known in the art.

[0095] Chimeric antisense compounds of the invention may be formed as composite structures of two or more oligonucleotides, modified oligonucleotides, oligonucleosides and/or oligonucleotide mimetics as described above. Such compounds have also been referred to in the art as hybrids or gapmers. Representative United States patents that teach the preparation of such hybrid structures include, but are not limited to, U.S. Pat. Nos.: 5,013,830; 5,149,797; 5,220,007; 5,256,775; 5,366,878; 5,403,711; 5,491,133; 5,565,350; 5,623,065; 5,652,355; 5,652,356; and 5,700,922, certain of which are commonly owned with the instant application, and each of which is herein incorporated by reference in its entirety.

[0096] G. Formulations

[0097] The compounds of the invention may also be admixed, encapsulated, conjugated or otherwise associated with other molecules, molecule structures or mixtures of compounds, as for example, liposomes, receptor-targeted molecules, oral, rectal, topical or other formulations, for assisting in uptake, distribution and/or absorption. Representative United States patents that teach the preparation of such uptake, distribution and/or absorption-assisting formulations include, but are not limited to, U.S. Pat. Nos.: 5,108,921; 5,354,844; 5,416,016; 5,459,127; 5,521,291; 5,543,158; 5,547,932; 5,583,020; 5,591,721; 4,426,330; 4,534,899; 5,013,556; 5,108,921; 5,213,804; 5,227,170; 5,264,221; 5,356,633; 5,395,619; 5,416,016; 5,417,978; 5,462,854; 5,469,854; 5,512,295; 5,527,528; 5,534,259; 5,543,152; 5,556,948; 5,580,575; and 5,595,756, each of which is herein incorporated by reference.

[0098] The antisense compounds of the invention encompass any pharmaceutically acceptable salts, esters, or salts of such esters, or any other compound which, upon administration to an animal, including a human, is capable of providing (directly or indirectly) the biologically active metabolite or residue thereof. Accordingly, for example, the disclosure is also drawn to prodrugs and pharmaceutically acceptable salts of the compounds of the invention, pharmaceutically acceptable salts of such prodrugs, and other bioequivalents.

[0099] The term “prodrug” indicates a therapeutic agent that is prepared in an inactive form that is converted to an active form (i.e., drug) within the body or cells thereof by the action of endogenous enzymes or other chemicals and/or conditions. In particular, prodrug versions of the oligonucleotides of the invention are prepared as SATE [(S-acetyl-2-thioethyl) phosphate] derivatives according to the methods disclosed in WO 93/24510 to Gosselin et al., published Dec. 9, 1993 or in WO 94/26764 and U.S. Pat. No. 5,770,713 to Imbach et al.

[0100] The term “pharmaceutically acceptable salts” refers to physiologically and pharmaceutically acceptable salts of the compounds of the invention: i.e., salts that retain the desired biological activity of the parent compound and do not impart undesired toxicological effects thereto. For oligonucleotides, preferred examples of pharmaceutically acceptable salts and their uses are further described in U.S. Pat. No. 6,287,860, which is incorporated herein in its entirety.

[0101] The present invention also includes pharmaceutical compositions and formulations which include the antisense compounds of the invention. The pharmaceutical compositions of the present invention may be administered in a number of ways depending upon whether local or systemic treatment is desired and upon the area to be treated. Administration may be topical (including ophthalmic and to mucous membranes including vaginal and rectal delivery), pulmonary, e.g., by inhalation or insufflation of powders or aerosols, including by nebulizer; intratracheal, intranasal, epidermal and transdermal), oral or parenteral. Parenteral administration includes intravenous, intraarterial, subcutaneous, intraperitoneal or intramuscular injection or infusion; or intracranial, e.g., intrathecal or intraventricular, administration. Oligonucleotides with at least one 2′-O—methoxyethyl modification are believed to be particularly useful for oral administration. Pharmaceutical compositions and formulations for topical administration may include transdermal patches, ointments, lotions, creams, gels, drops, suppositories, sprays, liquids and powders. Conventional pharmaceutical carriers, aqueous, powder or oily bases, thickeners and the like may be necessary or desirable. Coated condoms, gloves and the like may also be useful.

[0102] The pharmaceutical formulations of the present invention, which may conveniently be presented in unit dosage form, may be prepared according to conventional techniques well known in the pharmaceutical industry. Such techniques include the step of bringing into association the active ingredients with the pharmaceutical carrier(s) or excipient(s). In general, the formulations are prepared by uniformly and intimately bringing into association the active ingredients with liquid carriers or finely divided solid carriers or both, and then, if necessary, shaping the product.

[0103] The compositions of the present invention may be formulated into any of many possible dosage forms such as, but not limited to, tablets, capsules, gel capsules, liquid syrups, soft gels, suppositories, and enemas. The compositions of the present invention may also be formulated as suspensions in aqueous, non-aqueous or mixed media. Aqueous suspensions may further contain substances which increase the viscosity of the suspension including, for example, sodium carboxymethylcellulose, sorbitol and/or dextran. The suspension may also contain stabilizers.

[0104] Pharmaceutical compositions of the present invention include, but are not limited to, solutions, emulsions, foams and liposome-containing formulations. The pharmaceutical compositions and formulations of the present invention may comprise one or more penetration enhancers, carriers, excipients or other active or inactive ingredients.

[0105] Emulsions are typically heterogenous systems of one liquid dispersed in another in the form of droplets usually exceeding 0.1 82 m in diameter. Emulsions may contain additional components in addition to the dispersed phases, and the active drug which may be present as a solution in either the aqueous phase, oily phase or itself as a separate phase. Microemulsions are included as an embodiment of the present invention. Emulsions and their uses are well known in the art and are further described in U.S. Pat. No. 6,287,860, which is incorporated herein in its entirety.

[0106] Formulations of the present invention include liposomal formulations. As used in the present invention, the term “liposome” means a vesicle composed of amphiphilic lipids arranged in a spherical bilayer or bilayers. Liposomes are unilamellar or multilamellar vesicles which have a membrane formed from a lipophilic material and an aqueous interior that contains the composition to be delivered. Cationic liposomes are positively charged liposomes which are believed to interact with negatively charged DNA molecules to form a stable complex. Liposomes that are pH-sensitive or negatively-charged are believed to entrap DNA rather than complex with it. Both cationic and noncationic liposomes have been used to deliver DNA to cells.

[0107] Liposomes also include “sterically stabilized” liposomes, a term which, as used herein, refers to liposomes comprising one or more specialized lipids that, when incorporated into liposomes, result in enhanced circulation lifetimes relative to liposomes lacking such specialized lipids. Examples of sterically stabilized liposomes are those in which part of the vesicle-forming lipid portion of the liposome comprises one or more glycolipids or is derivatized with one or more hydrophilic polymers, such as a polyethylene glycol (PEG) moiety. Liposomes and their uses are further described in U.S. Pat. No. 6,287,860, which is incorporated herein in its entirety.

[0108] The pharmaceutical formulations and compositions of the present invention may also include surfactants. The use of surfactants in drug products, formulations and in emulsions is well known in the art. Surfactants and their uses are further described in U.S. Pat. No. 6,287,860, which is incorporated herein in its entirety.

[0109] In one embodiment, the present invention employs various penetration enhancers to effect the efficient delivery of nucleic acids, particularly oligonucleotides. In addition to aiding the diffusion of non-lipophilic drugs across cell membranes, penetration enhancers also enhance the permeability of lipophilic drugs. Penetration enhancers may be classified as belonging to one of five broad categories, i.e., surfactants, fatty acids, bile salts, chelating agents, and non-chelating non-surfactants. Penetration enhancers and their uses are further described in U.S. Pat. No. 6,287,860, which is incorporated herein in its entirety.

[0110] One of skill in the art will recognize that formulations are routinely designed according to their intended use, i.e. route of administration.

[0111] Preferred formulations for topical administration include those in which the oligonucleotides of the invention are in admixture with a topical delivery agent such as lipids, liposomes, fatty acids, fatty acid esters, steroids, chelating agents and surfactants. Preferred lipids and liposomes include neutral (e.g. dioleoylphosphatidyl DOPE ethanolamine, dimyristoylphosphatidyl choline DMPC, distearolyphosphatidyl choline) negative (e.g. dimyristoylphosphatidyl glycerol DMPG) and cationic (e.g. dioleoyltetramethylaminopropyl DOTAP and dioleoylphosphatidyl ethanolamine DOTMA).

[0112] For topical or other administration, oligonucleotides of the invention may be encapsulated within liposomes or may form complexes thereto, in particular to cationic liposomes. Alternatively, oligonucleotides may be complexed to lipids, in particular to cationic lipids. Preferred fatty acids and esters, pharmaceutically acceptable salts thereof, and their uses are further described in U.S. Pat. No. 6,287,860, which is incorporated herein in its entirety. Topical formulations are described in detail in U.S. patent application Ser. No. 09/315,298 filed on May 20, 1999, which is incorporated herein by reference in its entirety.

[0113] Compositions and formulations for oral administration include powders or granules, microparticulates, nanoparticulates, suspensions or solutions in water or non-aqueous media, capsules, gel capsules, sachets, tablets or minitablets. Thickeners, flavoring agents, diluents, emulsifiers, dispersing aids or binders may be desirable. Preferred oral formulations are those in which oligonucleotides of the invention are administered in conjunction with one or more penetration enhancers surfactants and chelators. Preferred surfactants include fatty acids and/or esters or salts thereof, bile acids and/or salts thereof. Preferred bile acids/salts and fatty acids and their uses are further described in U.S. Pat. No. 6,287,860, which is incorporated herein in its entirety. Also preferred are combinations of penetration enhancers, for example, fatty acids/salts in combination with bile acids/salts. A particularly preferred combination is the sodium salt of lauric acid, capric acid and UDCA. Further penetration enhancers include polyoxyethylene-9-lauryl ether, polyoxyethylene-20-cetyl ether. Oligonucleotides of the invention may be delivered orally, in granular form including sprayed dried particles, or complexed to form micro or nanoparticles. Oligonucleotide complexing agents and their uses are further described in U.S. Pat. No. 6,287,860, which is incorporated herein in its entirety. Oral formulations for oligonucleotides and their preparation are described in detail in U.S. applications Ser. No. 09/108,673 (filed Jul. 1, 1998), Ser. No. 09/315,298 (filed May 20, 1999) and Ser. No. 10/071,822, filed Feb. 8, 2002, each of which is incorporated herein by reference in their entirety.

[0114] Compositions and formulations for parenteral, intrathecal or intraventricular administration may include sterile aqueous solutions which may also contain buffers, diluents and other suitable additives such as, but not limited to, penetration enhancers, carrier compounds and other pharmaceutically acceptable carriers or excipients.

[0115] Certain embodiments of the invention provide pharmaceutical compositions containing one or more oligomeric compounds and one or more other chemotherapeutic agents which function by a non-antisense mechanism. Examples of such chemotherapeutic agents include but are not limited to cancer chemotherapeutic drugs such as daunorubicin, daunomycin, dactinomycin, doxorubicin, epirubicin, idarubicin, esorubicin, bleomycin, mafosfamide, ifosfamide, cytosine arabinoside, bis-chloroethylnitrosurea, busulfan, mitomycin C, actinomycin D, mithramycin, prednisone, hydroxyprogesterone, testosterone, tamoxifen, dacarbazine, procarbazine, hexamethylmelamine, pentamethylmelamine, mitoxantrone, amsacrine, chlorambucil, methylcyclohexylnitrosurea, nitrogen mustards, melphalan, cyclophosphamide, 6-mercaptopurine, 6-thioguanine, cytarabine, 5-azacytidine, hydroxyurea, deoxycoformycin, 4-hydroxyperoxycyclophosphoramide, 5-fluorouracil (5-FU), 5-fluorodeoxyuridine (5-FUdR), methotrexate (MTX), colchicine, taxol, vincristine, vinblastine, etoposide (VP-16), trimetrexate, irinotecan, topotecan, gemcitabine, teniposide, cisplatin and diethylstilbestrol (DES). When used with the compounds of the invention, such chemotherapeutic agents may be used individually (e.g., 5-FU and oligonucleotide), sequentially (e.g., 5-FU and oligonucleotide for a period of time followed by MTX and oligonucleotide), or in combination with one or more other such chemotherapeutic agents (e.g., 5-FU, MTX and oligonucleotide, or 5-FU, radiotherapy and oligonucleotide). Anti-inflammatory drugs, including but not limited to nonsteroidal anti-inflammatory drugs and corticosteroids, and antiviral drugs, including but not limited to ribivirin, vidarabine, acyclovir and ganciclovir, may also be combined in compositions of the invention. Combinations of antisense compounds and other non-antisense drugs are also within the scope of this invention. Two or more combined compounds may be used together or sequentially.

[0116] In another related embodiment, compositions of the invention may contain one or more antisense compounds, particularly oligonucleotides, targeted to a first nucleic acid and one or more additional antisense compounds targeted to a second nucleic acid target. Alternatively, compositions of the invention may contain two or more antisense compounds targeted to different regions of the same nucleic acid target. Numerous examples of antisense compounds are known in the art. Two or more combined compounds may be used together or sequentially.

[0117] H. Dosing

[0118] The formulation of therapeutic compositions and their subsequent administration (dosing) is believed to be within the skill of those in the art. Dosing is dependent on severity and responsiveness of the disease state to be treated, with the course of treatment lasting from several days to several months, or until a cure is effected or a diminution of the disease state is achieved. Optimal dosing schedules can be calculated from measurements of drug accumulation in the body of the patient. Persons of ordinary skill can easily determine optimum dosages, dosing methodologies and repetition rates. Optimum dosages may vary depending on the relative potency of individual oligonucleotides, and can generally be estimated based on EC₅₀s found to be effective in in vitro and in vivo animal models. In general, dosage is from 0.01 ug to 100 g per kg of body weight, and may be given once or more daily, weekly, monthly or yearly, or even once every 2 to 20 years. Persons of ordinary skill in the art can easily estimate repetition rates for dosing based on measured residence times and concentrations of the drug in bodily fluids or tissues. Following successful treatment, it may be desirable to have the patient undergo maintenance therapy to prevent the recurrence of the disease state, wherein the oligonucleotide is administered in maintenance doses, ranging from 0.01 ug to 100 g per kg of body weight, once or more daily, to once every 20 years.

[0119] While the present invention has been described with specificity in accordance with certain of its preferred embodiments, the following examples serve only to illustrate the invention and are not intended to limit the same.

EXAMPLES Example 1

[0120] Synthesis of Nucleoside Phosphoramidites

[0121] The following compounds, including amidites and their intermediates were prepared as described in U.S. Pat. No. 6,426,220 and published PCT WO 02/36743; 5′-O-Dimethoxytrityl-thymidine intermediate for 5-methyl dC amidite, 5′-O-Dimethoxytrityl-2′-deoxy-5-methylcytidine intermediate for 5-methyl-dC amidite, 5′-O-Dimethoxytrityl-2′-deoxy-N4-benzoyl-5-methylcytidine penultimate intermediate for 5-methyl dC amidite, [5′-O-(4,4′-Dimethoxytriphenylmethyl)-2′-deoxy-N⁴-benzoyl-5-methylcytidin-3′-O-yl]-2-cyanoethyl-N,N-diisopropylphosphoramidite (5-methyl dC amidite), 2′-Fluorodeoxyadenosine, 2′-Fluorodeoxyguanosine, 2′-Fluorouridine, 2′-Fluorodeoxycytidine, 2′-O-(2-Methoxyethyl) modified amidites, 2′-O-(2-methoxyethyl)-5-methyluridine intermediate, 5′-O-DMT-2′-O-(2-methoxyethyl)-5-methyluridine penultimate intermediate, [5′-O-(4,4′-Dimethoxytriphenylmethyl)-2′-O-(2-methoxyethyl)-5-methyluridin-3′-O-yl]-2-cyanoethyl-N,N-diisopropylphosphoramidite (MOE T amidite), 5′-O-Dimethoxytrityl-2′-O-(2-methoxyethyl)-5-methylcytidine intermediate, 5′-O-dimethoxytrityl-2′-O-(2-methoxyethyl)-N⁴-benzoyl-5-methyl-cytidine penultimate intermediate, [5′-O-(4,4′-Dimethoxytriphenylmethyl)-2′-O-(2-methoxyethyl)-N⁴-benzoyl-5-methylcytidin-3′-O-yl]-2-cyanoethyl-N,N-diisopropylphosphoramidite (MOE 5-Me-C amidite), [5′-O-(4,4′-Dimethoxytriphenylmethyl)-2′-O-(2-methoxyethyl)-N⁶-benzoyladenosin-3′-O-yl]-2-cyanoethyl-N,N-diisopropylphosphoramidite (MOE A amdite), [5′-O-(4,4′-Dimethoxytriphenylmethyl)-2′-O-(2-methoxyethyl)-N⁴-isobutyrylguanosin-3′-O-yl]-2-cyanoethyl-N,N-diisopropylphosphoramidite (MOE G amidite), 2′-O-(Aminooxyethyl) nucleoside amidites and 2′-O-(dimethylaminooxyethyl) nucleoside amidites, 2′-(Dimethylaminooxyethoxy) nucleoside amidites, 5′-O-tert-Butyldiphenylsilyl-O²-2′-anhydro-5-methyluridine , 5′-O-tert-Butyldiphenylsilyl-2′-O-(2-hydroxyethyl)-5-methyluridine, 2′-O-([2-phthalimidoxy)ethyl]-5′-t-butyldiphenylsilyl-5-methyluridine 5′-O-tert-butyldiphenylsilyl-2′-O-[(2-formadoximinooxy)ethyl]-5-methyluridine, 5′-O-tert-Butyldiphenylsilyl-2′-O-[N,N dimethylaminooxyethyl]-5-methyluridine, 2′-O-(dimethylaminooxyethyl)-5-methyluridine, 5′-O-DMT-2′-O-(dimethylaminooxyethyl)-5-methyluridine, 5′-O-DMT-2′-O-(2-N,N-dimethylaminooxyethyl)-5-methyluridine-3′-[(2-cyanoethyl)-N,N-diisopropylphosphoramidite], 2′-(Aminooxyethoxy) nucleoside amidites, N2-isobutyryl-6-O-diphenylcarbamoyl-2′-O-(2-ethylacetyl)-5′-O-(4,4′-dimethoxytrityl)guanosine-3′-[(2-cyanoethyl)-N,N-diisopropylphosphoramidite], 2′-dimethylaminoethoxyethoxy (2′-DMAEOE) nucleoside amidites, 2′-O-[2(2-N,N-dimethylaminoethoxy)ethyl]-5-methyl uridine, 5′-O-dimethoxytrityl-2′-O-[2(2-N,N-dimethylaminoethoxy)-ethyl)]-5-methyl uridine and 5′-O-Dimethoxytrityl-2′-O-[2(2-N,N-dimethylaminoethoxy)-ethyl)]-5-methyl uridine-3′-O-(cyanoethyl-N,N-diisopropyl)phosphoramidite.

Example 2

[0122] Oligonucleotide and Oligonucleoside Synthesis

[0123] The antisense compounds used in accordance with this invention may be conveniently and routinely made through the well-known technique of solid phase synthesis. Equipment for such synthesis is sold by several vendors including, for example, Applied Biosystems (Foster City, Calif.). Any other means for such synthesis known in the art may additionally or alternatively be employed. It is well known to use similar techniques to prepare oligonucleotides such as the phosphorothioates and alkylated derivatives.

[0124] Oligonucleotides: Unsubstituted and substituted phosphodiester (P═O) oligonucleotides are synthesized on an automated DNA synthesizer (Applied Biosystems model 394) using standard phosphoramidite chemistry with oxidation by iodine.

[0125] Phosphorothioates (P═S) are synthesized similar to phosphodiester oligonucleotides with the following exceptions: thiation was effected by utilizing a 10% w/v solution of 3,H-1,2-benzodithiole-3-one 1,1-dioxide in acetonitrile for the oxidation of the phosphite linkages. The thiation reaction step time was increased to 180 sec and preceded by the normal capping step. After cleavage from the CPG column and deblocking in concentrated ammonium hydroxide at 55° C. (12-16 hr), the oligonucleotides were recovered by precipitating with >3 volumes of ethanol from a 1 M NH₄OAc solution. Phosphinate oligonucleotides are prepared as described in U.S. Pat. No. 5,508,270, herein incorporated by reference.

[0126] Alkyl phosphonate oligonucleotides are prepared as described in U.S. Pat. No. 4,469,863, herein incorporated by reference.

[0127] 3′-Deoxy-3′-methylene phosphonate oligonucleotides are prepared as described in U.S. Pat. Nos. 5,610,289 or 5,625,050, herein incorporated by reference.

[0128] Phosphoramidite oligonucleotides are prepared as described in U.S. Pat. Nos., 5,256,775 or 5,366,878, herein incorporated by reference.

[0129] Alkylphosphonothioate oligonucleotides are prepared as described in published PCT applications PCT/US94/00902 and PCT/US93/06976 (published as WO 94/17093 and WO 94/02499, respectively), herein incorporated by reference.

[0130] 3′-Deoxy-3′-amino phosphoramidate oligonucleotides are prepared as described in U.S. Pat. No. 5,476,925, herein incorporated by reference.

[0131] Phosphotriester oligonucleotides are prepared as described in U.S. Pat. No. 5,023,243, herein incorporated by reference.

[0132] Borano phosphate oligonucleotides are prepared as described in U.S. Pat. Nos. 5,130,302 and 5,177,198, both herein-incorporated by reference.

[0133] Oligonucleosides: Methylenemethylimino linked oligonucleosides, also identified as MMI linked oligonucleosides, methylenedimethylhydrazo linked oligonucleosides, also identified as MDH linked oligonucleosides, and methylenecarbonylamino linked oligonucleosides, also identified as amide-3 linked oligonucleosides, and methyleneaminocarbonyl linked oligonucleosides, also identified as amide-4 linked oligonucleosides, as well as mixed backbone compounds having, for instance, alternating MMI and P═O or P═S linkages are prepared as described in U.S. Pat. Nos. 5,378,825, 5,386,023, 5,489,677, 5,602,240 and 5,610,289, all of which are herein incorporated by reference.

[0134] Formacetal and thioformacetal linked oligonucleosides are prepared as described in U.S. Pat. Nos. 5,264,562 and 5,264,564, herein incorporated by reference.

[0135] Ethylene oxide linked oligonucleosides are prepared as described in U.S. Pat. No. 5,223,618, herein incorporated by reference.

Example 3

[0136] RNA Synthesis

[0137] In general, RNA synthesis chemistry is based on the selective incorporation of various protecting groups at strategic intermediary reactions. Although one of ordinary skill in the art will understand the use of protecting groups in organic synthesis, a useful class of protecting groups includes silyl ethers. In particular bulky silyl ethers are used to protect the 5′-hydroxyl in combination with an acid-labile orthoester protecting group on the 2′-hydroxyl. This set of protecting groups is then used with standard solid-phase synthesis technology. It is important to lastly remove the acid labile orthoester protecting group after all other synthetic steps. Moreover, the early use of the silyl protecting groups during synthesis ensures facile removal when desired, without undesired deprotection of 2′ hydroxyl.

[0138] Following this procedure for the sequential protection of the 5′-hydroxyl in combination with protection of the 2′-hydroxyl by protecting groups that are differentially removed and are differentially chemically labile, RNA oligonucleotides were synthesized.

[0139] RNA oligonucleotides are synthesized in a stepwise fashion. Each nucleotide is added sequentially (3′- to 5′-direction) to a solid support-bound oligonucleotide. The first nucleoside at the 3′-end of the chain is covalently attached to a solid support. The nucleotide precursor, a ribonucleoside phosphoramidite, and activator are added, coupling the second base onto the 5′-end of the first nucleoside. The support is washed and any unreacted 5′-hydroxyl groups are capped with acetic anhydride to yield 5′-acetyl moieties. The linkage is then oxidized to the more stable and ultimately desired P(V) linkage. At the end of the nucleotide addition cycle, the 5′-silyl group is cleaved with fluoride. The cycle is repeated for each subsequent nucleotide.

[0140] Following synthesis, the methyl protecting groups on the phosphates are cleaved in 30 minutes utilizing 1 M disodium-2-carbamoyl-2-cyanoethylene-1,1-dithiolate trihydrate (S₂Na₂) in DMF. The deprotection solution is washed from the solid support-bound oligonucleotide using water. The support is then treated with 40% methylamine in water for 10 minutes at 55° C. This releases the RNA oligonucleotides into solution, deprotects the exocyclic amines, and modifies the 2′-groups. The oligonucleotides can be analyzed by anion exchange HPLC at this stage.

[0141] The 2′-orthoester groups are the last protecting groups to be removed. The ethylene glycol monoacetate orthoester protecting group developed by Dharmacon Research, Inc. (Lafayette, Colo.), is one example of a useful orthoester protecting group which, has the following important properties. It is stable to the conditions of nucleoside phosphoramidite synthesis and oligonucleotide synthesis. However, after oligonucleotide synthesis the oligonucleotide is treated with methylamine which not only cleaves the oligonucleotide from the solid support but also removes the acetyl groups from the orthoesters. The resulting 2-ethyl-hydroxyl substituents on the orthoester are less electron withdrawing than the acetylated precursor. As a result, the modified orthoester becomes more labile to acid-catalyzed hydrolysis. Specifically, the rate of cleavage is approximately 10 times faster after the acetyl groups are removed. Therefore, this orthoester possesses sufficient stability in order to be compatible with oligonucleotide synthesis and yet, when subsequently modified, permits deprotection to be carried out under relatively mild aqueous conditions compatible with the final RNA oligonucleotide product.

[0142] Additionally, methods of RNA synthesis are well known in the art (Scaringe, S. A. Ph.D. Thesis, University of Colorado, 1996; Scaringe, S. A., et al., J. Am. Chem. Soc., 1998, 120, 11820-11821; Matteucci, M. D. and Caruthers, M. H. J. Am. Chem. Soc., 1981, 103, 3185-3191; Beaucage, S. L. and Caruthers, M. H. Tetrahedron Lett., 1981, 22, 1859-1862; Dahl, B. J., et al., Acta Chem. Scand,. 1990, 44, 639-641; Reddy, M. P., et al., Tetrahedrom Lett., 1994, 25, 4311-4314; Wincott, F. et al., Nucleic Acids Res., 1995, 23, 2677-2684; Griffin, B. E., et al., Tetrahedron, 1967, 23, 2301-2313; Griffin, B. E., et al., Tetrahedron, 1967, 23, 2315-2331).

[0143] RNA antisense compounds (RNA oligonucleotides) of the present invention can be synthesized by the methods herein or purchased from Dharmacon Research, Inc (Lafayette, Colo.). Once synthesized, complementary RNA antisense compounds can then be annealed by methods known in the art to form double stranded (duplexed) antisense compounds. For example, duplexes can be formed by combining 30 μl of each of the complementary strands of RNA oligonucleotides (50 uM RNA oligonucleotide solution) and 15 μl of 5× annealing buffer (100 mM potassium acetate, 30 mM HEPES-KOH pH 7.4, 2 mM magnesium acetate) followed by heating for 1 minute at 90° C., then 1 hour at 37° C. The resulting duplexed antisense compounds can be used in kits, assays, screens, or other methods to investigate the role of a target nucleic acid.

Example 4

[0144] Synthesis of Chimeric Oligonucleotides

[0145] Chimeric oligonucleotides, oligonucleosides or mixed oligonucleotides/oligonucleosides of the invention can be of several different types. These include a first type wherein the “gap” segment of linked nucleosides is positioned between 5′ and 3′ “wing” segments of linked nucleosides and a second “open end” type wherein the “gap” segment is located at either the 3′ or the 5′ terminus of the oligomeric compound. Oligonucleotides of the first type are also known in the art as “gapmers” or gapped oligonucleotides. Oligonucleotides of the second type are also known in the art as “hemimers” or “wingmers”.

[0146] [2′-O-Me]--[2′-deoxy]--[2′-O-Me] Chimeric Phosphorothioate Oligonucleotides

[0147] Chimeric oligonucleotides having 2′-O-alkyl phosphorothioate and 2′-deoxy phosphorothioate oligonucleotide segments are synthesized using an Applied Biosystems automated DNA synthesizer Model 394, as above. Oligonucleotides are synthesized using the automated synthesizer and 2′-deoxy-5′-dimethoxytrityl-3′-O-phosphoramidite for the DNA portion and 5′-dimethoxytrityl-2′-O-methyl-3′-O-phosphoramidite for 5′ and 3′ wings. The standard synthesis cycle is modified by incorporating coupling steps with increased reaction times for the 5′-dimethoxytrityl-2′-O-methyl-3′-O-phosphoramidite. The fully protected oligonucleotide is cleaved from the support and deprotected in concentrated ammonia (NH₄OH) for 12-16 hr at 55° C. The deprotected oligo is then recovered by an appropriate method (precipitation, column chromatography, volume reduced in vacuo and analyzed spetrophotometrically for yield and for purity by capillary electrophoresis and by mass spectrometry.

[0148] [2′-O-(2-Methoxyethyl)]--[2′-deoxy]--[2′-O-(Methoxyethyl)] Chimeric Phosphorothioate Oligonucleotides

[0149] [2′-O-(2-methoxyethyl)]--[2′-deoxy]--[-2′-O-(methoxyethyl)] chimeric phosphorothioate oligonucleotides were prepared as per the procedure above for the 2′-O-methyl chimeric oligonucleotide, with the substitution of 2′-O-(methoxyethyl) amidites for the 2′-O-methyl amidites.

[0150] [2′-O-(2-Methoxyethyl)Phosphodiester]--[2′-deoxy Phosphorothioate]--[2′-O-(2-Methoxyethyl) Phosphodiester] Chimeric Oligonucleotides

[0151] [2′-O-(2-methoxyethyl phosphodiester]--[2′-deoxy phosphorothioate]--[2′-O-(methoxyethyl) phosphodiester] chimeric oligonucleotides are prepared as per the above procedure for the 2′-O-methyl chimeric oligonucleotide with the substitution of 2′-O-(methoxyethyl) amidites for the 2′-O-methyl amidites, oxidation with iodine to generate the phosphodiester internucleotide linkages within the wing portions of the chimeric structures and sulfurization utilizing 3,H-1,2 benzodithiole-3-one 1,1 dioxide (Beaucage Reagent) to generate the phosphorothioate internucleotide linkages for the center gap.

[0152] Other chimeric oligonucleotides, chimeric oligonucleosides and mixed chimeric oligonucleotides/oligonucleosides are synthesized according to U.S. Pat. No. 5,623,065, herein incorporated by reference.

Example 5

[0153] Design and Screening of Duplexed Antisense Compounds Targeting MAD1-like 1

[0154] In accordance with the present invention, a series of nucleic acid duplexes comprising the antisense compounds of the present invention and their complements can be designed to target MAD1-like 1. The nucleobase sequence of the antisense strand of the duplex comprises at least a portion of an oligonucleotide in Table 1. The ends of the strands may be modified by the addition of one or more natural or modified nucleobases to form an overhang. The sense strand of the dsRNA is then designed and synthesized as the complement of the antisense strand and may also contain modifications or additions to either terminus. For example, in one embodiment, both strands of the dsRNA duplex would be complementary over the central nucleobases, each having overhangs at one or both termini.

[0155] For example, a duplex comprising an antisense strand having the sequence CGAGAGGCGGACGGGACCG and having a two-nucleobase overhang of deoxythymidine(dT) would have the following structure:   cgagaggcggacgggaccgTT Antisense Strand   ||||||||||||||||||| TTgctctccgcctgccctggc Complement

[0156] RNA strands of the duplex can be synthesized by methods disclosed herein or purchased from Dharmacon Research Inc., (Lafayette, Colo.). Once synthesized, the complementary strands are annealed. The single strands are aliquoted and diluted to a concentration of 50 uM. Once diluted, 30 uL of each strand is combined with 15 uL of a 5× solution of annealing buffer. The final concentration of said buffer is 100 mM potassium acetate, 30 mM HEPES-KOH pH 7.4, and 2 mM magnesium acetate. The final volume is 75 uL. This solution is incubated for 1 minute at 90° C. and then centrifuged for 15 seconds. The tube is allowed to sit for 1 hour at 37° C. at which time the dsRNA duplexes are used in experimentation. The final concentration of the dsRNA duplex is 20 uM. This solution can be stored frozen (−20° C.) and freeze-thawed up to 5 times.

[0157] Once prepared, the duplexed antisense compounds are evaluated for their ability to modulate MAD1-like 1 expression.

[0158] When cells reached 80% confluency, they are treated with duplexed antisense compounds of the invention. For cells grown in 96-well plates, wells are washed once with 200 μL OPTI-MEM-1 reduced-serum medium (Gibco BRL) and then treated with 130 μL of OPTI-MEM-1 containing 12 μg/mL LIPOFECTIN (Gibco BRL) and the desired duplex antisense compound at a final concentration of 200 nM. After 5 hours of treatment, the medium is replaced with fresh medium. Cells are harvested 16 hours after treatment, at which time RNA is isolated and target reduction measured by RT-PCR.

Example 6

[0159] Oligonucleotide Isolation

[0160] After cleavage from the controlled pore glass solid support and deblocking in concentrated ammonium hydroxide at 55° C. for 12-16 hours, the oligonucleotides or oligonucleosides are recovered by precipitation out of 1 M NH₄OAc with >3 volumes of ethanol. Synthesized oligonucleotides were analyzed by electrospray mass spectroscopy (molecular weight determination) and by capillary gel electrophoresis and judged to be at least 70% full length material. The relative amounts of phosphorothioate and phosphodiester linkages obtained in the synthesis was determined by the ratio of correct molecular weight relative to the −16 amu product (+/−32+/−48). For some studies oligonucleotides were purified by HPLC, as described by Chiang et al., J. Biol. Chem. 1991, 266, 18162-18171. Results obtained with HPLC-purified material were similar to those obtained with non-HPLC purified material.

Example 7

[0161] Oligonucleotide Synthesis-96 Well Plate Format

[0162] Oligonucleotides were synthesized via solid phase P(III) phosphoramidite chemistry on an automated synthesizer capable of assembling 96 sequences simultaneously in a 96-well format. Phosphodiester internucleotide linkages were afforded by oxidation with aqueous iodine. Phosphorothioate internucleotide linkages were generated by sulfurization utilizing 3,H-1,2 benzodithiole-3-one 1,1 dioxide (Beaucage Reagent) in anhydrous acetonitrile. Standard base-protected beta-cyanoethyl-diiso-propyl phosphoramidites were purchased from commercial vendors (e.g. PE-Applied Biosystems, Foster City, Calif., or Pharmacia, Piscataway, N.J.). Non-standard nucleosides are synthesized as per standard or patented methods. They are utilized as base protected beta-cyanoethyldiisopropyl phosphoramidites.

[0163] Oligonucleotides were cleaved from support and deprotected with concentrated NH₄OH at elevated temperature (55-60° C.) for 12-16 hours and the released product then dried in vacuo. The dried product was then re-suspended in sterile water to afford a master plate from which all analytical and test plate samples are then diluted utilizing robotic pipettors.

Example 8

[0164] Oligonucleotide Analysis—96-Well Plate Format

[0165] The concentration of oligonucleotide in each well was assessed by dilution of samples and UV absorption spectroscopy. The full-length integrity of the individual products was evaluated by capillary electrophoresis (CE) in either the 96-well format (Beckman P/ACE™ MDQ) or, for individually prepared samples, on a commercial CE apparatus (e.g., Beckman P/ACE™ 5000, ABI 270). Base and backbone composition was confirmed by mass analysis of the compounds utilizing electrospray-mass spectroscopy. All assay test plates were diluted from the master plate using single and multi-channel robotic pipettors. Plates were judged to be acceptable if at least 85% of the compounds on the plate were at least 85% full length.

Example 9

[0166] Cell Culture and Oligonucleotide Treatment

[0167] The effect of antisense compounds on target nucleic acid expression can be tested in any of a variety of cell types provided that the target nucleic acid is present at measurable levels. This can be routinely determined using, for example, PCR or Northern blot analysis. The following cell types are provided for illustrative purposes, but other cell types can be routinely used, provided that the target is expressed in the cell type chosen. This can be readily determined by methods routine in the art, for example Northern blot analysis, ribonuclease protection assays, or RT-PCR.

[0168] T-24 cells:

[0169] The human transitional cell bladder carcinoma cell line T-24 was obtained from the American Type Culture Collection (ATCC) (Manassas, Va.). T-24 cells were routinely cultured in complete McCoy's 5A basal media (Invitrogen Corporation, Carlsbad, Calif.) supplemented with 10% fetal calf serum (Invitrogen Corporation, Carlsbad, Calif.), penicillin 100 units per mL, and streptomycin 100 micrograms per mL (Invitrogen Corporation, Carlsbad, Calif.). Cells were routinely passaged by trypsinization and dilution when they reached 90% confluence. Cells were seeded into 96-well plates (Falcon-Primaria #353872) at a density of 7000 cells/well for use in RT-PCR analysis.

[0170] For Northern blotting or other analysis, cells may be seeded onto 100 mm or other standard tissue culture plates and treated similarly, using appropriate volumes of medium and oligonucleotide.

[0171] A549 cells:

[0172] The human lung carcinoma cell line A549 was obtained from the American Type Culture Collection (ATCC) (Manassas, Va.). A549 cells were routinely cultured in DMEM basal media (Invitrogen Corporation, Carlsbad, Calif.) supplemented with 10% fetal calf serum (Invitrogen Corporation, Carlsbad, Calif.), penicillin 100 units per mL, and streptomycin 100 micrograms per mL (Invitrogen Corporation, Carlsbad, Calif.). Cells were routinely passaged by trypsinization and dilution when they reached 90% confluence.

[0173] NHDF cells:

[0174] Human neonatal dermal fibroblast (NHDF) were obtained from the Clonetics Corporation (Walkersville, Md.). NHDFs were routinely maintained in Fibroblast Growth Medium (Clonetics Corporation, Walkersville, Md.) supplemented as recommended by the supplier. Cells were maintained for up to 10 passages as recommended by the supplier.

[0175] HEK cells:

[0176] Human embryonic keratinocytes (HEK) were obtained from the Clonetics Corporation (Walkersville, Md.). HEKs were routinely maintained in Keratinocyte Growth Medium (Clonetics Corporation, Walkersville, Md.) formulated as recommended by the supplier. Cells were routinely maintained for up to 10 passages as recommended by the supplier.

[0177] Treatment with antisense compounds:

[0178] When cells reached 65-75% confluency, they were treated with oligonucleotide. For cells grown in 96-well plates, wells were washed once with 100 μL OPTI-MEM™-1 reduced-serum medium (Invitrogen Corporation, Carlsbad, Calif.) and then treated with 130 μL of OPTI-MEM™-1 containing 3.75 μg/mL LIPOFECTIN™ (Invitrogen Corporation, Carlsbad, Calif.) and the desired concentration of oligonucleotide. Cells are treated and data are obtained in triplicate. After 4-7 hours of treatment at 37° C., the medium was replaced with fresh medium. Cells were harvested 16-24 hours after oligonucleotide treatment.

[0179] The concentration of oligonucleotide used varies from cell line to cell line. To determine the optimal oligonucleotide concentration for a particular cell line, the cells are treated with a positive control oligonucleotide at a range of concentrations. For human cells the positive control oligonucleotide is selected from either ISIS 13920 (TCCGTCATCGCTCCTCAGGG, SEQ ID NO: 1) which is targeted to human H-ras, or ISIS 18078, (GTGCGCGCGAGCCCGAAATC, SEQ ID NO: 2) which is targeted to human Jun-N-terminal kinase-2 (JNK2). Both controls are 2′-O-methoxyethyl gapmers (2′-O-methoxyethyls shown in bold) with a phosphorothioate backbone. For mouse or rat cells the positive control oligonucleotide is ISIS 15770, ATGCATTCTGCCCCCAAGGA, SEQ ID NO: 3, a 2′-O-methoxyethyl gapmer (2′-O-methoxyethyls shown in bold) with a phosphorothioate backbone which is targeted to both mouse and rat c-raf. The concentration of positive control oligonucleotide that results in 80% inhibition of c-H-ras (for ISIS 13920), JNK2 (for ISIS 18078) or c-raf (for ISIS 15770) mRNA is then utilized as the screening concentration for new oligonucleotides in subsequent experiments for that cell line. If 80% inhibition is not achieved, the lowest concentration of positive control oligonucleotide that results in 60% inhibition of c-H-ras, JNK2 or c-raf mRNA is then utilized as the oligonucleotide screening concentration in subsequent experiments for that cell line. If 60% inhibition is not achieved, that particular cell line is deemed as unsuitable for oligonucleotide transfection experiments. The concentrations of antisense oligonucleotides used herein are from 50 nM to 300 nM.

Example 10

[0180] Analysis of Oligonucleotide Inhibition of MAD1-like 1 Expression

[0181] Antisense modulation of MAD1-like 1 expression can be assayed in a variety of ways known in the art. For example, MAD1-like 1 mRNA levels can be quantitated by, e.g., Northern blot analysis, competitive polymerase chain reaction (PCR), or real-time PCR (RT-PCR). Real-time quantitative PCR is presently preferred. RNA analysis can be performed on total cellular RNA or poly(A)+mRNA. The preferred method of RNA analysis of the present invention is the use of total cellular RNA as described in other examples herein. Methods of RNA isolation are well known in the art. Northern blot analysis is also routine in the art. Real-time quantitative (PCR) can be conveniently accomplished using the commercially available ABI PRISM™ 7600, 7700, or 7900 Sequence Detection System, available from PE-Applied Biosystems, Foster City, Calif. and used according to manufacturer's instructions.

[0182] Protein levels of MAD1-like 1 can be quantitated in a variety of ways well known in the art, such as immunoprecipitation, Western blot analysis (immunoblotting), enzyme-linked immunosorbent assay (ELISA) or fluorescence-activated cell sorting (FACS). Antibodies directed to MAD1-like 1 can be identified and obtained from a variety of sources, such as the MSRS catalog of antibodies (Aerie Corporation, Birmingham, Mich.), or can be prepared via conventional monoclonal or polyclonal antibody generation methods well known in the art.

Example 11

[0183] Design of Phenotypic Assays and in Vivo Studies for the Use of MAD1-like 1 Inhibitors

[0184] Phenotypic Assays

[0185] Once MAD1-like 1 inhibitors have been identified by the methods disclosed herein, the compounds are further investigated in one or more phenotypic assays, each having measurable endpoints predictive of efficacy in the treatment of a particular disease state or condition. Phenotypic assays, kits and reagents for their use are well known to those skilled in the art and are herein used to investigate the role and/or association of MAD1-like 1 in health and disease. Representative phenotypic assays, which can be purchased from any one of several commercial vendors, include those for determining cell viability, cytotoxicity, proliferation or cell survival (Molecular Probes, Eugene, Oreg.; PerkinElmer, Boston, Mass.), protein-based assays including enzymatic assays (Panvera, LLC, Madison, Wis.; BD Biosciences, Franklin Lakes, N.J.; Oncogene Research Products, San Diego, Calif.), cell regulation, signal transduction, inflammation, oxidative processes and apoptosis (Assay Designs Inc., Ann Arbor, Mich.), triglyceride accumulation (Sigma-Aldrich, St. Louis, Mo.), angiogenesis assays, tube formation assays, cytokine and hormone assays and metabolic assays (Chemicon International Inc., Temecula, Calif.; Amersham Biosciences, Piscataway, N.J.).

[0186] In one non-limiting example, cells determined to be appropriate for a particular phenotypic assay (i.e., MCF-7 cells selected for breast cancer studies; adipocytes for obesity studies) are treated with MAD1-like 1 inhibitors identified from the in vitro studies as well as control compounds at optimal concentrations which are determined by the methods described above. At the end of the treatment period, treated and untreated cells are analyzed by one or more methods specific for the assay to determine phenotypic outcomes and endpoints.

[0187] Phenotypic endpoints include changes in cell morphology over time or treatment dose as well as changes in levels of cellular components such as proteins, lipids, nucleic acids, hormones, saccharides or metals. Measurements of cellular status which include pH, stage of the cell cycle, intake or excretion of biological indicators by the cell, are also endpoints of interest.

[0188] Analysis of the geneotype of the cell (measurement of the expression of one or more of the genes of the cell) after treatment is also used as an indicator of the efficacy or potency of the MAD1-like 1 inhibitors. Hallmark genes, or those genes suspected to be associated with a specific disease state, condition, or phenotype, are measured in both treated and untreated cells.

[0189] In Vivo Studies

[0190] The individual subjects of the in vivo studies described herein are warm-blooded vertebrate animals, which includes humans.

[0191] The clinical trial is subjected to rigorous controls to ensure that individuals are not unnecessarily put at risk and that they are fully informed about their role in the study. To account for the psychological effects of receiving treatments, volunteers are randomly given placebo or MAD1-like 1 inhibitor. Furthermore, to prevent the doctors from being biased in treatments, they are not informed as to whether the medication they are administering is a MAD1-like 1 inhibitor or a placebo. Using this randomization approach, each volunteer has the same chance of being given either the new treatment or the placebo.

[0192] Volunteers receive either the MAD1-like 1 inhibitor or placebo for eight week period with biological parameters associated with the indicated disease state or condition being measured at the beginning (baseline measurements before any treatment), end (after the final treatment), and at regular intervals during the study period. Such measurements include the levels of nucleic acid molecules encoding MAD1-like 1 or MAD1-like 1 protein levels in body fluids, tissues or organs compared to pre-treatment levels. Other measurements include, but are not limited to, indices of the disease state or condition being treated, body weight, blood pressure, serum titers of pharmacologic indicators of disease or toxicity as well as ADME (absorption, distribution, metabolism and excretion) measurements.

[0193] Information recorded for each patient includes age (years), gender, height (cm), family history of disease state or condition (yes/no), motivation rating (some/moderate/great) and number and type of previous treatment regimens for the indicated disease or condition.

[0194] Volunteers taking part in this study are healthy adults (age 18 to 65 years) and roughly an equal number of males and females participate in the study. Volunteers with certain characteristics are equally distributed for placebo and MAD1-like 1 inhibitor treatment. In general, the volunteers treated with placebo have little or no response to treatment, whereas the volunteers treated with the MAD1-like 1 inhibitor show positive trends in their disease state or condition index at the conclusion of the study.

Example 12

[0195] RNA Isolation

[0196] Poly(A)+mRNA Isolation

[0197] Poly(A)+mRNA was isolated according to Miura et al., (Clin. Chem., 1996, 42, 1758-1764). Other methods for poly(A)+mRNA isolation are routine in the art. Briefly, for cells grown on 96-well plates, growth medium was removed from the cells and each well was washed with 200 μL cold PBS. 60 μL lysis buffer (10 mM Tris-HCl, pH 7.6, 1 mM EDTA, 0.5 M NaCl, 0.5% NP-40, 20 mM vanadyl-ribonucleoside complex) was added to each well, the plate was gently agitated and then incubated at room temperature for five minutes. 55 μL of lysate was transferred to Oligo d(T) coated 96-well plates (AGCT Inc., Irvine Calif.). Plates were incubated for 60 minutes at room temperature, washed 3 times with 200 μL of wash buffer (10 mM Tris-HCl pH 7.6, 1 mM EDTA, 0.3 M NaCl). After the final wash, the plate was blotted on paper towels to remove excess wash buffer and then air-dried for 5 minutes. 60 μL of elution buffer (5 mM Tris-HCl pH 7.6), preheated to 70° C., was added to each well, the plate was incubated on a 90° C. hot plate for 5 minutes, and the eluate was then transferred to a fresh 96-well plate.

[0198] Cells grown on 100 mm or other standard plates may be treated similarly, using appropriate volumes of all solutions.

[0199] Total RNA Isolation

[0200] Total RNA was isolated using an RNEASY 96™ kit and buffers purchased from Qiagen Inc. (Valencia, Calif.) following the manufacturer's recommended procedures. Briefly, for cells grown on 96-well plates, growth medium was removed from the cells and each well was washed with 200 μL cold PBS. 150 μL Buffer RLT was added to each well and the plate vigorously agitated for 20 seconds. 150 μL of 70% ethanol was then added to each well and the contents mixed by pipetting three times up and down. The samples were then transferred to the RNEASY 96™ well plate attached to a QIAVAC™ manifold fitted with a waste collection tray and attached to a vacuum source. Vacuum was applied for 1 minute. 500 μL of Buffer RW1 was added to each well of the RNEASY 96™ plate and incubated for 15 minutes and the vacuum was again applied for 1 minute. An additional 500 ™L of Buffer RW1 was added to each well of the RNEASY 96™ plate and the vacuum was applied for 2 minutes. 1 mL of Buffer RPE was then added to each well of the RNEASY 96™ plate and the vacuum applied for a period of 90 seconds. The Buffer RPE wash was then repeated and the vacuum was applied for an additional 3 minutes. The plate was then removed from the QIAVAC™ manifold and blotted dry on paper towels. The plate was then re-attached to the QIAVAC™ manifold fitted with a collection tube rack containing 1.2 mL collection tubes. RNA was then eluted by pipetting 140 μL of RNAse free water into each well, incubating 1 minute, and then applying the vacuum for 3 minutes.

[0201] The repetitive pipetting and elution steps may be automated using a QIAGEN Bio-Robot 9604 (Qiagen, Inc., Valencia Calif.). Essentially, after lysing of the cells on the culture plate, the plate is transferred to the robot deck where the pipetting, DNase treatment and elution steps are carried out.

Example 13

[0202] Real-time Quantitative PCR Analysis of MAD1-like 1 mRNA Levels

[0203] Quantitation of MAD1-like 1 mRNA levels was accomplished by real-time quantitative PCR using the ABI PRISM™ 7600, 7700, or 7900 Sequence Detection System (PE-Applied Biosystems, Foster City, Calif.) according to manufacturer's instructions. This is a closed-tube, non-gel-based, fluorescence detection system which allows high-throughput quantitation of polymerase chain reaction (PCR) products in real-time. As opposed to standard PCR in which amplification products are quantitated after the PCR is completed, products in real-time quantitative PCR are quantitated as they accumulate. This is accomplished by including in the PCR reaction an oligonucleotide probe that anneals specifically between the forward and reverse PCR primers, and contains two fluorescent dyes. A reporter dye (e.g., FAM or JOE, obtained from either PE-Applied Biosystems, Foster City, Calif., Operon Technologies Inc., Alameda, Calif. or Integrated DNA Technologies Inc., Coralville, Iowa) is attached to the 5′ end of the probe and a quencher dye (e.g., TAMRA, obtained from either PE-Applied Biosystems, Foster City, Calif., Operon Technologies Inc., Alameda, Calif. or Integrated DNA Technologies Inc., Coralville, Iowa) is attached to the 3′ end of the probe. When the probe and dyes are intact, reporter dye emission is quenched by the proximity of the 3′ quencher dye. During amplification, annealing of the probe to the target sequence creates a substrate that can be cleaved by the 5′-exonuclease activity of Taq polymerase. During the extension phase of the PCR amplification cycle, cleavage of the probe by Taq polymerase releases the reporter dye from the remainder of the probe (and hence from the quencher moiety) and a sequence-specific fluorescent signal is generated. With each cycle, additional reporter dye molecules are cleaved from their respective probes, and the fluorescence intensity is monitored at regular intervals by laser optics built into the ABI PRISM™ Sequence Detection System. In each assay, a series of parallel reactions containing serial dilutions of mRNA from untreated control samples generates a standard curve that is used to quantitate the percent inhibition after antisense oligonucleotide treatment of test samples.

[0204] Prior to quantitative PCR analysis, primer-probe sets specific to the target gene being measured are evaluated for their ability to be “multiplexed” with a GAPDH amplification reaction. In multiplexing, both the target gene and the internal standard gene GAPDH are amplified concurrently in a single sample. In this analysis, mRNA isolated from untreated cells is serially diluted. Each dilution is amplified in the presence of primer-probe sets specific for GAPDH only, target gene only (“single-plexing”), or both (multiplexing). Following PCR amplification, standard curves of GAPDH and target mRNA signal as a function of dilution are generated from both the single-plexed and multiplexed samples. If both the slope and correlation coefficient of the GAPDH and target signals generated from the multiplexed samples fall within 10% of their corresponding values generated from the single-plexed samples, the primer-probe set specific for that target is deemed multiplexable. Other methods of PCR are also known in the art.

[0205] PCR reagents were obtained from Invitrogen Corporation, (Carlsbad, Calif.). RT-PCR reactions were carried out by adding 20 μL PCR cocktail (2.5×PCR buffer minus MgCl₂, 6.6 mM MgCl₂, 375 μM each of dATP, dCTP, dCTP and dGTP, 375 nM each of forward primer and reverse primer, 125 nM of probe, 4 Units RNAse inhibitor, 1.25 Units PLATINUM® Taq, 5 Units MuLV reverse transcriptase, and 2.5×ROX dye) to 96-well plates containing 30 μL total RNA solution (20-200 ng). The RT reaction was carried out by incubation for 30 minutes at 48° C. Following a 10 minute incubation at 95° C. to activate the PLATINUM® Taq, 40 cycles of a two-step PCR protocol were carried out: 95° C. for 15 seconds (denaturation) followed by 60° C. for 1.5 minutes (annealing/extension).

[0206] Gene target quantities obtained by real time RT-PCR are normalized using either the expression level of GAPDH, a gene whose expression is constant, or by quantifying total RNA using RiboGreen™ (Molecular Probes, Inc. Eugene, Oreg.). GAPDH expression is quantified by real time RT-PCR, by being run simultaneously with the target, multiplexing, or separately. Total RNA is quantified using RiboGreen™ RNA quantification reagent (Molecular Probes, Inc. Eugene, Oreg.). Methods of RNA quantification by RiboGreen™ are taught in Jones, L. J., et al, (Analytical Biochemistry, 1998, 265, 368-374).

[0207] In this assay, 170 μL of RiboGreen™ working reagent (RiboGreen™ reagent diluted 1:350 in 10 mM Tris-HCl, 1 mM EDTA, pH 7.5) is pipetted into a 96-well plate containing 30 μL purified, cellular RNA. The plate is read in a CytoFluor 4000 (PE Applied Biosystems) with excitation at 485 nm and emission at 530 nm.

[0208] Probes and primers to human MAD1-like 1 were designed to hybridize to a human MAD1-like 1 sequence, using published sequence information (GenBank accession number NM_(—)003550.1, incorporated herein as SEQ ID NO:4). For human MAD1-like 1 the PCR primers were:

[0209] forward primer: AGGCTGCTGGCCAAGCT (SEQ ID NO: 5)

[0210] reverse primer: CTCAACCACGAATCTGGAAAGG (SEQ ID NO: 6) and the

[0211] PCR probe was: FAM-AGACCATGGGCCTGAGCATCAGGA-TAMRA (SEQ ID NO: 7) where FAM is the fluorescent dye and TAMRA is the quencher dye. For human GAPDH the PCR primers were:

[0212] forward primer: GAAGGTGAAGGTCGGAGTC(SEQ ID NO:8)

[0213] reverse primer: GAAGATGGTGATGGGATTTC (SEQ ID NO:9) and the PCR probe was: 5′ JOE-CAAGCTTCCCGTTCTCAGCC-TAMRA 3′ (SEQ ID NO: 10) where JOE is the fluorescent reporter dye and TAMRA is the quencher dye.

Example 14

[0214] Northern Blot Analysis of MAD1-like 1 mRNA Levels

[0215] Eighteen hours after antisense treatment, cell monolayers were washed twice with cold PBS and lysed in 1 mL RNAZOL™ (TEL-TEST “B” Inc., Friendswood, Tex.). Total RNA was prepared following manufacturer's recommended protocols. Twenty micrograms of total RNA was fractionated by electrophoresis through 1.2% agarose gels containing 1.1% formaldehyde using a MOPS buffer system (AMRESCO, Inc. Solon, Ohio). RNA was transferred from the gel to HYBOND™-N+ nylon membranes (Amersham Pharmacia Biotech, Piscataway, N.J.) by overnight capillary transfer using a Northern/Southern Transfer buffer system (TEL-TEST “B” Inc., Friendswood, Tex.). RNA transfer was confirmed by UV visualization. Membranes were fixed by UV cross-linking using a STRATALINKER™ UV Crosslinker 2400 (Stratagene, Inc, La Jolla, Calif.) and then probed using QUICKHYB™ hybridization solution (Stratagene, La Jolla, Calif.) using manufacturer's recommendations for stringent conditions.

[0216] To detect human MAD1-like 1, a human MAD1-like 1 specific probe was prepared by PCR using the forward primer AGGCTGCTGGCCAAGCT (SEQ ID NO: 5) and the reverse primer CTCAACCACGAATCTGGAAAGG (SEQ ID NO: 6). To normalize for variations in loading and transfer efficiency membranes were stripped and probed for human glyceraldehyde-3-phosphate dehydrogenase (GAPDH) RNA (Clontech, Palo Alto, Calif.).

[0217] Hybridized membranes were visualized and quantitated using a PHOSPHORIMAGER™ and IMAGEQUANT™ Software V3.3 (Molecular Dynamics, Sunnyvale, Calif.). Data was normalized to GAPDH levels in untreated controls.

Example 15

[0218] Antisense Inhibition of Human MAD1-like 1 Expression by Chimeric Phosphorothioate Oligonucleotides having 2′-MOE Wings and a Deoxy Gap

[0219] In accordance with the present invention, a series of antisense compounds were designed to target different regions of the human MAD1-like 1 RNA, using published sequences (GenBank accession number NM_(—)003550.1, incorporated herein as SEQ ID NO: 4, GenBank accession number BM818088.1, incorporated herein as SEQ ID NO: 11, GenBank accession number BC009964.1, incorporated herein as SEQ ID NO: 12, GenBank accession number BG768276.1, incorporated herein as SEQ ID NO: 13, GenBank accession number BG769861.1, incorporated herein as SEQ ID NO: 14, GenBank accession number BC018870.1, incorporated herein as SEQ ID NO: 15, and a genomic sequence of human MAD1-like 1 represented by the complement of residues 56000-403000 of GenBank accession number NT_(—)007784.8, incorporated herein as SEQ ID NO: 16). The compounds are shown in Table 1. “Target site” indicates the first (5′-most) nucleotide number on the particular target sequence to which the compound binds. All compounds in Table 1 are chimeric oligonucleotides (“gapmers”) 20 nucleotides in length, composed of a central “gap” region consisting of ten 2′-deoxynucleotides, which is flanked on both sides (5′ and 3′ directions) by five-nucleotide “wings”. The wings are composed of 2′-methoxyethyl (2′-MOE)nucleotides. The internucleoside (backbone) linkages are phosphorothioate (P═S) throughout the oligonucleotide All cytidine residues are 5-methylcytidines. The compounds were analyzed for their effect on human MAD1-like 1 mRNA levels by quantitative real-time PCR as described in other examples herein. Data are averages from three experiments in which A549 cells were treated with the oligonucleotides of the present invention. The positive control for each datapoint is identified in the table by sequence ID number. If present, “N.D.” indicates “no data”. TABLE 1 Inhibition of human MAD1-like 1 mRNA levels by chimeric phosphorothioate oligonucleotides having 2′-MOE wings and a deoxy gap TARGET SEQ ID TARGET % SEQ ID CONTROL ISIS # REGION NO SITE SEQUENCE INHIB NO SEQ ID NO 275615 5′UTR 4 157 tgctttcgcgattacagaga 44 17 1 275616 Start 4 171 aggtcttccatggttgcttt 54 18 1 Codon 275617 Coding 4 239 cctccacacgctgagagatg 52 19 1 275618 Coding 4 291 tgcatctgcagagaacctgg 31 20 1 275619 Coding 4 300 tgctggtactgcatctgcag 21 21 1 275620 Coding 4 323 ctctttcctccagctgcatg 54 22 1 275621 Coding 4 328 ctctgctctttcctccagct 73 23 1 275622 Coding 4 333 atctgctctgctctttcctc 66 24 1 275623 Coding 4 389 tcagctccatctgcattttc 70 25 1 275624 Coding 4 427 ggctgctctctccagctcca 76 26 1 275625 Coding 4 432 gtgctggctgctctctccag 60 27 1 275626 Coding 4 557 gcctgttgcgctccagctgc 81 28 1 275627 Coding 4 663 tccgagatcctccccttcag 65 29 1 275628 Coding 4 692 tctcctggtccatcacgctc 67 30 1 275629 Coding 4 723 tgcttctccgactccaggcg 64 31 1 275630 Coding 4 785 ggattttctgattggcttcc 62 32 1 275631 Coding 4 860 gggacagcttctgctccaga 57 33 1 275632 Coding 4 874 atcctgctcttgcagggaca 59 34 1 275633 Coding 4 990 agcccgttggtctctctcat 63 35 1 275634 Coding 4 995 ggagcagcccgttggtctct 68 36 1 275635 Coding 4 1081 ctcgttctccagctccaagc 69 37 1 275636 Coding 4 1099 cagcttggccagcagcctct 73 38 1 275637 Coding 4 1105 gctttgcagcttggccagca 65 39 1 275638 Coding 4 1179 agctcaaccacgaatctgga 67 40 1 275639 Coding 4 1194 agctccctctgctgcagctc 63 41 1 275640 Coding 4 1295 gctggccgctgacctgccgg 60 42 1 275641 Coding 4 1307 tctcctccaacagctggccg 65 43 1 275642 Coding 4 1314 ttcttcctctcctccaacag 57 44 1 275643 Coding 4 1352 tctggagcctccgggccagc 56 45 1 275644 Coding 4 1527 gacagctgagcctccatctc 73 46 1 275645 Coding 4 1646 cctccctggagaacaggaag 30 47 1 275646 Coding 4 1662 Ctgagcgtgtccgcctcctc 67 48 1 275647 Coding 4 1679 gctcctcgaccttcaacctg 49 49 1 275648 Coding 4 1740 cgctccagctgtgcctccag 38 50 1 275649 Coding 4 1763 catagtcaccctgcagagct 52 51 1 275650 Coding 4 1791 atgtgcagcactttggtcct 50 52 1 275651 Coding 4 1849 cagctggctgtggtcctcgc 53 53 1 275652 Coding 4 1968 agctctgccacctccttgga 38 54 1 275653 Coding 4 2010 agccgctggttcttcagctc 24 55 1 275654 Coding 4 2015 ccttgagccgctggttcttc 21 56 1 275655 Coding 4 2020 aacctccttgagccgctggt 60 57 1 275656 Coding 4 2025 tggaaaacctccttgagccg 31 58 1 275657 Coding 4 2031 ttggtctggaaaacctcctt 32 59 1 275658 Coding 4 2036 ggatcttggtctggaaaacc 45 60 1 275659 Coding 4 2041 ctcctggatcttggtctgga 26 61 1 275660 Coding 4 2046 cggaactcctggatcttggt 47 62 1 275661 Coding 4 2087 tgatgtcgatctggtagccg 36 63 1 275662 Coding 4 2148 gatgagcagtcgcctgggtg 15 64 1 275663 Coding 4 2164 ggctggtggccttgaagatg 12 65 1 275664 Coding 4 2264 aaggcagggatgctgtcctg 25 66 1 275665 Coding 4 2270 ctgaggaaggcagggatgct 29 67 1 275666 Coding 4 2475 ccagcaggaagcccgacgta 28 68 1 275667 Coding 4 2483 tggccgccccagcaggaagc 46 69 1 275668 Coding 4 2555 gaacccaggctggtggccga 6 70 1 275669 Stop 4 2581 gagaagattttatttcacaa 3 71 1 Codon 286270 Coding 4 271 gctcagccgctcgcagccag 70 72 1 275671 5′UTR 11 68 tggagtgctgctcagccgct 65 73 1 275672 5′UTR 12 2 ggagaggaagagcctcgtgc 26 74 1 275673 Coding 4 1175 tctcatctcccgcaggtgcg 74 75 1 275674 Coding 13 111 gctgtgcagcttcctcgaga 26 76 1 275675 Coding 13 231 caggctattcattctgcccc 34 77 1 275676 Exon: 13 430 cccccgggcgcagcagtgaa 43 78 1 exon Junction 275677 Coding 14 15 tgatacgctttggctgcgtc 0 79 1 275678 Exon: 14 266 gcgccggtggctgccatgag 47 80 1 exon Junction 275679 Coding 15 12 tcttcaccatcctacggagc 19 81 1 275680 Coding 15 291 ggcagccctgccgctgggcc 40 82 1 275681 Exon: 15 462 catagtcaccctggaccagg 0 83 1 exon junction 275682 Intron: 16 11292 cgacctcacgctgttaagag 50 84 1 exon junction 275683 Intron: 16 84823 ccaggtctacctgctggtga 24 85 1 exon junction 275684 Intron: 16 145014 gcgcctcacccggtggctgc 32 86 1 exon junction 275685 Intron: 16 145181 agattctcaccagcagtgaa 41 87 1 exon junction 275686 Intron 16 165284 atgctccagcgacctctgct 68 88 1 275687 Intron 16 284193 ctacagaaatgtcaggtaag 11 89 1 275688 Intron: 16 286350 gccctcacctgcagagctcg 36 90 1 exon junction 275689 Intron 16 294614 aaaccaaagacgtggatctc 38 91 1 275690 Intron: 16 303821 gtttgcagacacggctcgct 26 92 1 exon junction 275691 Intron: 16 303892 acatgctgacctggaccagg 34 93 1 exon junction 275692 Intron 16 328782 agagatgaaccccctgccct 28 94 1

[0220] As shown in Table 1, SEQ ID NOs 17, 18, 19, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 48, 49, 51, 52, 53, 57, 60, 62, 69, 72, 73, 75, 78, 80, 82, 84, 87 and 88 demonstrated at least 40% inhibition of human MAD1-like 1 expression in this assay and are therefore preferred. More preferred are SEQ ID NOs: 26, 28 and 75. The target regions to which these preferred sequences are complementary are herein referred to as “preferred target segments ” and are therefore preferred for targeting by compounds of the present invention. These preferred target segments are shown in Table 2. The sequences represent the reverse complement of the preferred antisense compounds shown in Table 1. “Target site” indicates the first (5′-most mucleotide number on the particular target nucleic acid to which the oligonucleotide binds. Also shown in Table 2 is the species in which each of the preferred target segments was found. TABLE 2 Sequence and position of preferred target segments identified in MAD1-like 1. TARGET SEQ ID TARGET REV COMP SEQ ID SITE ID NO SITE SEQUENCE OF SEQ ID ACTIVE IN NO 191833 4 157 tctctgtaatcgcgaaagca 17 H. sapiens 95 191834 4 171 aaagcaaccatggaagacct 18 H. sapiens 96 191835 4 239 catctctcagcgtgtggagg 19 H. sapiens 97 191838 4 323 catgcagctggaggaaagag 22 H. sapiens 98 191839 4 328 agctggaggaaagagcagag 23 H. sapiens 99 191840 4 333 gaggaaagagcagagcagat 24 H. sapiens 100 191841 4 389 gaaaatgcagatggagctga 25 H. sapiens 101 191842 4 427 tggagctggagagagcagcc 26 H. sapiens 102 191843 4 432 ctggagagagcagccagcac 27 H. sapiens 103 191844 4 557 gcagctggagcgcaacaggc 28 H. sapiens 104 191845 4 663 ctgaaggggaggatctcgga 29 H. sapiens 105 191846 4 692 gagcgtgatggaccaggaga 30 H. sapiens 106 191847 4 723 cgcctggagtcggagaagca 31 H. sapiens 107 191848 4 785 ggaagccaatcagaaaatcc 32 H. sapiens 108 191849 4 860 tctggagcagaagctgtccc 33 H. sapiens 109 191850 4 874 tgtccctgcaagagcaggat 34 H. sapiens 110 191851 4 990 atgagagagaccaacgggct 35 H. sapiens 111 191852 4 995 agagaccaacgggctgctcc 36 H. sapiens 112 191853 4 1081 gcttggagctggagaacgag 37 H. sapiens 113 191854 4 1099 agaggctgctggccaagctg 38 H. sapiens 114 191855 4 1105 tgctggccaagctgcaaagc 39 H. sapiens 115 191856 4 1179 tccagattcgtggttgagct 40 H. sapiens 116 191857 4 1194 gagctgcagcagagggagct 41 H. sapiens 117 191858 4 1295 ccggcaggtcagcggccagc 42 H. sapiens 118 191859 4 1307 cggccagctgttggaggaga 43 H. sapiens 119 191860 4 1314 ctgttggaggagaggaagaa 44 H. sapiens 120 191861 4 1352 gctggcccggaggctccaga 45 H. sapiens 121 191862 4 1527 gagatggaggctcagctgtc 46 H. sapiens 122 191864 4 1662 gaggaggcggacacgctcag 48 H. sapiens 123 191865 4 1679 caggttgaaggtcgaggagc 49 H. sapiens 124 191867 4 1763 agctctgcagggtgactatg 51 H. sapiens 125 191868 4 1791 aggaccaaagtgctgcacat 52 H. sapiens 126 191869 4 1849 gcgaggaccacagccagctg 53 H. sapiens 127 191873 4 2020 accagcggctcaaggaggtt 57 H. sapiens 128 191876 4 2036 ggttttccagaccaagatcc 60 H. sapiens 129 191878 4 2046 accaagatccaggagttccg 62 H. sapiens 130 191885 4 2483 gcttcctgctggggcggcca 69 H. sapiens 131 191888 11 59 ctggctgcgagcggctgagc 72 H. sapiens 132 191889 11 68 agcggctgagcagcactcca 73 H. sapiens 133 191891 12 1022 cgcacctgcgggagatgaga 75 H. sapiens 134 191894 13 430 ttcactgctgcgcccggggg 78 H. sapiens 135 191896 14 266 ctcatggcagccaccggcgc 80 H. sapiens 136 191898 15 291 ggcccagcggcagggctgcc 82 H. sapiens 137 191900 16 11292 ctcttaacagcgtgaggtcg 84 H. sapiens 138 191903 16 145181 ttcactgctggtgagaatct 87 H. sapiens 139 191904 16 165284 agcagaggtcgctggagcat 88 H. sapiens 140

[0221] As these “preferred target segments” have been found by experimentation to be open to, and accessible for, hybridization with the antisense compounds of the present invention, one of skill in the art will recognize or be able to ascertain, using no more than routine experimentation, further embodiments of the invention that encompass other compounds that specifically hybridize to these preferred target segments and consequently inhibit the expression of MAD1-like 1.

[0222] According to the present invention, antisense compounds include antisense oligomeric compounds, antisense oligonucleotides, ribozymes, external guide sequence (EGS) oligonucleotides, alternate splicers, primers, probes, and other short oligomeric compounds which hybridize to at least a portion of the target nucleic acid.

Example 16

[0223] Western Blot Analysis of MAD1-like 1 Protein Levels

[0224] Western blot analysis (immunoblot analysis) is carried out using standard methods. Cells are harvested 16-20 h after oligonucleotide treatment, washed once with PBS, suspended in Laemmli buffer (100 ul/well), boiled for 5 minutes and loaded on a 16% SDS-PAGE gel. Gels are run for 1.5 hours at 150 V, and transferred to membrane for western blotting. Appropriate primary antibody directed to MAD1-like 1 is used, with a radiolabeled or fluorescently labeled secondary antibody directed against the primary antibody species. Bands are visualized using a PHOSPHORIMAGER™ (Molecular Dynamics, Sunnyvale Calif.).

1 140 1 20 DNA Artificial Sequence Antisense Oligonucleotide 1 tccgtcatcg ctcctcaggg 20 2 20 DNA Artificial Sequence Antisense Oligonucleotide 2 gtgcgcgcga gcccgaaatc 20 3 20 DNA Artificial Sequence Antisense Oligonucleotide 3 atgcattctg cccccaagga 20 4 2608 DNA H. sapiens CDS (180)...(2591) 4 agctcgccgg cctttggtct ccaggacttg tcccagcagc ccctcgaact gagaattaca 60 ccatcggacc cctggctctg aggccttcag acttggactg tgtcacactg ccaggcttcc 120 agggctccaa cttgcagacg gcctgttgtg ggacagtctc tgtaatcgcg aaagcaacc 179 atg gaa gac ctg ggg gaa aac acc atg gtt tta tcc acc ctg aga tct 227 Met Glu Asp Leu Gly Glu Asn Thr Met Val Leu Ser Thr Leu Arg Ser 1 5 10 15 ttg aac aac ttc atc tct cag cgt gtg gag gga ggc tct gga ctg gat 275 Leu Asn Asn Phe Ile Ser Gln Arg Val Glu Gly Gly Ser Gly Leu Asp 20 25 30 att tct acc tcg gcc cca ggt tct ctg cag atg cag tac cag cag agc 323 Ile Ser Thr Ser Ala Pro Gly Ser Leu Gln Met Gln Tyr Gln Gln Ser 35 40 45 atg cag ctg gag gaa aga gca gag cag atc cgt tcg aag tcc cac ctc 371 Met Gln Leu Glu Glu Arg Ala Glu Gln Ile Arg Ser Lys Ser His Leu 50 55 60 atc cag gtg gag cgg gag aaa atg cag atg gag ctg agt cac aag agg 419 Ile Gln Val Glu Arg Glu Lys Met Gln Met Glu Leu Ser His Lys Arg 65 70 75 80 gct cga gtg gag ctg gag aga gca gcc agc acc agt gcc agg aac tac 467 Ala Arg Val Glu Leu Glu Arg Ala Ala Ser Thr Ser Ala Arg Asn Tyr 85 90 95 gag cgt gag gtc gac cgc aac cag gag ctc ctg acg cgc atc cgg cag 515 Glu Arg Glu Val Asp Arg Asn Gln Glu Leu Leu Thr Arg Ile Arg Gln 100 105 110 ctt cag gag cgg gag gcc ggg gcg gag gag aag atg cag gag cag ctg 563 Leu Gln Glu Arg Glu Ala Gly Ala Glu Glu Lys Met Gln Glu Gln Leu 115 120 125 gag cgc aac agg cag tgt cag cag aac ttg gat gct gcc agc aag agg 611 Glu Arg Asn Arg Gln Cys Gln Gln Asn Leu Asp Ala Ala Ser Lys Arg 130 135 140 ctg cgt gag aaa gag gac agt ctg gcc cag gct ggc gag acc atc aac 659 Leu Arg Glu Lys Glu Asp Ser Leu Ala Gln Ala Gly Glu Thr Ile Asn 145 150 155 160 gca ctg aag ggg agg atc tcg gaa ctg cag tgg agc gtg atg gac cag 707 Ala Leu Lys Gly Arg Ile Ser Glu Leu Gln Trp Ser Val Met Asp Gln 165 170 175 gag atg cgg gtg aag cgc ctg gag tcg gag aag cag gac gtg cag gag 755 Glu Met Arg Val Lys Arg Leu Glu Ser Glu Lys Gln Asp Val Gln Glu 180 185 190 cag ctg gac ctg caa cac aaa aaa tgc cag gaa gcc aat cag aaa atc 803 Gln Leu Asp Leu Gln His Lys Lys Cys Gln Glu Ala Asn Gln Lys Ile 195 200 205 cag gaa ctc cag gcc agc caa gaa gca aga gca gac cac gag cag cag 851 Gln Glu Leu Gln Ala Ser Gln Glu Ala Arg Ala Asp His Glu Gln Gln 210 215 220 att aag gat ctg gag cag aag ctg tcc ctg caa gag cag gat gca gcg 899 Ile Lys Asp Leu Glu Gln Lys Leu Ser Leu Gln Glu Gln Asp Ala Ala 225 230 235 240 att gtg aag aac atg aag tct gag ctg gta cgg ctc cct agg ctg gaa 947 Ile Val Lys Asn Met Lys Ser Glu Leu Val Arg Leu Pro Arg Leu Glu 245 250 255 cgg gag ctg gag cag ctg cgg gag gag agc gca ctg cgg gag atg aga 995 Arg Glu Leu Glu Gln Leu Arg Glu Glu Ser Ala Leu Arg Glu Met Arg 260 265 270 gag acc aac ggg ctg ctc cag gaa gag ctg gaa ggg ctg cag agg aag 1043 Glu Thr Asn Gly Leu Leu Gln Glu Glu Leu Glu Gly Leu Gln Arg Lys 275 280 285 ctg ggg cgc cag gag aag atg cag gag acg ctg gtt ggc ttg gag ctg 1091 Leu Gly Arg Gln Glu Lys Met Gln Glu Thr Leu Val Gly Leu Glu Leu 290 295 300 gag aac gag agg ctg ctg gcc aag ctg caa agc tgg gag aga ctg gac 1139 Glu Asn Glu Arg Leu Leu Ala Lys Leu Gln Ser Trp Glu Arg Leu Asp 305 310 315 320 cag acc atg ggc ctg agc atc agg act cca gaa gac ctt tcc aga ttc 1187 Gln Thr Met Gly Leu Ser Ile Arg Thr Pro Glu Asp Leu Ser Arg Phe 325 330 335 gtg gtt gag ctg cag cag agg gag ctt gcc ttg aag gac aag aac agc 1235 Val Val Glu Leu Gln Gln Arg Glu Leu Ala Leu Lys Asp Lys Asn Ser 340 345 350 gcc gtc acc agc agc gcc cgg ggg ctg gag aag gcc agg cag cag ctg 1283 Ala Val Thr Ser Ser Ala Arg Gly Leu Glu Lys Ala Arg Gln Gln Leu 355 360 365 cag gag gag ctc cgg cag gtc agc ggc cag ctg ttg gag gag agg aag 1331 Gln Glu Glu Leu Arg Gln Val Ser Gly Gln Leu Leu Glu Glu Arg Lys 370 375 380 aag cgc gag acc cac gag gcg ctg gcc cgg agg ctc cag aaa cgg gtc 1379 Lys Arg Glu Thr His Glu Ala Leu Ala Arg Arg Leu Gln Lys Arg Val 385 390 395 400 ctg ctg ctc acc aag gag cgg gac ggt atg cgg gcc atc ctg ggg tcc 1427 Leu Leu Leu Thr Lys Glu Arg Asp Gly Met Arg Ala Ile Leu Gly Ser 405 410 415 tac gac agc gag ctg acc ccg gcc gag tac tca ccc cag ctg acg cgg 1475 Tyr Asp Ser Glu Leu Thr Pro Ala Glu Tyr Ser Pro Gln Leu Thr Arg 420 425 430 cgc atg cgg gag gct gag gat atg gtg cag aag gtg cac agc cac agc 1523 Arg Met Arg Glu Ala Glu Asp Met Val Gln Lys Val His Ser His Ser 435 440 445 gcc gag atg gag gct cag ctg tcg cag gcc ctg gag gag ctg gga ggc 1571 Ala Glu Met Glu Ala Gln Leu Ser Gln Ala Leu Glu Glu Leu Gly Gly 450 455 460 cag aaa caa aga gca gac atg ctg gag atg gag ctg aag atg ctg aag 1619 Gln Lys Gln Arg Ala Asp Met Leu Glu Met Glu Leu Lys Met Leu Lys 465 470 475 480 tct cag tcc agc tct gcc gaa cag agc ttc ctg ttc tcc agg gag gag 1667 Ser Gln Ser Ser Ser Ala Glu Gln Ser Phe Leu Phe Ser Arg Glu Glu 485 490 495 gcg gac acg ctc agg ttg aag gtc gag gag ctg gaa ggc gag cgg agt 1715 Ala Asp Thr Leu Arg Leu Lys Val Glu Glu Leu Glu Gly Glu Arg Ser 500 505 510 cgg ctg gag gag gaa aag agg atg ctg gag gca cag ctg gag cgg cga 1763 Arg Leu Glu Glu Glu Lys Arg Met Leu Glu Ala Gln Leu Glu Arg Arg 515 520 525 gct ctg cag ggt gac tat gac cag agc agg acc aaa gtg ctg cac atg 1811 Ala Leu Gln Gly Asp Tyr Asp Gln Ser Arg Thr Lys Val Leu His Met 530 535 540 agc ctg aac ccc acc agt gtg gcc agg cag cgc ctg cgc gag gac cac 1859 Ser Leu Asn Pro Thr Ser Val Ala Arg Gln Arg Leu Arg Glu Asp His 545 550 555 560 agc cag ctg cag gcg gag tgc gag cga ctg cgc ggg ctc ctg cgc gcc 1907 Ser Gln Leu Gln Ala Glu Cys Glu Arg Leu Arg Gly Leu Leu Arg Ala 565 570 575 atg gag aga gga ggc acc gtc cca gcc gac ctt gag gct gcc gcc gcg 1955 Met Glu Arg Gly Gly Thr Val Pro Ala Asp Leu Glu Ala Ala Ala Ala 580 585 590 agt ctg cca tcg tcc aag gag gtg gca gag ctg aag aag cag gtg gag 2003 Ser Leu Pro Ser Ser Lys Glu Val Ala Glu Leu Lys Lys Gln Val Glu 595 600 605 agt gcc gag ctg aag aac cag cgg ctc aag gag gtt ttc cag acc aag 2051 Ser Ala Glu Leu Lys Asn Gln Arg Leu Lys Glu Val Phe Gln Thr Lys 610 615 620 atc cag gag ttc cgc aag gcc tgc tac acg ctc acc ggc tac cag atc 2099 Ile Gln Glu Phe Arg Lys Ala Cys Tyr Thr Leu Thr Gly Tyr Gln Ile 625 630 635 640 gac atc acc acg gag aac cag tac cgg ctg acc tcg ctg tac gcc gag 2147 Asp Ile Thr Thr Glu Asn Gln Tyr Arg Leu Thr Ser Leu Tyr Ala Glu 645 650 655 cac cca ggc gac tgc tca tct tca agg cca cca gcc cct cgg gtt cca 2195 His Pro Gly Asp Cys Ser Ser Ser Arg Pro Pro Ala Pro Arg Val Pro 660 665 670 aga tgc agc tac tgg aga cag agt tct cac aca ccg tgg gcg agc tca 2243 Arg Cys Ser Tyr Trp Arg Gln Ser Ser His Thr Pro Trp Ala Ser Ser 675 680 685 tcg agg tgc acc tgc ggc gcc agg aca gca tcc ctg cct tcc tca gct 2291 Ser Arg Cys Thr Cys Gly Ala Arg Thr Ala Ser Leu Pro Ser Ser Ala 690 695 700 cgc tca ccc tcg agc tct tca gcc gcc aga ccg tgg cgt agc ctg cag 2339 Arg Ser Pro Ser Ser Ser Ser Ala Ala Arg Pro Trp Arg Ser Leu Gln 705 710 715 720 gct cgg ggg cat agc cgg agc cac tct gct tgg cct gac ctg cag gtc 2387 Ala Arg Gly His Ser Arg Ser His Ser Ala Trp Pro Asp Leu Gln Val 725 730 735 ccc tgc ccc gcc agc cac agg ctg ggt gca cgt cct gcc tct cca gcc 2435 Pro Cys Pro Ala Ser His Arg Leu Gly Ala Arg Pro Ala Ser Pro Ala 740 745 750 cca cag ggc agc agc atg act gac aga cac gct ggg acc tac gtc ggg 2483 Pro Gln Gly Ser Ser Met Thr Asp Arg His Ala Gly Thr Tyr Val Gly 755 760 765 ctt cct gct ggg gcg gcc agc acc ctc tcc acg tgc aga ccc cat gcg 2531 tcc cgg agc ctg gtg tgt ggg cgt cgg cca cca gcc tgg gtt cct cac 2579 Ser Arg Ser Leu Val Cys Gly Arg Arg Pro Pro Ala Trp Val Pro His 770 775 780 ctt gtg aaa taa aatcttctcc cctaaaa 2608 Leu Val Lys 785 5 17 DNA Artificial Sequence PCR Primer 5 aggctgctgg ccaagct 17 6 22 DNA Artificial Sequence PCR Primer 6 ctcaaccacg aatctggaaa gg 22 7 24 DNA Artificial Sequence PCR Probe 7 agaccatggg cctgagcatc agga 24 8 19 DNA Artificial Sequence PCR Primer 8 gaaggtgaag gtcggagtc 19 9 20 DNA Artificial Sequence PCR Primer 9 gaagatggtg atgggatttc 20 10 20 DNA Artificial Sequence PCR Probe 10 caagcttccc gttctcagcc 20 11 562 DNA Homo sapiens 11 agtgtcgcga taaatgggcg ccggcggagc ggagggagat ccgagcggcg gcggcaagct 60 ggctgcgagc ggctgagcag cactccaagc tcgccggcct ttggtctcca ggacttgtcc 120 cagcagcccc tcgaactgag aattacacca tcggaccttt ggctctgagg ccttcagact 180 tggactgtgt cacactgcca ggcttccagg gctccaactt gcagacggcc tgttgtggga 240 cagtctctgt aatcgcgaaa gcaaccatgg aagacctggg ggaaaacacc atggttttat 300 ccaccctgag atctttgaac aacttcatct ctcagcgtgt ggagggaggc tctggactgg 360 atatttctac ctcggcccca ggttctctgc agatgcagta ccagcagagc atgcagctgg 420 aggaaagagc agagcagatc cgttcgaagt cccacctcat ccaggtggag cgggagaaaa 480 tgcagatgga gctgagtcac aagagggctc gagtggagct ggagagagca gccagcacca 540 gtgccaggaa ctacgagcgt ga 562 12 2703 DNA Homo sapiens CDS (223)...(2379) 12 ggcacgaggc tcttcctctc ctctcctcaa cagcagcact ccaagctcgc cggcctttgg 60 tctccaggac ttgtcccagc agcccctcga actgagaatt acaccatcgg acccctggct 120 ctgaggcctt cagacttgga ctgtgtcaca ctgccaggct tccagggctc caacttgcag 180 acggcctgtt gtgggacagt ctctgtaatc gcgaaagcaa cc atg gaa gac ctg 234 Met Glu Asp Leu 1 ggg gaa aac acc atg gtt tta tcc acc ctg aga tct ttg aac aac ttc 282 Gly Glu Asn Thr Met Val Leu Ser Thr Leu Arg Ser Leu Asn Asn Phe 5 10 15 20 atc tct cag cgt gtg gag gga ggc tct gga ctg gat att tct acc tcg 330 Ile Ser Gln Arg Val Glu Gly Gly Ser Gly Leu Asp Ile Ser Thr Ser 25 30 35 gcc cca ggt tct ctg cag atg cag tac cag cag agc atg cag ctg gag 378 Ala Pro Gly Ser Leu Gln Met Gln Tyr Gln Gln Ser Met Gln Leu Glu 40 45 50 gaa aga gca gag cag atc cgt tcg aag tcc cac ctc atc cag gtg gag 426 Glu Arg Ala Glu Gln Ile Arg Ser Lys Ser His Leu Ile Gln Val Glu 55 60 65 cgg gag aaa atg cag atg gag ctg agt cac aag agg gct cga gtg gag 474 Arg Glu Lys Met Gln Met Glu Leu Ser His Lys Arg Ala Arg Val Glu 70 75 80 ctg gag aga gca gcc agc acc agt gcc agg aac tac gag cgt gag gtc 522 Leu Glu Arg Ala Ala Ser Thr Ser Ala Arg Asn Tyr Glu Arg Glu Val 85 90 95 100 gac cgc aac cag gag ctc ctg acg cgc atc cgg cag ctt cag gag cgg 570 Asp Arg Asn Gln Glu Leu Leu Thr Arg Ile Arg Gln Leu Gln Glu Arg 105 110 115 gag gcc ggg gcg gag gag aag atg cag gag cag ctg gag cgc aac agg 618 Glu Ala Gly Ala Glu Glu Lys Met Gln Glu Gln Leu Glu Arg Asn Arg 120 125 130 cag tgt cag cag aac ttg gat gct gcc agc aag agg ctg cgt gag aaa 666 Gln Cys Gln Gln Asn Leu Asp Ala Ala Ser Lys Arg Leu Arg Glu Lys 135 140 145 gag gac agt ctg gcc cag gct ggc gag acc atc aac gca ctg aag ggg 714 Glu Asp Ser Leu Ala Gln Ala Gly Glu Thr Ile Asn Ala Leu Lys Gly 150 155 160 agg atc tcg gaa ctg cag tgg agc gtg atg gac cag gag atg cgg gtg 762 Arg Ile Ser Glu Leu Gln Trp Ser Val Met Asp Gln Glu Met Arg Val 165 170 175 180 aag cgc ctg gag tcg gag aag cag gag ctg cag gag cag ctg gac ctg 810 Lys Arg Leu Glu Ser Glu Lys Gln Glu Leu Gln Glu Gln Leu Asp Leu 185 190 195 caa cac aaa aaa tgc cag gaa gcc aat cag aaa atc cag gaa ctc cag 858 Gln His Lys Lys Cys Gln Glu Ala Asn Gln Lys Ile Gln Glu Leu Gln 200 205 210 gcc agc caa gaa gca aga gca gac cac gag cag cag att aag gat ctg 906 Ala Ser Gln Glu Ala Arg Ala Asp His Glu Gln Gln Ile Lys Asp Leu 215 220 225 gag cag aag ctg tcc ctg caa gag cag gat gca gcg att gtg aag aac 954 Glu Gln Lys Leu Ser Leu Gln Glu Gln Asp Ala Ala Ile Val Lys Asn 230 235 240 atg aag tct gag ctg gta cgg ctc cct agg ctg gaa cgg gag ctg aag 1002 Met Lys Ser Glu Leu Val Arg Leu Pro Arg Leu Glu Arg Glu Leu Lys 245 250 255 260 cag ctg cgg gag gag agc gcg cac ctg cgg gag atg aga gag acc aac 1050 Gln Leu Arg Glu Glu Ser Ala His Leu Arg Glu Met Arg Glu Thr Asn 265 270 275 ggg ctg ctc cag gaa gag ctg gaa ggg ctg cag agg aag ctg ggg cgc 1098 Gly Leu Leu Gln Glu Glu Leu Glu Gly Leu Gln Arg Lys Leu Gly Arg 280 285 290 cag gag aag atg cag gag acg ctg gtt ggc ttg gag ctg gag aac gag 1146 Gln Glu Lys Met Gln Glu Thr Leu Val Gly Leu Glu Leu Glu Asn Glu 295 300 305 agg ctg ctg gcc aag ctg caa agc tgg gag aga ctg gac cag acc atg 1194 Arg Leu Leu Ala Lys Leu Gln Ser Trp Glu Arg Leu Asp Gln Thr Met 310 315 320 ggc ctg agc atc agg act cca gaa gac ctt tcc aga ttc gtg gtt gag 1242 Gly Leu Ser Ile Arg Thr Pro Glu Asp Leu Ser Arg Phe Val Val Glu 325 330 335 340 ctg cag cag agg gag ctt gcc ttg aag gac aag aac agc gcc gtc acc 1290 Leu Gln Gln Arg Glu Leu Ala Leu Lys Asp Lys Asn Ser Ala Val Thr 345 350 355 agc agc gcc cgg ggg ctg gag aag gcc agg cag cag ctg cag gag gag 1338 Ser Ser Ala Arg Gly Leu Glu Lys Ala Arg Gln Gln Leu Gln Glu Glu 360 365 370 ctc cgg cag gtc agc ggc cag ctg ttg gag gag agg aag aag cgc gag 1386 Leu Arg Gln Val Ser Gly Gln Leu Leu Glu Glu Arg Lys Lys Arg Glu 375 380 385 acc cac gag gcg ctg gcc cgg agg ctc cag aaa cgg gtc ctg ctg ctc 1434 Thr His Glu Ala Leu Ala Arg Arg Leu Gln Lys Arg Val Leu Leu Leu 390 395 400 acc aag gag cgg gac ggt atg cgg gcc atc ctg ggg tcc tac gac agc 1482 Thr Lys Glu Arg Asp Gly Met Arg Ala Ile Leu Gly Ser Tyr Asp Ser 405 410 415 420 gag ctg acc ccg gcc gag tac tca ccc cag ctg acg cgg cgc atg cgg 1530 Glu Leu Thr Pro Ala Glu Tyr Ser Pro Gln Leu Thr Arg Arg Met Arg 425 430 435 gag gct gag gat atg gtg cag aag gtg cac agc cac agc gcc gag atg 1578 Glu Ala Glu Asp Met Val Gln Lys Val His Ser His Ser Ala Glu Met 440 445 450 gag gct cag ctg tcg cag gcc ctg gag gag ctg gga ggc cag aaa caa 1626 Glu Ala Gln Leu Ser Gln Ala Leu Glu Glu Leu Gly Gly Gln Lys Gln 455 460 465 aga gca gac atg ctg gag atg gag ctg aag atg ctg aag tct cag tcc 1674 Arg Ala Asp Met Leu Glu Met Glu Leu Lys Met Leu Lys Ser Gln Ser 470 475 480 agc tct gcc gaa cag agc ttc ctg ttc tcc agg gag gag gcg gac acg 1722 Ser Ser Ala Glu Gln Ser Phe Leu Phe Ser Arg Glu Glu Ala Asp Thr 485 490 495 500 ctc agg ttg aag gtc gag gag ctg gaa ggc gag cgg agt cgg ctg gag 1770 Leu Arg Leu Lys Val Glu Glu Leu Glu Gly Glu Arg Ser Arg Leu Glu 505 510 515 gag gaa aag agg atg ctg gag gca cag ctg gag cgg cga gct ctg cag 1818 Glu Glu Lys Arg Met Leu Glu Ala Gln Leu Glu Arg Arg Ala Leu Gln 520 525 530 ggt gac tat gac cag agc agg acc aaa gtg ctg cac atg agc ctg aac 1866 Gly Asp Tyr Asp Gln Ser Arg Thr Lys Val Leu His Met Ser Leu Asn 535 540 545 ccc acc agt gtg gcc agg cag cgc ctg cgc gag gac cac agc cag ctg 1914 Pro Thr Ser Val Ala Arg Gln Arg Leu Arg Glu Asp His Ser Gln Leu 550 555 560 cag gcg gag tgc gag cga ctg cgc ggg ctc ctg cgc gcc atg gag aga 1962 Gln Ala Glu Cys Glu Arg Leu Arg Gly Leu Leu Arg Ala Met Glu Arg 565 570 575 580 gga ggc acc gtc cca gcc gac ctt gag gct gcc gcc gcg agt ctg cca 2010 Gly Gly Thr Val Pro Ala Asp Leu Glu Ala Ala Ala Ala Ser Leu Pro 585 590 595 tcg tcc aag gag gtg gca gag ctg aag aag cag gtg gag agt gcc gag 2058 Ser Ser Lys Glu Val Ala Glu Leu Lys Lys Gln Val Glu Ser Ala Glu 600 605 610 ctg aag aac cag cgg ctc aag gag gtt ttc cag acc aag atc cag gag 2106 Leu Lys Asn Gln Arg Leu Lys Glu Val Phe Gln Thr Lys Ile Gln Glu 615 620 625 ttc cgc aag gcc tgc tac acg ctc acc ggc tac cag atc gac atc acc 2154 Phe Arg Lys Ala Cys Tyr Thr Leu Thr Gly Tyr Gln Ile Asp Ile Thr 630 635 640 acg gag aac cag tac cgg ctg acc tcg ctg tac gcc gag cac cca ggc 2202 Thr Glu Asn Gln Tyr Arg Leu Thr Ser Leu Tyr Ala Glu His Pro Gly 645 650 655 660 gac tgc ctc atc ttc aag gcc acc agc ccc tcg ggt tcc aag atg cag 2250 Asp Cys Leu Ile Phe Lys Ala Thr Ser Pro Ser Gly Ser Lys Met Gln 665 670 675 cta ctg gag aca gag ttc tca cac acc gtg ggc gag ctc atc gag gtg 2298 Leu Leu Glu Thr Glu Phe Ser His Thr Val Gly Glu Leu Ile Glu Val 680 685 690 cac ctg cgg cgc cag gac agc atc cct gcc ttc ctc agc tcg ctc acc 2346 His Leu Arg Arg Gln Asp Ser Ile Pro Ala Phe Leu Ser Ser Leu Thr 695 700 705 ctc gag ctc ttc agc cgc cag acc gtg gcg tag cctgcaggct cgggggcata 2399 Leu Glu Leu Phe Ser Arg Gln Thr Val Ala * 710 715 gccggagcca ctctgcttgg cctgacctgc aggtcccctg ccccgccagc cacaggctgg 2459 gtgcacgtcc tgcctctcca gccccacagg gcagcagcat gactgacaga cacgctggga 2519 cctacgtcgg gcttcctgct ggggcggcca gcactctctc cacgtgcaga ccccatgcgt 2579 cccggagcct ggtgtgtggg cgtcggccac cagcctgggt tcctcacctt gtgaaataaa 2639 atcttctccc ctagaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa 2699 aaaa 2703 13 733 DNA Homo sapiens 13 gcggggacgc agccaaacca tatcaccttg gctgtggcct ccactgtgcc tgggactggc 60 cacagagagc tgtgtctccg tggctgcctt ctccttgcct gtttgcgtgg tctcgaggaa 120 gctgcacagc agggcccgag tcggccgtgt gagccgctct ccctgtcaaa gcacacccat 180 ccctgcctgc tttgacctga acttggtgac cttcaggcca tcagtggagt ggggcagaat 240 gaatagcctg tcctggctca tggcagccac cgggtgaggc gcctgcatgc gtggctcgga 300 ggccttctgc aggcacaacc cccaccgtgg gcctggcagc ttgtgtggga ggcgtgcggg 360 tcggtggcag agggtgagca ccagccctgt gtgaaccttc acaactcctc tgtggaccct 420 ggacttggct tcactgctgc gcccgggggc tggagaaggc caggcagcag ctgcaggagg 480 agctccggca ggtcagcggc cagctgtcgg aggagaggaa gaagcgcgag acccacgagg 540 cgctggcccg gaggctccag aaacgggtcc tgctgctcac caaggagcgg gacggtatgc 600 gggccatcct ggggtcctac gacagcgagc tgaccccggc cgagtactca ccccagctga 660 cgcggcgcat gcgggaggct gaggatatgg tgcagaaggg tgcacaggca cagcgccgag 720 atggagggct cag 733 14 772 DNA Homo sapiens 14 gggatttcca cggggacgca gccaaagcgt atcaccttgg ctgtggcctc cactgtgcct 60 gggactggcc acagagagct gtgtctccgt ggctgccttc tccttgcctg tttgcgtggt 120 ctcgaggaag ctgcacagca gggcccgagt cggccgtgtg agccgctctc cctgtcaaag 180 cacacccatc cctgcctgct ttgacctgaa cttggtgacc ttcaggccat cagtggagtg 240 gggcagaatg aatagcctgt cctggctcat ggcagccacc ggcgcccggg ggctggagaa 300 ggccaggcag cagctgcagg aggagctccg gcaggtcagc ggccagctgt tggaggagag 360 gaagaagcgc gagacccacg aggcgctggc ccggaggctc cagaaacggg tcctgctgct 420 caccaaggag cgggacggta tgcgggccat cctggggtcc tacgacagcg agctgacccc 480 ggccgagtac tcaccccagc tgacgcggcg catgcgggag gctgaggata tggtgcagaa 540 ggtgcacagc cacagcgccg agatggaggc tcagctgtcg caggccctgg aggagctggg 600 aggccagaaa caaagagcag acatgctgga agatggagct gaagatgctg aagtctcagt 660 ccagctctgc cgaacaggag cttcctggtt ctccagggag gaggcggaca cgctcaggtg 720 aaggtcgagg agctggaaag gcgagcggag tcggctggag cgacggaaaa ga 772 15 1324 DNA Homo sapiens 15 ggcacgagga ggctccgtag gatggtgaag aggttgagat gctgtccagc ccacagaggc 60 cccggaaagc cagtgccgcc cgtcagaggg gtctcctgag tgcgtgtggg tggctggatt 120 ctgcatactg ggttatctta accccggctg tgaaaactgg atgaagtagc aatcctttca 180 accccaagag tctgtgattc agccagagtt acaagatgtc tcttcatcct ctgaggttta 240 caaggttctc agaaaacctg tgaagagctg cgcggatcct ctcctgcccc ggcccagcgg 300 cagggctgcc gcctccctct cccctgggcc tgagtgggtg gatttcccct cccctcctcc 360 ttcccaggag aagcacagag ggagcggcca agcgagccgt gtctgcaaac cccgcttccc 420 tctgcggcgg cctctgccat cgtgtcatgg ggccggaggt ccctggtcca gggtgactat 480 gaccagagca ggaccaaagt gctgcacatg agcctgaacc ccaccagtgt ggccaggcag 540 cgcctgcgcg aggaccacag ccagctgcag gcggagtgcg agcgactgcg cgggctcctg 600 cgcgccatgg agagaggagg caccgtccca gccgaccttg aggctgccgc cgcgagtctg 660 ccatcgtcca aggaggtggc agagctgaag aagcaggtgg agagtgccga gctgaagaac 720 cagcggctca aggaggtttt ccagaccaag atccaggagt tccgcaaggc ctgctacacg 780 ctcaccggct accagatcga catcaccacg gagaaccagt accggctgac ctcgctgtac 840 gccgagcacc caggcgactg cctcatcttc aaggccacca gcccctcggg ttccaagatg 900 cagctactgg agacagagtt ctcacacacc gtgggcgagc tcatcgaggt gcacctgcgg 960 cgccaggaca gcatccctgc cttcctcagc tcgctcaccc tcgagctctt cagccgccag 1020 accgtggcgt agcctgcagg ctcgggggca tagccggagc cactctgctt ggcctgacct 1080 gcaggtcccc tgccccgcca gccacaggct gggtgcacgt cctgcctctc cagccgcaca 1140 gggcagcagc atgactgaca gacacgctgg gacctacgtc gggcttcctg ctggggcggc 1200 cagcactctc tccacgtgca gaccccatgc gtcccggagc ctggtgtgtg ggcgtcggcc 1260 accagcctgg gttcctcacc ttgtgaaata aaatcttctc ccctagaaaa aaaaaaaaaa 1320 aaaa 1324 16 347001 DNA Homo sapiens misc_feature 182656-192655 n = A,T,C or G 16 aatctccatc aggaatctgg ggctctgtcc agctccccga aggaaactgc gggtcagatg 60 ttttgatttt tttttttctt tgagaaacag aatctcactc tgtcacccag gctggagtgc 120 agtgaagtga tcttggctca ctgtaagctc cacttcccgg gttcacgcca ttcggcctca 180 gcctcccgag tagctgggac tacaggcgcc catcaccacg cccggctatt tttttttttt 240 ttttttgtat tttcagtaga gacggggttt caccgtgtta gccaggatgg tctcgatctc 300 ctgacctcgt gatccgcctg cctcggcctc ccaaagtgct gggattacag gcgtgagcca 360 ccgcgcccgg ccgccagatg ttttgacttt tcattttatt tctggttgca gtcaggttgt 420 taagtccagg gactcttgcc ctactccacc tcgttctctt attccatttc attcccgggg 480 cacacaactt ggaagtcttt ctctgaaaga aggaaaattc attgcagacc cttaggaaca 540 gcatcttctt agagggaagc caggggctgg gcagagacgg gaggaggaga ggaagagaat 600 atggaaacga gtaaggcaca ctcttctcag gaaggctcca atttgaagga tagacaaagg 660 ttaccataat aatggtgggg cctgacctca ccccattgga tgctgtgccc tggcttgcag 720 agcactggga aggtagccta gtagcataaa ttgcatttct agtgggccca gaaaaaagca 780 aaataacgga ttgattcaag ctgatactga gtagcaaaat tttgggaaga gtcaacggtg 840 caagtttgtc cgaggaggct gccgtgggcg cggctattcc acacattacg gcgcgaggcg 900 aaagccttag tggaagcgcg tcctgcgcaa agccgggggg cccccgactg cgccttggct 960 cagccttcgg ttccgagtcc tttccgtgcg gagtctccca ggggtggcgg ctccgggtgc 1020 ggacgcggag tccccaggat cagccggtgc gcagactcgg ttctttacgg cccgattgcc 1080 acgcaggtct cgcgagagcg caggcgcaag tgtcgcgata aatgggcgcc ggcggagcgg 1140 agggagatcc gagcggcggc ggcaagctgg ctgcgagcgg ctgaggtaag cggcccggct 1200 cgcgcgggcg gcggggtccc ggggtcccgg gggtcccggg aatggcaagg gaggggccga 1260 gggcccggac cgggtgtgct cgccagggtg gggcacaacg acccagaccc cgtgcctcag 1320 gaccccgcgc ccgccccgtc tcccatgggc gcgctctcct ctctgtgctc tcccctcctc 1380 tccccactcc cctgtcccca ctcccccttt gggctgtgct ggggacagcg ggcccctcgc 1440 ctgggtctcc gcagccgtcc cttgtgccag ggcgggcggc cgaggggcgc gtgctcgtgg 1500 tcccagcccc ggggtcccgc tgcctaccgt gtgggtcccc gggctagggt gccggcgcgc 1560 cgaggaaggg gcctgagctg gcgcctggtg gagaagtcgg ggctgcaggg gctcttggca 1620 tcctggtggc tcgcgccggt ccgctctcag gaagggggcg tgtgggcccg gtttcccctc 1680 ggggatggca agggccaccc tgatctcgtt tgggcaatgg aggaattggg ctgtggagcc 1740 tccttccagg cgggcctgcc tctgcggggc tggcagcctg gggagctcag gcctctgctt 1800 gcaccaggcc aaggttcttg ttaaatggaa actcagaaac tgtgcagctg cagaagttct 1860 acctttggct tttaaacgcg cttggctgtt ccctagttgt ggctggtggg ccggcctgcc 1920 atgagcccat agtaagcgcc ggtgttgggg gtgcaaagtt ctttactgcg gtttgtcttc 1980 agccttccaa agccagacag acccaagttc caatctccgt tctgtaactt tttgaagctt 2040 cggtttcatc atctctagaa tctgtgtaaa aagacctaat tcaccaccct gttgagactg 2100 agcttacaaa tatagtgctg gtcaacctgc agccgtattc ccatcatcta gcggtggaag 2160 acttgaggga tattggcccc gttccccaca actttgcaag tagatttcac tgtcatgagt 2220 ttacagatga ggaaactgaa gttcaagaag tctcggtgct cggaaatgtc agataccttt 2280 ctttctgata cctagttgaa aatagtagta gtacttatta atgtcactag aaataaacaa 2340 tgaaaatgag cacagctgtg atgatcatca tctttactgt cactgttgca tgcctcgttt 2400 ctgattccca gaggccagat ttttttttta attaattatt attatttttt gaaacggagt 2460 cttgctctgg cacccaggct ggaatgcagt ggcgcgatct cagttcactg caacctccat 2520 ctcctgggtt caagaaaatc tcctgtccca gcctccggag tagctgggat tacaggtgca 2580 cgccaccaca tctggcttta gtagagatgg ggtttcacca tgttggccag gctggtctcg 2640 aactcctgac ctgtggtgat ctgcccatct tggcctcaca aagtgctggg attacaggca 2700 tgagcaacag tgcctggctt atgtttattt atttatttat tcattcattt atttattttg 2760 agacactgtc tcaccccgtt acccaggctg gagtgcagtg gtgcggtctc aggtcactgc 2820 aacctctgcc tcccagtttc aagcgattct tgtgccacag cctcctgagt agctgggatt 2880 acaggcgcac accaccacac ccggctagtt tttgtatttt attagaggtg gggttttgcc 2940 atgttggcca ttctggtctt gaactccgga cctgcctccg cctcccgaag tgctgggatt 3000 agaggcgtga accaccctgc ctgggcaaga ggccagactt tgctgtgagt gctcctggta 3060 ggtagtttca ggcatcaact gactggattc aggaattcct agaaacctgg gaaagcatca 3120 tttttggttt tgggtgtgcc tgttgagggt gtttccagag gagatgagct tgggagtctg 3180 agtggaccag gtgctgaaga tccatcctca gagtcagggg cagtatctaa gagcctgggg 3240 gcctggagag gacaaaaaca gagaaaaggc gaatgtgtcc atctgcctgc aggagctggg 3300 atacactctt cctctcctct cctcaacagc agcactccaa gctcgccggc ctttggtctc 3360 caggacttgt cccagcagcc cctcgaactg agaattacac catcggaccc ctggctctga 3420 ggccttcaga cttggactgt gtcacactgc caggcttcca gggctccaac ttgcagacgg 3480 cctgttgtgg gacagtctct gtaatcgcgt gagtcagttt ccccaataaa gcccttctct 3540 tgtgtctgtc tctgtgtcct gttggctctg tgtctctgga gaaccctctt acagtgcagt 3600 tgggggacgt gccacctgag tgctgagccc cgcctcccgg gcgccagctg tccatctgtc 3660 catgtgcaac tgagactcaa ttggtggctt gctggtgggg atttggtggc atgcttcctt 3720 gcttccattt tttgtctggt aaattggcag catggctccc agttgccatt gaagaatgtg 3780 gttacaggca tgggtgtatt atgagctcca atgtgcgtta ggggagtggg gctgtccaga 3840 ggctctgctg actgcacggc tgatggcacg tggaaaggct gcccctgacc agtcctttgt 3900 ctgtccccgg aaggaaagca accatggaag acctggggga aaacaccatg gttttatcca 3960 ccctgagatc tttgaacaac ttcatctctc agcgtgtgga gggaggctct ggactggata 4020 tttctacctc ggccccaggt tctctgcaga tgcagtacca gcagagcatg caggtgagtg 4080 gcatgtgcct gggtgggagt ctgctctggg gagaccctgg gcccgggcag gacctcttca 4140 agtcttctgt agttgaggtg ggtcggtatt agcagagcct agagacagct attcgtctcc 4200 caggtctcac tatgggcact cctcattttg gggtcgtagc tggaggctag ttggggccct 4260 gagccatcct ggcttaaagg cctgccttgt tagcgccctg agtgggcctg gcgctcagca 4320 ttgcgttcac acaagtgcac tcacagaccc tggtgacagg atcggaaagc cagttcattc 4380 atctaattga ggacagaacc caaactgcct gggggagtga gcaccaggac tgtcgggaag 4440 gctgtgttgg aaacacagtg ctgagagtgc ctgggcagcc cagagacaaa gccacagcag 4500 tgagcagaag gactgggtgt tttgtggtct cagactgtgg agggccattt acagattttg 4560 gggtgatttt tacagttttc ttctataaaa tagttgtatt ttgtttcatt acaagttctt 4620 ggggtttctc actgtagaca caactgcaga ggattcaggc ctcctgaagg acttcaggct 4680 ccaaagagtg atgagcccag tcccagttgg ggctgcgata acggggcccc caagttgtag 4740 ggagtggtgg ggagtggagt gctggctagt agtgtctcca gccttgcctg ggccctgtgg 4800 ctgcgcaggc tcctctaggc tcctctgcct ggaccctctt tcccagtccc tgctgcggtc 4860 cccagagccg ttctgtagtt ctgtccgcat tagaggaggc tctggcttcc tgcgctctca 4920 gagcccagat gaggccctgc tgcatttggt taaactgtgt gtgcgtgtgc atttgttttg 4980 ttgcataatt gaattaatgt gtgtttatta gaatgctagc ttgtggccag atgtggtggc 5040 tcaggcctgt aatcccagca ctttgggagg ctgaggtggg cggatcatga ggtcaggaga 5100 tcaagatcat cctggctaac acggtgaaac cctgtctcta ctaaaaatac aaaaaattag 5160 ctgggcgtgg cacctgtagt cccagctact cgggaggctg gagcaggaga atggtgtgaa 5220 cccgggagtc agagcttgca gtgagctgag attgcgccac cgcactccag cctgggtgac 5280 agagtgagac cctgtctcaa aaaaaaaaaa agaatgctag ttgctagctt gctcactgcc 5340 ctttcttgat gaggactgtt ttttattctg agattaggtc atatatatat atgtgtgtgt 5400 gtatatatat aatatttatg taaatgttct tttgtgaaat tatgaaggta atagatggta 5460 gttgtttttt atcactgaca aaatgagaag tggccaactc tgagctggtt gcagtggctc 5520 atgcctataa ccccagcact ttgggaggct gaggtggctg gatcacttga ggtcaggaat 5580 ttgagaccag cctgaccaac atggtaagac ctcatctcta ctaaaaatac aaaaattagg 5640 cgggtgtggg cacctgtaat cccacctact cgggaggctg aggcaggaga atcgcttgaa 5700 cctgggaggc ggaggttgca gtgagccatc gcgccactgc actccagccc gggtgacaga 5760 gttggcaact ctggtctgaa atgctgtgat tttagtgttg cgaatgtctg ggacctcttg 5820 gcctgtctgt caaagctgtg ggattctaga gtctgtcttg gggctcggag gcccccagtg 5880 ctcactggta aaggcctctc ggtgagggga tcagtgatgg agtgcggtag tcagagcaag 5940 gtggtgagcg gagtgatggc ggcaagacca gccttggtcc ctggcccctg tcacatccca 6000 ttcctggact tcgtcgtggt tctctctctc ctgctgagcc cccggcgtgg cagggagggc 6060 ctggagaaca tggcaggccg ggggaatgtg tgctgtctgg tttctcacac atcgtgttga 6120 tttaacgtaa gggtaaactt tcagggttcc tttctttccg ttgtagtcag ctccaggcag 6180 aggtggcaca cggatcaggt gtgtctggga ctcctggtcc ctgccggtcg tgccccctgc 6240 aggcggggtg cccacccttc tcgagaggct caggcttgac tgcagacaca gaagtgagac 6300 caggaaggct gctgagtttg aagggcagtc ttaggaacgc ccaaacagca gcagctgaga 6360 atcgagacac agtaacatag gagtaaagga agtgtgggct tgggccacca gagaacacag 6420 gtgggaggac agagaaactt ccctcccctg tcccaggctt tcctggcctt ggcacgcttg 6480 gcatttgggc tgggtaattc ttttttctca ggactttctt gtgcattgtg ggctgtttaa 6540 caacttccct ggcctctacc ccctggatgc cagccagcag cagacacatg tgaccacccc 6600 cctgtgacaa tcaggtgtct ccagacaggg ccagatgttc ccaggggcaa aactggaccc 6660 cactgggaac caccactcta ctctggtgct tctcaacctt tcatgtgcat gtgaacgccc 6720 tgagaatgtg tctaaaaaga agtttctttt tttcttttgg agatagggtc ttactctgtc 6780 atccaggctg gagtgcagtg gtacaatgtt ggctcactgc agcctccgtc tcctgggttc 6840 aagtgattct ccctcctcag cctcccgagt agctgagatt acaggtgcgt taccaccaca 6900 ctcggctaat tttcatagtt ttgagtagag acagggtttc accatgttgg ccaggctggt 6960 ctcaaactcc tgacctcaag ttatgtaccc accttggccc cccgaactgc tgggattaca 7020 gacgtgagcc accacgcctg gcctagattc ttttgttttt ttttttttga gacgaactct 7080 tgccctgtca tccaggctgg aatgcagtgg tgtgatcttg gctcactgca accttcgcct 7140 cctgggttca agcgattctc ctgcctcagc ctgagtagct ggggttacag gtgcgtacca 7200 ccacgaccag ctaatttttg tatttttagt agagacgggg tttccccatg ttggccaggc 7260 tggtcttgaa ctcctggcct caagtgatcc acccgccttg gcctctcaaa gtactgggat 7320 tacaggtgtg agccaccaca cccaacctaa agagaagatt ctgactgagt aggtctgggg 7380 tgtagtctgc gactctgcat ttgttaagtg ccgggagatg ctgcactgca aggctctggg 7440 ccacgtgaag agtcagtgac tctgcctttt cctccagctg agcaggtcgt acccaaaggc 7500 cggctctgga actatttggc aagtcttctg gggctctttg aggctcagct aacctgtaat 7560 cactagccct gtgtggtagg cagacttctg agagggcccc caggagctca gctcacctgt 7620 aatcactagt cctgtgtggc aggcagactt ctgagagggc ccccagaggc tcagctcacc 7680 tgtaatcact aaccctgtgt ggtaggcagg cttctgagag ggcccccaga ttccaggctc 7740 cttgtgcaca ctcaccttcc tactgcctcc caggtttcag tccaatactg agtaggtttc 7800 attgctgtgg gattgtgcag atgtaattaa ggtctaagat ctgttgacct tgagataggg 7860 agattacgtg ggtgggcttg atccactccc tggtgggctt gatgtactca cctgagccct 7920 ttaagtctga gtccagacgt ccgaggccga gcagtcaaga gacatagcag gagagggatt 7980 tgatgaggga gattggacgt ggttgacttt ggagatggag agggccgtgt ggcaagggat 8040 gtgggcagca cctaggagtt gatggctgta ctgggctggc agccagtcgg gaaggagacc 8100 tcattctcca tctctgagct ccacgtgaga acatgtcctg gccgactgca ttgattttta 8160 gtctgggaga ccctggtcag agaatgcagc cacctacgtc tggacttccg acccacggag 8220 ccgttggctg gtaaataaat gggtggcatt cgaggccgtt gccttcacta atatgcttaa 8280 tgtcatctca aaagacgtct tcctcttccc aggctttttc accttcccgt ttcctgcccc 8340 tcccctgttc cccagcctgg agcccagtgg ctgggccaca tcaagactta gcacgggacc 8400 tgcgggaatg ggtcctcagg gagtgtgtct gctgcactga gtcactcacc tggtttgatg 8460 ccgtcactga ggattctgtt tttctttggg tgcgacctgc tcagctggag gaaagagcag 8520 agcagatccg ttcgaagtcc cacctcatcc aggtggagcg ggagaaaatg cagatggagc 8580 tgagtcacaa gagggctcga gtggagctgg agagagcagc cagcaccagt gccaggaact 8640 acgaggtggg ttcaggcggg gcgagggtcg gcccagacag ccccaggaag caagggggct 8700 gtgcacggta cctgccaggt tataagaaat cacatcctag tccctgggag caagggggct 8760 gtgcacggta cctgccaggt cttaagaaat cagatcccag tccctgggag caagggggct 8820 gtgcacggta cctgccaggc cgtaggaaat gagaacccag ctggctggaa gcctgacacg 8880 ccctgtgtca tggttgccag gacattcctt ctgaggccac tcatgctgtg gggcaggtat 8940 cagttatgct tgatgtccta gaggagggtg gcatgaaatg ggaacacttg ctgtgtctgt 9000 tcattgaggc tgcggtgctg gcacagattc ttttgctggg tctcctggtt tcctcttccc 9060 tctggaagaa ttggaatgca ggtctggcag aaatgccaag tggtgtagga gtgacaggct 9120 taggaggtca tggggtggat cagggtctcg ggtccatgct gggtcttggg gttggagggc 9180 cctagcaaag ggtgccggtc tcaatggcgg ctctgtgttg ctcctggctc cccagggcag 9240 cagggaaaac accctgtcct tggggaggga attaggtttc cactgagtgc gcggatcccc 9300 tctgctctga ttaacagcac tttgccaggg tttcagtcag tgctgatcag ttgtggaaat 9360 gctgccaagg ttcaggcaga gtattgggcg gaaagtctcc ctggcctccg tgccctctct 9420 tggcgggtgg atgtccagcc ccgccctgac atcatgcggt gtattcacac actctcctgg 9480 gccctagaaa aatagctcac gtcttccggg gtgtgatgct ggttggattg cttgcccctg 9540 gcctgcagat cctgactgcg gtgtgcgttg tgtgggctca gtgagactga ggcaccgctg 9600 gggtgggggc cactgcctca gggttggctc cgttgctgct ttgagagctg ttttccctga 9660 gaggtggggc gtttgctcat ggcctgggtg ggtcctagga gggacagtac tggaggaatt 9720 ggtgggaagg ggagggagag tccacaggag tctccctaac tactgagatt cccttgttag 9780 gggtggagag gagccaccag gtcattggtc tggaggcagc atgctgatgg tatggctgtg 9840 gctgtcaggc aggagggaca gtgtgcagct gttggagttc ctctaggccg agagtccctg 9900 agggcagggc ccacccgact ctgcccagga tctccattgt gtggcacagc ttatggcatt 9960 ttatgggtgc tcacaaatgt tggattgagg gaggggtcat tgtagggtct ccgggaaccc 10020 tgtcttgggg aaatccaagg atgcaggtga ctgggcttac acctggggct ccctgctgag 10080 ctccagccac cttctaacag gactgtcctt ccttgcccgc agacacagct gcatgggacc 10140 ccaggaacag tcagaaccag tagttttcca attgttcctt ggagttccac ctggaaatac 10200 ctattagggg gcgagactta agtgtctgaa gtccaaagac ctgctggctg ccctgtctgc 10260 gctgggactg gcagttccag gcccggtgcc gcatctggct gtgatggtgc tgagcggagc 10320 cccgtgccaa ccccagctct tgtcctgcat cacagaaggg tctcttggtt gttgtgaggc 10380 agcccttgca gctcacaagg gctggagtcc ctccgaggtg cgcgggtcag cctctctcag 10440 aaggtggcca cctctgtcac agctctcctg ggttttgggc tggagtaccc tggatgagga 10500 cagcacaagc tcgtactcca cccggggctc cgggagtgct tggtgcttcc cgaggaaggc 10560 agggtgagag ggtcccggag tgccgggctc caccaggact caccgccttc acctcctggg 10620 acgccggtac ctggcagtga actctggagg gcctgcgggt cattagagtc aggaggtctg 10680 agcgtggtgc ttggtcatgt cccatcccaa ccagtgagag ccacgcggcc tccctaaggc 10740 cagtcgtggg gggtggctct ggaggtttgt ggtttgtgtg agagggggtg catgtgtggc 10800 agatttgagc ccagtgtaaa ctgcttctgc ccacagcctc ctgtccacgc tgcctgtctc 10860 tgcccctgtt gtctgctcgc tgggggagtg ccagctcctt tcagtgccgg acagagcgta 10920 attagacagg atttgctggt gctatgaaag ctcagcttct ccccaaggtc aatgctgaat 10980 tttagatttc ccatgccccc tctccctgca gaggcaactg ctgagcagac ggtgtgataa 11040 atgtgtgtgt gatctgtgcc aagtgccctt cctgggagcc ctgacctcgc acagtgctca 11100 ccgtcatggt gccacagcgg gggtgccaac gctggggctg ggtcccaggt cccgtcctgg 11160 ttctgcttat gacttggctc atgggtcctg ctcggctctt ttttgtgcct cggcatgttc 11220 tgagagaggt gtgggggtga gggctccccg ctgaccctcc cgtgggcggc acgtggcatc 11280 tgactcttgc tctcttaaca gcgtgaggtc gaccgcaacc aggagctcct gacgcgcatc 11340 cggcagcttc aggagcggga ggccggggcg gaggagaaga tgcaggagca gctggagcgc 11400 aacaggcagt gtcagcagaa cttggatgct gccagcaaga ggctgcgtga gaaagaggac 11460 agtctggccc aggctggcga ggtgagcggg gcctctgctg cgcagggagc tgttttcccg 11520 aggagaggga gtgcatgctc ttgtttgcca ctgcagtgcc cgcttgtgtt ttcacttgtg 11580 cttcccacac gggcagctgc gttttgtaca tagttgtcat cagtagaagt attaattttc 11640 cattctgtag ttttcagtta aaaagttgag actttgggcc gggcgcggtg gctcacgcct 11700 gtaatcccag cactttggga ggccgaggtg ggtgtatcat ctgaggttgg gagttggaga 11760 ccagcctgac caacatggtg aaaccccatc tctactaaaa atacaaaaat tagccatgcg 11820 tggtggtgcg cacctgtagt cccagcctgt gggactcggg aggctgaggc aggagaatcg 11880 cttgaaccca ggaggtggag gttgcagtga gctcagatca caccattgca ctccagcctg 11940 ggcaacacag caagactctg tctcaaaaaa aaaaaaaaaa aagttaagca cttttttgcc 12000 tttgtaatta tgaatttaaa tggatgatga atctgttttt tgttgtttgt ggacgtttag 12060 tgtgtttgtg ttcgctcatg tatgtatgcg acaggtagcc cttccctcag ccctcgcttc 12120 tgttgacttt ggacagaccc ctaggactgg gttataaggt ccctagcgat ggcggtctct 12180 gcagccgttg tgctcagagg cctggctgag ggctccaatt tccccgtagc cttccctgtc 12240 gtggatggtg gtcttttctg gaaatagctg ttgttttgtc aggaggctta aggaggcacg 12300 tctggatttg catatctttg actgtctgca aggtctacag gcatctgatg gcgtcggata 12360 attgcctctg aactggagcc tgtgtgaact gcagtcctgg tgaaggttgc ttgcatttta 12420 gaaacagccc agacatgggc actggtggaa attggaatct tctgacctct cctgtccttt 12480 gtctgtggcg atcaagatcg ctggtgccaa gaggaaacat gaaaatctgc tggtgtgggg 12540 gtggaggcgt ggtaggggtg gggtgggcgt gcagcggggg tcctggaggg gtccagaaac 12600 tggccgcggg tccttcctgt ggccgtgctg gggaggcgtg ttcaggctgt tcccctatct 12660 gcttctggag ggaacgttgg caggagagga ggcgtgattg gctcccgaga agctgctctt 12720 gccttgccca tgctctgggt tccagttccc atgtgctggg ctgtgctgga gttgggccgg 12780 gggctgtccc cgctgcctgc gggcacctgt ggttccatgg gggagggtga gtcgtgccga 12840 gcacttcatg aggggcagag gagcaggaga ctgcaggagc cgcagggcgg tgcccggtgg 12900 ggtggggcat agtgagggga agatggtggc gctgcaggtg ctgctgcttt ggcctgtcat 12960 gtctaagccg aggtggcagc tcctcaggga agccctccct gcgcactagg ccttgactgc 13020 cttctcctgt cacagggtcc tgattgtcac gctccttact ctggaattat cttatgcgcc 13080 tcttccttgc caactgtccg gcgtccccta caacacgggt gaccctgtgg gcaggtgggc 13140 tcggccctgc atctggcctt gcccctggca cacggtgcgt attaattgag ttcagaagac 13200 ctctgggagg atgtgtttat tgttagtatg tttttaatac ctttcttctt tgttgactcc 13260 caggttgatg cttcactgtt gtggtgaagt aaaccgtaca tattgtgggc atgtggggag 13320 cacgcagccc ccatgcgggc cttcccagag cggcgtgggg tggacagcgg tgataggctt 13380 cagcaggccc taagctgggc acgttctcag ggacagggaa atgagtgctg aggcctcctt 13440 gtttgcggag ggtgccgccc agccaggccc acccaggtcg tttgctgtgt gagtttgcca 13500 ttgtcctgtc ctgggtgcgt ggtccccagg gctgacatca cgcccgtgtg tttccgtgtg 13560 ttaacttaca gtgatgcttc tcagggtctg tccggctttt cacattggct cgacccacgt 13620 gctctttctt tctctgagga cacctggggt tttctgagct tttccagagg gttagggtcc 13680 tcagaaggtc gcctggtggg agtggtcagg aggaagcctg gcggttctgt cgcgtgcggg 13740 ttccatgatg tcaggcagac ctgctgtcct ggaggctgcc agaggggctg ctggctttgc 13800 tcaggggccg cctccccagg ggcgctcctg cccgtgccgc gtgctcccgt tccaagcgca 13860 cggcctcccc agcaggtacc gccctgcccc ttgcacagcc tccgtctttg tcctgttggt 13920 tggccagtgc cttgctgtgg tgtgagggcg atgtcgctag caaacagccg tcatggtagc 13980 attggggtgg ctagggaggg atgacaggag ccacggttgg agggaagacc gaagtgatgg 14040 tgtggcgggt atgtggatgt ctgatgggac tttgggagcg tggggcactg gcacagagac 14100 tgccaggtgc caggcctgag agtccgggcc catcttggct ggtggaggct tttgcttctg 14160 aagccgcctc accaagcctc ctttccaggg cccctggctg gggcccggtc tcctctgtca 14220 gctcctgggt ggcttgtggc aggctctggg ctgtgctgct ctggagcacc aggaggaggg 14280 tgggccctgc gtgtgagcgt ctgcctgacc tgcatcctcc agaaggaggt ggctctgccc 14340 cctggccctc tgctcccctg ctcctcttcc ccctgccctc tgcccccctt gcccccttgc 14400 catctgcccc cctaccgctc tgccccccta cccctctgcc cgatgcccct ctgccccctt 14460 attcctctgc ccctctgcct cctgccctga ttatagcacg tgggtggtgt cgcctctcca 14520 ctcttctcat ctccatgtgc aggctccttc cacgcacggg ctccactcac tgagcggctc 14580 tctggtcccc tctactttta gaccatcaac gcactgaagg ggaggatctc ggaactgcag 14640 tggagcgtga tggaccagga gatgcgggtg aagcgcctgg agtcggagaa gcaggagctg 14700 caggagcagc tggacctgca acacaagtgg gcggggccag ggtgtggggt cgggggtcgg 14760 gtcacgtgtg ggggcatgcg tcccacctct ctcttggtgg ctgggtggga tgtggataca 14820 ctcccagatg ctgtcctaat tcacagacac tcaagagggg cagatgctga ggcctctgga 14880 gccaggaccg tgagcccaga aagtgtcctg atgttcctgg agcagaatgg gggcagcaac 14940 ttcctccccc tccttcttag agagggctcc tgcagagcca gattttactt tattttttga 15000 gacagggtct cactctgtcg tccagcctgg agtgcaatgg tgtaatcatg gctcactgta 15060 gcctcaacct cctgggctca agtgatcctc ctgccttagc ctcccgagta actgggtctg 15120 caagcatgtg cagtacacct ggctaatttt tttttttttg agattgagtc tcgctgtgtc 15180 acccaggctg gagtgcagtg gcaccatctc ggctcactgc agcctccgcc tcctgggttc 15240 agtgattctc ctgcctcagc ctcctgagta gctgggatta gttttgcacc tggctaattt 15300 taaaaaacgt tttgtagaga tggcggtctc gctttgtaac ccaggctggt cttgagctcc 15360 tggcctcaag cgatcctcct gcctcagcct cctagagtgc tgggatccca ggctgagccg 15420 ccgtaccctg ctgagggcta ggttgaaagg gcagcatcat gtgccttgga ggtggagggg 15480 gcgtggctgg gaagggatgt ccaggcacag ggctgagccg aggcacagac gtgagagcct 15540 tgtctggagg tgcggtcagg agactgtggg catctcctgc agacttggac ccttccatca 15600 gcagatgtcg ttttaggaga gttctagttc cgtagtagag aggagaggtc attcctgggt 15660 ggggccctac cgcagctgca ccagggctgg gggttgccgc aggcaggtga gagctgtggg 15720 ttccactgtt ggagaggtcc ttgcaggtgg cctgggctca ctacgcaccc cgtctgaatg 15780 agcagactga ggcctgagag ccagcccaca ggggctgggg cctgggacct tggggtaccc 15840 atgcagtgga gtgtgtgttg gcggggggcg gggggtctgt gccgtgggag gtcctgaacc 15900 ttggggtggg aatgaacgta tgtgggtctg tgctggggcg ggtctcaggc tgaggagaat 15960 tgttggcctt gccgcatgcc tgtttctgtg tgtgatgtat ttttctttca atagaaaatg 16020 ccaggaagcc aatcagaaaa tccaggaact ccaggccagc caagaagcaa gagcagacca 16080 cgagcagcag attaaggtga gtcactccct gtcagtgcct tgtggacatc cctgtggtgg 16140 ccttgactct cctgcccctg tcggcctttc tgcgctggtg ccgagctccg tggtccttct 16200 gtgaggttag ctgctgccct gtgtgctggg cactgtgctg ggcaccaggg atgccatggt 16260 gaatgaggca gatgcttccg ctcttgggag cgtgtattct agaggaggga gactgaccac 16320 aaacaccaag agaaaatgtc cgtgtgtgtg atgacgtcaa gtgctgatga gcgtgagaag 16380 atgctacagg catagagagg ttgagaaagc tgcccacagt tgcacagctg gagctgggtc 16440 tcagtcaggg catctgactc aagctcaggc tgtgccattt ccctgcggag gacgtgccag 16500 ggagacgttg actccagatc cctctcctgc ctcctgttgc ctggagagca gcctccagac 16560 cctgtgctct ggccgtgccc tctcagccct tatgcaccct cacctccagg cttcacacca 16620 gctcttcctg gctgcagagc tgcccggcac ccccagcctg gcctctgcca tgtccgctcc 16680 tggtggtggt ccctggcccc tcgcagccct cagtccacct ctcaggattt tctggctggc 16740 agggcgatgg actctgttag tgtttgttga atgaccgtct ggtttggtcg tggtttcata 16800 ctctgcctgt tcagtgactt gctgctcaca gatgccagct gtctgtgtcc caaggggact 16860 gggtaccgta gggaaaagcc tgtcctcact gttggaaaga ctgagctgtc acacgtgctg 16920 ctagagtggc agaagtgggc ttgacacggg aggggtggga tgttttacca tggagtgcca 16980 tcctggacca gacttgagac agacttttgc tcctggagag ctccccgagg gcaggtggtg 17040 agcacagcag cccggcagtg tgcagtgtga atgccagctc ccagtacgcg gagggctggg 17100 aggtcggcgc tgggaagagc tgccctggag tggatgctga ggctcagtat tggaagcagc 17160 ttcgaggccc ctggtgcagc ccaggaaggc ctcccacagg agagtcctga ggcatggagg 17220 ctgctgagga cctggggcag tttagcgaag gaactttgtg acctcaatga ctttaatttt 17280 taatggatgg tattttctag agcaatttta ggttcacagc aaaatgagca gaaggtaaag 17340 ctcctgtgta ccccctgcgc ccgctcctac acacacagcc taccctggta gagtggagca 17400 cgtgtgacgg tgatgaacct gcctggacac atcagtgtca cgcagagtcc acgggtcatg 17460 cgagggtcac tcttggagtg ggacagtgta tggttcgggc agatgtaaaa tgttctatat 17520 ttgccattag agtgtcacac agaaaagttt tactgcctaa aaatcctctc tgctccccca 17580 gtcaatccct gcctctctcc ttctgagccc ttgacaaccc cttcctttcc cagaacgtcc 17640 tgtggttgga tcctgcagtg tgtatagccg ttgcagaccg gcttccttct cttagccgtg 17700 tgcgtgtgat tttctccagg tctcttcgtg gctcattttt cccttcttct ctgtccctgg 17760 cctccatcag gatctggagc agaagctgtc cctgcaagag caggatgcag cgattgtgaa 17820 gaacatgaag tctgagctgg tacggctccc taggctggaa cgggagctga agcagctgcg 17880 ggaggagagc gcgcacctgc ggtgaggggt tgcgggggat ggggcagccg cctcgagtga 17940 gtctgggttt gtgcacatgg agcccactgt gcagaccctg taggggcagg gctcccgggc 18000 tcttggcctt atccctaggg tgtgtggcta tttgagcgac tctttgtggc actgccaggg 18060 agatgagaga gaccaacggg ctgctccagg aagagctgga agggctgcag aggaagctgg 18120 ggcgccagga gaagatgcag gagacgctgg ttggcttgga gctggagaac gaggtgaggg 18180 cctgtgtggt gtgcggttcc tgtgggtgtc ctctgccctg cctggaggag cctcggtatt 18240 gtggtcacgc ccaccagctg ctcacctaca acatggaggt tgctgtgatg gggtgggagg 18300 cagaatcgtg gtccccagag aggtccatgc ctcatcctca gagcctgtga acacagcacc 18360 ttccctggca gggcgaatga ggtgactggt cagctggccc acggcgggga ggggctcctg 18420 ggccatcctg ggggctcaga gtgatgtgag agggacttgg cagctcttgc tgggtgtgga 18480 gatggaggac gggccacaag ccaaggaatg tgggtcatct ggaagctgga aagagcaggg 18540 aagtggactg tcccctggaa tctgcagaag gaacacaacc ctgccaacac caggattcca 18600 gctcggggag acccgttttg gatttccgat ctaaagtact ataaaatatt acatttgtgg 18660 gctttttttt tttttttttt gagatggagt ctcgccctgt ccccaggctg gaatgcaatg 18720 gtgcgatctc ggctcactgc aacctccgcc tcccgggtac aagcgagtct cctgcctcag 18780 cctcctgagt agctgggact acaggcgtgc gccaccacac ccggctaatt tttgtatttt 18840 tagtagagat agggtttcac cacgttggct aggatggtct tgatctcttg gaactcgtga 18900 tccaccctcc tcagcctccc aaagtgctgg gattatagac gtgagccacc atgcccggcc 18960 aggcttttta aatgttaaat ttttttttgt agagatgggg tctccctgtg ttgcctaggc 19020 tggtcctgaa ctcctgggct caagtgaccc tcccgccttt gcctcccaaa gtgctgagat 19080 gacaggcgtg agcctctgtg ccgcaccaat ttgtgttgtt tgaagccact tagtttgtgg 19140 tgatctgttt cggttgcagc aggaaactgg tacagagggt gagtcagaat gcgtgtggca 19200 ctgtgaggat cagggctggc agggccctgt gctgggggtg ttctgtcttc accgcggcag 19260 ttggtaggaa ggtgtcagtg ctggaaaaca tcctgcagtc atgttgcggg cagaggagga 19320 aactgaggtt cagagaagct ccctctcttg cccggtgcac agcaagtttg gaccagaatt 19380 taggccttct ggcccctgcc tgggtcctct gtccttcatg ccacttccct gtggccacag 19440 ccactcccct ctgtgcctgg cacacctatg ccgcctttct ccggtggttg tggggcctgg 19500 caggagggca gactccatct gcagtgctct gcagctgccc agctgtccag ctggccactt 19560 ccagagtccc cttgggtggc gtggcgtctc tgtcctcttc agagctgtga tacagccaag 19620 gtcgttttgg ggccttggcc ctgtgaccca cggtgaggtg gctccctgtc agcgggggta 19680 tctggcaggg actcttctct caggtgctgg gttctgtagg agcttagcct gaaaagacag 19740 ctcccatgcg acatcttttc tctctcccgc ggtgtaattt attgtttgat ggttgaagag 19800 ttggggctct caagccacat tccgtagttg ggtgcttgct gctccatgtc cctgggccag 19860 ctccttcatc tccctgtctg tctccccgtc tgcacaggga ggagtggtgc tggctgcctt 19920 gtcaggactg tgaggctcac atgagtctat gcaaagtgct cagagcagtg cctggcgcgt 19980 agcgaatgtt ctgtagcgtt ggctgtcata tagttactag tcaagtgcgt gcctgcgcat 20040 aggaggggct gtgagaatac ctcactgact tgccgagtgg agcgttgata acagcatggt 20100 gcttggcact gggtggaggt gaagcgaggc cagaacaaag gcacagagtc cctgccctca 20160 gattgcttcc gtcctagaag ggccgtgaga ctcacctctt tgggatgcgg ctcagcatgg 20220 gacaggcatg tgacacagag gggtgggctg gcctgtaggc agtgtctcac cctccctcat 20280 gctccagggt ggctgccctc ctctcctagg gcctgctggt cctggtctgc tgtgtgatgg 20340 caggaagttt ggctccagga ctgagtctgt ctgctccagg gcttggttcc ctgaggagcc 20400 cctggaagat gggggaggga tgagtcctaa cggctcaagg acccgaggct gctccctggg 20460 gcacagtcaa ccccaggatc ctttctgagg ctgtctgcct tctccctcca cagccacacg 20520 ttgcttttag cttgctggga ttcacacttg aatttacggg gccaggaagg agtgaggcag 20580 gaagcgccag tgtggcttct gcagttgggg aataataacc cggccacttc caagcagact 20640 tggagcatgt agcgcccagc tcagagatga gggcaggctc tcctgagagg tcagggactt 20700 agcaccgtga tcatgattgt cagtcttatg tgatgatcct gtggcaggtg atgacagggt 20760 ctgtgctttt gttgtctttt cagaggctgc tggccaagct gcaaagctgg gagagactgg 20820 accagaccat gggcctgagc atcaggtagg gaagggcagg tgtctccggg gtcccgcctt 20880 ctttgaaggg tcctgggtga agagcagagc ctgcttccgg ctcaccagcg cagtctccag 20940 ccaggcatct ctgtggctgg tgcggggcat ttgtcctggg ctgctcaggt ttaatgaggc 21000 ctttcccagc ggatggggca gtggaaccca gtgactcatc ctgctgaagc cttagtaaca 21060 tcttcattca gaagcggaat atccacagca aaccagtggc aggcgtctga ttgccctgcg 21120 ttgcggggct ttgtgaaagg actctttttg gtgtataccg aggaaataat tgcttttggg 21180 ggaaatcatt cattttaggg aactgtaacc agtggagatg aactgagttt ttagaattaa 21240 gaaaaaccca ctgtattagg ctgttcttgc attgctataa agaaatacca gagactgggt 21300 aattatgaag agaagaggtg gaattggctc acgcttctgc agctgtacag gaagcatggt 21360 gctggcatct gctcggcttc tggtgaagcc gcagggagct ttcagtcatg gcggaaggtg 21420 aagggggaac aggcacgcca caatgcaaaa acaggaatga gagagcgaga gagtgagcga 21480 gcgtgagtag tgttgggagg gaggtgccac acacttctaa atgaccagat ctcatgagaa 21540 ctcactatca tgaagacaga cccaagctgt gagggatcca ctcgaggatc caaacacttc 21600 ccacggggcc ccactttcag cactggggat tacaattcaa catgaggcat ggggcaggga 21660 cacagatcca aacggttctc acccaccata gtggaagacg attgtctggt gcttgtagca 21720 gcctcttcac gcagtctgtg ccaagctgag tgccagcgct tgggtggtgg gatgtggggt 21780 ggagctgccg ggggaccacc ctgggtgctg gggatggtat tcttatagac aggtagctgg 21840 accgttccca ggtctggtcc tgtctgtcct cctgccccat ccttcccagg accctgtgct 21900 catctttctc cagcagccgc tcagttggcc cctgcccttc agtcgcggtg cccctgcagg 21960 tgaccacctc ctggcagctc tggtctggac ccctcttcct ggttgccctg tgtgcgccag 22020 gtctcgagga ggtgcaggag cgatgctttt gaaggagcca tcagagcccg gggctcaggg 22080 cccgaggtgc tggtgccgag gcggcctctt attgtgtttg cttgtgagat ttcaaggctt 22140 cccgcttctt gcctgtcttt cctgctgttc ttggaaacta ggctgagact gagactctct 22200 gaaagagcta tcctttgacc acaccgtccg actgctggtt ctggaatcca ttaccttctc 22260 atcagcatta ctggcttcag ttctctgtca cctgaaagtg cctcttcatt ttctttgagc 22320 tttgctaagt cagagcacgg cccgggctgc tgtctcctct tgaactcccc ctgtagaaca 22380 cagacttctg tagggccggc ctcagcgggg cctaaatgct ttgtgcttct gtctgttctc 22440 tgggcttatt aattgcttgg aaggcgaccc ttctgctccc aggcatactc tggccagatg 22500 agaaacctct gtgacttctt tcctgtgaag ggacatcaga ggcccccacg tgcctgatgg 22560 gcccggccct gctggagggt ccagtgtgca gtttgccctg gagcactggg tgtcagtcgg 22620 gcacgagacc tggcacagct ggctgctgtc tctggctggt ttcaaagtac tgtggatcct 22680 ttcagccctg ttcccgcatc tgagcgccct gcctgggcat ggcttgtgtg agggcgagct 22740 ggcctggggg tgctgcctgg gcgtggccag catgagggca tgctggcccc aggggttctg 22800 cctgcctgtg tcttctgtgt tcactctgcc ctccctggtg gccaggccct ggatgaggga 22860 gaggaggggt tggtctgtag ggctggtgga ggtgggctgc ctgtgcccac caccagctta 22920 aagtgggcgg gaagcaagtg gcatgcatgt gtggcgccct gcagctttga tgaggaacac 22980 agatagttct tcggaggctg gattcaaggc tccccctgcc ccccgccacc aacagtaaga 23040 cctgtgtcaa gtcactgcgc tgctctgggc cagtgttctc tttattgaaa gggggacacg 23100 gagctcttct ccccaactgc gtgtgaagat ccgacgtgat cgtgtacttg tggagggccc 23160 tgtgagttgg agaggggctg gtgcgagcgt cctctctgag cagccggagg ctgatggcca 23220 ggaaggtgga tggagccgtc ctcgctgtgg gggtcgaccc ctagtctcct gtgttggcct 23280 tggctgtggg cctggtagag ggcaggtttc ctcacgtgct gggttgcctg ccatgcctgg 23340 gccccttcag ggctccccgc tgctccttgt gttgtgctcc acagggcggg tgtctgagtg 23400 tggttctgca tcaggccgtg atctcgggtg actcacgctg gacgtcagtg gggtggtgct 23460 catgccgcag tccacgggaa tgcaggctgg cggtcccgaa tacggctcct agagagtcca 23520 cgggaatgcg ggctggcggt cccgaatacg gctcctagag agtccacggg aatgcgggct 23580 ggcggtcccg aatacggctc ctagagagtc cacgggaatg cgggctggcg gtcccgaata 23640 cggctcctag aatcaccggg agggtttggt aaacgtgtgc atttctggct gcgcacagtg 23700 gctcacacct gtagtcccag tggtttggga ggctgccgca gggggattgc tcgagcctag 23760 atgtttgaga tcagcctggg gaacgcagtt gagaccctgt gtgtaccaaa acaaaaatta 23820 gcggtgctca gtggtgtgca cctgtagtcc cagctactca ggaggctaag gtgggaggat 23880 cacctgagcc caggaggagc tgtgattgca ccactgcact ccagtgactg agtgagtccc 23940 tgtctctaaa aaacaaaaac aaaaaccaaa gtggatttct gggtaaacct gagatgcact 24000 gggctttctt ttctgttttt agggaccagg tttggggtag ttcttaggaa tttcccgtgt 24060 ctggcagcat tgaatgtggt ggtgaagtcg gcgacaggga cacagatgtg gtgagaagct 24120 ggggccacgg gggcccccat gggagggctg agtgcatttg ctgttcttgt gtggagacat 24180 gcgtgcctct gtgggcgagc ttggggatcc cctcctctca gccgtgggga cctgaggtga 24240 catcagatgt cctggaagca gagggctctg tggctgggag tgccctgggc ctgtgccggg 24300 tgggctggcg tctgcttgcc ttcgggccca ggctttgctg ggatttgggg cttgccgagg 24360 cccgaggccc cgtgggtgtg gaggagctgc tgccactagg tggtgccccc gccttggtga 24420 tccttcccac agcagcttcc cttgggtctc tctggcctag tggaccgctg ctctcccacc 24480 atgggacttg cttgctgaca ctggggtttt ggtcgatggg gatgtgaggg gcttgtggcc 24540 actgttcctg actgccttca ggggggcgct tctggctgtc ccatgcctgc cttgtttctg 24600 accagtgtcc tggggccctc aggcctgtgg gctctgggct gtgagctcct ggcgttgagg 24660 tcagacgtcc tttgtgtggg cccttcccta aggacagggt gctgacgtcc tgcagtcctc 24720 agagggctct tcggcctcgc cccgggcttg gataaaccct ggctgagccc caggagagag 24780 tggcctggtc accctcttcc ccatgtaggg cttcttatgt cttaggagag gaggctgggc 24840 aggctggctg gggtgggtca gtgaaaccat gggaagaccc tgtggaacga ggtccttatg 24900 tgtcacacag gcctgggcac atgtgacatg tgcagcacac gggttcacgc aggctggggg 24960 catgttagtt tctacgactt tgaagtcaca ggcaaggagg ggcacagtgc gtgtggatga 25020 gcctgcgtga acacacgtgg ggaagggcag gatgccagtg ccgggagtgt ggtgtggaca 25080 ccctcatcct tagggtgctg gaagttgggc tgagggagtt agcagcagtg cgaggcgtgt 25140 gtctggaggc agcgatgtga tcagcttggt ctcccaggag catggtctgt ctcggggagt 25200 gacttacggg tgaggaaagt ggaggccagc acacaccctt tgaggtacgt gtcatcctcg 25260 gcaagacctc gggcacagga gggggaggag gagtaataca gagaggccag tgggaaagat 25320 ggcgtgaggc tggagcccat ctgggaatgc aggatgcttg cttctctttg gaaaatcacc 25380 tgtttcagta gaatgaaagg gggtgcaggc catctctgta ggcgaacagc acaaccattt 25440 gtaacaatcc aagactcgtt tgtgatttaa agttctcagc aagctaggaa gagaagagaa 25500 cttcctcaac cagctaaatg atacctgcag aaaaccagct gatataatac aaggtggacg 25560 gactgcatcc ctgacatgga gaccaggcag ggtgtctgtt ccctgcaccc ctggttgcac 25620 tgtactggag atcttcacca gtataattag ggaagcaaaa agaaaagatg gacagactgg 25680 aaaggaggaa gtaaaactgt acctggagac aacataatta tctatagaaa ttcccaggga 25740 ataaatgaca agccagtagg actaaaccgt gaggtttaca gggtcacggg atacaaggac 25800 aatgtaccaa aatgggttat gtttctgtat actagcagtg agccactcga ggtacatacc 25860 atgtatgatg gcatcaaagt ccatgaaata ttaggaatgc atataagaaa atctgtgtaa 25920 gatttgtaca ctgagaagct taagacgcaa ctgagacatt aaagatcacc tgatgtagaa 25980 aaatggagac attgtaagag gaaaaatgaa ctcttttccc ctctgctctc acacagcctc 26040 tgacaccaga tactggaagg tttcccccac accaagcagt tctccagggg tcaccagctg 26100 gatgtcctgc agcctcatct gcacactctc cacctggagt tccatcagct tccaatgggt 26160 cagggcccag tcccacacat ctgtgccccc ttcagattcc aggtgcaagt agtaggccgg 26220 catctctgct tcattttacg gttttcttct cttcctcttt cactgacatc agctgtactt 26280 ctgactgaca ggctgttaaa cgaggcccct gctacccact ccttgggttt cattaattgg 26340 ctagtgtggc tcacagaact cgggaagatg ctttgttatg tttagtcatg tcttataaag 26400 gatgttacga ataatacagg tgaacaggtt ggcagagtga ggtgtgagga gaggcgcgga 26460 gcttccatgc cctctctggg cacaccaccc tccaggagcc tctgtgtgtg cagctctgaa 26520 ccctggcctt atttgtgggt ttttatggag gcttcatcac agaggcatga ttgattacac 26580 cattggccgt tggaaatcaa ctcacccttc ggcccctctc ccctcctagg aggttgaggg 26640 gtgggactca aagtcccaac cctctaatct caccttggtg tttcggataa ccaccctatc 26700 tgaagctgcc tgggggctgc caaccagcac tcagctcatt agttcacaag agacactctt 26760 ctcactccag ataaggagct gcatgtatgt cagggaacag aaagaccaaa tatatatttc 26820 agagtatcgt aaaggtactg tggtcgtgta ttggaagatt cattattgtt aagatggcag 26880 tttgctcaaa ttgacccaaa tatttaacat agtcccaatc aaagccccag cagaaattga 26940 tgaactgatc tctaaaattt cttttttttt tttttttttg agacggaatc ttactctgtc 27000 gcccaggctg gagtgcaatg gtgcgatctt ggcttactgc aacctttgcc tcctgggttc 27060 aagcaattct gcctcagcct ccccagtagc tgggactaca ggcatggacc accatgcttg 27120 gctaattttt gtatttttgt agagacaggg tttcgccatg ttggtcaggc tggtcttgaa 27180 ctcctgacct caagtgatcc acccgccttg gcctcccaaa gtgctgggat tacaggcgtg 27240 agccactgtg cccggctgac aatttctaaa atttctatgg gaatgtaaag tacctataaa 27300 ttgttatagc cataacagtt tcaaaaaaga acaagttata cagcttacac tggccaattt 27360 caagacacgt tgtaaattgc ataaattgag acactgtggt attaagtata gacatgtaaa 27420 tcaggagaac agagtagaat gttcagaaat gattgaagaa tacagtgttg attgttgtca 27480 aagtgtccag ataattcagt gggagaaaga atcttttcac cgagggtggt aaaccagtag 27540 gctcttcgtg gtgaggatga gccttaacac ctgtctcatg ctggacacaa gatttaactc 27600 aaatgacgca tagacctatg tgtaaaagtc acaaaatctg gaagctaggg tttggcaaag 27660 aggtcttaca atacaacgaa catgaaccat aaatgaaaaa attgataaat tagacttcat 27720 caaaattgaa aacttctgct ctcaaaagat acagtgaaaa ggcagaccat agactaggaa 27780 aatatttgcg agatattaac atgtatctga ccaaagatgt gctccaggat agagaaggaa 27840 ctcttacaaa ttagtaagat taccatagtt taaaaaatgg tcaaaagact tttaacagat 27900 actttattat ttatttattt ttttggagat ggaatcttgc tctgtcgccc aggctggagt 27960 atagtggcat gatcttggct cactgcaacc tccgcctccc aggttcaagc aatcctccag 28020 cctcagcctc ctgagtagct ggggttccag gcgtgcacca ccacacccgg ctaatttttg 28080 tattttaata gagacaggtt tcaccatgtt ggccaggcta gtctcaaact cctgacctca 28140 ggtgatctgc ctgccttggc ctcccaaagc actgggatta caggtgtgag ccactgtacc 28200 cggcctgctt ttaacagata ctttacaaga gaagatatat aggtggtaaa taaggacatg 28260 aaaagatggt caacattgtt agttattagg ggaatgcaaa ttaagactgt aatcgcccaa 28320 cagggttctt cttgctgccc agaaagccaa tgcactgaga acggcaggtg tggcagcaga 28380 gagggagttt aatgattgca gagccagccg agggaggtgg acgcgagata actctcacat 28440 ctgtctccct gagaattagg aggcgagggc ttgagggtgt tttggcgggc agcggcctag 28500 ggagtggtga atgctggttg gttgtgttgg ggatgcaatg ataggggtgt caggactgtc 28560 tccgtgcagc tgagtcagtt cctgggagat ggggtcacaa gtccaggtgg catctcttga 28620 tctgctgaaa tgctaaatct gaaaaatatc ccaaagacca gttttttagg tttcacagca 28680 gtgatgtctg taggagccgt tagggaagtt ccgaatctga caacgtctgg ttacgtgact 28740 ccgggtagca ggcactgtag aagagcaagc taagtaagca gtgacaggtc atggtttacc 28800 cgtgcctgtt ctttagcaaa gttcaggccc ctgtagcaat gccagtctta atctccaaac 28860 aaggacgggt gtcatttttc cttgccttga agtttaacta taaactacat tcctctcata 28920 gttatcttgg cctctgtatt agaataagca aaaaaaaaaa aaaagaaaag atcctgtgag 28980 gttagaagca aggtggagtc agtaatgtag atttctctcg ttacttaaaa ttctgtaaag 29040 gcggtttcaa gactgcagtg agataccact gggcacccaa taaaatggct aaaattaagc 29100 agactgacca tcctgactgc tggcagagat gcagagcagc caggcctgtt gcccctggga 29160 gtagcaagtg gtacggccac tttggaaatg gtttggtagc tttgtacaca cttacggtgt 29220 gaccctgcag ttccattcct cggtatttaa tctaagagaa acccaagaga aaatgtggtc 29280 tcatgaagac ttgtacagga atgtttgtag agccttattc taacagtctg agagcaggaa 29340 caactcaggt gcctgtcagc aggtgaaggg atacgtggac cgtggcgtct ccacgcagtg 29400 taatgcgcgg cagcggcggt gcttggaaac atgaaagggt ctctcttgct gagtgaagga 29460 agccagactt actgagttta tacttactat accatcccat tgatttgaac tttttaaaaa 29520 ggtaaaactg agcaacagtg atagaaagca ggtcagtgat ccctggagtc tcgtgctggg 29580 atatgattgg ggtcttatgg ggtgctagaa ataccctttg gcgtaatgga tgtgatcgcc 29640 gcacaggtgt acacgcagca aagctcatga cactgctctt gtcaaactgt tcacgtgcgc 29700 ggatcatacc tcactcaagc tggcctgtca acagcagacg gtcagctctt cggattagct 29760 gtgaggggaa ggaaaattcc ttagtggcga cttggactga attggagagt ggcctggggg 29820 tgctgtttaa gccagccttc atttggggag ggacccatcc cctgagttta tggaaggcct 29880 acggccacgg ctgcgtgcac ctcctgggtc tttgttacgt cacaggagtg ctgtgaggag 29940 tggcagcatg tggggtcagt gcaggctgca gagggtcaag gagtttcaca tttgatgaaa 30000 agcagaacaa gctgcataaa tgcaaatgaa tggaatgaaa agtggaacgt gttcttcctt 30060 tcctgccctc cctggtgacc tcactcaggg ctgggtgccc tgtgtcacag cttcctagcc 30120 atcgtcacct tgtgttctca gtattcctgg ggggctgttc cagaatagaa ctgattgccc 30180 cggaggtggg cagcagggcg tgctgtgctt ggccccggtt cgtctttcta ggcaatgcct 30240 gatgagtttc ctgtgtgtcg ttctggaaat gtgtgtacat agaagctctt tatgtactcc 30300 catcaccttt taaaattggg gctccttcca cagttttatt ctgcaactgt tttcactcag 30360 tttttgacag ttttttggcc ccagcgcagg ctggtctgct gaactacttt aaagaactgc 30420 agggtgtgct ggagtgcaga cggactcaga ctccagcagc ccctgttgat ggacacttag 30480 ggtgtttcca gcttctttcc ccaattagcc atgctatgct ggttgggtaa attcttaaaa 30540 ggatgatttt tagttcaaaa gagatgtgcg tttgagactc ctagctggtg ccacaccgcc 30600 ctcccgaaaa gcatgagtgc tgtgcgctcc cgtcacggcg tgtgactgcc gtcacctaat 30660 gggggtggtg tgctttcaac gtttctagag agattcagct cgaagtcaca gtacagtgag 30720 gagagcaggc atcttcaaag gcttggcttt tcaaaactgt catttagcag ctcccactga 30780 gggggaccct atgaaatagg aagggagtgg gtgtcaagtc ctgtagccga gcccccactt 30840 cagggaggaa atcatttgct cgtggccaag atgccgctgt tcttggctcc ttgcctgtcc 30900 cgttgtgcct gaatctggcc ttgcttccca tcccggcggg tgggcattat acccgtcagc 30960 aagggcaggc ctgagggggt gaggaggggc tgcagaggag gctgggctgg ggaggtggga 31020 ggcgggcatt gctggctcag agtcctggca gctgtgccca cctggaactg ctgacccatc 31080 ccctgtagtc aaagctgggc acctgtcagt gctgacctgg acattttccc aaaaactttt 31140 gtagactggt cagatgacaa gtctcagggc ccagcttccc tgatgtgtga ggccaattag 31200 gaggacagtg aggggatgca tgattttcct ctaaggaagg gtctaattga ccagcctgga 31260 cagttttatt atcctagtta ccgtgcgcgt gatttgtaat tacccggctg ttgagttgat 31320 caataccaga cgccctggtg gtgcttggga aggtgggcga ctgtcaggta tgttggtcca 31380 ttttaattgg cgccggtttg gttttctttg gggcatggga ggaggagggg gagaagcgtt 31440 tggccttctg gctacttgtg tgagcatggc ccttcttctg ggcctgcatg ccggatgcct 31500 cgtggtctgg gccacgtttc cccttttcgt ttgttcattc gttcaccatg agctgctctt 31560 gtggagccca tgatctggag ggagaaggat ccctcaggcc tgtgcgtctg tggtgtgcag 31620 gtcccaggac cctggagctg gagagtggcg agtgtgctgc cctccagagg tgcaggccag 31680 ggtggggcgt gagccaggtt cccagctccg tccgagcacg gtgcctgcca tctctcctct 31740 tctcaacccc agctcctcct gtggctgagt cctggccgct ttctgccttg gggttgtgtt 31800 ggttttccgt aaacgcatcc tctcaatcct gagcattgtg agttaagagc tggggtctcc 31860 ctttagcgcc cctgagccag acgtgcagta ggcgtgtgct gagcctttga agagtggagg 31920 accgagcgag ggcgtctctg tgccttgcag ttggtggtga tgtatgggcg gagcctccag 31980 tgctcttggc tgctgtgaca gggcccccct ggggtcctgc actatcccag cgagaccccc 32040 aaagcaaggc cagcagagag cttcctgaca gctgcctcgc tttggcgaca gccctggctg 32100 gggtgcagcc tgtgcccctc tccgccccct tgtgaagttt cggatgggcg ttcccagcag 32160 tgctgacagg ctcacgccgc ccttgggctt cattccaggt acggtcgggc aggctggaga 32220 ctgtcagagt ctgggggcgg tgctgtgggt gttgggaccc cgcagggaga ggcgagagaa 32280 gggcttccca gaagagaccg ttgggctcca cccctgcatg tgcctgactg cacagacagc 32340 tgagtgctct gcggcgtgtc cgggtggaaa cgctatcact tggtctcgga gctctttttg 32400 gggcttttct ccaagctttg tagatagggc tcttctactt ataggtctct ttttaaattg 32460 attttaaaaa gtctaaggcc agagtgacag gctttagaca agtccggctg ccgtaggttc 32520 caggatttat tttagaggag gcggtggcat ccctggtggt atctgggctg gtttttactc 32580 atgggtgctt actggggtcc tgttgcgtgc tgtcccctcc ttgtgggcta ggggctccca 32640 gggtgtccac gtccctactt ttacaggtag agcagggggt gccctggcgt ggaatggagg 32700 aagggtctgg gcagctttgt gacagggctg gtaggagggg gattttgaca ggcggcttga 32760 agccagcgcc agccgagggc cagaggcaga gaagctgaag gcctcctctg ggcagcccac 32820 cactacctgc ccttctctcc gaggacttcc cagcagtgcc atggccttcg gagagctggg 32880 gtctcaggca ggctacgggg ctccacagct ccccacccaa cattcctcaa cgtcagcttt 32940 ggggctgtga ggtgtgacct ctacaggatc acctggggtc actccctgca gccagctgta 33000 gctgtcattt gtgtcaggag ctgctggtct tgcctgcacc acccaccctt cccgccctcc 33060 acctaccctg cgtggcctgg gttcttggga ggaacaggag atcctgagct gttgaattcc 33120 tggaacccac ggtcactcgg cacccgcatc ccgctcctcc cagctcctgc acgcttctca 33180 ctggtgtggt cacctggaat caggtgccct gattctgctg gacaggcggg aggggaggct 33240 gggccgaagg gtggaccagc ctttgcacgc tcagtggctg caggggggcc gtgtgcatga 33300 agcaggcggt cctcgtggta gcaccgtttg tgcagagccg cggtggggag agcgggcttg 33360 cgttcacaga agtgctgtga gatgatcact tcatcacaag ccagtcagca ccagcctgtg 33420 gggcggctca tgtggactaa gtgatctgac tttcctggct tttgtttgac gatgtttcca 33480 ctgttatcca ggtgcagaga gctctgatct cccacgatcg gaagtaccgt gtgcgttgtc 33540 ttacctgggc agaatgcaga gaccttcact ggcagctgtg tgtggaccct ggggctctgt 33600 tacacagcca ggtgctgagg agcagggctc cgagccaggc cagcgaacct tccttagacc 33660 ccctgtgtgc aggcctggtg cctggtgtcg ggggcccagt ggagaacaag atccggctgt 33720 tgccatggga ctttcgtctg gtggggagtc ctgaggagga tgtggatgag gtggagaaga 33780 ggttccaggt gaacgcaagt gtccaccctg cattccaggg tggcaggcgg cccggggcgg 33840 gtgtggggtg gttgggtggg cgccccgcgt gctatgttag cgtagggtgg tgcacacctg 33900 gccggcaggc cttggtcccg ctcttcaccc tccacctgtc gtgggtgcgc cccgggaggg 33960 gtggaggatg gagggcaggc gtgggaagag ctctgagacc cttggcttca tggagagtgt 34020 tgggcagtta cccctccctt gccctcgggc ctttgtgagt gtggcttcct ggaactctgg 34080 gggatttgtc accagtgact gcagggggct ctcccgtccc tttcatccag gcttcactgt 34140 ctgccctaag ctggggactg gtccagctga cctggatggt gcggagtgtg ggccctgctg 34200 gccagcatgg cgttgggaag cacctaggtg ggtggtgggt tgggttgtgg ccttaccgcg 34260 gagtctgggc tgcagctgag aaagccgtct cctaggacca ggaatctggg tttgggaggc 34320 tggaggtctt ggcccagcag ttcagtggct gcccggtgtg tctgcctggc ctggccctcg 34380 tctggtttcc gttgtctggg aggcacccct gcccgtgcca ggcggggcac tgcgggggcg 34440 cggatgcgga gtggaagact gctgatttag gaatcgaaac tccagggaca tccgtgtagc 34500 agagtgattc taagatgatt aagaaaacca tcaatgattt aaagaaagtg ttcactgcag 34560 tccttattga gcggtttgcc gcgtgcaggg catgtggggg tggcgcacca ggctgcaggc 34620 gcccttcatg acggcaggca ggggacctcc taggagtctt ggctgtgaca cgtgaggtat 34680 gaaggccaga aaggtgaacg tgtggaatct gtgacccaga agtaacaaac tcctttcttg 34740 gagagcagtt aggtattcca ttccttagtc catatgccaa catttaaaaa ggccaaaacc 34800 agaggcctag aaaatgtatc tggaagttgc agtgagaccg tttttgatca ttgtggcctt 34860 cctggggctc agtttcctcg ctttgcaaat gccattttgg cagggatctg ctgtggggca 34920 tctccgtgca ggtggagctg gagttgcgca tctttctcag gctggcatcg tacaggcccc 34980 agtgcactct ggcagggagg ggcagccccc tcctggatag ccccgcccaa ggccgggagg 35040 actgtgaagg ggggatccca ctgcctgacc tcagcctgtc gggccccaca gcgcgtctct 35100 ctgtggactg gtcgccggct tcctgtggcc tgtgtgtcct ccgagtggct ggagctttgg 35160 aaccctattc tgtagcttgg agctcctgag cctcaaaggg caggggcctg gttccttgcc 35220 catccttgcc cagcctgatg gcctgtgctt gtggactgta catgggcacc tgctttaaca 35280 cctggaggag taggggctac caagagcatg tggctctggg cctccctggg agagtcactc 35340 agcggcagga gaactgagtg ggacacatca gggagtgtct gtctcatgga cgcctgttgg 35400 cctgcagcct ggagaggggg cctgaagtgt gtgttccatg ctcttgaccc ccaggaagca 35460 ctcgcctctg ttgaaagcct cgtgccgcag agcgcgattg ctgtcccggg tggacggcca 35520 tcacgggctc cttgctccgg cgatgccagc gctcctggtg ttgtgtgtgg ctggctcccc 35580 cttgtctcag ccctgggctt agagcaggcc aggtgctcag gcagtggttt tgttgcttga 35640 aggggggtgt gtacctggct gcagcctgtg gagagcgtga gtggctggca gaagcaaagg 35700 cgggctcttg ggagatgaga gcaggcagcc ggcctggagg cttccatggg gctggtcagc 35760 tcctgctggc tcttcctggc acaaatccac gctgggctgg gtgccttggc tcacacctgt 35820 aatcccagca ctttgggagc ctgaagtggg aggatcgctt gagcctggga gttcaagacc 35880 agcctgggca acactgtgag accctatctc tatttttaaa aataaaaata taaagataac 35940 ccttcctcca aaaaaaaaaa aaaaaaccca aactcatggt ggaccttggg atgagcgggg 36000 gcgcttgtgg ggcagaactg ggtgtggttg ccccgtcctg ggcctgttcc caggcctgct 36060 cttagaggag gggctgatgg gccctgtggg tgcagggaga tggggtcagt cacaggctgg 36120 ggcctggggg ctgggacctg ggggctggga cccgggggct aggaccagtt ttggctctca 36180 ggcagggagg ggttgtgaac tctgttttgg gaatgtgtgt ttgaagtgtc agtgatgtag 36240 ccagaaggag gtgtcagaca gcagccgatg tcaggcctgc atggctccta gaggagccct 36300 agggctggcc tgcccagtga ggggcaggga tgagccggcc taggggagtg gcagagccag 36360 agaagcagac agctggcccg agtctggagg gattttggcg tttgcaggtg gctttgagcc 36420 tgagggccag tgcctcaccg ggtcagagag ctctgcagcc cgccagtcct ggtcgtgcct 36480 gtgtccgagc ttgggcccgt gtgcagggag aaggtggctg tgcagtgcac gtcgtgtgta 36540 ccaggcgtcg gcggagtgat gcgtgggtcg gggcgggaga tgagaggagg agtgaggaga 36600 ggctagaagc ctccagagca gtggggtttc ttcctcttct tcactggtga gtgcttcttg 36660 aacacatagg tgtgcaggcc tggtgctggg tgctggggat acagctataa gtcaggggct 36720 gttttccagt cctctcagat ctagccgggc atatgtctgc taggtcaagc gtggctcctg 36780 aagagatgac acttgagagg ctggcagcat gttccagata gggtgggtgc tggcagcaca 36840 caggttggcc agatgctgcg tgttcggaca gtgttgtgtg gctccagctg gttctaacca 36900 cagttctcct gggatgtggc agaagctgga caggttggca gggatctgtc ctgtcctgag 36960 ggtggtttgg accgcgtcct gcaggtcaca ggagccgcag aaggtcttca tcagggagga 37020 gcacatccgc caattgtgaa ggggcctctt tcctcactga attcgcaggg cgaggacctg 37080 gcgccttggc aggaccctgc tggtggaagt ccctggggct gtctgacccg ctgcaggttt 37140 cagcagcccc gaagtgtggg gagggtgggc ggtgtttcct gttgtcagtt gagagcctca 37200 tggagtagga gccgtggagt cagctgcgtt gtagtgagag ttagaattga gctgcactgt 37260 tcctgtgagc agggagcccg aggccttctg acttctgaag agggttcgtg ttgaaggcca 37320 gactctccct gtttttctgt ttcctcttca ggtgaatgcc tgttcctttg tgaccacagt 37380 gtctgtgggt agcactgtga ttttggagac gctcgtttgt ttgttcatct gaacatttat 37440 ttggagacct gccgtttgcc aggctttggg ctggctctgg cgacgctgtg acgagcacag 37500 cacagtctgc ccacgtagtg cacacacaca gacagcttta aacaatgaaa acaacagggg 37560 tgcctcctca gatgcaatct tttggaagat gccgcaggag cgttttgcgg gagtatctta 37620 gttggagacg gccttgttgg atatgaatga cgctggtggg aatgaaggcc agacgttttc 37680 cctggtttgg aaacaggtgg cttacaagag tttctagagt ttatttgttt aaagacagag 37740 cctgttctca agacggtctt cactttgctg gcaggatggc actgttgacg gtggtggttg 37800 gctctggaga gctgctgtgt agttgacaaa gcctgttgat aatcagcgtc tcattcgttc 37860 ttcctcagaa ccctgtggac taagctgggt tctgggaggg gctgactggc ccaagggcat 37920 ccagtgaatt tgtggccctg ttgccggaat gcttggctga tcctggagta tggtgagctg 37980 tgccctcaat aacctccatc catctggctg gccacatggt gccatgcagc tggatcctgc 38040 atttttgtga gctgatcagc ccgatgctgg cactgaaagg attctgttgg gagctgccat 38100 ccatttagcc tgagcggaac tcagcacatg tgcgggcatg aagcccatca gctgatagct 38160 tctctttcag acctgatggc tcccagccga actttggcaa gaaggaccta ccagcctgct 38220 ggagggctga cctgcctgcc tttgctggga gccaagcacc tcctggcagt tctgggattt 38280 ggttttcagt gggaggaggc tctctgcaag gtagagtaag agcagtaatt acttgggaga 38340 ggaagcgttt aacttctgag gctgcaacac aatactatct tgttcgcgga ggtggctgag 38400 ttagaagatt agcaattaat tttttatcag gtgcaaacta ctcttcagtt tcatggaatc 38460 aaacagtcct cccacagcaa gggaggggca ggcttccacc ccgtgtaatt tttcagagca 38520 ctgctgtttg tctgcttttg agctgatagg aattatttac gagtctattt ggaggacatt 38580 ttgacacaca attcttggta ttcccatttg ctctttctag tttttacttt tcctgcattg 38640 ctagcgttta ctgcaattag gtctcaggag tattttgcct tttattagga ttgcaattac 38700 aaaatgcagg tatcaactag gttcctttaa atcaaagctc actttttatt gactcggata 38760 agaaaagtag gtatttttag tagactgagt tgaaaagagt gtcattggta gctattacaa 38820 gcatttcttt tagtttaggt gtttttattg tttacgagag cttagctgaa gtggcataga 38880 taacccagta ggggtcactg ctaagttatc tgtaagtttt ctaagcttga gctttagatt 38940 caaatacttt tttttttttt tttgagacag agtcttgctg tgttgcccag gctggagtgc 39000 agtggcatga tctctgcttg ctgcaacctc agcctcccag gttcaagcga ttctcctgcc 39060 tcagcctccc gagtagctgg gactacaggt gcgcatcagc acgcctggct aatttttgta 39120 ttattgtatt tgttttttta gtagagatgg ggttttggca tgttggccag gatggtcttg 39180 aactcctaac ttcaggtgat ctgccttcct cggcctccca aagtgctggg attatcagta 39240 tgagccactg cgtccagccc aaagactttt aataatagaa aaggtacttt ctcttgtttc 39300 atcatttagt atgctaggtt ttctttgagt ttctgtaact aaacagtggg tacctatgat 39360 aggttgggat ggatttaggg cagagtctgg tacgtttttt ctgtaaaggg ctgggtatta 39420 atagtaaata tttactttgt agctttgggg gccataaggt ctctgttaca attacttggc 39480 tctgcctttc tagcccagaa tagggtgatt agccctcacg gcttgtctga gactgaggag 39540 ttttgcttgg gaggtgggac ctttcatgtg aaaactgaga tgacccagga tgaaacagga 39600 ctgtcactga ttttagtgca aaagctgctg tagacagtgc gtaaatgaat ggatatggct 39660 gtgttccagt aagactttat tttcaagaca gctggggtgg gagtaggttt ggcctgaagg 39720 ccatgcctgc taactcctac ctgaggatac agggctagcc atttaatttt ggtttaaaaa 39780 atccatgcag aggctgggca tagtggctca cgcctgtaat ccccgcactt tgggaggctg 39840 aggtggtagg cagattgctt gacctcagga gttcaggacc agcctgggca acatagtgag 39900 acctcatctc tgcaaaagaa tacacacaca cacaaaaaaa ttagccaggc atggtggcac 39960 gcacccatgg tcccaacaac tcgagaggcc aagtcaggag gatcacctga gcccaggagg 40020 ccgaggctgc agtgagccga gatcatgcca ctgcactcca gcctaggtga tagagcaaga 40080 acccgactca aaaaaaaaaa aaaaaaaaaa aaaaatccat gcagagcctt gctgcctttt 40140 ccctgcagct tttctttccc atgcagagcc ttttgctgcc cacacagcat catggtggtt 40200 tcttcctttc cagatttggg acagttgggc gacggtgtgg ccttgcctga gggtggttgt 40260 ggaagagagc ctagggtgag actggcgtct cccggatcgc ggctcagcac ctgctctggc 40320 tggagccttg gcagtgcaca gtgaggtttt ccggaggaat ctggagttac ccgcggccgt 40380 gttacccctt ggtaataatt ttgaagggat aaaaccctta taaatttgct cccagggttg 40440 agaagtgctc atttctgtct cgcctttttt tctggtagcc gagggttccc aggagcacat 40500 attgtgatca cgtctgttcc attcaacaaa tatttgttga gggcttatga cgtaccgtgg 40560 tgtatactgg ctgggagatg cagcagagag caggacgcac ggtccctgtg ctgaaactca 40620 gcacagcaat gtggtgctgg gggcggaggc ggggaagggc tttgaggacc aagagttgga 40680 gggccttgct gttctaggac aaggaccgtc ctctgggcgg ggacgctttc tctccaggac 40740 gtggtggctg tcggagctgg gtggcccttg tctcaccccg gttgcttggg caagtgagta 40800 tgctggggcg tggcttgggc cgatggtttg tgagcctgca cctgtcagcc tcagtttggg 40860 ctccctgtgg ggcgtgtgag tccctgttct gactgagggt tgggttaggg tttccagcct 40920 ccctgcccct gggaagaggc tccaccctcc tccacgagtg ctgagctccg ggtctatttg 40980 tactgtgagg agttgctttt gtctccatca aaaacatgaa ccactgtttg gagcacttcc 41040 atttactgac aacccttgcc aaattaattt tatttaatta tctcccaggg ctaagcttga 41100 atacattttg tgttaagttc acagtttttt ccttttctaa acgaaatgga cttaatatcc 41160 ttgttaaaat ctgattaaaa ctaaaattga gttttttgaa gtctgattat cccatgaaat 41220 ggaattttaa acctaattac agatggattt gcatatactt ttcagcacca ttgaaaagaa 41280 acttggtata aatttattaa tgacatcctt ttctctcgtt tccttggggc atgacgttag 41340 tttaggagca tgagggaggt ggggagaaac accacccttc tccccgccct tccttagaat 41400 tttttaaaaa actttactct gtggagaatc agttccctag gagcctgggg catagtcaca 41460 ctttcattct catctttgct gctttaccgg cttaggtggc tgatagtttt cctgaattgt 41520 ttttcaatac tcagagctct tgtctttcgg aagatggaag aggagcatgc acgatcatag 41580 ctgctggtgt gtcttccctg tcagcttaaa acgcagattt ggccgggtgt ggtggctcac 41640 gcctgttatc ccagcagttt gggaggccga ggtgggtgga tcacctgagg tcagaagttc 41700 gagaccagcc tgacaaacat ggtgaaaccc tgtctctact aaaaataaca aaaattagct 41760 gggcgtggtg gcatgtgcct gtaatcccaa tgacttggga ggctgaggca ggagaatcgc 41820 ttgaacccag gaggtagaga ttgcagtgag ccgagatcat gccattacac tccagcctgg 41880 gcaatcagga caaaactcca tctcaaaaaa aaacaaaaaa aacaaaaaac cccatggatt 41940 tatatttaac gtgctacctc caccctgatt taattttagt ttttaatttt aagttttatt 42000 ttatgtattt ttttttttat cgagacagag gctcgctctg tcacccaggc tggagtgcag 42060 tgacgcgatc tcagctcact gcaacctctg ccagccgggt tcaagcaatt cttccgcctc 42120 agcctcccga gtagctgaga ttacaggtgc ctgccactgc gcccggctag tttttgtatt 42180 tttagtagag acgaagtttc accatgttgg ccaggctgat ctcgaactcc tgacctcatg 42240 atccgcctgt cttggtctcc caaagtgctg ggattacagg cgtgagacac cgcacccggc 42300 ttaatttttt ttaatttttt tgagacagag tcttgctttg tgacccaggc tggagtgtag 42360 tggcacaatc atggcttact gcagtctctg cctcctgggc tcaagccatt ctcccacctg 42420 agcctctgga gcaggtggga ctacagacac ttgccaccac gcccagctaa tttttgtatt 42480 tttagtagag acggggtttc accatgttgg ccagactggt ctcgaactcc tgagctcaag 42540 tgatccgcct gcctcagcct cccaaaatgg tgggattaca ggtgttagcc tccaccctag 42600 ttttagatac atttgtatta ttaaaaaagt aaaaacaaac tctaaatgac cattaggtga 42660 aataaacaag aaatttccaa agggccatgt tcctgttctt tgagaaatcc cacttttcca 42720 ggagggctgt ttgctattgt gtctggactc atgctgcctg ttgcgacttc ctagtggcag 42780 gtggaggtaa caggctccca gcgtacttgc cctcagtctg gctgtcaccg tggttttgtt 42840 tcgtctggaa ttatgtggga atggaatcat acgtcatgca gtcatttgtg tctggtgatt 42900 tcactggcag aatgttttct gaaaagcatt cattcacatt tgttgcttgt atcggttgtc 42960 cttgttatat cgaacggata taccataatt tttaatccgg ttttttgctc ttgcagataa 43020 agattctgtg aacatttgta ttcaagtctc tttatgtatg ttttcctgtc tcttgggata 43080 atacctagga gtggggcctc tgggtgatat ggtatgtttt aattttagaa aaagctgatg 43140 agccaaagtg gctgcctaat tctgtcccct ggccacccgt gtgtgagaat tccgctggcc 43200 ccacatcccg agctctttca ttgaattccg ctggccccgc atcccgaatg cattcattgg 43260 ccaccttcac tttagccatc ctggtgggtg tgtgcggtat ttccttgtgg ccttcattcc 43320 tgttgccctg gtgactaatg atgttgaaca tctactcatg tacttaactt gacggccata 43380 tatcttcttt tgtgaagtgt cttttcaaag tcttttcccc attttttaat tggactgtca 43440 tcttctgagt tggcagagta ctatatatat tcatgacaga gtcttttgtc agatgtatgg 43500 tgaatatttt ctcccggtac gtggcttcct tttcattttc ttagtgtctt ttgaagggta 43560 aaaactttta attttgctaa gtctgattta tcaattcatt ttctttatgg tttgtgtttt 43620 ttgtatctgc ctaacccaag cttttagaaa ctttctagct ttaactttac tgttaatttt 43680 gagttaattt ttgtgtgtag tgtggtcaca gttgagggtc gctttcctgc cccacaatac 43740 gtatgtctgt ttcccatttg aatttccttg gcacctctga tgaaagcctg tcagccatac 43800 attcatgggc ctttgctcga ggtcttcttt cattgaatca tgtgtctgtc ctttctccag 43860 tatggtaagg tcgtaattac tgtcacttcc taatactctt tgaaagaaca tagtaagccc 43920 tccagctttt tctttgtaag aattgtcttg gctattttag tttttttatt ttcagataaa 43980 ttttacattt agctttcagt ttgttttctt tccccccatt tactttttat ttcgtttatt 44040 ttttcttgcc ttagtgcact cactgggacc tccagtgcag ttttacctgg gcatggtgag 44100 aatggctgtc ctggccttgt cagccttaga gggaaagcgt ttagattttc ctgaagcatg 44160 aggttagttt tagggtcttg cgagatactg ttcatcaggt tgaggaggat gcttttcttt 44220 tccccgattt gttgtattgg gtcaaataca tatacaataa aattgactgt taactgtttt 44280 taagtgtaca gttcagtagc tttaagaaca ttcatattgc tgtgcaacca tcaccaccat 44340 ccacctccaa aactttatct tcccaaagcc aaactctgta cccattaaac gctcgctccc 44400 tgtgctcccc cgttggctct aggacccacc attctgcttc ctgcctctgt gattttttac 44460 tacagtaggg acctcataga aggagaatca tgaaatattt gtccttatgt gactggctta 44520 tttcacttaa cataatgtcc tcagggatca tccatgttgt ggcatgtgcc aaaatgtcct 44580 ttctttctaa ggctgagtaa tattctgttg tatggataga cgatccgttc ttcttatcca 44640 gtcacctgtt gatggacact taggttgctt ccacattgta gctactgtga ataatgctgc 44700 tctgaacacg agcgggcaga tatctcttag agcccctgct ttcaacctgc tggatcctgt 44760 ggttcaactt ttaactattt taggagccac tacattgctt tccacagtgg ctgtaccatt 44820 ttacgttctc atcagcagcg cacaggagtt ccagtttctc cacatcatca ccatgtgatg 44880 tgattttttt tttggtggta gccatcctaa tgagtgtgag gtggtgtctt gttctggctt 44940 tgatatgcat ttccctaatg attagtggtg tggagcaccg ttccatgtgc tccttggcca 45000 gttgtgtgtc ttctttggaa aaatgtctat gcaggttctt cgcctgttct tgaatcgcgt 45060 tattttcatt gttgttttag gagttccctt gtatgttttg aatatttttc tcttacagat 45120 acggtttcca aacattttct cccattctat aggttgtgtt ttcagtctgt tgatagtgtc 45180 ctttgacaaa tttaaaattt aaaaatttac caagatttca tttgtctatt ttttttttgc 45240 tgttatctgt gcctttgatg tcatatccaa gaaatctgtg ccaaatccca tgtcataaac 45300 cttctcccct gtttttttct aagagtttta tagttttagg tcttacattt aggtctttga 45360 tttgttttgg gttaattttt tgtgtatggt ttaagggccc aacttcattc ttttgcatgt 45420 ggagaccagt tttccagcac catgtgttga aaagcttgtc cattcctcat tgaatggttt 45480 tggcaccttt gtcaaaaatt atttgagcat acgaaagtgt ttatttctgg gatctctact 45540 gtatttcatg ggtccatatg cctgtcattc tgtcagcacc acactgtttt gattactgtg 45600 gctttgtagt aagttttgac ttaaagtgtg actctttcaa ctttgttcta acttttcaag 45660 attgctttgg cgagggacct ttgggtccct tgagattcca tatgaatttt aggatagatt 45720 ttcctatgtc tgcaaaatat ttagttaggt cttgataggg attgcattga acgtctagat 45780 ggctttgggc ggtgttgaca tcttaacagc aagtgttcca cacgtagtgg tttctggaag 45840 gttagttgtg gtacggaata atcttttcaa actgttgtac taaaattcat tggtctcttg 45900 cactttgaat ggacctttat ccatgcatgg ttatgtaaca tcatacattg ctcatttgaa 45960 aatatcgacg cactgaatta tgtaggtctt ttattatgcc ttattaaaga aattacaagc 46020 taatcaccac aagttattga aaagtcttta aacgttagga atccatcaag cttgtggtgg 46080 tagatacaaa tttttaagaa tttagatatg tgtttggcag cttgagtttt attattgtca 46140 acaaatactc gtggttgtat tctttcaaat gataacgttt atttaattcg tttttgagaa 46200 aatgtctacc agatgctcaa gcctgagtaa ctattgttgg tcagttagtt tttaagtaaa 46260 atattttaca taaaaagggc tagttcagtt cacaactcaa acatggaaga ccaaccatcg 46320 cactttagta tgcaccagaa atgtcttaca tgtgctttct atttcttcac acagaatgtt 46380 gagatcttat caaggggtta agatttaatg aagtgaatat tttaactggg cccagtactc 46440 ctgtagttcc agctgctcgg aaagttgagg tgggaggatg gcttgggccc aggagtttgt 46500 ggctgttggg agctgtgatt gtgcctgtca gtagccattg cagtccagcc tgggcagcat 46560 agcgagaccc cacgtggtgc ccctggtttg ttttgctaac gtgttatacc catcagtgct 46620 tttgtatctt cagttcaaat gtcagcacag ttagaagaaa aaaggcaaat aatagcttat 46680 tattattatt ccttgttttt ttggagacag agtcttgctg tgtcacccag gcttgagtac 46740 agtggcatga tcttggttca ctgcaacctc aaccttctgg attcaagtga ttctcccacc 46800 tcagcctccc cagtagctgg gaccacaggt gtacgccacc atgcctggct aatttttgta 46860 ttttttggta gagatgaggt tttgtcatgt tggccaggct ggtctcgaac tcctgacctc 46920 aagtgatcca cttagtatta ttatgaaaat agttttgatg gccaggcaca gtgactcacg 46980 cctgtagtcc cagcactttg ggaggccaag gtgggcagat cacctgaggt tgggagttca 47040 agatcagcct ggccaacatg gcgaaacctc gtctctacta aaaataaaaa attcgccggg 47100 cgtggtggcg catgcctgta atcccagcta ctggggaggc tgaggcagga gaatcacttg 47160 aacctggtag gtggagcttg cagtgagctg agattgtgcc actgcactcc agcgtggggg 47220 acagagcgag agtccgtctc agagaaaaaa aaaaaaaaga aaaagaaaat agttttgatg 47280 ttacaagact gcctagaatg gtgtctgcag accacactta gtgaactgtt gtcctagcgc 47340 ttagtccctc aaggcgagaa gaggctcaca agttggactc acatgtgatc ctacagctct 47400 gtgacatgct tttcaaaaat attgtacagg ataatgtaaa tccatcctca ctacaaagaa 47460 agctcaaaca gtacagaatt aaagtgaaac tttcttggat ttctctgctt tttcaaattc 47520 tgctgtatcc caggttaaca ttagcagttt gctataagtc cttacataat ttttatgtgc 47580 atggacgtct tacgtacata acaaatggca tcatacggcc tgtattgtta tattattttc 47640 ccttggattg agttacttga aatgtctggt gtttactctt tagtagccat tattccatcg 47700 tagaatgcac atattttaac tatttcctta ttagcataca ctacagttgt tgccaatttt 47760 ttctttttgc tattaacaca cagatttagt gaataccatt tcattaaaca tattttttaa 47820 gtgtatctga aacattcttt ttattgatgg gaatgctaag acatagagta tgaatattta 47880 acactttaat aatttttgcc aaattacgtt ccaaaattat acttctgtta acagtactta 47940 agattgccca tttttctgat aacattcatt gatgttgtca gtgtttccga tttttgccct 48000 ttacttaaag tcagctgctg tattcttagc acagtgcttt ctgtgacaga tgtttcagat 48060 gacagtgctt cctgcctgca ggctcatctg tctgccctgg tagctttcag gctctcaggc 48120 accctcccta atggaccgac tggggtcaag ggctctgaaa atgctgccca ccctggccca 48180 agggcctcct gaacaggtag gctgggggtg ggggtgagtc cggtggctta gatgacaaat 48240 ggaggtagag gacgcattct cgcctgttat ttcgattttt ttctctcctc accctgactg 48300 tcacgttctc accttttcca cctcaatccc cagtcacact agcttcccag gattaaaatg 48360 gtctctctct catgaaactt gtttagaaat ctagaagcat taaaaaaagg aaaaaaaaaa 48420 tctagaagca tgcacgtggc ttagaaaatg cctttgtgtt gccagatgca attcccttgc 48480 tttgacagtg gcattcaatg tggtctttta aaaaaagaaa ctatctattc ctttaacatt 48540 tttttgagat aataattaca tacagtgaaa tggacagatc ttatgtatat aattgagtga 48600 gtattgaaaa tgtaccacct gtgtcatcac tgcctccgtc aggctgcaga aagtttccat 48660 tacctctgga agttccttct cgtcccttca atcaattcct acccccggga gacaagcact 48720 gttctgattt ctattaccat aaattagttt tgtgtgttct tgaattgtaa ataaatggaa 48780 ttgtactgtg tttattctta aattgctgtc atcttttgcc cagggctggg actaggggga 48840 ggcgagagag tgtgggatct acactgcaca ccccaagagt gagattctcc gagcaatcac 48900 ctcctgaaag tttgtacgcc ggcatctctc ttgcttcacc cttgtcctgg ccctgctttt 48960 ggacaacaga gtgcttttga ggttcagccc tgttttgggg agatgagtgg tacattatat 49020 tttattttta ttatttattt attttttaag atggagtttc actcttgttt cccaggctgg 49080 agtggcatgg tgtgatcttg gctcactgaa acctccgcct cctgggttcg agtgagtctc 49140 ctgcctcagc ctcccgacta gctgggatta caggcgtgcg ctatcacgcc tggctaattt 49200 ttgtattttt agtagagaca gggtttcacc atgttggcca ggctggtctc gaacttctga 49260 cttcaggtga tccgcctgcc tcagcctccc aaagtgctgg gattacaggt gtgaaccacc 49320 gcacccggcc cagtggttca tttttaactt gtacgaatct gcttgtttgt ttccccgttt 49380 gctgtccgag gacatctggg ttgtttccca gtagctgcct cttgtgagta tagctgtggt 49440 taattcacat ccacatctca tgtgctccta tgtttccatt ctctcgagtg agcacccaga 49500 agtcaaattg ctgggccttt taatgagtac gtgtataact tcataagaaa ttgccaaact 49560 gtcttccaag gtggtggtat gattttatgc tcctacctgg aatgtatgag attccatttg 49620 cattatattt tcaccagtat ttggtgtggc tgtttatttt taaaacatcc tttatttatt 49680 ccagcgggtg tgtggcgtta ccgacttttg gctttaactc acgttcccta atgaccagtt 49740 ccctagtcag tgaatatgtt gagccctttc tttttttttt attttaaaat ttttatttga 49800 gacagagtct cgctctgttg cccaggctgg agtgcagtgg cgcgatctcc actcactgca 49860 agctccgcct cccggattca tgccattctc ctgcctcagc ctcccgagta gctgggacta 49920 caggcgcccg ccaccacgcc tggctaattt tttgtatttt tttagtagag atggggtttc 49980 actgtgttag ccaggatggt ctcgatttcc tgacctcgtg atccacccgc ctcggcctcc 50040 caaagtgcca ggattacagg cgtgagccac tgcgcccggc tgagttcttt cttttgctta 50100 atagctttgt tttttatttt tatttttatt tttatttttt tattattatt atactttaag 50160 ttttagggta catgtgcaca acgtgcaggt ttgttacata tgtatacatg tgccatgttg 50220 gtgtgctgca ccgattaact cgtcatttag cattaggtat atctcctaat gctatccctc 50280 cccgctcccc ccaccccacg acagtccccg gtgtgtgatg ttccccttcc tgtgtccatg 50340 tgttctcatt gttcaattcc cacctatgag tgagaacatg cggtgtttgg ttttttgtcc 50400 ttgtgatagt ttgctgagaa tgatagtctc cagcttcatc catgtcccta caaaggacat 50460 gaactcatca ttttttatgg ctgcatagta ttccatggtg tatatgtgcc acattttctt 50520 aatccagtct atcattgttg gacatttggg ttggttccaa gtctttgcta ttgtgaatag 50580 tgccgcaata aacatagctt tgtatctgtt ccttgggaag tgtctgttct tagtcttttg 50640 ggaaattgta ttggtttgct ttctttctat tattgatttt tccaagttct ttattctgga 50700 tacaagtttt tcatccagtg tatgtcttgt caacattttt gccctgtctg tggcttgtca 50760 ttttctttag tttttaaatt attaaaatat acatgactac tactgtaaga ctgactgttg 50820 ttcttttttt tttttttgag gcagagtctt gctctgtcac ccaggccagg atgcagtggc 50880 gcgatcatag ttcacagcag cctctaactc ctgggctcaa gtgatccagc ttcctgagta 50940 gcttggaata caggtgtgag ccaccacacc tggctaattt tttctctttt gtagagatag 51000 ggtctcacta tgttgtccag actggacttg aacttgtgac ctcaagtggt tctcccacac 51060 tggcctctca gagggctggg attataagcg tgagccacca tgccctgccg cttgtctgtt 51120 ttaaagtgtt taatttggtg gtttttagta tatttgtaag gttgtacact catacctact 51180 gtctaattcc agaagattgt catggtcccc aaaggaagcc cagttggccg aagttccctg 51240 ttctcctttc cccagcccct ggcagtcact cctctgctct ttgtctctgg gtttacctgt 51300 tctggacgtt gtgtatcagt ggaatcacac cataggtggc ctctgtgctg gcgctttcct 51360 ctcagcacgt tctcaagggg cgtctaccct gtggcacgga tcagcgctcc cttccaccac 51420 atggcacgtg gtcatacccc attgtgtcat cagagctcat ttcagtgacc cattcatcag 51480 ctgtagacat ttgggttgtt tcactttctg gctattacga acattcaagt acagatattt 51540 gtatgagacc tttttttttc acttctcttg agtggaaaca ctgggttaca tggtagctct 51600 ttctttttta ggaattgcca aactattttc catagtaact acaccatttt acattcccac 51660 cagcagtata tgaagattcc ggtttctctg aatttttaac ccttattatg atgtcttttt 51720 tcttatggtt agccttgtgg gtgtggagtg gtatcttaaa gtggattttt ttttttaatg 51780 actgcatgat ttttcattgg atggatatac cataatttaa acaatgactt attgtgggac 51840 aaaaaattat ttccagttac attttatgat cttcattgtt tatatcagta gtagtttatt 51900 tttttaatgg gattttattt tttatttcaa tagtttttgg ggaacgtggt gtttgattgc 51960 atggaaaagc tctttagttg tggtttctga gattttggtg cacctgtcac ctgagcagtg 52020 tacactgtcc ccagagtcca ttatatccct cttacacctt tgtgtcctta tagcttagct 52080 tccacttata agtgaggatg tgagatgtct ggtttttcca ttcctgagtt tcttcgctta 52140 gaagaatggt ctccaactcc atccacgttg ctgcaaatgc cattatttca ttccttttta 52200 tggctgagta gtattctatg atatatatat atagagagag accacatttt ctttatccac 52260 tcggttgatg ggcatttagg ctggttccgt atctttgcag ttgcaaattg tgctgctgtg 52320 aacatgcgtg tgcacgtgtc tttttcgtag aatgacttct tttcctctgt aggattgctg 52380 tctcaaacgg tagctctact ttcagttctc gaaggaatct ttgtactgtt ttctgtagtg 52440 attgtactag tttccattcc cacgagcaat gtaaaagtgt tcctttttcc accacatcca 52500 cgccaacatc tgttattttt tgacttttaa attatggcca ttctggcagg attaaggtgg 52560 tatctcactg tggttttgat ttgcatttcc ctgataatta atgatattta gcatttttta 52620 aatcttatgt gctttttaat ttgtatttct catggctaac gtgtggaaac gtcagtggct 52680 gcatagaaca gagacacaaa cattacagaa ttagttcaga aaagtcatga aacaagtaaa 52740 aaacaactac agctggcagc accagcagcc agccctggca agggcagaga atctgattcc 52800 agagttgctg caaaattcgg aagacatgca agaagcaaga aagtataatt catacatggt 52860 ggagaaagca atcaatcagt agaagcagaa tatcaataaa aagaaactat aaggagaaac 52920 cacatagaaa ttctacagat gaaaagtaca gcaactgaaa tgaaaatttg gtagataagc 52980 tcaccggcat atttgagcag cagaagaaag aatcagcaaa cctgaagata ggtccgtcag 53040 gattctccgg taaggggaat aaagcagaga gagaagaaaa atgaagacag gatacgtgct 53100 ttctccactt ctgttcagca ttgtgctgga ggctctaccc aggacgttta tgcaaggaga 53160 ggaaatagaa gacatccaga ttggaaagga agaagaaaac tgtctctatt tgcagaagac 53220 atgattttat acattaaaaa actgaaagaa tacacattta caaagttatt agagctaata 53280 aacaagttca acagagttgc aggatacaag atcaatattt aatattatat ttaatataag 53340 ataatgttta atattatacg ttagcagtga acaatctgac aacaattatt atccccagag 53400 atattttgtc taattttctc attggcattt tgctttgttt cagatgctac agaaacaagc 53460 ccagtttcct tgacagttgc actattttta ttacaaaacc tcactagaca tttcacattt 53520 gaaaactctc agtcgtaaat taaccatggc catcaagtct ctgtgatctg tggacagttt 53580 tttgtttgcc tctaatgctt gtctggaagt tcggcatgct ttaggctaga tactcggtct 53640 taagcaaagg ccagtctcag aatgaatatt agccagagat ttcctgagat acctagaact 53700 ggtgagtcct tgatgagggg ctccggtgca cgctgggcca ggtggtggcc actctgcctt 53760 tgccctcatt tcctgcttgc tcagagcttc aaggtgagca ggagggagaa cccagggcct 53820 tcacaggcct ttccgagcct gtgcgcaaca tgcacggaca tggcccctta gaatctcagt 53880 ccccatggac agctcatttc ttagcttttc tgtgtcagcg ttctggtgag tcttttgttt 53940 gccactgctg tcactcaggc atttgtgatg ttgaagtggt tgacagactc attccccaac 54000 caagtttttg ccctgggaga gattagggga ggtgaaatca agacaggact ttctttcttt 54060 tctttttttt tttttttgag acggagtttt gctcttgttg cccagtctgg agtgcagtgg 54120 cacgatcttg gctcactgtg acctccgcct cccaggttca agcgattctc ttgcctcagc 54180 ctcccgagta gctggaatta caggtgcctg ccaccacgcc cagctaattt tttgtatttt 54240 tagtagggat gaggtttcac catgttggcc aggctggtct caaactcctg acctcaggtg 54300 atccacccac cttggcctcc caaagtgctg ggattacagg cgtgagccac catgctcggc 54360 gtaagacagg acttttaatt gggatcttaa ggtagtaagt gacccagatg ggtcaagtaa 54420 taactcttct ttgggaatgg tattttgaga gatgccagcc ccattctgtt ccctctgtcc 54480 tgggaatgta gagtgcgatt tttctttttt tttttttttt gagacagagt ctcgctgttg 54540 tcgcccaggc tggagtgcaa tggcgcgatc ttggctcact gcaacctcta cctcccgggt 54600 tcaagtgatg ctcctgcctc agcctcctga gtggctggga ttacaggcat gcgccaccat 54660 gcccggctaa tttttatatt tttagtagag acggggtttt accatgttgg tcaggctggt 54720 ctcaaattcc tgaccttgtg gtccatgtgc ctcggcctcc caaagtgctg ggattacagg 54780 catgagccac cgtgcccggt ctagactgat ttttcaaggc caccatggag ttgtggtgtg 54840 ggggctggga ccagggtgag ttaaaatgct ccaggcgcac tcttcttgag agccacctga 54900 ttttcttgac caaacgttcc cggattgctg taagcctttg gttagttttc agagttcaaa 54960 aatctgattc tgaccgtttt agtcactctt ctgttgcttt tatggtggag tgaacttcca 55020 taggctctta ctctgacatt tttactgaga tcttaatggt gttttggatg agtaaaaatt 55080 tttgattttg atgaaatcca attcatcaat tttttctttt gtgatagtag tttttctttt 55140 cttttctttt cttttttttt tgagactctg tgtcgcctag gctgaagtgc agtgatgtga 55200 tctcagctca ctgcaacctc cgtctcctgg gttcaggtga ttctcctgcc tcagcctccc 55260 aggtagctgg gattacaggc gcccgccacc acacccggct aatttttgta tttttagtag 55320 agacagggtt tcgccatgtt ggccaggctt gtctcgaact tctgacctca ggtgatctgc 55380 ccgccttggc ctcccagagt cctaggatta caggcgtgag ccatcgtgcc cagcctaatt 55440 tctgtgtttt aagaactgtt ccatttcatg gttgcaaatt tattttatgt tttctacctg 55500 tacatttggg tgaattcccc tcttcttgag gtcctcccag tatcctgagg ttcctgtctt 55560 tccagcaagt ggtcttaacc atctggaaga tgggagagtt ttgttgctgt tggctgcatg 55620 tgcaccgcca tctttgaccc ttcagagtag tttgtcatgc tttattgaat gagcattgtt 55680 ctcagatgac acgcaggtaa ggcactggtt gtacggtttg tccaattcta tcacgttaaa 55740 aaggaggaaa ggttcttatt gaacctactg ctgtgaaaat taaggagact cagtaagagt 55800 ttctgaattc tgggatacca gtgaaggtca aagatcattt gaaaatattt cgtttttatc 55860 aaagctgagt tcaacaaatt gttgtaggtt aaatagctta agaagaaaag gcaatgactt 55920 ccccttgtat ccagaaaata gaacataaaa ccagcatcca caaataacct cagtaaaact 55980 tccctcttca gttcatttag ttctgtgtaa ttaattctta tcctgttaga tctagggttt 56040 ataaactcat gaaaccattg cttcttgcct aaagtgaatt tggaaatgtg gacttaacct 56100 cctggtgtgt ttgaaagtgg tgtaagggtt gctcttgcct ccagagcctg tccccacagg 56160 tgtcagtcat ggcgatgtcg gctgcagtcc ttctccagag ccactgagac tgcccttctt 56220 gttgaagatg caaactctgg cctgtgagtt tatcccgagc tttcaggcag gcgtttacag 56280 agtcgagcag aaacttttca cagatgacaa agacttgatg gcaatggtta atttcttact 56340 gataattttt aagtgtgaaa tgcctgatga ggttttatat aattttcaaa catgaaatgt 56400 ctgatgtggt tttaatagta atgcaactaa tgaggaaatt gggttgtttc tgtggcatcc 56460 aaaacaaaga taaaaaggcg attaaaaaat tagacaaaat attactaagg ataataattc 56520 agcctgtttc aaagaagtca gtggatgtta acatctgatt cattgaaatg ggtgaacata 56580 atttttatga agaaaacagt cttgagatgt acaatgttga gacaaaatat tcccggaata 56640 taccaaagca tatcaaatga agagactggg taagtctgag atagagtgaa ccatttttaa 56700 tttcataaaa cctcatgaat acatctgctg tacatgaatg catagcacta ggccacttga 56760 gaaccagtgg cctagaaagt gccagattca aattaaagaa gtaatgtggc taatcatttt 56820 aggtcattga aattgtggct gtaacactat gttgttactg cctgatatca gggagagcac 56880 ttgaaggact cggatacaga aaaacttgac cagactattt cataagcatt ttggtctgtg 56940 tttctcctga cattaaaaca tattatggaa tgtgaaggca ttgacagatc tccagggatt 57000 tccactgaag cgcaccattt ctgaaatacg tcttttaata acatattagc gattcacagt 57060 tcacctggag aaggctgggt gtctcttctg atttcacaac cctggccaca cagctcacca 57120 agcaaacagt tattactagc gtatgttttt tagaggagct cttgcctatc ttttgataaa 57180 tttaatccta agaattttgt attattgatg ataatttgag tagaattttg aagactgtca 57240 cctttccaat atttgctgtt attgtataga cacagtatag tttactatgt tgacagtgtc 57300 ctgtgacttt gctggattct cgtgtataga gacagtatag tttactatgt tgacagtgtc 57360 ctgtgacttt gctggattct cgtgtataga gacagtatag ttttagtgtt ttgacagtgt 57420 cctgtgactt tgctgaattc agtcttagtg ccagtaaatt ttttttttta agattcctta 57480 ggcttttttt gtataaaaat agtgctattt gcaaataaag acaatgttac tccttcctct 57540 tgagctttat accttttgtt tcttttttat cacattatta cattggccgg gacctctggt 57600 acgacgtgaa atagcagtgg tggtagcaga tagcttgttc ttatttttga tctgggggaa 57660 aatgttcaat atttcactct tttatttatt tatttttttc ctggagacgg agtctcactc 57720 ttcacccagt ctggagtgca gtggtggaat ctcggttcac tgaaacctct gcctcccagg 57780 ttccagtgat tttcctgcct cggcttccgt agtagctggg attacaggca tgtgccacca 57840 tgcccagcta atttttgtat tttcagtagt gacgaggttt tggcatgttg gccaggctgg 57900 tcttgaactc ccaatctcaa gtgatccact caccttggcc tcccaaagtg ctgagattac 57960 aggtgtgagc caccgcaccc agactcatcc ttagactcgt atttaattaa agaaaatgta 58020 caatgcagac aggatggctg atgatagtcc ttttttcctg cctgattttg gttatttgtg 58080 ctttttctct tctctcttaa tatcttcaga tgtctgcaac tttattagcc ttttaaagta 58140 actgattttt gacttggttg atttctcacc gttgtagttt ttccatctgt ttttaatctt 58200 tatttcctgt ctttgggttt attttgcatg cttacaaaac ttcctgggtg attgtgtggg 58260 atggcctgga cggaagggac cagggcttca ggaggaggat gagccccacc ctttctgtgg 58320 tgggaatgcc tgagctctgt tgggctgcac atggctccta ctttggcagt cattcaacaa 58380 gcctgaggaa tgtggcttac tggtaaaata gaaaagtatg ttgccagagt ttttctagga 58440 ccagtttggg ggatggagag gatggtagat tgaatacata cacctacctt tttctttctg 58500 aaacctcata ctgcagtgag aagtgtggtg ggtttttttt tttttttttt ttttggcaaa 58560 ggttcatgtg aataaggaga aagtaaagtc atagcattcc tatttcagaa gctggaatgt 58620 aattggagag ttggtgatgg acttagctga cttgagaaaa ccaaatgcta atttgggagt 58680 ggggaaagct gagagctagc ttgatctgtg ctgcagagtt ttgaccacgc ttgggagctg 58740 tgactgctta cttccagagt ggccacacga ggacataaga gtgtgttgtg agccggctgc 58800 tcagaggccc tggtccttgc tcagcccagt gcagccgggg cgggcattag gcgtgctgag 58860 caggcggtaa agccgatggt cgtgcacttg gcgcttttcg ggacggggtg ccttatggac 58920 tacggtaagt gaactctgtg tgaccgccga gatgaccagc tttgtcccca ctcagcattg 58980 agtctgggct ggtggagcgt tgtccactaa gcaagagtag aagggcctcc tgtggggact 59040 gagactatcc agagggagga cagaaaggta ctgaagtcgc cacctcacaa ctctgttgcc 59100 gtgaaactta caggtggccg tcacagtcgc tcattcagag cctcctagac atctgaagga 59160 gtctctgatg taaaaggtat agaccaagca aacagaaaaa cagtgtagag gaaatggaaa 59220 ttatgcaagg ataaaacttc caggaagaaa cctctcataa gcatcctcag tgagataaaa 59280 gtggttattt taacaagaga agataatgaa acaagaaaaa tgtcctctgg aagaagcaca 59340 ttcagtgaac aagaagagtt ctgggaagtt aaaactacat gaacagatat ggggaaaaaa 59400 tcagtgtaag tgttggaaaa gttaaggaga tccggaaaga aaaaaaagat caaacaggag 59460 aaacggaata cactctgagg atcgggttct gtggaccaca ttcaacaagt accgcaaaga 59520 aacggcgggg aggacagcat aatgaaacaa ttgaaaaacc ctctcttgag cgtcatcctc 59580 ttctagactg aaggagccac caagtaccca gtccagtgga tgaacgtctg tgatcaaaga 59640 ccattgccat ggcatgttgc tggaccccaa atatcagggt aaagacagca tcctacacac 59700 cttcagaagg atgagaatag gttacatacg aagcgggaat caggatggct ttgtgcttct 59760 agacagcagc attggaattt agtgcacagt aaagcaatgt ggtctagagt tgcaggaaaa 59820 taattttcag cctttgattc tatacccagt gaaactaaca gtcgcatgag agagcagact 59880 aaaggcacaa tggagatttg caaagtcttt aaaaaagtca gtcatcctgg ccaggcatgg 59940 tgcttcatac ctgtaatccc agcactttca gtggctgagg tgggaggatc acttgagcgc 60000 aggagttgga gaccattatg ggtaatggta taggagagtg agaccccatc tgtccaacaa 60060 cagcaacaat agcagcagca gctgggtgtg ctggcctgct tgtagtccta ggtactcagg 60120 gtacggaggg ctgaggcagg aggatcgctt gagcccacga ggtggaggcc acagtgagct 60180 atgaccatac cactgcaccc cagcctgggt ggcagagtga gaccctatct taaaaacaaa 60240 ttatctccct caaatctttt ttcagaaagc tactggaggg tgcattgtac taaggaagag 60300 agagactgat gactgaggaa ggattggaac gcagggagca ggatatccgt cactggggga 60360 gaagcagctg aagatgatgc ctgtgcccgg gcagatggtg ctcagtcctc agagcaggaa 60420 gtggtgccga gaaagtctcc ccaaagacga gattgccagg cagcccgatg ccgggtgagc 60480 atggacatct ccagaggaga tttgaacagt ttaaagagcc agggtggaat gagcgataaa 60540 cagacagcta agcaagtgaa aaaccccttc tcctgttagc ttgaggggaa gcacaaagta 60600 ggaaggagtt ggaagtcacc atggtttcct ttgtggcctc agtgtgagtg gttgagcacc 60660 cagctgtgct cagctagaca cggggctcag ccagacgcgg ggcagctaga gctgtggtga 60720 tggtggtacc tgcggggcgg cagaggggtg gtgggagcaa agagccatgg cctcctcttc 60780 catcctgaga agtcacaggt aatgccccaa actgaagaat taggaaagtg gcaatgaaag 60840 cctatcgtct agaggaaggg aggtccgttt caacataatt gactcaaata acttagagtg 60900 tttgcttctg aggctgggaa ctgggccagg agatgcagag tggagttggg gatggctgct 60960 tgccataaca agccttgtag tttgactatg tacactttgt ttatgtaact tcacgaggaa 61020 tacgtataca tggaagaaaa ggagattcga ctgggaatgc caggggcatg ctagcaggtg 61080 ctgtagtctc agccagaggc atgtgtgcag ggtgcctggc accgtctggg gtcttctgtg 61140 cgcacagacc gcggtgtgca cgctcccagg agccatctga tggggcagcc tcgagcacct 61200 ctgacttctg acttcgcccc acgggagccc atctggggct ccagccttga cctggcagcc 61260 agcagggctg ggatgggact gcggccagcc acgtgggttc tcagctggtt agggcctcgg 61320 tcctctatcc cttacctctg tcccacggag acccgtgcga gggcccatca ggcactcgag 61380 ctggcaccac gaggactact gacggctttg ctggatgctg ctgggaagtt gagccggcca 61440 aggtggcgag tggctgcgcc tgggctgccc cgtcctggcg gcggcgccct cccgttttct 61500 gttctgggaa gcacacggtg caggcagtgt ttgtgccttt tcccagagga gccctttgtc 61560 ctgaggaggc gtggatgttc tctggagacc cggggccttt cgcagcggca ccgtgacttc 61620 ctgctgctgg gccctgggcc ctgtgtggag tcgaggcctg caggggcgag agtcagacga 61680 gagttggagt ctggggttca catgggattc tgcagcttcc cagcggtgta atcttgggcc 61740 agacacgtcc cacccgagcc tcgtgtgctt gtctgttgaa tgggaagggt cgtggtgtct 61800 cgcaaggctg tgaagaatga aagctgtgtg gtgaggaata atggcagaga acactcacca 61860 ggccctttcc aggtgctgct ccaagcactt cctgggcctt cactccagca gtcctccctg 61920 ccaccctttg aggtgggggc actgttgtca tactcatttt atgagtgagg aagtacaggc 61980 aggagaggtt agcagctgtc ctgaggactc acagccgatg agtggctggg atctgaaccc 62040 acacagcagt gttgcattgc cgtgtgctct tcccatcaga cttaggcctc gtggtgatga 62100 gcttgtgtgt ctatcccagg gaccctccag atgtggctga tttctggcat ctcttacggg 62160 tctggtcttg ggctgcgtgg tctcatggcc cctttggcag cctgcatggt gccctcttac 62220 tgggcacggt gaggcctcag gaacacagca gctccaccct ccaactgctg ggcttctctg 62280 ctgccctttg catggcggag gtgacccata tgtgtcccat ctccaccctc cagctgctgg 62340 acttttctgc tgtactttgc atggcggagg tgactatacg tgtcccatct ccaccctcca 62400 gctgctgggc ttctctgctg tcctttgcct ggtggaggtg acccatacgt ggcccatctc 62460 caccctccag ctgctgggct tctctgctgt cctttgcagg gtggaggtga cccatacgtg 62520 gccctgctgt aatccgccaa gcacttccgg gggtgaggtt gaggaatctt tgtggggcat 62580 gtgtgcacgt gtgtgcatgc tgtggctcca gcaccacagt gttgacagtc ctgtgagcct 62640 actgggtaag agcctaggtt gaggcctgct gcctcctttg gttgtgtggc ctcaggcagg 62700 ttatggaact gcacccatgt tttcatcttt aaattgggga gaatgagagt gcccttcgct 62760 ctgctggcac gatacgcagg aaacgttgct tctcttcagc agattattag gattctctga 62820 aagttctccc cagttctctt ttctacccca ttcattaatg gcagccacca gtggcgtagc 62880 agcaaggaaa attgggccgt tttgaagcac tatcgagttc tgcctgtctt gctaaatcat 62940 ctgtgttcca actgtgctct ttgaactgtt gaaggccaga agttgttttg cgtttgatca 63000 cctataaccg ccaacccccc atgtgtttct gcctgtgttt aactggtcac agggagcttg 63060 gggctcctcc ggttcccatc cttgggagag gcaggcccat ccactcagta cccacggcag 63120 gcacctggtt ctcatctctg acgccccgac tttcccttct cagcctgtgt cgcctttcct 63180 gtgatttcct ctccttgcct tcctgggatc ctgctagttc cagcccatcc ccactgccgc 63240 tacgccactt ggaaaccctt tctcgtgcag tggccacctt accgtccctg gcttcacttt 63300 tgcgtcttgc aactattctt cactccagca cttggaggga tctgcctgag atgaagcaat 63360 gaccacgaga ccctgctcaa agctgtttgt ctgtccctgc cgatgtcacg atgaagtcct 63420 catgtctcca tgtggctgac cagaagcctc ctgccattgc ctggctctcc cgcttctctg 63480 tcaccctcgc ctcagcctct gcaccagcca caccgaacat gagttctgtg ctttctccca 63540 ctccctctgc cctcccactt gccctcccct ttccctgtta cggcccactc cagccccgaa 63600 cacttagtgg ctttgaacag tgcttggtaa tttttcagga ttctgcaggt tgcctggggc 63660 caatctggtg gcagttgggg atgggacatc caggatggct ttatgtgcac gtgtgctgcc 63720 ttgttaatgg ccaggaggca gggctgcctt ctttcctcag gggctctctc tggctaggac 63780 gagctgcttc acgtggctgc caaagcccat agggacaagc cctggcatgc aggttcctta 63840 agcctgttgg ttgtggttgc agtagctgtg gccagagcct ggcccgggtg tttgtggaag 63900 ggacgacctg agggcacgag tccgggaggc agggcccctt cggatgcatt catcatttag 63960 ggtttatctg catcctgtct cgtctcagga agccttccgc aacccctcca cccagactgt 64020 ggtccagccc ctgctccgag tgcccccggt gggcctttgt gctctcagtc ctggccgacc 64080 cctccaccca gactgtggtc cagcccctgc tccgagtgcc cccggtgggc ctttgtgctc 64140 tcagtcctgg ccgacccctc cacccagact gtggtccagc ctctgctcca tgtgccccct 64200 gtgggtcttt gtgatctcag tcctggcacc ttgacccgct gcttgttctg ctctccttta 64260 aactccatgc acctgacctg ttaattgcac gcagcgcgga gcctggcacc tgcagtgtag 64320 acacactggc caccgctcag tgcaagaggg cccctttgct aatgtgcaca gctctttatg 64380 ccttttttcc tatgcctttt tggattggag caagagattt tttttttcca agtaaagaac 64440 aatttatgtt cctaaatact ttttttcctt gacatgacga agttgagcaa ggtggctgta 64500 gaactttttt tcttaatttt attgcacaag taatgttctt tacaaagtag ggaaatacag 64560 atacataaaa agaagactgc caatcccccg taatcccacc agtcgcatcc ctacccgctc 64620 ttaggagatt ccggtttacc tttgtagatt ttcactgtct acatgcggac tttaaaaggt 64680 gcagtcctgc aggcgaatgt gtagccgcct gcgtttgcgt cataggtccc gaatgtcctt 64740 tctgccacac aggaggccat cccacgcttg tcctgtcacg gatcgtttgc ctcctgtgaa 64800 tattcaggtt gtttccggtt cttcctgttc tgaacagcgc caggacaagc accgggtaca 64860 catttttgca ttttaaaaca catttagtaa ctcattcttc agctggggaa aagcccacgt 64920 aagagcccat cagcaagtcc gagcgcgtgt tcctcccgct tcagccgcca tccctggctc 64980 cttagcgtgt tcctcccgct tcagccacaa tccctggctc cttagcacac tcggaataaa 65040 acctgagtct tcccggtgtc ctctgggccc cacgccccgt gtgtctgccc cctgctccag 65100 gcttgtgttc ttcctccacc ctcccagagc tccttggtgt tccggcctca ggaccttgac 65160 ctcgtggcgc cctccacgcg ggagtatcgt cctgtgcctt ctcgcggctg gttcacccac 65220 accagccaca tcatcagaag gaagagattc ttaggcgatt tttgtttgct gaaggagaat 65280 cacagatcag gatgaggtct cctggtccct tcctcccttt taaggacaga taactgaagt 65340 tcaggaaagc ccaggccaca cagcaggcca gggaccagct ggggccacag cccaggcctg 65400 caggtgcatg gctgttgcct ttctagagtt ctgaggcctt ttctctccct ttattgctca 65460 gcaagttcaa agaacatctc gctaatgatg cacctttttc tgagtttctg ttcgttaaag 65520 tcctttgttc ccacattgcc tttgattgtt tctctagaag ccagatttac ttgattttca 65580 attcactgtt cttttttttt ctttttttag acagtctcgc tctgtcaccc aggttggagt 65640 gcagtggcac gatctcggct cactgcaacc tctgcctcct gggttcaagc cattctcctg 65700 cctcagcctc ccgagtagct gggactacag gcacccacca ccacgcctgg ctaatttttg 65760 tatttttagt agagatgggg tttcgccatg ttggccaggc tgttcttgaa ctcctgacct 65820 caagtgatcc acccgcctcg gcctcccaaa gtgctgggat tacaggcgtg agccaccatg 65880 cccgtccaat ttactgttct ttactctgca atctgctgcc tctttgccaa aataaatctt 65940 tgcaggtaag ataggtgcgg tggggagtgt gaaatttatt acagaatggt tattttgctt 66000 cttaaaaaat ttttgtttta agaggcagag tcttgccatg ttgccctggc tggtatcaaa 66060 ctcctggctt acacgatcct cctgccttgg cctcccaaag tgctgggatt acaggcatac 66120 accatcatgc ctggtctaaa atattgtgtt ttttttttta atttttttaa gagatgaggt 66180 tgcccaggtt ggagtgcagt gatgtgatca tagctcacta ctgcctcgaa ctcccgggct 66240 caagtggtcc tcccacctca gcctcctgag tagctggatt acaggtgccc accaccatgc 66300 acggctaatt ttaattatta ttattattat tattattatt ttttgagacg gagtctcgct 66360 ctgttgccca ggctggagtg cagtggcgtg atctcggctc actgcaagct ccgcctcccg 66420 ggttcacgcc attctcctgc ctcagcctcc cgagtagctg ggactacagg cgcccgccac 66480 catgcccggc taattttttt tgtattttta gtagagacgg ggtttcaccg tgttagccag 66540 gatggtctct atctcctgag ctcgtgatcc gcccgcctca gcctcccaaa gtgctgggat 66600 tacaggcatg agctgccgcg cccggcctgc taatcatgac taaaggtaga acagtcagga 66660 atgtcacctg ttatctctga agtcatagtc ccttggtttt ccctgacctg cctgctactg 66720 cgcccacttg cagcagcacc tccgttgccc agtgaagcat gctgccctgg tcttactgtt 66780 tcaccggcac tctcctatct gcgatgccac tgtccacagc ggggttgctt tagggtttcg 66840 agctcacctg gggccttcct gggttctagc cccgtgagct acaggcactt ctttgtaaaa 66900 ggggattcca ccagttaggc agattccggt tcagtctcca gcagcccggg gcccttcctg 66960 gaagagtgct ttgtgagcgg agtgcgccgc ccaggtgtgt agtggtgctt ctcaggccca 67020 tgggctgccc ttccctgggc ctcttctgtt tgaggccctt gtcactgggt tcgcctggca 67080 tgatgatgga ggccctgcag ctccctgcca ggcgtggttc cgcccaggtc attctcccgg 67140 cccagctgct gtggacagtg gacacacgct gtcacagcct caggccggcc gggccacgcc 67200 tcccggaagc gggcctgctt gtgtgtggtt gcatcccaag ctctccactt gctgcccctg 67260 ttctgagctt cttgccgaag ttgtgtttgg ggccattatc tagctttctt tttgaacgtt 67320 taaagcattc aaaagatcag cttttccaaa gagtgaggaa acagggagag aaaattatgg 67380 catttgtttg aaaggttctg agggcttttt tttagcttga acagttcaaa cagcgcctct 67440 tgttaatcag gaatgttctg gcatccctgg ggtggtcaca cgggcttaat tggaacccag 67500 gctgctttga agcccttgag atccttcctg agctgggaga aagagtgcga gggcagcaac 67560 tgtaaagccg gcatttcttc attttattta catgtgtctg gggacccttg taactcatgt 67620 ccctgcagca gttgagccaa gttgctgact tgtggacagc tcagagagat gggggccagt 67680 ttctggcaaa agagctgtaa aacatggcct gggtccaggg ctgcggcggg atcccctcct 67740 gggaggcgag gtctggatgg accacgtcac agtcgtggtg gcgtggactt tgctgctggc 67800 ggcctgttct tgtcagaagt ttccacatgg gagaacgtgt ggttttactg aagtcactta 67860 atgagtgacc ctaatagctc taagacgttc atcagtatgg accccaggac ttacttcctc 67920 tttcgcagag catgtggacc cacagtaacc acactggagt tccaggcaca ggtgtaccct 67980 gggggccggt cattctgcgt acacagacct gcctttgtca gcggggctgt gggcagcatg 68040 gggtggccat ccagccatgg ccatgttgct ccaagcccca ccgtggtcct caggggcact 68100 ctgtctcgcc ctgagcctcc agccaccttg cccgtcagtc tttccctgta cctcttgggg 68160 atggggagtc tgccacctag caaagcaccc acttgtccca ccccttccat tctgttgagc 68220 tgagacgcgt gttttggtcg tttcgtgccg tggacaccac cttggtttac agtgaaacac 68280 ggcgcagagt cccctctccc ctggaccacg tttccccatt tcagctccct gctgtgcacg 68340 gctgcttctt cccgctctgc agagggtggt cctggtggct ggagtgcggc aggcagcagc 68400 atcctcccat ggtggctcgc atcccagagt gtgaccgtgg gttcatgctg acggctcagg 68460 catcccctga gcctggacac tgaagtgtac agattgaggt gtgttgttgg atgagtcatg 68520 acaagtggaa catgtgcact cgtccagata acacacttct atcagtccag agttcccggg 68580 gtccccccag tgcagccctt catccccggc agctgtagct tagccttgtt tgttgtagaa 68640 cttcctataa attcttccct ttctattttt tttctttttc tttttttttt tgagatggag 68700 tctcactttg tcgcccaggc tggagtgcaa tggtgcgatc tcggctcact gcaacctcca 68760 cctcccgggt tgaggcgatt ctcctgcctc aacctccaga atagctggga tgacaggcgt 68820 gagccactgc gcccagccgt atttgtattg cccacctttt gtttcgttga atctgtgctc 68880 aggtgtcacc tttccctagc tagagccctt tcctggccct cccgggtcaa catgccccct 68940 tccctcagcc tcaggctttc cactcttctc cagatccggc cactggatca agccactgtc 69000 acctcctctg ggccttgggg atgtcacctg cccactcttg tcatggtcgg cctcctcagc 69060 gagccactca gctctagctg ccaaggactc tgtctgtttg tccatgtagt gtccttgctg 69120 ggcacacagt aggtgctcag ttaaatttgt tcactggatg cagattctgc aggcatcttc 69180 acagattatg ctgatggagc aggtgtgccc taccaccata tgtttctaca attgattttt 69240 ttttggtgca actgtcaaaa aatttatttt tcctctacca cccgcaaccc cccccccccc 69300 atttttcctg cttcttagtg tggttttaga ctctgattct gtcacttaac atatctgctg 69360 tctccatttg atgtgaccta caacctgata ggcatgccgt ctgcccctgc tcgggcgatg 69420 ggcgtgggca ccagcaaccg tcacaggggt ccagggtttt ccactgactg ccgggtgccc 69480 tcagcgcaga gctcctgcag gagggtcgaa ttgtctgttt catagaccag aaaactgagg 69540 ctcagctggg cccttcacct ggctgcctcc agagtgcggg ctttctgctg tgccaggctg 69600 ttctcttgcc tctcccattc ctttgcatca gtcggcactc tggaacagtg cctgaggatg 69660 ttagaatcac cttatgtctc ctctggaaag aggccagtgg atagagaaat atttatttct 69720 gatcttgtag tctctgttta tacagcggtt cgttatacaa gtaacctatt gagaagagga 69780 cataggtgtc tgcatgcatc cgcttctcag tgagtccatg ctggactgta actgttccca 69840 ttttcctgag gtggggggtt gaggtttgga gagctcagag tcacagattc gcaatgaatg 69900 gacttagaat tgagtgcttg actgactgca gacactaagg tgttaactct gctgcctctt 69960 tatgcttggg atggtttgca gaacctgctt tttgaaaaca agactattta catgcacgtt 70020 tctgttccca gtaattcttg gcatggatga gggagatgct ttgtgtcaga ttcgcatggt 70080 gaggaggggg cagctctgag aggagccagg cccaggctgc ctccagggcg tccagtgctc 70140 cccaggcttg cctaggagag tgtcgattcc tgctgcacag caactctcat gaccaagttt 70200 aaaatgcatt atacgtagaa aagtgtgctt ctgtggctca cgcctgtaat ctcagcactt 70260 tgggaggcca aggcgggcgg atcatgaggt caggagttgg agaccagcct ggccaacata 70320 gtgaaaccct gtctctacta aagatacaaa aaattagcca ggtgtggtgt catgcgcctg 70380 taatcccagc tactctggag gctgaggcag aagaatcgct tgaaccgggg gggcagaggt 70440 tgcagtgagc cgagattgtg ccactgcact ccagcctggg cgacagagtg agactctgtc 70500 tcaaaaaaca aaaaacaaag aatacatact gtcgcctgtg tgcccattct caagaaaaag 70560 gaaagtttct ttgaaaacat gtggaccttc cctagttcca tcccattacg cccccaaccc 70620 acactcccag agcaagcccc tgggctctgt gatcactcct gagttttgta aacactgtgg 70680 tgctcactca gtcctgctcc ctggaggcct tggccgccca tccttaatgt gccggtttgt 70740 gcctgttgca catcattgta attacatcat ttaattaaat atggaagctg atgaaaaata 70800 attatgtgta gagcaatgtt tctgtgaaga caaagctgaa tgctttggaa agtcccaaag 70860 gaaaattgct aaaaaattgc tattgaataa agcaaatagt gaaagattat gaggaaaagt 70920 tgtaaggtct gggaagatga cagggatcca ctttaaagaa acaaagctaa caatcatgag 70980 cggtgtgtcg tggacatggt tcatgcaaaa aaaaaaaaaa agatgaaact ccaattaatg 71040 gactcatgtt cgaagaaaaa gtttgcagct tgaaagataa ttgtgtgttt ttctgtttta 71100 agttgaaatg tttgagatac acgcatcatt tgattcctca cttagccaac ttctgggatc 71160 cattacgttt tttttttttt ttttttgtga gtggtggatt atagataact ttatttttat 71220 tctttgtgtt ttcctctttt aatggatttt ttttaagata tcatttaccc ctttaagttg 71280 gttttttgtt tttttttttt ttagtattta ttgatcattc ttgggtgttt ctcggagagg 71340 gggatttggc agggtcatag gacaatagtg gagggaaggt cagcagataa acacgtgaac 71400 aaaggtctct ggttttccta ggcagaggtc cctgcggcct tccgcagtgt ttgtgtccct 71460 gggtacttga gattagggag tggtgatgac tcttaaccag catgctgcct tcaagcatct 71520 gtttaacaaa gcacatcctg caccgccctt aatccattta accctgagtg gacacagcac 71580 atgtttcaga gagcacaggg ttgggggtaa ggttatagat taacagcatc ccaaggcaga 71640 agaatttttc ttagtacaga acaaaatgga gtctcccatg tctacttctt tctacacaga 71700 cacagtaaca atctgatctc tctttctttt ccccacattt cccccttttc tattcgacaa 71760 aaccgccatc ctcatcatgg cccgttctca atgagctgtt ggatacacct cccagacggg 71820 gtggtggccg ggcagagggg ctcctcactt cccagacggg gcggccgggt ggatgggcag 71880 gggccgcccc ccacctcccg gatgggcggg ggccgccccc cacctcccgg acggggtggc 71940 tggccgggtg ggggctgccc cccacctccc ggacgggctg gctggcgggc gggggctgcc 72000 ccccacctcc cggacagggc ggctgctggg cagaggggct cctcacttcc cagacagggc 72060 ggccagtcag agatgctcct cacctcccag acggggtggc ggtggggcag aggcactcct 72120 cagttcccag atggggtcgc ggccaggcag aggcgctctt cacatcccag acggggcggc 72180 ggggcagagg cgctccccac atcccagacg atgggcggcc gggcagagac gctcctcact 72240 tcctagacgg gatgtcggcc gggaagaggc gctcctcact tcccagactg ggcggtcggg 72300 cagaggggct cctcacatcc cacacgatgg gcggccggtc agagacgctc ctcacttcct 72360 agatggggtg gcggctgggc agaggctgca atctcggcac tttgggaggc caagtcaggc 72420 ggctgggagg tgaaggttgt agcgagccga gatcacgcca ctgcactcca ggctgggcaa 72480 cactgagcac tgagtgagtg agactccgtc tgcaatcccg gcaccgcggg aggccgaggc 72540 tggcagatca ctcgcggtca ggagctgaga ccagcctggc cagcacagcg aaaccccgtc 72600 tccaccaaaa aatacgaaaa ccagtcaggc ttggcggcgc gcgcctgcaa tctcaggcac 72660 tcagcaggct gaggcaggag aatcaggcag ggaggttgca gtgagtcgag atggcggcag 72720 tacagtccag cctcggctcg gcatcagagg gagaccgtgc aaaggggaga gggaggggga 72780 gggggaaggg gagagggagg gggaggggga aggggagagg gaggggaagg ggagagggag 72840 ggggagggcc agggggaggg ccagggggag gggcaggggc tccattatcg tcttgatgat 72900 tctgggtagg aaaccttgca gtgatatatt gctgccccat ttatagtgcc agttatttgc 72960 attgttatgc atagctgagc gtcagttagg aatgatagaa ttgttttgtt acaaatgttt 73020 ataattagat tttctctgca ttaatttgtt gtgggaatta tttttctttt tataaaattt 73080 ttatgtagta cctgattctg caatataagg ttgcaatact aggctttgaa aattacttat 73140 tgaacagcta ttgtattttc ttggtacaga atattgaaaa cattcaaaaa gtatccagtg 73200 gctagcccgg catggtagtg ggtacctgta atcccagcta ctctggaggc tgaggcagga 73260 gagcggagat tccagtgagc tgaggtcatg tcactgcact ccagcctggg cgacagagcg 73320 agcctctgtc tcaaaaaaga aaaaaaaata ggccgggggc ggtggctcac gcctgtaatc 73380 ccagcacttt gggaggccga agcgggcaga tcacaaggtc aggagatcga gaccatcctg 73440 gctaacacag tgaaaccccg tctttactaa aagtacagaa aaattagctg ggcatggtgg 73500 tgggcgcctg tagtcccagc ccctcgggag tctgaggcag gagaatggtg tgaacccagg 73560 aggcggagct ttcagtgagc caagattgcg ccactgcact ccagcctggg ccacagagtg 73620 agactctgtc tcaaaaaaaa aaaaaaaaaa aaataggatc cagtggcaag cctcctgcca 73680 tgttcttgtt ctccagcagg aggccattgt tattttcttg tttatctttt agattttttt 73740 tttttttttg agacagggta tcattctgtc tgtcacccag gctggagtgc cgtgcgcgat 73800 catagctcac tgtagcctct gcctcccagg ctcaagagat cctcccgcct cagcatcctg 73860 agtagctggg actataggca ctccccacca ggcctggcta attttttgta ttttttttgc 73920 agagacgggg ttttaccatg ttgcctaggc tggtctgaaa ttcctgggct caagtgatct 73980 acccacctct gcctcccaaa gtgctgggat tacaggcatg agccacagcg cctggccaga 74040 cttcttttgt gcaaaaatga atcaacacag ccatgcaggt tttgactttt ctgcacacgg 74100 cagcatagca tacttatagt ccgcttcttg tgtctgtatt tagcactgcc tttttggtga 74160 tctttcatgt taatatagga aaagatgtgt ttttttcctc ttacacaagt tccattgtat 74220 ggatagacta cgacatttaa cctgttatac cgaactttta atccagtggt ctgagttcag 74280 tagaatgact tgcgtagcat ttagtcggat agttactgtt ctggaatgat atgatttttt 74340 ttgctcattc tcttagtatt tattgaaaac gtattattgg gccagtggaa aaaaacagaa 74400 caaaataaaa aacagtccca tgcctttctg gagcctgcat tccagtggag ggggaaagac 74460 actaaataag caggtagaaa gatgcaggat ctcagctggt ggtgttctgt gaaggaggag 74520 agcaccagga ggagcggcca ggagccaggg ctcaggtgac attccattga agactcaaac 74580 aagtgaagag ggggcaggcc acgcaggcat ctaggggtgc ggtgttgtgg aagagggctg 74640 tgcagaggac ctgaggtggg aatgtggctc ccgttgtggg aggttttgag gcagtgacgt 74700 ggagaagcag atgcctcctg cacccctgtc ctgcacaggc agtgtgtggg acccacatcc 74760 ccgtaggaaa gtggttgctc cctgtgggag tcacagcgtg acgagggttt gctgctgcgt 74820 gggcctttgg gcttatggat ggggctggag agtagtggtg gagcagccag gcctgaaacc 74880 acaccttgcc tgggtccctt tccatggggt aagagtgacc tttcctctgt ctgctgggaa 74940 gagtgtgagt ggcatcgtct gccatgtggc cagggtgtca cggagcggcc caggctcttg 75000 gtgagaggga ctggtgcccc atgtgaatcc cctgacttgg ggttcctctg atcttgggac 75060 cagagagtct gagctccagc ttagtggcct caggctgggt gcagcaggtg cagcaggtgc 75120 agcctcaggc aggtggctcc tgcagaacct gacccagggc cgggtactgc acagcatggc 75180 attagtcccc tgtcttcagg aaaacaccag ctgctcctcc cgtgttctgg ggccatgcat 75240 ctctcccaac ctggcgaccc cacctttcca cacaattgtg ttgcatcagc cagaaaagtc 75300 cggctgacat gacgccctgt tgcccttgtg actttgcagt tgtgaatgct gattgtcctt 75360 tggtttgtag cactgaggtt ttgctgtcta atgtatttta ttcctatttc tgcatacttt 75420 tcgcaaaaca agccctgcag agacagcctg tgtcgcttgg gttgtgttcc ctgccttccg 75480 cagggctctg gctggagccc cagcctcagc agttttggac tgtggtccta ggccctgtgg 75540 atttctattc tttgaaagct tgaggtgtct tgtttgctaa ttagtttgat ggctgttgct 75600 gtttcattca ttttccacct cggagtcctc tgggtctcca gtttttcaga ctcggtgaaa 75660 ctggcacttt gggcttcagc tagagcccca acatctgcta ttagccccaa aatagctgtg 75720 gcttgggctg gagctgctct cgcctcggaa ggaaagcagt aggccggact ccccacagcc 75780 ctctgctgct ctgcgtgcag ctgggcttga gtcaaaattc agctgcagat agaacaaaaa 75840 gactttcttc cccttgaaaa cccaccagtt agaatttaaa aggcttcgca gctgaagccc 75900 gcgtgttcag cagcagatgt cacagcttgg actgcagttg gaactgtcac tgccgtgtca 75960 tctccgagct gaggctcctg aggcctctga atgccttcca ctttgtagtt ggtgaagtgc 76020 gggtttcaga atggactgtc gggagttatt cttaggccgt aataatactt ggcacggctc 76080 ctcctggtta cgagcactta gctaatcccc agagcaccct tggtaaacat ctctgagtag 76140 ctttaaccac acacaggtca ggaggcttct ggaaaataaa cactcttcct gccagttgga 76200 ggtgttgggg ctctggtctt ggatttgatg tgtggcgaag gctgcaattg tttaataacc 76260 cttcatgatt caacagctct tcaagaactt tcctctgttc ttgtgtggag ctcgtgacag 76320 ccagtggtgg tggagctcca gccctctctt cccacaggca caagccgggt tcctgagtcc 76380 cagggcttct cgggaggtgt ctgccctcct ctttcagaca ccctctgccc tgtgtcccag 76440 ggccctgggc ctgtgctgca ctgagcagag actgtagggg accggctctc ccactcctcc 76500 cagatgggca gcgtcttccg tgtcgggagc atgctgtgct gcttttctct tctcagtctc 76560 ttagtttttg cgggttctta cgcatgtgag gtgtggactt gcatggtggg gagctcaaat 76620 ggtaacatga aggggaggag ccctctgagt gctgtgattt gttccatcat taccgcttcc 76680 tgatcacggt gacctgcact gctggagtgg tcagtggagc caggcctccc cacaacagtg 76740 ttcccatcgc cttcttacta ttgatttcta ttcttaaaat attgtattac ttagcactct 76800 tttgaagacg ttccagtata tatcaaatga tcaaaagtcc ataaccttgt cctacgtaga 76860 agccaaaggt gtcatgcagt ttcaggtgtt cgaatttcca gaattcttgt gatgacattt 76920 gtaggattct tcttttagac ttggaccaaa ttctgtaacc taatatttgt ccttcagatt 76980 gacagagaac cgcaggcagt gttttctctg tcacacgtgt ggtgggtggc atcctggtga 77040 cataaagaat tgcctttggt aacttgccca gaaggctgta gggttatttt ctgcttagac 77100 tttcccctat ttctttcttt tcttttcttt tccttttctt tctttctttt tttttttttt 77160 ttgagatgga gtcttgctct tgttgcgcag gctggagggc aataccgtgg tctcagctca 77220 ctgtaacctc cacctcccgg gttcaagcaa ttctcctgcc tcagcctcct gagtaggtgg 77280 gattacaggc acctgccact gcacccggct aattttttgt atttttagta gagacggggt 77340 ttcaccatgt tggccaggct ggtcttgagc tcctgacctc aggtgatccg cctgcctcgg 77400 cctcccaaag tgctggcatt ataggcgtga gccactgcgc gcccagcctc ccctctctat 77460 ttatgcagat gatcggtagt tccggaagta gttgtgtgta agaatcacca gggagtttgt 77520 gtgcagcccc taagccccgc cttcaggggg gtcttgattc agtggggtgg ggtggggcgg 77580 ggcaggctgg agttgcctca gatgactctg gtgcaggtgg tccatgccat tagcccgacg 77640 tcatgacgcc acgcaccgtg aaaccatgca tccactgccc tcgccacacg cgccgtgaaa 77700 ccatgcgccc gctcccctcg ccacacgcgc cgtgaaacca tgcgcccgct cccctcgcca 77760 cacgcgccgt gaaaccgtgc gcccgctccc ctcgccacac gcgccgtgaa accgtgcgcc 77820 cgctcccctc gccacacccg ccgtgaaacc gtgcgcccgc tgccctcgcc acacgcgccg 77880 tgaaaccatg cgcccactgt cctggttaga gccgagcaca tcctcgtgtc ctgcgctttt 77940 tgcagcaact gcctgaccac ctttttgccc agcatcagct ttaatgggtg ttcagtgctc 78000 aatgttatgg ctatgaggac ttgcttattt tttttattgt tgagcttttt tttaaattaa 78060 aaactatgag atggagaaag taagttggtg cagccacagt ggaaaacagc ctgtggtggt 78120 tctcggaaaa accgaaaagg ggatgctctg tcagtgccgc ttctgcgtat ccacccgaga 78180 tcattaaaag cagcgtttgg aacaggcatt ggcacaccca tgttcctagc agcattattc 78240 acaacagcca aaaggtgaaa gcagcccagg tgtccaccga cgggtgagtg gataaacgtt 78300 gtgtagccac acaatggagt attactcagc cttcaaaagg aaggagagtc tgccacatgc 78360 tgtaacatgg atgagccttg aggacgtgat gccaagtaga gtgagcccgt cacagagaaa 78420 tgctctatgg ctccactcat gtggctggag tggtcgcatt cttagagacg gaaggtagta 78480 tggaggtggc tggggctggg agcagagggg ctgtgggagt tcctctttaa tgcgacaggg 78540 tttcagtttt gcaaaattaa gagttctggg gataggtgtg gtgctggttg cccaataaca 78600 tgaatatgct caacacgaca gaactgggga cttaaaaatg gttaagatgg tatattttat 78660 gttaagtgta ttttaccaca attaaaaaca tcccaacacg gtggcaggat gccaccgtgg 78720 ccaggtgtgg tgcttgtctt gggtttcctc aggatgtcct cttggaagag cgtggcaggt 78780 cagcaggtca ggcctgagga cccccctttg ctcgctctct tagcctcgtc cttttggagg 78840 gtccagtctt cctcaggtag caagccttct tgccaggcca cagaagcccc aagccggagg 78900 agcggctctc cggctcccgt gctgcttctc cgtgcaagcc tctctgagag ctcacagtcc 78960 acccctgtgg actcctccgc gtgcccagag cctcctgggc tcctcctccc caccccgctt 79020 ggttcaaggg tatgtccttt actccagatg gtggcctccg tccttctcca caggctgctg 79080 ttaatacgag aagagggcgc cggaatgctt cctgtagagt tcaggaggtg acctcctgac 79140 ccgtttgatc ggattccacc ttgttcttga tgggacctcc tttgtggcct cagaaatgtc 79200 cacatgttgg caaaaccatt tcatcttttc tttttctgat atggagtgct ctgaaaccat 79260 tgccttaaac ccattctgtt tccactagct aaagctcata cacttcatcc ccagagagcc 79320 cattttcttt tatttattta tttaccattt atttattttt atacataata ttttacatat 79380 ttatggagta cctgtgatat tttcttacgt gcacagaatg tggaatgggc aagtttaggg 79440 tatttggggt aaccatcact ttgagtattt atcatttcca cgtattggga aaaattctgg 79500 ttctcttcta gctactttga attatacaat acactgttaa ctctagtcac cctcctcttc 79560 tgtggaacaa ctgaatttat acctttcatc taactgtatg ttcgtaccca ttaactcaac 79620 tctcttcatc tgtggttccg ctcacccaga cctttcaatc cactagttcc tgtcattcta 79680 ctctctgcct ttaggaggtg aatttccaca gctcccatga gtgaagacgt gcagtttctt 79740 tctgttcctg gtggtttcac ctgacacggt cacctcccat tccagccacg ttgttacaaa 79800 tgacaggctc tcattctttc tttttttttg agatggagtc ttgctctgtt gccaggctgg 79860 agtgcagtgg cgtcatcttg gctcactaca acctctgact ccctggttca agtgattctc 79920 ctgcctcagc ctcctgagta gctgggatta caggcgtgtg ccaccacgcc tggctaattt 79980 ttgtattttt agtagagatg gagtttcacc atgttggccg ggctggtctc gaactcctga 80040 cctcctgatc cacctgcctc ggcctcccaa agcggtggga ttacaggcgt gagccaccgc 80100 gctcggccca gctcttgttc tttcttacgg ccggatagca ttccactgtg tgtacatccc 80160 cattttcttt atccattcgt ctgtcgatag acacaggtta attccgtatc tttgccatct 80220 ttgctgtgat aaacatggga atgcaggtat ctttttgata cagtgatttc ctttgagtaa 80280 atacccagtg gtgggattgc tggatcatgt ggtggtgttc tgttttcagc tttttgagaa 80340 atctccatac tgggttccat agcggtggta ctaatttaca ttccttccaa cagcagctga 80400 gagttccctt tcctctgcat cctcaccagc atctgtctgt gtgttttttg gtctgtttat 80460 tagccatttt aagctgaggt aaggtggtat ctcattgtgg ttttgatttg caattccccc 80520 gatgattagt gatgttgacc attttttcat atacctgttg gccatttgca tgtcatcctt 80580 tgagaaatgt ctctttgtgt cctttgccta ctttttcgtg ggattattta tgttttttta 80640 attgttgtta tttgagtttc ttttgagttg tattttggat gttagtccct tattggccga 80700 agagttgaca gatattttcc tgcattcaag aggctgtctc ttcactctgt tgattgtttt 80760 cttggatggg cagaagcttt ttactttgat gtagtcccat ttgtctattt ttgtttttgt 80820 tgcctgtgct tttgaggtct tagctataaa atctttgcct agaccaatgt cctgaagtgt 80880 tttccttgtt ttctttagta ttttttatat ttttgggtct taggtttcag cctgtaatcc 80940 atctccagtt gatttttgta tatggggaac acattttctt ttgattgaca ctgccgaaca 81000 aagggtatac aaaatttcac aacttttaac atgctggttg atgattgtac ttgaagtgtt 81060 ttctcctcat gtccccggcg acatccagac accgcctcca cggtgcatgt cctctcccgg 81120 cctcccaatg ccagtgtgaa aatgggcttg gattgcacac cctgaaaaca gcctccagcc 81180 tccctgtccc ttccacatcc ataaagttaa cggcataggg attgtcaggt aatagcagtg 81240 cactgtacct gtgccgtagg gttttggaag tgagccttag gaagcccagc cgagcaggta 81300 gggagttgag cctggagggg tcggggctgg ggctgagacc caggttttct cccatgggtc 81360 catctccttt tcctttaagg atgtcctggc cttccctctg tctctgcaag tagagtagac 81420 tggtcccgtg tgacgttctt gaaggctgtc atcgagctca ctgtgcttgt gcttttgagt 81480 ggaagctgaa ccctggtcat gagcaagaat ggccagacag ggctcacgag gcttggttta 81540 gccaaagtgg tgactgcggg tttttcagcg caagaggctg cgaagggagg gattccttct 81600 ggtgcccctg tgccctccag cggcttctgc ccgtgggagg tgttgggcac ggctgcccct 81660 gtggttggag ggctctggaa tagcaagccc tgcagcttca gtcctcccta tgatgggggc 81720 ctggtcgcat gggggctgag agccggcagg gatctggggg cctagggatg tggccagcaa 81780 gtatccaggc tgagagccca tcacgtgaca gtgctcccga gggctggggt ctgtgtggga 81840 ccatccgcct caggcgccag ccttctgcct cagggcaagc catgctctct gttcctgcct 81900 ggggcaggac aactccaggt cacacccacc tcaggcaagg aggagcgtgc aggggagcca 81960 cccggaagca gcctcctgca gagtcggtgg gaatgtggag agccagcctg ctccttgggt 82020 gatggagatg gatgccccgg ggctccagag tactcaggtt tctcctgtgg cccatcagtg 82080 ccagaatgag gcgttgaccc catgacatga gacagaggcc ttcctgggtg acgtaggaga 82140 ctgcctggtg cgtgtgccat ctgtgggcgc ccagcacttc agaagagagc tctgtcactg 82200 tcacttttca gttgatttga accactccca tttcccccct cattgctaaa tggttgcatt 82260 tatcatggtc ttggcatcac tgggaatcgc agaacatggt tagcagagcc tggccctctg 82320 agatcttacc ccagctccca gctttgctgg gtgggttcgt accttggggc aagaagcttg 82380 tttctaaatc ggtgtcaaat gctcctgacc ctgccttctg ctctgcaggc tgcagggagg 82440 cttccccaca gagggaggtg gcaggcagtg tgccctctgg tgagagagaa ccatcccagc 82500 tgggagaacc ctggggcctg gtactgcctg ccaaatgcct ctccactggc ctcctgctgt 82560 ttcaggtcca gtgacatgtg aggtccctga ggggtgtgag gcggggtggt cttggctgtg 82620 taggtggagc ctgtagcctg ccgcctgtga ccaccccacc tgccgctggt tctgggcaca 82680 ggggctggga ggcgccgttg cagatgtgga tatatgcgat ttttatttat ttgttgtaaa 82740 taaattcttt gcactgagtt agtgaaaatt tacaagcccc tttgattaat gcaaaacaac 82800 ttaaatatct cattcaaatg tttcagaaaa aatatctctt ggcttggaaa ggtttcctta 82860 ctttcgtact gatattttta actccctgag gttggaagct ttgggaaact ggagagaatg 82920 gtcacggcgt tcaagggcag ctgcaccttt catctctgtc ctagagttca gtttctcttc 82980 caaggtcttt cagtcataaa tggtttttcc acggagctgc tttctaaccc cggtttgcct 83040 gtgtgtgtga ggacagatgg ggtctccccg gtgccagcta ctccttctgc acccatcgct 83100 gtccccacta gatgttcagc aaggggcctg ttctttgggt gggcagagga ggcctctctg 83160 ggggacgtgg aagggagaag gccgtggcgt gctctgtgtg aattggctgt ggtcagaggg 83220 agggcttatg accggccctg ggtgtgtgtg agggctcagg gcctgggcca ggccgcagga 83280 catctgctca caggctcttg gtagctttgt tccagtgatg gaagacactc cagaaacacc 83340 aaactaatgc tgggcaaggc ggcctccagc tgtcctctgt gccgtgcaaa acaggcatgg 83400 gatggcgagg ggcgtggggg tggccagaga cactgtaagg aagtggccct tcctctgttt 83460 ggaggaggag ctgggtgctg gaagaccggg ggaggggctg tgtgagcgct ggatgagctg 83520 atgagggttt cgggggccca tgggtagggt gctcaagtga caggaaaggt cagtggctgt 83580 ctcagggcag agtctggtcg ggcccagtgc gtgaggtttg cagcgtgcgc gttttaggca 83640 gcaggatggc ttctgttagg ggtccgtggt tgcagtgtgc ctctccgtgg ccgtggctga 83700 ctcgcagaga ggagctcccg ggcaggctgc tgggagggtg tgcccgggat ccacccgagg 83760 ctgctctggg ggcctggctg acagagtgac tgggacctct ccttccaggg gtgcaggtag 83820 cctccttggc caatgtcggg gtccccgttg ctcattcagt ggtgcggtgc gggctccctg 83880 agtggggctg ggtggggctc tcacagcatt gccagcgcct gctttctatg tggacctgcg 83940 cttggtccat gacaggtgaa gagaagaaca aggatgggtc ctcgggcctg agctcacatg 84000 ccactgggtc agtctagcca gggagccttg gctttgtgcc ccaggttgtg aggctgggaa 84060 tgctcacaca ccactggcgt aactttgcat gcatggctca gatccttgct gtgtcctccg 84120 gagtcccagc gttgagttag aagatgtggc tcgggccgag ctcagctgtt gctgatcatc 84180 ggggtgcact ttgaactttg aagcggctgt ttcacattgg agtctgagtt tcctcgttta 84240 aaaaatgaaa acggtgaaca acagggttgc tggggcattc actgagacaa tctggaatcg 84300 tcctggaaag tagaaagcgc tacacctgga gatcgctgat tttactcttg ttgttatatg 84360 tgggtcttct gaaggagagg tgaggaaagg aacttaaaac tcgctgagca cctcccctgt 84420 gccaggggcc tggcgggtgc tttttaaaca tgatttcgtt tcctctgaag agtgacactg 84480 tcaggtcgtg tctctgtttc tacaggtgaa gtaaaatcgg ggctttctaa ggtcatctcc 84540 ccggtgttgc ataggggtgg gggctgtggt tgaccccagg ctgtagtgcg tgcatgctgc 84600 cctggacctg ggtccacaga gttcacacat cctgggtccc agagcatcag ctacagaggt 84660 tgcttttggc cttctgtttt gtgtgcagaa tcaggtttac ttctcgggga cagctggaac 84720 tgagtgtgcc ttgtttatcc tgcaggactc cagaagacct ttccagattc gtggttgagc 84780 tgcagcagag ggagcttgcc ttgaaggaca agaacagcgc cgtcaccagc aggtagacct 84840 ggccgcccag ggtgcttgtg gggatgcgtt tgctttggag agttaggggt gagtgagagt 84900 gtgtgccccc tggctcttgg gggatggctg tccttcatca tgtggttggc cctggtctgg 84960 gaggagatgg gggagcaggg atttgaggga agggtttgcc ccatgtttcc accatgtgct 85020 gtgagcctcc gctgaggcac caccgtccat cgttctgaca atgtgctaaa ctgccatggg 85080 gtctgggggt tggcctcctg ttgtggggtc cctccttgga tcaggagggt tcttgtcttc 85140 ccagcagggt tggggcctca tgtggtcttg ggaaccagcc cgtcggtcac tagcgggccc 85200 accctgagtc ttcacgtcag catgaatgca ggcgtgattg gaaggggctc actatgaata 85260 ccaagagaca tgcccctcac tcaggaagtc ccaagggctt cagggaacct gggatgacga 85320 tcagatatgt atttcttctt atcccacagc ccggctcttc tctggtttcg ctcgtggctg 85380 tgaggggcca tccaggctcc ggcatcacac ccagaggcgg aaatgagagg cctctttttt 85440 ggatcttttc tgtacaagaa agcgtttcct aggaccccca ctgccagcaa gggcccctta 85500 tgcctccttg gctaagaagg ggtcttatgc ctgcccctga ccagaaggtg gagctaccat 85560 gagggactga accccatccg gtgggacctg tggggctggt gggcagtggg gtgggcttgc 85620 ggcagaggga agggccgtgc aacggggccc caggggagct ctgcgccctg cacggctgac 85680 caggccgtgg gtctgtgcgg agggcctgaa gctcacctgt ttgccattga tgatcaagct 85740 cagccttgtc ctcctgtgga gagagtgttt taataattta ttaatagcca gaaggaggtt 85800 tcttattttg ggggctgatg tcactttgaa aattggcttt tagaagcatc tggttgtgtt 85860 ggacataatc acatcaattt actgaaaaac ctcaaatgat aaagattgcc ttttgctttc 85920 aaagccgctg tcagatgaaa caggcattaa aagtgatttg aagttaaagc gttcacactt 85980 taccaggcga tcctcatcat tttactttgg aaatgaaaca gaatgaacta ttaaaggaaa 86040 ggaaagttgc ctgtactttt ctcccaccaa acagggaggt gcttcctaaa attatttgcc 86100 ttgaccagca gcagcaggcc catctctgtg tccagggcca cacggaaggg aacattcgca 86160 tctgcatgct gcccatgttg ccttcgctgt ggtcagagat gtggattgag cccatggggg 86220 gattggtttg ggaatggggt ctctgtctca gggagcagcc tctacagtgg gcaggtggtc 86280 ctcacaaccc cagctgtggc tggcctctca ggacctgtgg gctccctctg agagctgggg 86340 cacccgccct ggggaagggt gagtcttggg gcatcccatg gacgcgcttg gtgctccgtc 86400 ctgttctgtg aaatggggtc ttgggggtga gacgaggtcc tcagtactgc gctggtctgg 86460 gaggccaaag ggagaagctg ccctgaaatc ctgggttctc acaagcgttt ccagcttgct 86520 ttcatgtgtg tgtctgtatg ctggcttctg tcccacgtgt ggcttattgc cctgtgtggg 86580 cttctttagc caaggtgcag gctccagatg gcgctggtca cccgtcgcca ggagcgctgg 86640 agacgcttcc ctgagatggg gcagtggaga ggcgcaggag gcctctgggc gtgaggttgg 86700 agctcccggt ccctcttgcc tgcaggtcct ggggggcggc tggtctgctc cttgctggtc 86760 atgtgacttg ggcaggcacc tggtcctctc ttcatctctg tgagctgaaa ggtactggca 86820 gtaacgactg ggttgctgtg aggtctgagc ctcctgaact gcgcctgggc actgagccgt 86880 ccccgggtct cagtgctgct tgctggtggg tggacacttc ccgaccaagg ctttctgggg 86940 cctggtgacg ctgagtgcct ggcccttttg tgcacttcca aggcccagga aggaggcaga 87000 ccctaggaca ggcagcgctg gcagtggcca atgaggtgtg gatgagtccc gtcgtggcct 87060 tggtgcttgc gttctggcct ctgggctgct gctctcttcc gtggcgggac accgtgttcg 87120 tcgcggcctg ccgtggcggg gtcagggagc ctcgcacggt tgaacagctg agcacatttc 87180 tacaagtctc ttacaggcag ttggacagaa attcagatga gcgtgaagga ggcggcatgg 87240 cagaagatgg gaggccacgg tggcccagat ccccgagggc tttgccaggc gggcctcatt 87300 ttaaagtcac ttttgtttgt ttctcattga aagtagcttg tagtcactga agaacagagc 87360 cctggtccag ctgaggtcac gggtcatgag agcagctgct gggcattttc cctcgtctgt 87420 gcggaccagc gggcacgtgc ttgtgaccac gtatgttctc ctctgcagtt tttaccaagt 87480 atgttggccg tgtccatctt tccctggtag tgaacgctgt tctcgccatc tgaggagctt 87540 ctcagggtgc ggctccactg ccctgttcct cgtagcccag tgcccggtgc tccctcttcg 87600 aggcggtgcc ctgttcctcg tagcccagtg cccggtgctc cctcttcgag gcggtgccct 87660 gttcctcgta gcccagtgcc cggtgctccc tcatcgaggt ggtaccctgt tcctcgtagc 87720 ccagtgcccg gtgctccctc ttccaggcgg tgctgctgtg acggtgccgc tggggtagct 87780 cacgtggcag catctcggaa tgcttgtgcc tcaggccgag cttctgaagt gacggctggg 87840 tcattcgtgt gcctgttttc aggagcttgg cttttagaag atgaatgttg cctatcagcc 87900 ggcgtagtgt gccgctgtga gcagcctaca ccacgcagtc ttgatgcact tcctgggtgt 87960 tgtgtaactt tccttctctg ctgatctgat gtgcggaaca gagcgccctt cccacagtcg 88020 ctgtcttggt gacttggtgt tcctttcacc aacatgacac atgtccacgt ccgtgaagcc 88080 agaagccagc aggtacctca gcaggtcctg tgggtcgggc tcctctgcgg agttcctgcc 88140 gttgctgcct ttttaaagtt tgcctcagtt tctctccata gttactgcag tagcattcca 88200 gcctgtttca gggaggatcc tggagctctc ccacccagag gagttccaag gtagggaagg 88260 ccgcccaggg agggtctgat gtcagcttgc cgtggaacct ggtgcaggaa acagatcatc 88320 ccgcagtgag cagatgccga gccggaagcc atcacctccc ttgtttgagg aagagaaaat 88380 gacaccatat ctcggagtta gctgctgggc caccaaccag cctggagcaa gaaggaattt 88440 tcctagcatt gagctatagt tttgacccct tttactggtg aagcacagtt ccaaacgctg 88500 ctgtgagctg gactgaagtt tctgtctgaa tgtttctgcg ctcttaggac tggaggctgg 88560 aagccccacg gtggcacctg tgctgcattc tggtcttggg gctggagttg gtagaggcaa 88620 gaagcttctg gaactctcag tgtaggactt actgctttcc agggttgcga ggagcctgct 88680 tgttagcttt atgcgggttt gctcaggtgc tgcactggaa ttcctgtctt acagcagaga 88740 gagtgtctgt ggggctgctt gaggattcag cgggatgacg ttggtaacgt gcctggtgca 88800 gcagctctcg gcagtccccg ggacgtggtg ctgtgacgaa gggtccgggg ctggctgtgg 88860 agccaggagc aggcagggct ctcagtgggc agcggggcag cctacagggc actggccgta 88920 aggcgctcca ggagggtggg gtgcttgagt gcattgcagc ctgggggttg ggtcagaacc 88980 accaaacctt gcctcctgtg tgtttctccc ttcctttagc cgtggacaga tggggcgtca 89040 ttggtcactg gtgtgagcag agcgtgtcag agatcctggg cctctttacc ttggagcagg 89100 agcttcatgg cagtgtaggg gagcctggcc tggtttacgc tcaagcctcg tttcggctct 89160 tagaatctga gaatggacct cctggttgtg gggctgagga cagggcatac tgttcagaat 89220 cagtgggtgg atctggtgcg ccctctgctc acgcttcaca cagggcaccc cggggctgcc 89280 ctgtagcctc ccttcccttt ccgggccctc ttagtctcct tggcccttag ggacccaagc 89340 acccctctgc ctggcgtccc cagctctgcc gtgggaagag ccgggacagg aggctgcagt 89400 cctctgtggc ccagcccgtg gccatgctgt catctttcag atctgggggg gaataggcca 89460 gcgtgctctg agggctcgtg aagaacaggg ctgggaagct cgggcaggga tgcgtggggc 89520 catgctcttg gcggtttctc tgctgtgctg gaaataagac cgtgctttgg agagggctgg 89580 tggcgggagc ggggcctctc aggaccccgt gagggctcca gggttcaggt gtatcatctg 89640 taatcccggc gatgaatgac gatggggacg ctgagagcag tcagtgtttg tctcgcatct 89700 gccctcacca tgcgctgcgc tgtgcttcat gcgcagcctc tcacttgagc ctcacagacg 89760 ctcccagctg gaagctctta tgattccctc ttttgcaggg aggaacttga gccccgggct 89820 aaacagctgg gaggtggtga aagcaggacg tgcgtccagg cctgtgggtc tccagagctc 89880 tgtgggatgt gtttgcaggt ggctcctggg tccctgtggg acacgttgtg tggctgccgt 89940 ctcggctttg gccttgcttc tctgcctcag cagagaccct gggtcatgga tcctgcctgg 90000 tgctgttttg cctgtttgaa gccccaggca tcctcctcga tgctgactta aggtagagcc 90060 ggctgagaag tccacagagg ggagcccctg agggccgtgg atgcagatgg agctcttcat 90120 gttggggtct gccctggcct cccctgcctc ccctctgtgc atcggctttc ccagaagtgc 90180 attccagcct gggctgtgat cgccgcagtt tgttttgaag atcccacctt gctgcctcca 90240 ggcagaagag cccttggcct gaagccacaa ggctggcatg tcctggagca cctggccgtg 90300 tggtgcttcc aggtgcctgg gcctggcctg tttcatctac tgctgccatc aggggcctgg 90360 gcagcgtcag gaggagtcag gcccttgtca agcataaggg actcgagagt cattgggtgt 90420 gatgagtgga tatcaccatg ttttctgtca cagacggtgc ttttctgagc ctcttcctgc 90480 ctcaggtttc tgtcacctcc caagagtgag tgaagatcag tttactagtt atgagtcttt 90540 cctgctgttg gtcccaggtg gttaggccgt cctctcaagg acgtaacaag gccttgtcac 90600 ctggcatctg aattatggtg cacttgagtc atccagagac cagcaaggca tacgagatcc 90660 atggtggctg ggctgttccc ctcttgcact tgaggggcct cccgctggag aagccaccac 90720 tggcccaggt tcctggggcc tgtgtttgca tttggctcta ccaggagtgg ctctccgagc 90780 gagtctttct ggtgatggtg actcctgttg ggggttttga ggctcagtgc agtcgcctct 90840 atggagcctg tggacggtgc tggctcaggg tgcaggtttt tagctagtcc ttgtcatcac 90900 tggcaccgtg tcctgctgtc actttttgag gtaatgggaa agtacaattt ctgggagcct 90960 tcagggcatg gcaggggtaa gttttccagg ggactctgtg gggcaggatg tctcctgtgt 91020 gtggccagtg gtgatgatca gacgggttag gcggtggggg catctgggag gtcaaggtga 91080 cggaatttgc cgtggatcag tgtgggtgag agagcacatc gggatggcca gttctggcct 91140 gcccttgaac tgaccatggc ctcagccatg tgttcccagc aagtctcatg ctcaacctga 91200 ccacctgctc tcggcataag ggggcccctg gggtttgaca tggccagagg ccttgttgcg 91260 tccgttcggc tttggcgcca ctcgatgtaa atggtctttg gcagaaggtg tggaatcagc 91320 ctgagtctaa tgggctgtct ccatgtattc cacggtggca gcctgccatg cctgtctggt 91380 ccagggctgt ggcagggcac gcgccaggag ctctgggtgg caccgtgccc ttcaccgtgg 91440 gctcagtggc agctaggggc gctccgtccg gcagcagaga acccgcgtga tctgtctgta 91500 tcctgctcct gtccccctct gccccttgtg cgtcccatgt ggggctggtc ccaagagttt 91560 ctcccgcagc cccggaccat gcctgggacg cacagtgcac ctgcgccata gaggcctcag 91620 cccccaaccc agccctgcac caggggacag ccttttgagg ctccttgtct gtctctagaa 91680 cggggccctt gatggcatct gctttcctgt ggtggttcca gtgcggatgc tggcacgtgc 91740 ctgccttgtt ctttggcgaa ggctgctcgg gttagtttgg ctagtgtggg ccctttgaaa 91800 agccgtctct ctcgtgagtc agttgtctgt ctgtaggata gccccagtga gcgggttttt 91860 ggggaaatgt gagggacatc cctgtgcctg gggtctggca ccatgcactt gaacatggac 91920 ccctcagtga gtcaggtgcc ccagagtgcg ctgctcaagg tgacagggga gcaggcccat 91980 tctgtgctca cggctgtgcg gtccacctgc tggccggtga tggctgcccc ggcgaccctg 92040 gcctggctgg tggcctctgc ctgtcctttt ggttctcagt ccccctctct tctccactgg 92100 gactttagta ggaaaagagg acttggcggc acctgtcccg ggagccaggc catgtggagg 92160 agctgggcct tccccaggct gtctgtgcgg cacctgcctg cagtgcccag acttggacgt 92220 gagatggtgc ctgtggcatg tgcagccgcc cgctcctctg tgctcagctt agaacctcct 92280 cgtggggcct cctcagcggg ggtgggtggg taccaggcct gtacattttg tggccaatta 92340 gagggagaga gagaaggggg gcatggcatg gagatgtctg ggtgagcggg cgtctgtctt 92400 ggggcctccc tccctcatgc ggtgccttct tgttcctcca gtcctttcct gatcagggct 92460 agtgaagtcc cgggttgggg gacatagacc cggtgcccat cctgccaatg ccgggttctc 92520 tgtggccccc cagtatggtc tgggggcctg tctgaggcac catcatgttt caggctgcag 92580 ctggctgctg ggcctgagat cgagccccat ctctcctgag agggggtcca gcccatcctg 92640 gctccagggg aaagcctggg tcatcagcag gcatggtcgg gtgtcatggc tgtgccccgc 92700 agcacgcggt gtctgcctgc ttggaggggc ctccgcagtg gggcactgcg tggccctgta 92760 ggatgcaggc aggctttggc aaggctggcc ctgctctagg tgggtgtctg aacctgttcc 92820 ctccccaggc agagcccgca aggcgagcac acgctccttc atgacggggc cgggtccagc 92880 gtccgctgcc gctgggctct ggggtctgtc cggggtgcct ccgcctgctg ctttagccag 92940 cttgtgttgc ttctttcagc aagatgagct gccgttaata tttcacaccc agactgtttc 93000 cctgaatgtt ttgcatttcc atatttaaaa tggcatttac atattcatgg ctttttaaat 93060 aagtttttat tgttaaggga tgtggaagtg gatgaaatgt gaaactcccc cttttattca 93120 agcactagaa aaaaatttca tcccaaatgc aatcactttc tgagtgttta gctctgtggc 93180 agttgccata ggagattgtt ccagaagcca gtgggtccca gggccatgga gccgcccttt 93240 ctggcatgca gggactgggg gaaggcaact gccatcagca ttgctttcca gccgaggttg 93300 ggcatggagg cctggttgct ccttggggtt tctcctggcg ggggcctggc ctcgtgctgg 93360 gatgcggggc cggctcccac ccacatccat ggctcttgtt ttggaggaag tgtctaaggc 93420 agacgaggct cttcatcttg gaagtggcta agccagggat gcctggcttc ttttctccct 93480 tctccctggt cactcggcgt ccctgccctg gttggcctct tgctcccggc tttgcggctg 93540 cggctgcagc tagggcctcg gagggccatt cggccctggt gcactctccg attctgaggc 93600 gtggagggtg gcaccggcac ccttcaccct tcagggtcct ttgagggtcc tgtgtaagaa 93660 catgtgcagg gcggacgggg gctgctggag gggtgctgga gtcactgttt tacgtttggg 93720 cagtggtgaa tgtggctgag cctttgcctc tgggacactg gcctggggaa ggcccagagg 93780 aagccaccaa ggattgacaa gagtgggagg ccttgggaga ggcgtctgca ggggccacct 93840 gggcttggac gctgtgtagg tgatcttgag ccaagcacag gtcacagaag gatgcacgtc 93900 ctgcagggaa gtagttgagg gctttggaag cctggccacc tggcctgtgg cgtgctgtgc 93960 tgcagtggag cagggcaggg actggggggg ggcggggtcc agatagtaga ccataaaaac 94020 agggaaactg aggcctgtgg ggggaaagag actctacttg gtggagtgaa gcctagagca 94080 tggatttttc tgatctgtat tgttactttt taatattttt aggcataaaa ttgtttttta 94140 tcatctcagg cctaaaccac ccacaaaacc ttagccttga gggtcggggg aagtgtggtc 94200 cgagctgcag ctggcctctc cacgcagagc ccctcacact ggcccctgct ggagccatct 94260 ggacgggggt ctgccgaagc ccggcttcct cccccatcag ccttgaagga gagtggcggg 94320 tgtcctctgt ggctgtggag ttctcagcct tgaaggagag cggcgggtgt cctctgtggc 94380 tgtggagttc tcagcagtct gcctttggcc ccagcccctg gcagcttctc ccagcatgag 94440 tgttgtattt tccatactct cagggtgctg ggtcattggt agtgtctggt tcctcctgag 94500 accagaggca ggacacagag ctcagggctg tggccctggg ggcatggctg ggggagtcac 94560 cttcactgct gagggtgggg ggcatctcag tgtgcgtcct ggggcccgca gcgctcccgc 94620 cttggcaagc cctggactgc agcctgtgag ctcagaggga gggtggtccc gtgagctagg 94680 gtggggtggg ggtgcgggga gggtgctccc atgggttggc tgagagtaca ttgctggctc 94740 agggggtcgg gccgtgtgat ccccgtggca gccagggctt aggctgtgga catggtgtgg 94800 ggtgcttcct gggggttggg ccctcctcac agtcctcgcc ctgtctgggt gggctggcca 94860 cacaggaggg tgaggctgag gcagcctcgc ctgctcttcc tcctcgcctc tggcctcggt 94920 accggggcgt ctgctgagga ggaagaccgc ttgtcctgct gggaccttgg gcctctccga 94980 tgcatgttga ctccagctga gaggtgttct ccttgcctgt cctgcttttc atctggaaaa 95040 tcaggtccag gactcttgct ttgcaagatg agtggagaat tgaagatttc agaagttccc 95100 aacatcaagc aggtgctcag ggaatggcgg cattgtttgc aggagtgggg tctgtggtct 95160 ctgtcactgg gtcctgctca cttgaccccc gagcctttct ttcctcattt gtattagggt 95220 cagttccacc ctcaatgggt ttctttgaag ggtatgtgca gcctgcctgg gggaaggcag 95280 cggagtgctg gccttcctct cagtgcttgc ttggcccctg ggcctggggt tctcagagtg 95340 aggtgctgca ggcgatggcg gtgtggcctt gagagcgggg gaggccccat ctgctgcttc 95400 ccctccggct gacttctcct aacaagccgg aagtgtgcgt ctggcattca tgcccccaat 95460 ccccacctct tgatgtggtt ccttccgttt tgtcagtagg atctgttttc aacctctgca 95520 tgctgaagtg ctcatctctc taggccactt ggtctggcgc ccacctcgtc gtggttctca 95580 ggatgcctca tttcattagg ctgagtggct ctggactaag tgcacctgca gagctgaccg 95640 ccccaccgcc agcctgctga gcgctgccgc agccaggacg gtggccaggg agcacgtccc 95700 ctggggcagc agatgcatcc ccttcctttc tccttccctt tggaccctgt atgcacccct 95760 gcattctctc accctcttta gcaagttaaa aaaaagctgg catttcctcc cacccccatg 95820 aaaccctttg taacagcagt ctcaggtccg cagtgtcagg ggctgcccag tggtggtgag 95880 agcgcagcgt gggtgcagcc ctggtgaagg gcctgggact cacagctctg tgctctgatc 95940 atgggctggc ccgcgctgtc agtacagaaa cgccctgtga acttcagctg ccatcatggc 96000 ctgtgtcgtg tggctggtgt cgtgtggccc tcgcatagtt atccgacatg gcaccgtcgg 96060 cacagaaacg ctctgtgagc agcagctgcc atcatggccg gtatcgtgtc ctcgtgtagt 96120 tgccccatac gtccacctcc tgcttggctt cccctctttg gagcctccag ggccagagga 96180 gcacagttca gaaactgctg gtcaggagac ctttcctgga gaagtttctg ttccggttgt 96240 ggatctggcc tgtgtgggag cctgaggtgg catctttgag gtgacccggg accatgggga 96300 aagcgctctg tttcctggct gaggttttca ggcagtgcca tggcacaagc ctgtctgcac 96360 ctggggctag aggtggcacg tgcaagtcac agaagggaag gaggagacag cctgggcccc 96420 tcactcacct gggccagagg tggtgtgtgc aaggtgcaga agggaaggag gaggcagtgt 96480 gggcccctca cttgcatggg ccaagcagac cggtaacatg cctgccgctc tgtgacgttt 96540 ctgttagaga gcggaaggtg tctgacctca gctccccaaa tcagaaaacg gcatctggag 96600 tgccatatac gtttgagaag agggtgcttg ggtcagttct gtcctttgca agcgaacatc 96660 tttcttggcc cccaaaaggt ggtagtagaa tgtagatttc ctcaaacatt tggagaaaac 96720 acagaaatga atactacttg aatgttgttt attgttgctt caggaagaga atagggagat 96780 gggagaaggg cccttgctgg ggttggtccc taagtatttt ggtgccctga acttctgttt 96840 ccttgcttat tttgaagggg tttgtgtgag cctaacccca ggagagcagc ccacacccca 96900 cagcggagcc tagagcaggg tcagggctgc caggagctgc tatctgggga gactgaggtg 96960 gggtcctcga ggcctcctct ctcatgcccg gcactgccaa gcccagggca tcatcagtgg 97020 acttgggagc atcctcttat gaacgctttt cttgagtttc cctgtaactt gttgtaaact 97080 ttgtaagctc tgagccaaga gcttccttct tagccttgaa gctggccact gccggctcct 97140 ttccatgccg agctgggatt cttggtgtgc aggtgtggag agcagctccg gtgccatcag 97200 gcgattggag tacgctttcc ttccttgttt ggcagaacat aaaatcagtc tcaggccctc 97260 ccaccatggc ctccactgct gagccccgag gagatgccaa gagatgggaa gggcccccac 97320 cgaggaatgc agctggctca gagtctgcct gtggagaaca ggagcccctg gaaggggcag 97380 gctttgggca ggtgagtgca cttggtctga gggagggtgt tggtgttgcc agcatcctga 97440 gctcgagttg gtgccataga cctgggaggg tctctcgatc ctgttaggaa acttgggtaa 97500 gagagtcgga acaaagaaac atccactgct aggcacctgt gggtaccagg cactccacac 97560 gtgtccccct gccctggcac tgatcctgcc tgctggcggg gagcctctcg ctttgcccca 97620 gtttccccaa ggttgtggag ccactcagcc tggagtctgc ttgtgagctc agggctggct 97680 gtctcctaag cctgtgccct ctcaccacgt tgcctctcat cagggcgatg ctttttcaag 97740 ctcagatatc acaggtcgct tccgcagggc atgaagcctc ttaatgctga ccctttttta 97800 atactgtggc cgagaaacac agttgcgcag agtctgcagg aggaacagtg tggacgtggc 97860 tgtgacaggc atttttggtc agcgtggggc aagtgcggct tcctgtttct gtctcattga 97920 gcttggagtg gacatagggg ctctaggaga aggaaggctg tgacccctgc cctgaaggag 97980 ctttccctct gcctgggaag agaaaccagc agtgaatccc ttaggggact agagagcgtt 98040 gggccgcgtg gtcctgatca tggccacgct tcccaaatgc ctggctgctt gtgagttata 98100 tggcgaaaag agcctgaaaa tagagatcct tggactcacc tccaaaggct cagattcagg 98160 tctctgctga ggccgttgct cccttcatga gtgtactttc ccttgggcct gggacatgtg 98220 cacacacgtc accatgagag gtggcaggca ggactcccat atgtggccgt gagaggtggc 98280 gagagctggt gggcattgtc ccgagggtcg ctgtgagagc tggggggcag gaggcccgga 98340 cattgcccac cacctgagcc ttcctctgca ccagcattgc cctcacttgt cagtccaggc 98400 ccctttaatg ataaacaatt accgaaaaca aagagttttt atttgtgggg aatcataact 98460 atcagtattt accatctttg gaaattaaaa ttaaaattaa atcattattt acaattatat 98520 ttataatctc attaaaaaca attcattatc acttaacaaa atatatttat gaaaaatgca 98580 ttttctaaca caaaacgaga cagtgagagg aatggcattg ttttttactt tttacaaatc 98640 tcttcagtgt ctggtgaaat agaagatggg agcatctcgt gtctgcgtcc atctgccacg 98700 gtctcttctt ttggagtctg tggaataagt ctggccccgc acaggtgtgc agttggaaga 98760 aggagggcct agtggcctga gggccccaca cacaggttct gctcagcctt gcctgctggg 98820 tgggtgaggg ctgaaggcag gtgcgctcac cgttccttca cacctttcgt ggctagtctt 98880 acctttctgg gtagtgtttg ctcaaaattc tgattagatt gtagggggtg ttttttgtgt 98940 gttgaacatg aacatcatta atgaacgtca gtcattgaat gtctgggaag gtgtcctcag 99000 ttctggtttt tctggaaacg gtgactcatg tatcctagaa aaggcccact ttgcagcatt 99060 ccgggcagtt gaaggaagat ggctcaaccc ataagcagca gagctgactt ctttcaggtg 99120 ttcttgccct agatgagcag caggggtgtc cctggggcct ggagatcatg cccacctgat 99180 ttctggtgga gccaggaact tgggcagcca caagttgctc tctgagaacc ccacaaatcc 99240 aagactagtc cttaagagag ggtggcctct ccagagacgt gtgcagctgc tggacacaat 99300 tgggctctgg tgactggtcc tgtttaaatg ggcagatttt tctttttgtt gtcatagaga 99360 agctaatttc ttattacttg tcaactattt ccgtcttaaa accaagtaag aaactagaag 99420 ctttctcgct aagatcaggc acgaggcaag gagtcccact caccactcct attcgctgtc 99480 gtactggaag tactagctat agtgcagtaa gacaagaaga gggaataaag gaaggaagaa 99540 ataaaactgt ctttgtttgc agatgacatg atcgtctatg tagaaaattc tgagaactaa 99600 caaaagaact tgtagaataa tgagtggtga gagagagcag ggtatgggcc atacacgccg 99660 tcagctgctt tcctgtgtac cagcaacaag cagagggaat ttgaaatcaa cacccagtac 99720 tatttacatt agcaccaaaa aacagtgtag acacagagac cggtacaggt tatgtgtgag 99780 gaaatcacca gacctgatga aagaaatcaa agccgtaaat caatgcagcg gcattctatg 99840 ttcacgggta ggaggagtca atatattatc agttctcccc agagggtctg tgcagtccca 99900 gtcagaatcc cagcaagtta tatttgtgga tatcaacaga ttctaaagtt tatatgggaa 99960 ggcaaaagat ggcaatggcc agcacaacac cagtgaacaa caccggaaaa ctgacactcc 100020 ccgacctcaa gacttagcgt aaaaccacag tgatcaaggt ggtgcgctgt tgatggaaga 100080 atggacgaac aggtctgtgg aacaggtcag agagccacga gatagaccca cacagatata 100140 ctcggctgat cgtggaccgc agagcaaagg cagctcagag gaaaacggtc ttctcagcaa 100200 atggtgctgg aacagcggaa cagccacagg ggaaaaatct agacacagac cttacacctt 100260 cctcaaaaat caactcagag tggatcacat acctgagtgt aaagcacaaa actttaaaac 100320 tcctagaaga tagcggcgga aatatctagc tgactctcaa ttaggcagtg acttttaacg 100380 tacaacacca aaggcacagt ctgaaagaat tgatgagatg gacctcgtta gagttggaaa 100440 tggctgctct gcgaaggaaa ctgttgagaa taaaaggaga agccccaaat ggagaaaata 100500 tttttcaccg tcatgcaaaa gacatatctg ataagggctg ttatccaaat tatacaaaga 100560 actcttcaaa ctcagtggta aggaaacaga ccacccaatt aaaaaatggg tgagctctga 100620 acaggcgcct caccaaagca gacacgcggg tgacggagaa gcacgtgcgg agatgctcag 100680 cattgaaaat gggtgagctc tgaacaggtg cctcaccaaa gcagacacgt gggtgacgga 100740 gaagcacatg aggagatgct cagcattgaa aatgggtgag ctctgaacag gtgcctcacc 100800 aaagcagaca cgtgggtgaa ggagaagcac atgaggagat gctcagcatt gaaaatgggt 100860 gagctctgaa caggtgcctc accaaagcag acacgtgggt gacggagaag cacgtgagga 100920 gatgctcagc attgaaaatg ggtgagctct gaacaggcgc ctcaccaaag cagacgcagg 100980 aagggggaga gcagggagac gccaggctcc ctgtaacaat catctctcct ggtaactgat 101040 gaagtgagga ctgctcttca gcatgagccg tcatgaggga cccaccccca tggcccaaac 101100 ccctcctctc aggtcctgct tccaatcgtg gggatcagtt gtcaacctga gatttggagg 101160 ggtcgggaac cacacagtaa cagtgtcctt ccatgggtga atggataaaa gatggtatgt 101220 ccattcactc aaatactgtt ctgagctaaa aagaaatgag ctaccaagct gtgaaaagac 101280 gtggaagaat cttaaatata tattgcacag tgaaagagga cagtctgcaa aggcggtgta 101340 ctgtgggatt tctcctccgt ggtattctgg aaaaggcaga actgtggaca cagtaaaaag 101400 atcggtggtt gccagggatg gacaagaggg atgcgcaggc ggacccagag gatttttggg 101460 gaatgaacct actcttcacg cggccgtgat ggtggacacg cagtcgcacg cagcagtgga 101520 ccgactgcac gcggccgtga tggtggacgc gcggtcgcac gcagcagtga accgactgca 101580 cgcggccgtg atggtggacg cgcggtcgca cagggactgc agacatgcgt tcgtctaaac 101640 ccgagaatgt aagacatgac aagtgagccc acgtgtccac tgtggacttg ggttcatcag 101700 ttgtaatgaa tggactgcag tcgtgcacgg tgcaggggaa tctgcctggg ggctgaaggg 101760 tagatgagaa ctctcatttc tcctcagttt tcctgtaaac ctataattgc ttgaaaaaag 101820 aatatctgta aatttaaaac aaaaattagc aagtaagatg aggctagaga gagctgtccc 101880 aggggtcaga ttgagacaaa atgcagttgg ggccagcttc ctcctgagtc agcctcactg 101940 actgcttgga gaagagaggg accacgctga gcgtcaggag gcagcgccgc ggcgggtcta 102000 cgaggcacat ctttcaccag cctttccatt agaggcacct gagcagccct ccatcatttc 102060 acgtgtgcat ggtcaggccc ttgtgggggg ctcacaggac ttgtgtgact gccagttgcc 102120 gaaagaagga agcaggtccc ttgtcatgac cagagagacc ccaggtgcga tggctgtcac 102180 atcctgctga ccttcccagc ctgagccagc tcgggccagg gtgaggacaa gggctgatgg 102240 gggctgaagg gcacagagca cccctgggga ggcgtgtggg cctgggggac acacctgagc 102300 tgtccctgtt gctgctctct ggatgagaac ctgggggccc agctggtgca ggcacgaatg 102360 ttccagcaca tttgtgagga tgagctggga ggccttgagc aaggacacca tcagtgcctg 102420 cgcagaggtc ccctgggact gacaagctcg tcggggaaca gaagcagcgc tttgaatttt 102480 aaattggtta aattcctttt cctgtcacag tctcagctgc tccctgtttc cttagagagc 102540 cagggagttt agtgtcctct catctccatg ctctgccaat tttactgcct ttccgtattt 102600 cctcaccatg aatagaactg attttatggt gcgtaagcca tttttaatgt agcctctcat 102660 cacaaggtgg agaagtgagg gggattgtgc ctctccagac catagtacat gcgtcccttc 102720 tgtttttaag catttgggcc aagactgcct ttgcagattc ctgaagtgcc tgggatgagt 102780 gtttatcgtg tgcagggtcc gctctggggc ccgaagaagg ctgacacgct gctcatccat 102840 ctcttgaagg agctcatagt gcagtatgtc aacccaaaat actccaaagc gtccgaatct 102900 agtttaaaga gagcttattc aagtgcaagg ttcttccagg acggccacca gggaagcaca 102960 gattccaaag aatggaagtc agtgttccga agcgtggaag ttccggatca ttcatgtaga 103020 caagtttagg gaagcttagc agatctcagc atccttctgc gagaggctta atgcatcatt 103080 agaaagatcg gattcgatgc ggtggccttt atctttccgg gaaggttgat ttggcattcg 103140 cactgaagat gtagcaggca tcttgtgcca tctggtctgt aggtgcagga cagtgaaaga 103200 ggcagtgaat ccatcacaaa gatcggtgac tggaagtggg agaggtgtgg tgtttggtct 103260 ctcctagtta tttacggaac aagagctaag aggaagagag agtcgcggac acgctcccag 103320 cttcggcctc cggggcttaa ctttttcccc ctggcataat aaactgagag ggtcctgaca 103380 ttttattttc ttttacaagt aggagtgata ggacacacct ttggaattga gtttatgttt 103440 ggaatcattg gggtcccaga gagagagaga ggcccaagac tatgtgggaa gctggtctcc 103500 tttcccagac ctgccgcaga cgacgtagag agttaagctc tggcctctca attgcttcct 103560 tattccaaat ttctcggtct gttcatctgg tgtgcccctg gggaactcct gggagttggg 103620 ggctgtaatg gcgtggagag agctctgggc ttggggactt ggcctcgagg tgctgtgtgt 103680 ccaggctagc ttttctctag ccccaggacg tggtgactga aatatttcag cggggaggca 103740 cctgaatgct gctggcacag ctccctggac ctctcaggtg agctccatgg ctgcgcccag 103800 ccaggcacct gctgcgggcc gaaggcaggg cagggaaatc caagaggagg gcatttgcct 103860 cctgacatgt ggaggtgctt ttgatgcagt gaggcgcatc ggggcagcca ggtggcattt 103920 cctgcaccca cttggtgctg gagtctgtct gcctgcccag gtgcttttaa ccccatccct 103980 gcccctctgt tgggtagtgt tttcttcacc cttctgctgg gccccagaag gacagctttt 104040 tggactggtt gggagcttcc tggcagcggg tgccatggga accatgagtc cgtctgcacc 104100 tgctgaccca gctgcctgcc tgtgtgcccc tccgacggtg gtggctgtgt tgtgcacctt 104160 ccttgtgtgt agacaggatc ctgggggagg ccgttggctc gagcctgggg tgcagagagc 104220 actccttgga ctgtctctga catgcgtgta aaaataactg catttgtttt tctgatctct 104280 gggcagaagc tcgagcctgc gtgtccagct gtgtctgtct tgccaccttg ctctcgtcag 104340 ggagaccatc tttgttagac aggcagcctc cagagggatg ggatcgtgtg tgtgctctct 104400 cctcatgacg ggaggcacct ggggttcctg tcctgctgcc tcgtgtgtga ctggactctg 104460 agaagcgcgt gttcctcgcg tcctcgtcac tggcaggtga cggattcaga cccacggcag 104520 gaggggcgct gcctagcagg agccgtgtgg acaggagccg ccgtgagcct gctgggtggc 104580 ttggcctgct cgtgcctgtc cacattcaca gtcccgcgga gacagacctt ttactcttct 104640 atacctgcca cagcacattc agatgtccac aggcaaaaac ctgggctttc cctcttccag 104700 gcgtcttgtt ctttcactcc ctccctgccc cctggcctgc ctggtgttgg cctgctgcac 104760 atgtgagctg cctggcggtg ggttagccct ggtggcccca gctcccccgg gatcctgcgg 104820 gcccctcatg gaatgcgcct gcccggtccc tgccccttcc agctggctct gggactggaa 104880 ggaatttccg atcagagagc tgcctgccca caaacccaat tttgtcctcg tggtggggtc 104940 gtgcaccacc tccactctgc ccagttggtc agcgccagca gcactcccca tctcctcaag 105000 gtccagatgc cctgaagcct tgggaaggtc tgtgtccccc tctggctttt ctcctcctcc 105060 ctgtggtccg tgtgcctgac tgccgcgtgg gaagcctgaa ggtgtgggag cagagagact 105120 gcagtgtgag ctgaagatgg ggccttgtgc tcctggggag gcgtggtgtg gcctgacggg 105180 cttgagggtg gccgaatgaa ccttctgagg gcaggtccca gcagccacct gtcctgtccc 105240 cagggtgaga agggcagagg gagccggttt cagcccctct gtgtccccgc caggatccct 105300 gcaatggcca aggccccagc tgagccttca gccctcttgc agacacatcg tgttttctgc 105360 tttgccgctc atccttccat gttacacagc ctctggtggc gtgcctgtgc cctttgcgag 105420 gcctctgggt gtagggactc ccgtcagggc cttccctcag gcagggcagg tcacctggcc 105480 tctcctgaac ggccatcttc cagaagcagc cttcctgttc gtgttctgtg ctttttgtga 105540 ctcccgtgct gatgagcgag tgtttcatga actctgaact gcctaggtct ttcacggtgg 105600 tctggcctcc tccgccctct ctttctggca ccagggctgc atttcgggga ctctaggcat 105660 ggatggccct gccaggtttc agtagtgctg tttgggagat gagaggtggc tgagctgctg 105720 atgacaaatg cgattcagtg acagaaaatg cagaataatt agtctgggac cagagaactc 105780 taaagaatgt atgcaaacca ggacaattgt ccggcttcat gagaaccatg ttaatttaga 105840 aataatctgg gagggcgtca gcagctcctc aacaggggat gaggccggac cagagcccga 105900 gttgatgagt tgtaaccgac gactgtgatt taaaaagcgt tttatttatc gaatgtctct 105960 cagtgtcagg gcctttcatc catttgttct catcatgaag ttccgagagg tggacactgt 106020 cttaatctct caggtgcgag cagaagtctc ttgcttgagg tcacagccgc tggtcggagt 106080 cagttcagac cggctctggg gccattgcca gctgcgtgcc tgcgtgggta gtggggttct 106140 gaggccccag caactccacc ctaggctttc tcattcctag caggcgtctg ctcccctgac 106200 gcccacagtg ccggctgctc ttgcacgttt cccggagtgc aggggtcttt ggtgggcgtg 106260 agattgtaat tgcaggtggg ttcctgcggg ttcctcctct ccgcaggtgg gttcctgtgg 106320 gtccgctcct ctctgcaggt gggttcctgt gggtctcctc ctctcttgcc ttttttcccc 106380 accctagacc ccaggtcgtt tctgctccct cattgcccac ctacaccagg ttcctgacgt 106440 ctggaccttg gtctttccta ccggtcggtg tggtcgggcc cgctcccccg tgtgcagctg 106500 ctcctccgtg gcacagcacg aagcagcttc ccaagaggct gtgtgtccat tgccctcagg 106560 agaatcccct ctggagcaag tgtgctgggc tgtccctgct gccctctcct tgccccttgg 106620 gtgctccatc aggggcccca ctctacagcc tcctgtgtct tgctggggct gggtgagttg 106680 ccgctccttt gtgcccctct gatcacttca gattttcgtc catctccccc ttgtcataag 106740 taggggaggg cggggacgtc ttctctgtgg cactcccatg actagcaaag gcccgtgggc 106800 tcatgccagc cctgagcacc tctcttctgg aacaagcggg tcaggccagc actgtggaag 106860 actgtcccca aagtggggtc actgagaggc cccctccagg agagtgttca gatgtcttca 106920 tcccacccgc gtctgctctg ttcttccctg ggaacgaggc ctcggatgtg cttcgtgact 106980 gaactcacac ctgacttggc ccgctggctt tatcccaggt tctcagttgt aatctgccgt 107040 tgtttaaaat gccctactgg atacatagaa gcattgctga tcagctgatt tgcctggcag 107100 tgtgagaggg ggttattcat tctgaggtct gtggtttcta atgaagcccg acccatgggg 107160 acagtgtcag tgagcacctg cctggcggag gctcgtggct cactgcaggg ttgacgacag 107220 gtgtaaagct gcccagcggt cactctgctt ccttgcagaa ggaacctact aagctgcatg 107280 tttaaaaact ctgagtgaca gaagaggccg gtccccagag atgctcctgg gcctcctcac 107340 actgcctttc agagctgggc tgggcctggg ttgtgcttgg tcccaaggaa ggctggcggc 107400 atcggcctgt gtcgattctt agtggccata tggtgcacaa tcattgtgcc tggcctgggc 107460 tgtcaggtca ggtgtccccg ctgcccccca ggcctgaggg gggaagatag ctccgcagct 107520 gtgcacagga cctccaggct cctggggtcc aggctggggg cctccagtgg tctggtccac 107580 atctgctgcc ctggggttct gccctttctg tgcatgcccg agtgcctgtg tgtttattga 107640 aaatggaatt cgaagctgcc cttgttacca tccccttcta ggtggagtct tcaacctggg 107700 gccctccgag ggttgcactc tgtgggcgtc ccccgtccat gggccgcgca ctgagccttg 107760 cctgtgtctg ctctcggctc ccgagacgct ctccttcatc ctgcccggtc tttgcaggaa 107820 cctaggccat atggcagagg tgccatccct cgcttcacag gagggccgcc tggcaggaag 107880 tggcagtgag gaccgaagcc tgggtctgtc cccgagtcca ctgctccagc gccccgggct 107940 gcagccccac ctgtggaaag cagcccatgg aagatgaccc ctctccagga ggccgcctgg 108000 ccccactcac tttctcacct gtggcgctgt aaacgtgagg aggcccaggg gccaactggc 108060 tgcttcctca gatgccagtg ctggctcaac gcttaaaaca gacgcgtaag ctgactttca 108120 ggtagtccgt tctcctgatt ttaaagcggg acaaatgtca ggagtctctc ttgatattgt 108180 ctcctcagtt tatttttcag agctgtggta aatgacccca ggaagccctt agctggaggt 108240 gggagctcag tctgagctgc agtttctgga gcactcgtgc tgcttggtgt ctgggcgcct 108300 gcctctgggt gagagggcca gtggctcact gccctgtttg gagtcgtcag aaacctcgag 108360 ccagcctcct gccggtgagg tgctgcctca cctggtgggg gttgtagcta gaattgggtt 108420 tgccacagca ggccctcgct cacctgggca gatgagaact cgtaaatatt caaaggatat 108480 ctcagatgcc ctgttacagt ctcatcctga gtgtacggtg gagctcgctc accaggctgc 108540 ggagacatca ctacccattg ttttgagctg tcgcccgggg gacacatggg gccagcatga 108600 ggaggaagga tgcgtgggtg gctcggctca gggctgctgc ttgtgtcctc tttgtcccca 108660 cctgggcatc tgtccagtca tcagaagggg caccaccccc acccaccttg tcagcacctg 108720 cctcgtggcg ccgcccccac ccttgggtcc aggacctgct ggagtgcacc tggcaacagt 108780 ggcggtgact tgccctgctg ctgctgtgcc actgtgggct gcatgacccg gggtctgacg 108840 caacctttct gtggcaggtc ctgtgtctgt aaagtgcagc cctgacagca gggacttcct 108900 ggggtcgctg tgaggaccgg atccttagtg tgggccggga gcccagcagg gaaggggccc 108960 gggatgcaga gcaggaacca cctgcatccc tgtgccctca gccatgccca tgtgtgtcct 109020 ccgtgctcac tggtgtctcc tgccctgggg ctggaaggcc gcctgcagct cctgcaccct 109080 tctcaagctc cagggaggcc cgctggcatc actggccgag cccctgcgtc ctccttcacc 109140 cggaggtgcc tctgttgtat gtgatgtcac cgtgcttggc actgagcaag gctcctgaat 109200 tcagagtttc tcccacaagc gccgggcacc caggtggaat ggctgtctcc tgacccagag 109260 gagggtgggg cagggtgggc ctggccctcc cggggtgtgt gagaacccag caggtctgcc 109320 cctggggagg cgtggagccc catacgctcc ttgccgagct cagagcgggg gcttcgtgac 109380 ctcctctctg ccagagtctt cctagccatc ctgccctcac tgcacccctg ggcagtctgc 109440 ctctgttggc tggggtgggc cacatgcagg ccggctgtcc cctcaggctg tgggtgcagc 109500 tgtttcctca ctagccctgg tagcaggcag gccttctgcc cactcatctc ccaggtcttc 109560 ttactctctg tcctggggga gcctgctctt cctttcggca cgttgggctc ttcccaaatc 109620 agttccacgc cccgtggtag ttccacaccc ccgtgtctgt gcgttttgct cctgggcgag 109680 ggtctttgga gccctcgtgc ccctggagtc ttggaagagg cctgtctggg tgggcttgcc 109740 tcctctccat gtctcgaccc ttgtgggtcc tgcaccgctg cccgatggcc tgcccctcct 109800 gccttgctgc tctgcgagtt gagcaggggc gtggcgtggc ctctgacctg tggagagctg 109860 ggggctcccg gctgcatctg tactgggggt actgagagcc ttcgccttgc tcctggaggt 109920 gtttgcccgg cttccccgtc tagaggagga gcctgacctg gctacagggg gcttcccagg 109980 aagcagagtt cttgcccccg gggcctaagc ccccgcccct tgctgcctgg gctgcctttg 110040 cttgtgtgca gccttgcagg actctggtgt atttggagaa gctaaaaagc ccttgccaga 110100 gcggaaaagg gcgctggcta attggcagct ttatttattt atttctggct tgagtggtaa 110160 acagcgctga ttctttgcac agcaggaaca gattgggagg catttacctg actgattcct 110220 cacctgcagc accacgccgc cggaggatct atcgattcag cgccgcctgc gaagtgcact 110280 ctgaaacagg cttaattgcc tccgactcgc ttcctggtat cgcatgtccc cgtgagtcct 110340 cgcttgaggg ctgctgccct ccagcggatt gacgcctccc atgcgtgccc ttggcggggc 110400 tggctcctcc tgggtgctcc ctgggtggac tggggtgctc tcctgcttga cagggaagga 110460 aaccctaccg tcaccagctc aagcgcaaac agagcccacc gggtgtcagc cgccctcaca 110520 cacaggacca gggcctcacc agcgccctct ctccgtcctg caccccagcc cagtttcgct 110580 tgctgggagc cctcccgcaa tgtctccaag ctgtagcgtg cagtttcatc tcagtccctg 110640 agctggctga gctcccctgc tgcttttttt tttttttttg agatggagtc tcgctctgtc 110700 gcccaggctg gagagcagtg gcccgatctc ggctcactgc aagctccgct ttccgggttc 110760 atgccattct cctgcctctc agcctcccga gtagctgaga ctacaggcgc ccaccaccac 110820 gcctggctaa tttgttgtat ttttagtaga gatggggttt caccacatta gccaggatgg 110880 tctcaatctc ctgacctcgt gatccacctg ccttggcctc ccaaagtgct gggattacag 110940 gtgtgagcca ctgcgcccgg ctcccctgct gctttttaag ccagactcag cagaagggag 111000 gcaggtgagg taccggtcgc cttgataata cacttctcta ccagggcagg atgggcagac 111060 ggtgacgggg aagctcacct gggaggggcg ctgggtggac ggcggccgtc accacccaca 111120 ctgacgccat ggcctgcaca tgtgcagctc tggacagatc ctgcgccttg acttcccagc 111180 tgcgcctggg ggtgagcttt agcaaccctt cacccgtgca cctgcacagg tggcagtcgt 111240 ggctctggca ctggggctga cttgccagct gcttggacca aggctgcatc cttcctgcct 111300 gagtctcacc tgcctggagc aggccagcgt caactccctg gtttgtgatt ctgggacctg 111360 gtgattggct gttttttttt ttgaaacaga gtctcgctct gtcgcccagg ctggagtgaa 111420 gtggcctgat tttggctcat ggcaacctcc gcctcccggg ttcaagtgat tcccctgcct 111480 cagcctcccg agtagctggg acctggctga ttttgtattt ttagtagtaa cggggtttgt 111540 ccgtgttagg ctggtctcga actcccaacc tcaggtgatc tgcctgcctc ggcctactaa 111600 acttttagga ttacaagcgt gaaccactgc acccagccag ggattggctg ttttaagtaa 111660 cagttatcaa ggtgctagat aatattttaa gacactttga ggtatgagat taggcaaggc 111720 acacgaggtg gacaggtctg acgcgggcag tctgagcatt tctccagccc ccgcgggttt 111780 cctctgtccc agccctctgg ccacatgcgg ggtggccact gctccgacct ctcttggtga 111840 tggcttttct gtggatgaca tgagacagtg gcagttctgc ttgtccctcc agacaagcca 111900 ggaagacact tttaaaactc aaggcctttt cccaagagtt cctctgtccc tccagtctcc 111960 ccctccccac cccagaagct acttttaaca cccagggtct tttccccagt gtcttggtgc 112020 gtcttggctc tctagccctt ctgtgcgcct ttgccggtcc ctcaggtgtc cacgtgtccc 112080 cacatctggc tgctgcacgg gtctgtgttc ctgctgtgcc agcccctgcc cggtgctgga 112140 gagggtggag agcgaggcag acacacctca ccgtctggag ggacagtgag acagacctca 112200 caggcctgcg agggaggtgg gacatcatca ggctcgtaga aaggtgtgac ctttccctcc 112260 ccacccaacc ctcgaggact cctggccccc aggctctagt gctggaggct gagtttggcc 112320 accttggctc tgggcccaag cggcctcctg ctggcaacat ttccaggatg ccgtgatctg 112380 cagcatagtc ctgccccact ccctcccagg agcccagagg cctgttattc tgaggtctgt 112440 ggtttctaat gaagcctgac ccatggggac agtgtcagtg agcacctgcc tggtggtaca 112500 cctctggcca ccgggactct gttaacgacc ctcccgtggg ggctgtgagg tcgtgcctgc 112560 cactgcccgg gaggctccag ctggaccgag tgtgtgtggc gtatccgcag cctccctcat 112620 ccctgcctgt ccccacggtg cctggcaggt gctgggggcc tggtgcagag cctcgctctg 112680 acgctgaaca gaggttggga gaggcggagg agccgcatct gggcttgtcc tcttggcagc 112740 acccagcgcc tacacctcac atggaaatgg ggctcaccag tgagtggaga ctcagatcgt 112800 gaggcctcag gcgggaaggg ccccagagcc acctggtcca gctcgtcctg gtgaatgctg 112860 tggcggggcg cctgccctgg gagcctgcgc cgggagtgtc cttgcggctg gggctggtgt 112920 gcctctgcag gagccctgcc gtcaccgtgc gactccactt gggcccatct ccctcgagtc 112980 cacctgtgct gtgatggcag ccgcctgtct tccttgctgg gcctccccac gtcaggtctg 113040 cgcctgccct agagcaggtg caggggtgaa gaccttcctc gccccgccct ggaggccaca 113100 ccagcctgtt gggatccttt tctgatccct gcctgcagcc ttggaaacgg aagcagctcc 113160 tgaggccctg ctgtcccccg agttcctccc atgggggctc gcaggctgcc tcccgcctcc 113220 tgtcccgcac cccctgtctt tcttggcata tactcttgtt tacaagtctc tctcgaagtg 113280 atactctcag ataattatta tgtttctgaa acgccttggt tttgtgttgt tggggaaaca 113340 gagcaacaga agacacagtt cctggctctg aggaagcctc tgggtggggt gggcaagagt 113400 cagacccgtg ggggcacggg gagtctggca gaaggcagcg ccctgggtgt ggggcttccg 113460 cttggttcct gcactgcgag tgcctcctcc ctgtgccagg ctctggaagc cgtgcagatt 113520 gcagggtggt gaccccaagg ctgcgccccc aggctctcca gggtgtggcg gccagtccta 113580 ggctttctca gaaggtggtg ctggctgtgg aggcagaggc tgctgcagcg cagccttcgt 113640 tatcagctgg gaggaagtgg tggcgggtgt tgagctgggt cagactttag gaggtgccat 113700 ttgctgtaac atacaggcgg ggctgttggg gtaagcacac gccgcagcca gtctgtaagg 113760 aatggtcctg aaggacaggc aactggggaa gggagactgt gttgggcaaa gccagcaggt 113820 ggagagggcc aagagagggg gaggtggcct taccatagac ccagtgtggg gcgtgggact 113880 gcaggaggct ccacttcatt tggaggagtg aaaaggcagg tgccacctgg tccccaggga 113940 gagctggagg gcctgatctg aggatggaga gcatgaactg gggctcctcc acctggggca 114000 ttgctaggga tgccttgggc gcatgctggg aggaggtgga gtgaggagga tgctgagggc 114060 ggctttcagg gaataaggag ctcctggttg gatgcttgga aggaggggag atcccagatc 114120 agagtcctgg accccagcga ggagccagca ggaaagagcc taggggtctg gaacagttgt 114180 cgtgggacgt gtgtggctgc catctgtgtg agctgtatgg gtgcagccag gactgtgctg 114240 aggggtcccc tgctggactg gcaggctctc cctcctcagg agcactctgg gtttcggggt 114300 gcattgtcac tcagcacagg ttaccctcca gagctccagc cctctgtcct gcagctgtag 114360 cccacctgcc actaagtcaa gggcttggag gcctctgatg tctgcatgtg ggtcagagct 114420 cgggcacgtg ctgtccccac agtcgggacc tgagagctgc ctggggtcaa cttgcacagg 114480 gccaggagga tgtaaagagc tgctcttgtg gcgtcgtcca gctttggcca gctacagaga 114540 gtgtgcgccc cacgacagct cctgctcatc gcatctgggt gggagatgga ggactctcac 114600 cccgtcctaa accatgtggg ccactgtcag aaagggtggg tgatggagat gcgataggga 114660 aggcgctgcg gagagccatg gcctgggagc ttctcatgtc tgtgaaccag gggcggggca 114720 ctcctttggt cacttgtttt ggggggataa tggagaggga gaggagggca ctgggacagg 114780 agaaatgtca cagtagatga aacacagcag gagtccaggc tgcctggcct gaaccttctt 114840 gctttgtgga aacacggctt caccaagagc accgggcagc agtcaccctg aagccctgga 114900 gctcgagccc agccgctcct gcttgtccgc gcaggggtct gggaggcaga ccgtcacgtg 114960 gggctggagg ctggggcgag cccaggcagc tgggcgtgtg gagcttttgg ccttgatgga 115020 ggacgtctca gctccaggtc tgcactgcag gtcaaggaga gagacgggag gcacaatcgc 115080 ggggtggctt ctcctctgag agcaggctgt gacccagacg gctgtggaat gctagggacg 115140 tgtctgcgcg tgcctcacgt cacctgtgaa atgcctgtga gatatgacgt ggcttttgga 115200 gggatgtgct tagctggtgg tagcccctta tccggaagga agactgtgag ccgagcctgc 115260 tccttggcgg catgaacctg ccatggaggc agtgtgtggg cagcagtatg tgggcagggg 115320 ctgggaggga cggccctgtt ccttcacttc cgtcacctgc cccagggaac ttggacatcg 115380 agggcctgtc accaacaaca gccttgatag tgcttgctgg ggagaaaatg ctggcccagt 115440 gtgttgagta gtgtgtatct tgccgcgttc atgccacgca ctacggatgc tgggcagacc 115500 cctgtgtgct caccgcgccc acacggccaa gctcccgtgg ctctgacaca ccactcaggg 115560 ctgacctcct gcttctggga gcctgatggc agcacagggg gaggtcctgc tggtcaggag 115620 ggagggttca cctgcacagt gtgccgtgta gatctgtgac cgccaaccac gtcctgcgtg 115680 tgtcaggctc aggccccgtt ctgcagagga gcccccagag cagggctggc actgtgccct 115740 ggatgctgcc ccatccactc cagtggaggg tctgacaggc tgtggctgag tggcacccct 115800 ggcagcacag cgtccggcat tgtggtcagg agtggccggc tggcggcttg ggatgagtgt 115860 cgggtgcaca gggtggaggg tgggtaaggg gcactgagct ggcctgatgg gctggagcct 115920 cctagggcag ttgggtggcc tgatcctctc ctgtcctgcc ccatgctgag ggacactagg 115980 gaacatttgg gggtgtactt gaggggccat tgctgtgcaa gggactgggg ccagggatgc 116040 tgagtgtctg gcagttgttg ggatgtttgt ggatacaagt gagttgcttt gcgccaaagg 116100 ccagtggggc cctgtggata cacacacttc atggttgggt gcttcctgct gctgtcctct 116160 ccctggcagg gcttctctct tctcttaccc ctgtgttagt tcactctcac agtgctagtg 116220 aagacatacc cgagactcgg tgatttataa aggaaaaagg tttaattaac tcacagttta 116280 tcatggctgg ggaggcctca ggaaaatgac aatcatagtg gaaggggaag caaacacgtc 116340 cttctttaca tggtgacagg aaggagaagt gccgagcaaa agggggaaaa gtcccttata 116400 aaacagtcac ctctctcgag agctcactat cacgtgagca gcagtatggg ggtaactgcc 116460 cctgtgattc actcacctcc catgacatgt gggcattatg gaaactacag tttcagatga 116520 gatttgggtg gggacacagt cagaccatat catatcatgc ctcctccttg tgaatgggca 116580 gctgcctgtc tgtagagacc acgaccatgt gggtggcctc tgtttgtggg tttctcccag 116640 cctctgtgcc gtccgcacca gcagtgcttg tggagctgga ctgcctgtta gtttgcacag 116700 gggttgactt ggcttgggaa ggtgcccttg ggaatggggt gcagcttccc tgcagagcct 116760 tgctcctccc tgacggtggc ccccagggcc cgctagactg ttcaggaagg aggggcctgg 116820 ggaacgtgga tgttgcagga gactcttagc tgcttctggt ctttcctgcc cgctttggct 116880 gcctgcctgg ctgcctctgc caggcctatc tctagaaaag gctgtgttcc cagcgttaga 116940 gcctggatcc ctctcctgct gcattgggag ctccccaagg tcgggtttcc ttgtcttcgg 117000 gtggtgccca gtgctgtgcc atgctgggtg tttgctgtgg gccttcactt gttcattgca 117060 aatacttctt tgtctccact gtcctcttta ccaagggcac acttcaggat ctcctgggac 117120 tttgtgcagc accgcccagg cctgcagagg cagggtgcag accacctcgt acttggtgat 117180 gtgcctgcct ccttggctaa ggccctctca ctaactctgg gacatccaga cgccttcctc 117240 cccgttgggt ctggtggcct gtcctgcttc ttcctcaggc ttcttctctg gtttttctgc 117300 tccagtccga tggacctggg ccccctgcaa cagtatgaca catggcctgt tactgctttt 117360 ccgctgaccg ccacctcctg cagccctgtg tacacacagg agcccccccc ccccccaacc 117420 ctctggcctg ccacgtgtgg gtacctgcct tatccaggcc ctgcccacct ggggtcttgc 117480 tggggacacc tcggtttccc tgccctggca ttcatcgtct gcgctggctc tctgggggct 117540 ccccagtcct ccctggcaag gctcttgtct cttagaggac agaggctcct tgtcgctccc 117600 gttcaggaag cgtttgttca acacctgctg tgtgcagccc actttaggtg cttcaggaat 117660 atgagatgag tcaggcctga gtcttgttcg tcctcccggc acttggcaca cacacagccg 117720 cctgccctcc agctgcaccc acgcactccg ctccctgggc ctggctctcg ctcccttctg 117780 tgctgggaag gggcacaaga ggatcctgga gctggggcca ctgggagcag cagccaacac 117840 gtcagtgtgg acagtgaggt cctgctcacg cccttcagct ttttctgtgg tcaccttggc 117900 ccttatttag tgttgaggaa acagagggat attcgggtta gggagtgtgg ttaagtggtg 117960 ggcagtgggg ctgggcccca ttcccactga gccttatccc ccctccaccg tctccggcag 118020 cgcagccgca ttctgtgttt aggtggtggg gtgctggcag gagagggtgt gggcctgggg 118080 caggaggaag gggaagtggg acagcccgcc ctgctctgag agcttcttcc cgcagggccc 118140 gccaccgttc ccctcctgat ggcagcacct cagtgcgttc cctctgctcc gagcgctcca 118200 tgcaggtcat gcgcggcagg tccttctgtt tggccaggaa tagtcctgac cttgggggca 118260 gggccgtggc ttccctggat gtggccatgc gggaaccatg cagactgagt gtccacaggc 118320 ccggcattga cacgccatgt ggagcctcta tccagcctcc tgtgaccggg gaacacgcgg 118380 ggaccctgtc cagcgcctcc tctgatcccg gaacacacgg ggaccctgtc cagcgcctcc 118440 tctgaccccg gaacatgcgg ggaccctgtc cagcgcctcc tctgaccccg gaacacgtgg 118500 ggaccctgtc cagcctcctc tgaccccgga acacgcgggg accctgtcca gcacctcctc 118560 tgaccccaga acacgtgggg accctgtcca ccgcctcctc tgaccccgga acacgcgggg 118620 accctgtcca gtgcctcctc tgaccccgga acacgtgggg accctgtcca gcctcctctg 118680 accccggaac acgcggggac cctgtccagc gcctcctctg accctggaac acgtggggac 118740 cctgtccagc gcctcctctg accccggaac atgcgggaat tgctgggaag ggtcctgagc 118800 cagcgccccg tggtgtgaac gtggcctcat gtcctcctgc gggagtgctt ccgcagtgtg 118860 ccagtggtgg gccccggctt ctgggggagc cttgggtcgc ggggcgggga tacagactga 118920 gctggcgcct ccagctgttc gggctctgat gcaggtctcc caggcgctct gctcttctct 118980 gctgcactgg cccgtcactg tttctaccct gggaacagat tcttccggaa ggttccctgc 119040 tgctgcagcg gtgctcaccg gaaggcgggg cttcgaggcc cttgtgtttg caaagcagat 119100 tcttaccgag atcccagaac tacctgtggg cctcaaaaga tgggtctgac aagtgtcttg 119160 tgtgaagggc cagaacggac tctttggggt ttgccgggca ggtggtctct gtcgaagacg 119220 ctgaactctg ccatcgtgct gtgagagcgg cagcggcgat tcgtatttga ttctgggtgg 119280 ctgtgctcca tcaaaacttt gttaaaaaaa caaaagttgt ttacaaaaac aggctgtggg 119340 tgggatttgg ccacaggctg tagttgttgg accctgttaa gaaaccaccg ttcaagtcgt 119400 agccatgctc atcttcatga agatccttct gccacgtgac gtcggcttgg gccttgctgc 119460 agggaggtga cccgcaagat tgatcccggc agccaggctt tcatttctcg caattgtctc 119520 tttcaggaaa gatgccctag gaccatacac tttgtggcct taaggaggat ggcgtcctct 119580 ggtgttggcc ccggctgggc ggtgctgcag ggtgggagct gtgctctgtg tagggaaggc 119640 cccctggttc cctgctcaga ccgtgggctg gctcagggct ctcccgcccg aggtgtgttg 119700 agatggcctt tgggatgagt cattaccatc cggccatttg cccttttgtc tttctcatgt 119760 gtctggcatg ttcttctggg aacttttcat tttgacataa tgttacactg acaggaaagt 119820 tgcagaagtc gtggagaatg tttcgacgca ccctccgcca gctttcccga gggtaacgtc 119880 ttgtgagccc gtgtacagtt atcagaagct gtaaggcctg ggtgcagcag gcgcgggtcc 119940 tgactgcgtt caggtcttgc cggctctccc actgagctcc tttttctgtg ccaggatctg 120000 gcctgggatc cccatggcgt ttggtggccc tgtcctgccc tgcactctgg gacaggagag 120060 aatctgctcc tcggtctctc ctgtcgtcgt gaccccgcct cttcgagagc acgggctggt 120120 gttttgtgga tgttcctcag ttggagcgag tctgatgtta tacatgatta ggttgaagct 120180 atgcattttt ggacagaaaa tcttaaaagg gatgtcatgt ccctctgggt gtgtgatgtc 120240 ggggtgtgcg acatcaccat gttctgttgc gggtgtggtc actccggtca cctggcgaag 120300 gcctccctaa atgcatggct gcggcttttg ttctgataat aagtatcttg gggaagatgc 120360 tttgagaata tgcaaatatc ctatttattt tattttattt ttttgagata gagtctcgct 120420 ctgttgccca ggctggagtg cagtggtgta atcttggctc actgcaacct ctgcttcccg 120480 aattcaagca attctcctgc ctcggcctcc caagtagctg ggaccacagg cgcctgccac 120540 cacgcctggc taatttttgt atttttagta gagagggggt ttcgccatgt tagtcgggct 120600 ggtcttgaac tcctgacctc aggtgatcca cccacctcag cctcccaaag cgctgggatt 120660 acagctgtga gccaccgtgc ccagccccca tttcttacaa aaacttctcc tcctagttca 120720 agcatctatt ggtgcatctc agctgcgggg cttgtcacca tggccccagg gcggttttct 120780 gtccgcccgt ctcttccgtg tttcctgagt gggacgcttt gctgagggag gctctgcccc 120840 tcgtccccgt ttcctgagtg ggacgctttg ctgagggagg ctctgcccct cgtccccgtt 120900 tcctgagtgg gacgctttgc tgagggaggc tctgcccctc gtcgagtagg ttatttgtgt 120960 cagttgcttc cttctctgtt ttacttcacg gccgtgaccc agtgctctgc ggattcggtt 121020 cattcacggt atttcagcct tggtcactgg gagctctcac agttgggctc tcgtgccctg 121080 tgatttgccc tcatcttttt ttaaagcctt tttttttttt caaactatct ggcactgcag 121140 gatgctctaa acttagatgt ttttcctgcc cttttcctgc agtccgccac tttcccagtg 121200 agccctgttt cctcttgttg ccgagtgctg cttagagatg agatgtgggt gtggggtgct 121260 gcctgctccg ggtgtgtcag ggccccaggg cccctcggtg gacaccctga cactggctcc 121320 atccagcacc cctgggctgt cctcgcctcc tgtgctgtct ccttggtctt gagaagccca 121380 ggtgtcagca cacaccatgt tttacttacc catccagtcc tcacgtgcgc acagggtctt 121440 tctggaattg ctaatccatg gctctgtgag gagaggttga cttgcgaggg tgcagtgtct 121500 gtggacaggc cgttctgtcc ttggcctacc gttcccagtg gaagtggcgt tttctcagca 121560 ccgtgggtgc cgttgtgttt cccactgcct ggtgttgtgt tctttgtttg tggttccctt 121620 aggtttaccg cttagagctg gtgtttcatt ttgagtcttt ttcattctgg ttgattaaaa 121680 aaaactgtct atacagcctc atttgccctt ctgctgtgca gctgcgcatt ttcacatgcc 121740 tggggctgac ttgcggcccc accaccccag actcccctcc ctggccaccc cagcatgctt 121800 tctgtctggt gattttgcct tttccagaac gtcatacaaa tatggcatct ttggctcatg 121860 gaggtgcatt tgggactcac cgcgtggctg tgtgaatcgc agcgctgctt ttcgttgctg 121920 agtgatgctc caggcacggc tgctctggga cttgtttatt cgttcactgg ttgaaggaca 121980 tctgtattgt ttctgggttt ggtgaaatgg agtaaagctg ctggaaatgt tggctttgta 122040 tgatctaaac tcttactttt ccttgagcac atacttagga gtgggactgc tggatcctgg 122100 catcctttta acttcagaag acattgcctt gtgggtctcc acagcgggaa gcatccggtg 122160 tgtgcgttcg cggtgtgtgc gtttgctgtg tgtgcaggtc cactccgcac aggcctgctc 122220 ctgctgggcc acgccagggt tttgggctta gctgccccca cagggctgtg tgggctgtgt 122280 gttgcgtttt ccagcgtgcg gctgctggcc ccaacctggc gtcagacagt tgctgtggtg 122340 ctttctgcag cccccagccg tgttggcttg cacagccctc tggacttgtg gtcatcatgg 122400 agttgtagcc ccttttcccc acctgatttc ccacgtatcg ggatcaaatc taagctggtt 122460 tcgttttgct tcctctcaag tcttttgtct ttcctccctt cctccttttt cattgatctc 122520 tgttctccgg tgactttagg gaaagactgt acctcattca ttccgaggca cgctccttga 122580 ctagagcaga gagcaagggc tgagcagcca cggtctcgaa agctccttgc cgcctgggag 122640 gcttccacgc ctgggactgg gggctgggca gccagcgtgc agaggtggag gggtgcatgg 122700 aggcgcctgc gggctctgag gcctggcttc ccgagcccct ctagtcttca tctgtgggac 122760 gatcacacag accgcatggt gtggggggag cgaggggcgg gcacagtgga cgctcggtgt 122820 gtgtgctcct cctctctccc tgtttcttct ttgttcctct tgtctttaat ttacttttcg 122880 tcggaggact tggccgcagc gtgccctgtg gacttgagac cgaagctctc ttctgctctt 122940 tgtaccctgc tgcttcctga tccgttcttc ctcccctcac ttgtgtacag gactcgaggg 123000 agggatgggg tgagagcaga gcaagccagg gatgtagtga gctttgtttg gacaggaagg 123060 gtttgcccgc gccgtcatct cctcggctct gctgggaaac tgtgtttgag ggagatggtg 123120 gggtctgagc gcagacggct gttgtcctgt gagatgcaga aagcgcttct tatgggcgtg 123180 caccatggaa ttccctgctc ggaccgcact gggggcaggc ggtgagtatc ggtatagaag 123240 tagcttttat taattggtga agcccgtcac agatctgaaa gcatcttaat agtctgaaat 123300 gatggctctt cagcaagaaa aatttgattt gggacaaaag ggagacactt gagacccaaa 123360 atgacttggc tgtgttgagg atgggaagga ggccttcatc tgccgcacgt ctgagtcact 123420 ccagagtttt ctccactgcc agtgtgagtc agagcgaatc actgttgggt tgtgacttca 123480 gaagaagtga actctgtctc aggctgtatt aatagaagta gatgcttcac aggagaggag 123540 gtgtctgtgc gagtcacagc cctgcggggt ctgatttccg ctttgggcgt ggcttctgag 123600 ccgggacctc gaggcgccaa gggaacagga gcagccgggc agctgctcgc ttggttgtgc 123660 ctgctgtgta ccgaggcgtg gggcatggcg gcacggctgt gagcgcacag tccagccaca 123720 gaaggaggct tcaagaatct ttgcggtgct gccatctgga catctgtgtc attgaagtca 123780 caggaggagg cttcaagaat cttcgaggtg ctgccatctg gacatctgtg tcattttgat 123840 aacgtgtgtg agatcagtgg aggggagcct taggaaaatc ggctgtggtt taataaactg 123900 aacttcccgc tgctttgagc cggagcctcc tggactggaa aggcgtgggc ctcatggcca 123960 cctccggcct gcgcagctgg gtctgcactc tcacaactgt gctgagccca cgcttgtgcc 124020 cttactagtg gcctgacctc tgcgctgtgg agaagggtgg atattgtcgc caactctcag 124080 acttcttgtg tgtgttcaga aagtacccaa acggattcaa aggaataatt agcgtatcct 124140 gtaagatatg aatcttaatt cctaaattac atatttagca gattgtccaa aatagcactt 124200 gtaatggcaa cattcaatta gtttaaaaaa tgtatattat tgcaacactc gccatgagtt 124260 ttatttagag gtttctaaat ataatgctat aaaaacacag aagtgtttaa aactatttag 124320 acccacgcag ccgcagtgag ctcttgctaa acttcctacg ttaaccagct cttgacaatc 124380 ttggattgtg gggaagtctt ctgatgtagt ccctaaagct gacacgccag agcatctcga 124440 ggctgttggg ggctgttgct gggatcctga ggccgcacac ctccctgcta tgagttctga 124500 cgtttacaaa cataggaagt gagttgaaat gacagagtcc ttggggcccc actcttgagt 124560 gtcctcctgg ggttggcggg cgtggggctc ccgctgtgcc gggttcggct cctgtgttgc 124620 cgtgttccct gcggctgctg cagccgcttc tcgtcacctg attgtgtgtg cgcctccagt 124680 gctctcatgg gctgcttaag gcagggacta tccatgtggc ctgaagaaga agccgaggcc 124740 cggggaagtt gcatgtaatt gacaccagag ggctggcctc atttcaggag gagcagagct 124800 cgggttttcc gtctaggtgg gagatgggat ggtgatgggc ccacaggcag ggcctgtcct 124860 ctgatgggaa tccgaagtgg gtgcggagga cccagagctg agggtgagca gctctgagct 124920 gcagagcggg tgcggggagg ctgtgtgcgc agcacaggga ggcgtctgga atggccgggt 124980 gggggtctgg aacccatact tggtagcgcc tgtttggtct gtcccgtgct cttcctgcga 125040 gccctcgcgg gggccctgca cttccccagg agctgcctca gagatgtgcc agtgaagaag 125100 ggatggaact gatcgtggat cgggccggct cctggaggcc acctgggccc atttctgaca 125160 gccgctcctg ccgcgtccct agctcagaag gagctcgagg ctgagccgtt tccccagggc 125220 tgctgccttt gtttctccca ttctgaaagg agatgaaagt ttctactgac cttagagaga 125280 aagccagagt gaaaccccct ctgccaaccc ctggctccct gtgaaaagcc ttcctggtaa 125340 tcaagtgttt acagaggaag gctttgttca gaccctttct ggggctctgt atgtttaaac 125400 aaagagcttt ttagacctaa acacagatgt tcatttgaaa atgaaaaatc aaattaagca 125460 gaaccagcct ttgaaagtta atgccctata gcaagtaaaa caaagggaga aaaacactgt 125520 gttgtaaatt ttacttaaat aactttttat tttaaataaa gttttaaact aaaaaagtat 125580 aatttgaaag ccactcatct tcctctctgt cctccagtag aacatctgtg ctgattctga 125640 cgcggatgaa tgacatgaat taaaccaaaa ccgtcggagc gctcttttta ccataattac 125700 accttgttcg tttgtgagac acaatgtggg gatgaaatgc caattaagcc tgctatgata 125760 atgaggtggg gcctgaatag tgatcagcgg acatgaatcc caccggaatt catttgctac 125820 agcccccaag tttgttctct tctgatggga atgttatcgt acataatgaa aatctttagt 125880 gctccttgta tttaaaaatg atccattttg gggtttttgg tcagcaagtt ttaaaacagg 125940 tgttttccga gcacctggat gggtttcatg tccccactga gcatcctgtt ggtggggggt 126000 gggggggtgc cggtgtctcc tgtcccctgc ctggactctt ctgtggagag ctatggtgtc 126060 acagcccggg acacagtcca gcgacatgtg ccaggcacca tccccatggg tgcccttgca 126120 ggtctgggtg gcagctgaga aaccattttc acccatcact gtgtccaagc atttaccatc 126180 tccgaccctc aaataccctc taatgttttg aaacatagga agtgcgttga aattattgaa 126240 agcactgtga aggaaatgct ttgggtgttg tggaatgaca gggtgggaaa gacgtcactg 126300 ggggccaggc agggccttac caggaggcag catctgagca gaggcctgag ggcagccggg 126360 ggctgggcag gggtgaccaa gcgggacaga cgagctgctg ggacgccagc agggctggca 126420 cagtgcgggg atcacagcat gattgcagcg ggcagctgtt gaagactgga agcgcggcag 126480 tggcatggtt acctcacaca gtcggaagag cgacctggag aaagaggcct tcgggatggg 126540 gagcaggaag tgtgtcggtg cgtgaggatg caggggtcca gcgaagaggc tgtgggtagt 126600 tcagggggag gtggtggggt ggcaaagacc accctgcagt gaccacataa tcctcgaggg 126660 ccagccccct ctgccccagg gctgctgtgg cttgggctgc agcctctgga ctgggcttcc 126720 tgccaccgga tgctccggca gcgagacctc accaactctg actgtcccgc cccacacact 126780 cctggcttac cgcctgcagg gaaggtgctt gcgactcctc tgtgttgcta gggatgttgg 126840 ccctgcctcc ttccacgcct cccggtgcgc tgccatcctc aggccctccg gctgtcccag 126900 gcagccaggt gctgagtgat gctgtatgtg ggtgcccttc ctgtccttgg gagccaggct 126960 gtggggccgg gccctgtgag aacacacggc gtcaggagcc tcctggctct ttcacactag 127020 actacgctcc tctaggggac tgggccagct gcgttctgga cccccgggcc cctgcccagg 127080 tctgcactca gctgtctctc agccagggcc aggagggtct ccatcacgag tcctcctggg 127140 ggctgaaggg tgactggctc ccagctgaga gagccggctg cagcatggac tcatgacagc 127200 tggggagggg cagccctgca gaagggactg aatggtgact ttcctctctc aggtttcgtg 127260 gaggccctac agcccatgcg ggacaacacg ttccagtgca gctgcaggcg tcttttgcgg 127320 gatgggccga gagtgtgacg ggctatgcta gcctgggtct ggtgggctgg agaggaggga 127380 ggcggtctcc taggagggat ttgtgcccct ggcctgcctt ctccccccac ccctgggaga 127440 gtggagctca cgtgtcctcc ttggtgttag gcagggttgg agagggagcc tcggagagcc 127500 tgctggcttg gcacaggttt ccaggagcgc atgtgggaag ggcagggtgg ggccgggcct 127560 gggaaagggg gagagtgagt gaccatggcc gtctccaggg atgggcatgt atatccgata 127620 gagaaggaag ggcagggtgg ggccgggcct gggaagtggg gagtgtgagt gaccatggcc 127680 gtctccaggg atggacatgt ggatccgata gagaagcggc ctgccgtgct cgcacctttc 127740 acgcaaggca ccgacgcagt ggaggggtgc tgccgatgtg ccagcactaa gggcccaatt 127800 cctagcctag gcgtaatggg gcaagggccc tgtgctgggg gtgggaggcg ggactgtgtg 127860 ctgggcaggg tggaggggcg gggctgtgtg atggctggcg ctgtgtgtga tagataggtc 127920 tggggggtgg ggcttcgtgc tgggcagaat ggaggggcgg ggccatgtgt ggggcagggg 127980 cggggccata tgtggggcag gggcaggggc agggctgagg tgttggtgcc ctttggttgt 128040 ggggccgcag ctggataggg ctctgggact gtgctccaga aggtgttgct aggtggcatc 128100 tgtgacgatg ggggcctttc ctgctgccct accctggagc tggggagcgg ggtgggtgag 128160 gagcgttgag gaggagagag ctggagctgg tggtactggg gttttggctg ggcgtctcac 128220 gtgcctggac tttctggtct catctggaag gtggtctctt actggaccgt gcgggggtga 128280 ggagacaggc cgaggccacc aggtaaagca gggctgtggt gagagaggcc ccattttccc 128340 tcagaacctt cacagtgcgt ggctggcctt ggcaaggctg catggctggt cccagggctt 128400 cctggcctcg ttacttcctg gcttcagggc agtgtaggag cagccacaaa gcagacattt 128460 gggttgtcct ttatgaatgc ctcgggtgat gatccacgct ccctgccttg ccccagcgca 128520 ggctgtgccc gcccaccctc ccgtggagcc cacgctttgc tctgcctgct gctgccaggc 128580 cagcagagac cgccccgtag ggcactgcgg tttctgcggc ctgttctgcc ctgagtggcc 128640 ttcctcccct gctcttagct gggccccctc actccacctc gctgctggct ttgttgcctt 128700 tcaggctgtg accacctgaa gccagctcgt gtgttagtgc cctttgttag taaccaaccc 128760 cttgtcggca gagaccttcc ctttctgctc actggaatat ccccaagcag gacggtgcgg 128820 tgtttgtggc ctcagagagt gaggctctcc cgggctgcag aggcacagcc agtttcttcc 128880 cggcagacct cttttcagaa cagcccctca ctgcggtgtc cggcccctgg ggaagccggg 128940 ctctgactgg gtgggtcagc cctcaggctg tgccaggaat cccatctcca ggcgggctgt 129000 gcgtagttcc cttcgtgttt taacatttag gaggtgagcg gtttccttcc ctgagctccg 129060 gaaagagtcc ccagggcttg cggggggacc taccctgcat tgcacgttgg aaggagaggc 129120 agctgcaggc tgagcccaca tggctgtgca cggcctggcg tgggagctgc agtgatttat 129180 gtgacctgtg ctcagataat taaagtggga tttggcagtg aggtctttca tggcaaaggc 129240 gttagggatg tcacaatgag gcatgtaagt ataaaacagt tatgttttca aaggcgttag 129300 ggatgtcaca atgaggcatg taagtataaa acagttatgt tttcaggtta agaatttaac 129360 gaggagtaaa ttcatttaaa ccgaagagct ggcttaaggg gagctttcgt ggaagatctg 129420 tagttgctgg catttcattc cttctcattt gagcccagcc tgtctctggt ggcagagcgc 129480 gtgttccgag tgtccaggtg ccgcagccgc cccctgtagg caccagcgtg tttgacatgc 129540 gggtcaggga tctgacgcaa caggccgcct ccacatgcca gactgcgtcc cccttggcct 129600 gctattgcgc cgccgtgacg gctctccttc gcggaggggc ggggctgtgg gggctgtctt 129660 cctgtgtttt ctctccgggg cctcatctgc cttcaggagc ctgtgcagtg ccactcgggc 129720 tgagcagcct ccgccagtgc acaggggact ccgggcttgc ctctgtggag gagtttgccg 129780 ctatctgctc tgcctttgtc ctggttcccc aaatggaggc ccagcctgcc gtggttctaa 129840 tccaggtttc tggtcatcaa agcagcatgc ctttaataac agatatggcc tgttgtgcag 129900 ttggcccgga gagctctgat cattacttat ctgccacgag atgcttttgc tcaaggcagg 129960 ctgctgagga gcacactcct taccttcatt gaatgatttc cagacaccgg ctgcatattt 130020 gattctctgc catgtgtctg ggggcctctt tctccgacgt ccagcggggt ggagtgttgt 130080 atggcgtggc atcagaactg gtggtctccc cgcattcctt gccttttccc accccatctc 130140 cagagtccgg acaccacctg tgagactgtc cctctgcctg gggatgcgga gggactccgt 130200 gcacagtggt tcagggggtc tgcttatgcc acactgctgg gatctgggca gggaggagga 130260 cagcacctgc cctctgagta gccgcctccc tggctcctcc tcgtggccgc tccctccttc 130320 tcccctgtgg gatcgagtct cagtgttctg gctgtgctgc ccggctcctg agaggccttc 130380 gcaggggctc ccagggctgc ctggtggtgg gctttgcccc agtgctggcc catctgcggt 130440 tgccccgccc aacaaagagc acggtggtcg agagccccgc cgctgtgcag tggcctcggg 130500 ggcgggtgag atctgctgca ctgctgtatc gcctcaccct ctgtcctctc aggtgctcac 130560 ccacttcttc caaacagaaa cgtcatcact aggcatggcg atgtcccatg tgccgtctac 130620 tgagcggcgg ggcaggcagg cccaggcctt cactgagtgc aggagcgcag gtatgactgt 130680 gtgtgcaggg cccgtcgggg cagccatggc ttgggctgcg acccggccct cagcgtggcc 130740 ggatggacgg cctccctctg gacacaccat gtgggctgag agctgaagcg tggtcggagc 130800 tgcccctttg tagggtgcag gggcagggga gagagcccgt tccaggcaga ggcagcagca 130860 agcgcagggg ccctgaggtg ggagaggacg cgcgtctcca gcaggcaggc agcgtggcca 130920 ggcctgaccc agcgctgacc caggtgttgg cagcatcacg gaggctgcct cctctgagtt 130980 gtggagctga tgtcctgaga ggggacagtg ccacctctgc cgaacctgtt ttctccgtgt 131040 gccttataca cctgaggaga ggcccgcttt aggagtgggt aggagaagac gccatctctg 131100 ggcattgtct ctggagtgac aaggatgcgt ctcatgctga ggatggcgtg gagagtggtc 131160 ctgagagtgc tggtgacggt ggagacggtg acggccatga tggtgcgagg gtggcggtga 131220 ccgtggtgtc actgatggtg acagtggtga tggtggggac gtggtgagag tgctggtgac 131280 ggtggtgatg gtgtggagag tggtcctgag agtgctggtg acagtggaga tagtgacagt 131340 ggcgatgatg gtgcgagggt ggtggagacc gtggtgtcac cgatggtgac agtggtgatg 131400 gggatgtggt gagagtgatg gtgacagttg tgatggtgac ggtggtggtg atggtgacgt 131460 gagaatggtg gtgatggtgg ttattggtga cagtggtgag tggtgacagt agcagtggtg 131520 gtgagtggtg acagtagcag tggtggtgag ggtgacagtg gtgatggtga catggtgaga 131580 gtgctagtga tggtggtggt gatggtgacg gtggtgatag tgacggtggt gatggtggcg 131640 gtggtgatgg tgatggtgac ggcggtgatg gtgacggtgg tgatggtgac agtggcggtg 131700 gtggtggtga tagtgatggt ggtgatggtg acagtggcgg tggtggtggt ggcggtggcg 131760 acggtggcgg tggtgacggt gacggtggtg atggtggttg tggtgacagt ggcagtgttg 131820 gtgatgatgg tgggtgcagt ggcaggactt ggcatctgtt gagagtctgc cctgtgactg 131880 gtgccaggac ctagcctgcg ttttcacctt atcctgtgct ctcagcctct tctgctgggg 131940 agactcagtc ctgagtcaga caggagggtc caaggtcagc gaggctgtgt gatctgccca 132000 ctcccaccca tggcagattc agacctccag tcagggtctt cccagctgca gagccccctg 132060 tgtgcactgg actgcactcc tccttctcct gcctggtatg tgtttatcca gcatgtgtca 132120 ggcgtgggcc agcttgggct gtgatggtga ctgagacagc tgtggccctg tgtgcacgga 132180 gccaacagtc tagtgggtga gcagcataga agctgttcac tttggtgagc atggagccgg 132240 tagtctggtg ggtggcagca tagaggctgc tcactttggt aagttgaggg aagaagcgtc 132300 tttgttcttt actggctctc agggtccagg tgcacagcct cctggatgga ggccctttag 132360 gaatggagcc ccagtctcac gccaggcacc cggatggaga ccctttagga gtggagcccc 132420 agtctcctgc cacccacctg gatggagacc ctttaggagt ggagccccag tctcatgcca 132480 cccacctgga tggagaccct ttaggagtgg agccccagtc tcatgccacc cacctggatg 132540 gagacccttt aggagtggag ccccagtctc atgccaccca cctggatgga gaccctttag 132600 gagtggagcc ccagtctcat gccacccacc tggatggaga ccctttagga gtggagcccc 132660 agtctcatgc cacccacctg aatggagacc ctttaggagt ggagccccag tctcgcgcca 132720 ggcacagtgg ctgtggccct tccccccagg gcagacccca tagcacaaaa gcccgcatcc 132780 tctttggtgt atgaatgttc ccacagtgga aactagggtt tttccagtcc cttgtgacaa 132840 aggattatga gttttttccc attgaagggg agcaagtttc tgagggtggg aaggaagccg 132900 ttgaaaacaa attggcagca ctccccccat cctcttgctg atggggaaag tggttaatta 132960 ggtgattttt ctcttcccct gacacgtgca aatgaggctt cgttaataac tgcactgtta 133020 cagaaatgat acgactttaa caccaacgtc aagttgtcag gcgtgtctgc agagtggagg 133080 tggggggcac tggaggcccc tgcgcccctc ccgacaggag tcatgctgga gccgcgcctc 133140 cagtcgctgg ggcttggcct tgggcaacga gctgttcccc tcccaccctc caaccccctt 133200 cagggccagc ttaattattt aaaactgatg ataaaaacag aatgagctgc caagatgaag 133260 tgatgatttg cggccaggac ctggggcttg ggtggacgcg gctcccactc tccctgcttg 133320 ctgtgtgctg gcccagtgcg gccgtttcca aggacgcctt ccggtttgca gccagggccc 133380 aggacacgga cagcatctct gctctcaggt gtcaggaggc ctgcagatgg tgcagggccc 133440 gctcagggct tgtcctgcca ggacgaggca gacgcgccgg gtgggcaggt gggtagggta 133500 aagcagaagc aaagcggcag taccacagag caaggcacca gcattgtaat gtctggagtg 133560 tggcaccccc tccaggaagc aggtgcttca cgctcagaag cgcctggctg tggcatgctt 133620 cttactatct gtcagaaggc tcaaggtcaa aaggccgtgc tttctgccat agagtttcaa 133680 gagtaaagga gaacgcggag atctagtcag ctgggattcc tagctctgct cagaaacagg 133740 ctgggctttg agaccttttc ctcctcattt tccctgctgg tctggaacag aaagtacttg 133800 cagctgactg cgctggccgt cgtaaagcag tgtgcacctg tctctcaaac ctcaatggtt 133860 gcctgggatt tgcttctcac ctatgtcctt atccatcaac aggtagttat taaatgccca 133920 tgtccctgag acggttttgg gctttgtgtg gctgggggcg aagtgtaagg aatgacctct 133980 acctgtaagg agctcacagc cagccccttg gcttgagctg tgagaagttt gaaaatccat 134040 gtgctaggtt agcccagatg acaccaagag cattggtgct ggttcttctg agtcatgcct 134100 ggggcatcga gggctgggct ggtgggaggt gactcctcac agtcggcagc cagtcccact 134160 ggggatagtt tcatggccag aatggcctac caggggctcc tccctgcagg gttgagagct 134220 cacgcctgag gactgttcac aggaagccac ggcccgggtg cttcctgggt ctcgggtagg 134280 agtacctctt ctgaaccacg tctaatgggt tttttgaaga gaagagaaat gaatctccca 134340 gtgctgactt ctgagattcg gctgtctccc agcccgatgc gctcacttcc gtccacgctc 134400 ccgcctggcc tctgggtggc gggttgttag tacagtaaag attgctagct gtctcttttg 134460 caaatctaaa atgagatttc atttttttaa ataaaaagaa aaaagtgctt gaacatttgc 134520 agctgggaga tagcacagat tagaaacatt acttatctct gctgcacaaa agaaggcagc 134580 gagagaggaa taaattgctg ttgaatgcta acgaagccaa ggcggcaggg gctgcgggaa 134640 acaactcctg ttgaggaaca gagcgagcac ctgacctgca ccctccacag tgggccgggc 134700 gccggagtgc acagggcagg cggggctgtg ggtccaggtg agacaggctg tggctgctgc 134760 atgttgacct ggcggtcggg gtggagtctg gtcaccagtg ttagcggtgc gttgggggat 134820 gctccttcct ggaccatggg aggctgtgct accactgcgc ttaggagcct cagtgaagct 134880 caccctcttc agccacgtgc actggggtca cttgtgtttc tgtcaccctt gccacccatc 134940 gtgtcaggag gcctccgtgt ccatgccagg gtgccctcca tccccagaca ttccggcacc 135000 ttcctgttgt ttcctctata agaattccca cctgccctct tggcttagca aattccagct 135060 cagcctttga ggtccagttc gagtagcgtc ttttctgacc cctttatttg gccctccagg 135120 ggctttcctt ctgttcctcc atttcccctt gggcccacct ctggggacgc cgggccttgg 135180 tgcgtgatgc ctggcgtgtg gtgtgagccc tgtggtgtgt agatcttcat tgcctctggc 135240 tcatgccggg cagctatcgg gtgtggtagt gcgctccctt gggcctcctg gagcagtggc 135300 agcaggcggc tcttgcatgt gccgtgtcct ccgtgaccag ggctgtgctg gatggacgtg 135360 tctgccgtgc tgtgctccct gcccatttgt ttgagggggc cgtccttagc gtagccttcc 135420 tgacttgtta accaggcaag agaccataca catgatggct tgggtgactg ctgctgcgta 135480 cggcatggtt ggtgggaccc caggcagcag gggagaggga ccctggctat ttggatctct 135540 gcggtgagtg ggagggactc ttgcccactt tgtgtctggt tgtcacaggg tttagggccc 135600 gaggtctctt gttcctgtct ggactgagca cctgggtccc cgtggcgtgt gctgcgcagg 135660 cctcatctgt ggacggaggg tgtttgccat gcgccttctg cgcagaggcc tggtgtgtga 135720 ctggcgctct ggtgctacgg ggctttggca gaggacggcg ctgtgcagtc agccccagtc 135780 ctggggcctc aaagactcaa ggtcattttg agtcctccaa agcaaggtga ttccaagtgt 135840 gtcttcagag tctgaagtcg cgggcgtcct cactgatctg tcctctgtgc cccgagaaga 135900 cagagctgtg tggcatggag ccgccgcatg agtgattccg ctgccttcct cccgctggag 135960 gtgaagcttc ctctcagttc cgtcttactt tgatccagtg cgacaccgcg ctgctgagcg 136020 tgccctcccc gttggtctgg gagacctgag tgcagaagcc tacagcaggg gcaccccttc 136080 tgctttcccg gccctcgtcc cttgctgagg aacactgccc aggcatgagc ctcagaatgg 136140 gctgagtctc gatgcaggcg ctgctcccag gggtcccaga cgcctctgca gcctcaaggc 136200 ctcactgtct cccttcccca ctcagcacca ctccctgctg gtccgggcag cccctgctgc 136260 tgctgtgtgt ctcttgcctc atcccctgtg ccaggggcgt gcccttctgc acctccagag 136320 gcctggtgcc cgtggatggc cggctgtggc tgtgggtgtc cgcacctcct gctgcctggg 136380 ttctcaccct catagcttct ctaggtgtga gaagcacttt ctcattcact gcctggctcc 136440 cagcttgggt tccttggcat tctcggaccc attgttcctc ggccccattg ctttctcagt 136500 ggtgtggact gagatgaatt ggagcagtcg cctgtctgag gcctgggcgg agtgagaccc 136560 cctccccagg tgtcccggct ctggccccca cgtcctcgct gcctgcattg tgctgctttg 136620 gattttgggc tggttttgag tcctgtccac ttggtcttgg ctgaggaggc cttagcggtc 136680 atctcctctt gtgtgtcccg gaaacaagga cgttgaggcc tgagtggggt gagcgcgtgc 136740 ttgggtgccg tggggtgggg tgtggcagag ccaagagggg tgagcgcgtg cctgggcgcc 136800 gtggggtggg gcgtggtgga gccgagtagg gtgagcctgt gcctgggtgc catggggtgt 136860 ggtggagcca ggagcctgga ggctgccccc ttcccctttc acatctcccg ccttgcagct 136920 ggtgtggggg atacccgtgg tgcgtttatc ataaccatgt caactgtggt ccactgcttg 136980 ctttctgtgc ctggcagggt ccccgggtgc gctgtcattc ctggcagtcc tggagggtgc 137040 ccgcctgtgg gtggcagcct ggaggtacag tggcagacct gctggccggg ggtcaccggc 137100 tatgagggtg gggcccacgc ctgggccagc gtcctctgct gtcgggctgt accatgggtc 137160 tgtgccccca gcctctgctg ggcggggtgg tggtggtcgt ggggcagctg cagcctgccc 137220 cctcccttat gtctgtggct gggcctcgtg aaggggcctg agttgacgag tttgcctgag 137280 acacatgcag gaaggttctc tgaggctgag tctggcctcg ttcctcctgt cctctgccga 137340 ggagctgtag ggtctcgctg tagcggggga agctgtcctc gaagtcttca attcagatgc 137400 cccttggaga gctgtttcag tgcccgcccc gccctgccca atgcacacac agaataaaat 137460 agaagagtcc cctggtccca tgaaggcagc taacaaattc aaagctctgt ggaaaagcag 137520 cgtaggagga gacctggctt ttgagagtga aagccgagtc cgcactgagg ttcggccagg 137580 ctcatgtgtg cccagagcca gattgcaggc atgagccccg ccacccccag atgtgtgcag 137640 gcgcagaggg tcagcaccac agctctttgc gccggaggac tgggtctttg tgtgagttct 137700 ccctgggatc acagggccct ttcctcctgg gagcccttgt gtccgacgag gacgaccttg 137760 tggctggcaa gtgtcctgga ggctggtccc tcaggaccct ccctgtcctc atctggaatt 137820 cacctttctt ctgagcacag cctgtgtggc gtcgtgtgct ctgatggcct tacccagagg 137880 ccaccttggc cgccggcctt gctttctcct gtttgtgggc tgcgagctgt cattacgtga 137940 ctgagtcctg atcaggcctg ggggagcccg attctaacga ccctgaggct catgagggac 138000 cccgtctctc ctgctgtgtc tccccgcgga cccgcgctct ccttccttca cagaagcaaa 138060 gctcccttga gggagacacc tcgcctctct ccttcaggca cccccaccca ccctagggct 138120 gccggcaagt gtgcgtggat gcactctgcc cttcccctta gagacggctg gggtgtccgg 138180 cctgcaccca cagctgtccc tattgtcctt gccctcctct cctcacggct tccctgcgtt 138240 ggccccgccg gctgagcctt gtgcgcctgt gtgtccctgt gcccctctcg cagtaggcag 138300 gtgatgacag cggctcaggg aggaagtgct gcctcgcccc accctgccca gcattgctgc 138360 tgtccacctc gcctccttgc gttttctgtt tagcaacagc cacagcacgc actatctccc 138420 ctctggttac gctgcccttc tctttaacag cgaccgcggc ttcagcactg cccatctccg 138480 tttgcagcct gggagccgcg ctaacccact caggctgctt tgcatctctt ctgctatttg 138540 aagttaaggg tgtgtggata aagggatgtg tgcttggctt tttcttttct tttctttttt 138600 tatctttcca aaaacatttt attttaaaat atttcttgca ggctgggcgc cgtggctcat 138660 gcctgtaatc ccagcacttt gggaggccga ggcgggtgga tcacgaggtc aagagatcga 138720 gaccatcccg gctaacatgg tgaaaccccg gctctactaa aaatacaaaa aaatgtagcc 138780 aggcgtggtg gcgggtgcct gtagtcccag ctacttggga ggctgaggca ggagaatggc 138840 gtgaaccccg gaggcggagc ttgtagtgag ctgagatgga gccactgcac tccagcctag 138900 gcgacagagc gagactctgc ctcaaaaaaa aatatgggga gatatatata tatatattta 138960 ctatttaatg attgctcagt ttgaaaaact tcattttgct catgtttcac tgtagtgtat 139020 gtagtgtgta tatagagagc tgcacaaatt atccatgaac acggcatcac catcacccgg 139080 tcaggaaaca gcgtgatcag ctgagtccct cctgcccccc cacttcctgt tcctggaact 139140 cccacccagt tcccatcgcc ctgggtcact tttgccgtgt ttggtctcta tgtagatggg 139200 tcatgtggtt tcgttggttg gagtccttcc cccttgctgc tttgcacctg cgagctgtgc 139260 tcctgccccg gggcctttgc acctgccatc cacgctcctg tcccggggcc ttctcacctg 139320 ccagccccgc tcctgcccca gggcctttgc actggccagt cctctttctg gagcaccctg 139380 tctggatagc agcagccttc ctgactttcc ttcctgtctt tcacaactgt tacctcctcg 139440 tgggccttcc ctgcccacct gtgaaacatc atgactgtct gttccctgtc ttgctgtcac 139500 tttttcccgt caagcacatt atagactttg gttttttgtg tcttatttct catccgtctt 139560 gtcacttgaa gggtagcgcc tcctcagcag tgttgtgaac aggttccaac acacaggggt 139620 gctcgggcat cctctgtcga gagtgtgggt gagtgcgtgt cccgttcccg atgtgagagc 139680 tgtggattct gcatccagag ggattctgca tccagaggga gtgctggcca ctgggagccc 139740 tttagggaca cactcctcca cactgaccat gggtgggtcc ctgctcagcc tcctgggagg 139800 gctgtccctt gtggctggcg ttgaggccac ctgttcccag cagctcagca agggctgtga 139860 gtttgctcat ggctgggcgt gtgctcccag cgggctcccc actcaccagt gctgtcctcc 139920 ctggcctctg ctttccttgg ccctgcaagc tgcacagacg accgtctgcg cccgcgtggc 139980 ctgagagctc tgtgtggatg ctgtggctct gaggttcctg tcctctccct gccttgctgt 140040 catgagttcg ggagcagctt ctgggggttc cgactgccga cctgacatcg tcacctgagg 140100 cttttcagct gatggagcct ctccttgtct gttgccccgt gccccacagt ggctttgtct 140160 gcgttcctgg gttccgcgtt ccgtgctcct ctggctgatg gagcgcagct gtggactctc 140220 ccgtgcgttg cccagccagt gccagtgtgt ctcatagggg tggatgagac ggagctgtct 140280 tgggggccac ttcctcttct aggttcgccg gatctgcttt ccccacattc tgtgagctgt 140340 gttcccacac ctggaaggaa ggaggaggag agcgaagggg atgtcagcat tttatttgaa 140400 ttcctttctg agtctgatta caaaagcaac acactttgat tcagaacact cgagaatgtg 140460 gaggagacag caaagctgag aagaaaggtt tcccgtcgtc cctcttccca gggaaagctg 140520 ctgtgactgt tttggccagg atccttcctg gcatttttat atacatggaa catgtttttc 140580 taatgggatt ttaggagaaa atactgcatg cactatttac tgagtcatct tgttttgttt 140640 aatcttttgt gaacattttc catgttaaat attcttttaa aacataactt tttggctatg 140700 tactgccctc cctctgaatt tttttttttt tttttttttg acacggagtc tctctgtgtc 140760 ccccaggctg gagtgcagtg gtgctatctt ggctcactgc aacttctgcc tcctgggttt 140820 aagcgattct tccgcctcag tctcccgagt agctggggtt acaggtttgt gccaccatcc 140880 ccagctaatt tttgtatata tttttttttt tgtagagacg gggtttcacc atattggcca 140940 ggctggtctt gaactcctga cctcgtgatc cacccgcctc agcctcccaa agtactggga 141000 ttacaggtgt gagccactgc actcggccca aatgctttta tatgcattac ctggttaccc 141060 atgaagaagg ccctctgatc tgctagagga agatagagga gcaaatctgt gtgccctggg 141120 gttggacgat gagtttttag gtataacact gaaaggaaat ccataagaga aaaaatttga 141180 taaatttgcc ttgttaaaga ctcttgctct gtggaagata ctgttaagag gacgaaaaga 141240 caaaccacag aatgggagaa aatatttaca agtcagatat ttgacaaata actggtatcc 141300 agaatatata aggccttctt aaaactcaat aataggaaaa caggcaacct aattgaaaga 141360 tgggcaaaat gtctgaaaag acagtcactg atatccagag ggcaggtgtg tgaggggagg 141420 atgctcgggc ggggcatggt tgaaaacaca gtcaccgata tccagagggc aggtgtgtga 141480 gggaggatgc ttaggcgggg cgtggttgaa aagacagtca accgatatcc agagggcaga 141540 tgcgtgaggg aggatgcttg ggtggggcgt ggtcatgcac acctgtgatc ctagcatttt 141600 aggaggctga ggtgggagga ttgcttgaac ctgggaattt gaggctgcag tgagctgtga 141660 tcacaccact gcactccagc ctgggagaca gagagagacc ctgtctcaga aattaaaaaa 141720 taaaaagagg atgctcagga gtatttgtct ttgggggatt gcaaattagt acaaccatga 141780 gacatggcca cacactgtgg gaatggctaa aaactgtaag atcactgacg gcactaaatg 141840 ctggtggaga cgtggagcca caggaactct cacgcactgc tgggaggagt gcaaaatggt 141900 gccaccactt tgaggcagcg tggcagcttt ttacaaagcc aaacacggtc ttatcgtatg 141960 acctgatggc cctgtctgtg ggctcttaac cacgggaatt gaaaattgtg tccacacaga 142020 gacctgaatg tgcgtgttta tagcaggttt attcatagtt aactaaaaac cagaagcacc 142080 acaacaccct gtaacagagg aacagataaa caaattagta catttgtgca atggaatcct 142140 gttcagtgag agaatgggac aaggtatcga tcatacaaca acatagatga atcttttttt 142200 ttttttttga gatggagtct cgctctgtcg cccaggctgt agtgcagtgg cgtgatctct 142260 gctcactgca agctccgcct cctgggttca cgccattctt ctgcctcagc ctccagagta 142320 gctgggacta caggcgccca ccactaagcc cggctaattt tttgtatttt ttggtagaga 142380 cggggtttca ccctgttagc cagtatggtc tcgatctcct gaccttgtga tccgcccacc 142440 tcggcctccc aaagtgctgg gatcataggc gtgagctacc gtgtccggcc agatggatct 142500 tgaatgtatt tttctaagtg agaaaagcca gaccccagcc agacatcagc atgaactcct 142560 gactggctca acacaagtag acagattcag aaggaactgc aggcagatgc gtctgtgtat 142620 gcagggctgg cacatacctg tactgctgcg gggcccggag gcaggcacac ccagcaacag 142680 ggagctgacc ggggcccaga gcagggcttc caagcactgt tctcggtagg aggacctggg 142740 cgtctttgga aagatacctg gttttaggac tggggtagga aatacacagg aggagcctgg 142800 agtgtcttct agttccagaa agtaaggaaa tgcagaaaac ccaaaaggat ggggcgtgtg 142860 gatgggacac aggagccaga ggaaagcatt cctgtggctg aaggcgaaac acttgcagca 142920 agaaaatgaa gtggagtgac ttataacccg acgcgtcaaa taaacgcggg tgaatcaggc 142980 tgaccgaaat aaatgatggc gtgactcaat ggggcagatg cagctcctcc ctccggaagg 143040 attgcagata aaatggatgt agttctctgc cctcaagaga tggaacttaa tccccctagg 143100 gtaggccagg ctccgtgacc tccttccaaa gagtggagta cccaaaaggt aacgttgcct 143160 gcctggaggg gcctggtggg cagcaccttc ccggagcgat gagggccccg cccgggctcc 143220 aagggatgat ggggacgctg cgtctgtggt tctttacaga cctgtagctc cagtccagcc 143280 tcaacacaca cctgaccctg cggggggcct gcctgggcca gtcctgctca gaactgccaa 143340 gtccatgaga aacaaggaaa ggctgacaaa tgagaggaga ctcaggaggt gtggcaacta 143400 atggcaccct gatccaaccc tgggaaggaa caaggacgct gaaggacaga cacactggtg 143460 ctgtccaggc agagtcccag gtccgttcgt gacaccgttc cagtgcttgc actgggaggc 143520 tgggttcctg ggaactcact gtactgtcct gacaactttt ctgtacacct agtcgttcca 143580 aaatcaaaat caaaatttac tttaaaaacc cctgaggtaa ggatcattgg gaggttttga 143640 agtgttcagg acgcttgcct gagttcccca aagcaagcga ccgcagaacc agattcaact 143700 ggcagtggac ctggcccctc cccgagcgcc ggtgactcag tggacctgct ttgtcttctg 143760 gcctaccctt ctctcacctc caccttagaa ccccaggggt ggtgcctgct cggcactagc 143820 ctttgaggcc ccttaccgac catttggatg tgtttggtga ggagtccctg gcggtgaatg 143880 acttcttcct aatgaagtta aacacgacca tgccattcct gacaagggaa cctgccgttt 143940 cctgtcactc ttccttgtcc gcctgccctc aaagctttcg ttgcatagct ggtagcaaac 144000 caacatcact agggttggtg ttccctgtcc ctggccggag ctccttctgc agctcgaaag 144060 gtctggggag agcagccctt cagcccactc tgatctcatg gcaggtgtgt gttagcctgg 144120 ccttaattaa gcctggcctt cgagatggat gtcagaacag catgattatt ggacactttg 144180 ttttggaagc ccgttccttt agaaggtgtg cacttggaag tgtgattaaa cacgatgcac 144240 gtgatggggt gggccccggg gacaggtgtt ggaagtgtga ttaaacacga tgcacgtgat 144300 ggggtgggcg tgtggggtgg gccccgggga caggtattgg aagtgtgatt aaacacgatg 144360 cacgtgatgg gtgggcgtgt gcggtgggcc ccagggacag gtgttggggc ttggttgctt 144420 tccctgtgta ttagtctgtt ttcatgctgc tgatacatac ctgaaactgg aaatacaaaa 144480 aggtttaatt ggacttatgg ttccacatgg ctgtggaggg ctccgaatca tggtgggagg 144540 caaaaggctc ttcttacatg gtggtagcaa gagaaaatga ggaagaagca aaagtggaaa 144600 gcctggataa acccatccga tctcgtgagt cttattcact atcacgagaa tagcatggga 144660 aagacgggcc cccatgattc agttacctcc ccctgggtcc ctcccacagc ctgtgggaat 144720 tctgggagat gcaattccag ttaggatttc cacggggacg cagccaaacc atatcacctt 144780 ggctgtggcc tccactgtgc ctgggactgg ccacagagag ctgtgtctcc gtggctgcct 144840 tctccttgcc tgtttgcgtg gtctcgagga agctgcacag cagggcccga gtcggccgtg 144900 tgagccgctc tccctgtcaa agcacaccca tccctgcctg ctttgacctg aacttggtga 144960 ccttcaggcc atcagtggag tggggcagaa tgaatagcct gtcctggctc atggcagcca 145020 ccgggtgagg cgcctgcatg cgtggctcgg aggccttctg caggcacaac ccccaccgtg 145080 ggcctggcag cttgtgtggg aggcgtgcgg gtcggtggca gagggtgagc accagccctg 145140 tgtgaacctt cacaactcct ctgtggaccc tggacttggc ttcactgctg gtgagaatct 145200 ggtgtgtgct ttggggcacc caggaaatgg agttgagggc gtctaggttg tacttgagag 145260 atggcccggc tccgtcggtg tccttccttc aggctgaaga gctgcatgga gtgtgacaga 145320 tggcactccc tccacccgtc cccttgctgc ctctcgctca tggccactgc tgagtgctgg 145380 gagtgcccca ggctgtgcca caccgtcctg atctccccgg cctcccaggg agatggatgt 145440 gcacgtgcag tggcagctcc agagctgtca tggtggcact cgaggctggg gcggtgttcc 145500 ctggaggcaa gcggggagcc tctctggggt tcagtggagc tcagactgcc atggtgggac 145560 ggagcggggc gggggctgtg gtgggaatag gtggctcagt gtgggccaga aggttggagg 145620 gctggcgccg acacggaacc agggtagcac gagaccaccg tgctggtaac cagatggcgc 145680 agcctgtgat gggggcctgg attgtgttcc agcggcaaca ggcccgtcgg caggtttcag 145740 gcaggggtgt gaggaggcgt gaagaggcgc gatgtgtgat ccaaggtcgc tttgctgccc 145800 gacctcgtcc actgttctgt ggccatgcac gtgggccccc atatttccac tcagcctgtg 145860 cgggtgcttt gtgtgtagac ttttaaaggg gagaagtcag tgtggtccga gtcccagtct 145920 tcttcttctc taactctcct agagcctcaa gcctcgatct gctgggaaac ggatccagtt 145980 agctgtgaga ggggaagtgg cagctttgct gagtttcact ggatcttctc agaggcaccg 146040 gctgttgaat tctgtttcct ctccccacac gctgttgtgg ttttcccttc agctgctagc 146100 gccgtgctgt cttggatgct aaggggcgcc tacggtgttc catgaagctg ttctctgtgg 146160 acaggcagga tctctctaaa catacagttg gcgctagctt tctttcagct ccccagtccc 146220 tgctcctggc catgggacat cattcctttt acaacaaaga ggatcctgtc tcttcccaag 146280 taccactgtt cctttgcgat cggcacaggc aggagaggtc cgccctgcca ggcctgggtc 146340 agtggagctg tgcagactgt ggtatagaag ctgccttcaa cagttgtatt ccatttgggc 146400 ttctccattt cctgattagt agtagtatta ataatattat tttcaagacg gagtctcaca 146460 ctgttgccca ggctggagtg cagtggtgcg atctcggctc actgcaacct ccatttcccg 146520 ggttcaagtg attatcgtgc ctcagcctca tgagtagctg agattacagg cgcgcgccac 146580 caggcctggc taatttttgt attcttagta gagacagggt ttcgccatgt tggtcaggct 146640 ggtcttgaac tcctgacctc aagtgatctg tccgcctcac cctcccgaag tgctggagtt 146700 acaggcatga accaccatgc ctggtccatt tcccgattat ttattggtag taaaattcac 146760 tttgaggtgt gtggctctgt gggtcttgac agttgcactg agcatccccc accacagcca 146820 tgattcagtt ccatcaccct aagagtttct cctgcctccc cttggtcaca gcgctcttcc 146880 cctgccgcca gcagccatgt gggtacgttt ttaaagagaa gagcttccat gaggtttgaa 146940 gcccagtttc tccatgcatg accaccacct cctccatgct cttctcaaag tgatgttgct 147000 ttttcttgtt ttaaaacttt ttcctgaact cagcttgtaa ctcttaggat tcctggccac 147060 atctcccgtc ttcctgcacg tgatttctct gccacccttg cttttagtcg cagaagataa 147120 cagcaattgt gctgggcgcg gtggctcatg cctgtaatcc cagcaatttg ggaggccgag 147180 gcaggtggat caactgaggt caagagttcg agaccagcct ggccaacaca gtgaaaccct 147240 gtctctactg aaaatacaaa aaaaattagc tgggtgtggt ggcaggcaac tgtaatccca 147300 gctactctgg aggctgaggc agaattgctt gaacctggga ggcggaggtt gcagtgagcc 147360 gagagcgtgc cattgcactc cagctctggg ggacaagaac gagactttgt ctccaaaaag 147420 aaaaaaaaag aaaaagagca attgtggctg gcctgtctcc ctgcctgcag cgtttacggc 147480 tttcccatgg gcagaggccg tgtgtggctc cgtccccagc cggctgtgct gtctctgtcg 147540 tgctccttgg cactgactga ctgacctgtc tggagcctcc aattaaaggt cactggcagc 147600 acttccccta attaccatgc cataaggact tggcaggttt tgtggctgtg gtgtgagcga 147660 gggcgtgcct gtgcttcagt gatgcgttac ccagtgctga gttgttgagc tgcaccttcc 147720 tttggatggg atgcattttg gggaggagga cggagaatct gagcttcttc cctaccaggc 147780 atcttgtcct cactgggcct gtggggaggg aggggctcat ccttaggagc tcagttgctt 147840 gtctttagga gctccttggg gctgctggcc aggagggagg gaggtgacgg gtcttgccgt 147900 cctcccccgc agcgtggagt cctcccgggc agggtgggat tcctgggggt aggtggagct 147960 gcgcacggag gtgatgggtc tcaccatcct ccaggccttc atacatgcct gatgggcctg 148020 tgaagttggc gggagtgggc agtcggcgcc ctcgtacgca cctggtggtc ctgtgaagct 148080 gcatctgccg tgagcgtcca gtgggtcttc agaggttagg cggtcactgg atgacccagc 148140 aacttccctt ctaagtgcgc acccaagaga attgataaca tgtttgcacg aacactcgtg 148200 tcatcgttca tagcagcatt gctcatagta gccaagagat ggggccaacc caaatgcccc 148260 tcagctgtga ctaaaaacaa cacggctgtc cacccagcga ggagttattg agccataaga 148320 gatggaggct gatgtatgct gcagcaggga ctggccttga agacatgatg ccaagtcaat 148380 tcaacagtat gaaaggccac cacctgtatg atgacattaa tatgaagtgc ccagaatagg 148440 caaagtcccg aactcaaagc agggcattcc tgagacactg ccgtggcctc atgtgctcac 148500 tgtgggcaga aatatcagag tggccactgc cctgggagaa ccaggtggcc gagaggcaat 148560 ggcggctgca ggcagggaca gctacatgcg ctgctctcct ggggtgtgta ctgcgtggct 148620 gtgcggcggg gagacagacc acacggtgag gtgggagggt ggagcttgtt agcaggcacc 148680 gttacttgct ccgttacact tgtcttttgt taaccttttc tacctttgag cttctttgag 148740 gacagtcacc attgtgtctg ctttgcctgg aatggtggct gatacacagt gggtgcttga 148800 ggtgagcgtg gagttacggt tctgagaccc gtggctagca tgtgagctgc agtaacgaac 148860 agtgtagtca ctgtcaggac tgagcaagac cggcgttgaa ttcttgctca tcactgactg 148920 ctggcccttt agcaggctct ctgatgtctt ctcagctggg ccatctcgtc tgtaaaggac 148980 atgatgatag tccttggctt ggggtggtgg gaaacacata aacgtgacga tgtatgttca 149040 ggaaacgatg acggcaatga taaggtctct tttacccaca tgtggcgagt ttcttactct 149100 acaaggctac agagtcgcag gctcttcacc tggagggttg ggagcaccct cctgcccccg 149160 tgcttggccc tgtatttgtc acggctcctt cctttttctc ctccctgccc cagtctggct 149220 ctggtggctc ccagggttat ctggggccgg acatcaggac gttccaggag atgtccagag 149280 gtgcgaggca agttctgagg gaggttctcc aatgcaggga tcaagctggc ggtaggtgac 149340 acattgagtg gtgtgctggc ggctgcagtg gccgccaccg tggctcagga agtaggtttt 149400 ctgggctagg actccgcact gagctgggtt tcctgcctct aatctgctct ccagcagtca 149460 ggcctgccag agcctgggga cctccgtgag cacaggtacc tgctccctcg tccccggcac 149520 gtctgcgtgg gcgcagggcc ttctctggca tcaccctgcc cgggcagcgc cactcgcatg 149580 ctctgccccc ttgcagtgct ctgctcccag caagtgaagg tcatggccct tggcattcct 149640 ggcctcgcgc tgcccgtggc tgtctctgtg gcgggtccgg ccacacctgt ggacaggccc 149700 tttctgtccc ccctggactt tgaggaaatg aagtcagtat tcaccagcac agcagagctt 149760 tatttttcta cacatacgca gaaacttcca ttgtgtttcc tgaattattt tgacccaagt 149820 cttccagatc ctgcggagtg tccaccgcac accctgccag cagtgctgcc ttggaatgcc 149880 tttcgggtgt ccagaggaag ccgctggtta actgatagcg agaaagggaa tggcggctcg 149940 gatgtgagca ttcttctccg agttgggtgc atgtggaaaa ccggaccttc actgggtggg 150000 ggtccatgcc cagtctgcgc ccgcttcccc agtgccttct tgcccaagct cctccccacc 150060 ccagggtctg actgcgctgg aatcactggg agcatcctgc agccggccca caggatgggc 150120 ccagcagaca ctcacagtga ccaaccagga ggtcctggag atgggaacgg gcgctcctgc 150180 agtatcagga acagatctgt ttcttcccac gtgcttttcc ctgaagaact gggaggagga 150240 aatgttggtc ttcttggtac acagcctgct gcaggtcagt ggcggaggcc gggtttcaac 150300 ccaggtctcc caggtcttcc tagcgtccga tgccgttgcc tcttccatct tggccacggg 150360 ggacatcttg cagtctgtta cgtctggagt ctcccgacag cccgccctgc gctggcctcc 150420 acccactgac ccaccttgga ggcctctccg ctgatttacc tgcccgagtg ctgagcgccg 150480 tgcctcgaga ctgggggcac tcaccccgca cctcctctcc gtgctgtgta agccaagaag 150540 tgctcagtga ttccaacaag cactaaccct gccttttaaa ggtcattcct gtctttgtca 150600 gttcttaaag ttcaagagga aataaactgc ttagagctgg catttctcaa gtcaagtgtc 150660 agccctccaa gccccccgcc cggcacggag gaagcgaggt tcataaatga gctgccgggt 150720 gactcagtga tgggcgaatg ggtgccttcc tctctccagc tcctgctaga aaggaatgaa 150780 agggaaacta ataattccga aaatctcatt ttctccttaa agttttgtta ctcagcacgg 150840 ggaatgcttt ggagatgttt ctttattggt cgagtgacag cgtttagagg ctgtcagccc 150900 tgggtaccca ggacgtcacg cgcagggagg gacggctctt ccccctgggg gcctgtgcca 150960 cccgttcctg attgacgggc aggggagctc tccctgcagc gcgagagaca gcagaggccc 151020 catgaaggtg ccacacctaa cggggtattg acttctgtgc tttgggtcaa ggatggcaaa 151080 atcaatggga aaataaacag gccgaatgtg cttcattacc caggtagcgc tgaagcagct 151140 ggagtggtcg tgcggcgcac aggcgtgggc ggaggctggg ccgagtgcag gcgccgggct 151200 ccatcaattg tcatgggcac tagagcctca gcttcagagc tgctaattgg gctatcgggt 151260 gattccaaag agagacgcca cagagatcgc tttgcctctt cttttaacta tttgtctaat 151320 ttgatgcaag cctcagttaa acggggtatg tgagcccctt gatcctcaga gctcaatctc 151380 ctcagcctgg tccttccact tggcctgctg cctctctaga gtgctgcact cccacaccag 151440 acccggcgac gccggccaga gcccagctcc atgcctcacg gctctgattc actggccaca 151500 tggtgctgaa gtcacggctc cgacagcagc tccgctgagc tcccaggccc ggctccttcc 151560 ctctggtctc tccttctgtc tctcccatct cccttgctga gctccccagg cctggctcct 151620 tccctcctgt ctctcccgct ctctcccttc tccctcctgc actctgtctc acacacggcc 151680 ccatggtccc cgctctcctt cccttccctc cctccttccc tggcttttct ggtttcccgt 151740 gcagctgttg tgggatgtgc acagccccct cacactcaca catggcctcc tggtccccgt 151800 cccctccccc tcctgcctcc cttccctttc tctggcatct cctgcgcagg tgttcccggg 151860 agcttgttct ccgttcttta ttcctcggtc tctgcttttc cttcttacat aagttcttgt 151920 gctttgacat ctcttcttgt cacttcagtg tggccagact tcagagtctc tatctttggc 151980 tccaacctct ctcctaatct ccatgatcag attttcctct gtccctggaa gctgctacct 152040 tgctgttatt gctcctgacc ttggggccat gtcaggcgtg ccctgctgtc tccccagggg 152100 tcccgtgatc tctgttggcc actcgcatga aggcccagcc tccccaccct gacggcaggt 152160 gtgtctcccg ctttcccacc agctaggcca ggcggccttc ccctctctaa cctgtgctcc 152220 ggcttttctc cctcgcactt agctcctgcc ccctccgccg ggcctgggcc gttgtgctcc 152280 gccgaccacg ggggctggaa cagtgacggc ggacccctgt gtggaggaca gagcccggaa 152340 gagagaagtc ctggggcctg ctggctggtc gagggagtga aggggtgcat gatggtgtcc 152400 tgggctgcag tgatgcaggg agcgcccccc gcctcctgtg tggggtgggt tccggcccga 152460 tgcggggatt tttggcagtc cctgagaccc acagtccctc cacaggctgg tgtcctccag 152520 ctgagatgtg tcctgaggtt tcccgggtcg cacgatggcg ttctggaaat tggagaagtg 152580 ttggtggagt gggactgata cgtggatgct gtgattttcg ttcctttacg cgtcagtttg 152640 agggaactcg atggactttc gctagaacct atgatccaga tgaggaaggg gcaaggagcc 152700 cagtgtggca accctggccc caagtgactc ctctgcccac aggccgcttt ccaccaccgg 152760 ctcagagcct ccccacctcc ccaccccggc ccagcttgtc tgtccatatc tgtttccaaa 152820 cacccttccc gctggctctg ccattcccac cctgcgtcat ccccagtcct gtccttggtt 152880 cctggcctgg ctcctggacc atcacagcag ctctctcctc tctcttcctg ggctcaggca 152940 tcttctcacc cttcaggaac ggggaaccag ggagaggggg cacagagtct ggaccttggg 153000 catgctgaga ggcagctgag ggttaatgag gccaagatat aatgtcacaa agtgcaggcc 153060 acgtcccggc ggtaccgcct gtgagccagg tcccctggaa tgccactctc ccccagcatt 153120 tgtgtcccta accgagaaat gaggcgaaaa cgtctccctc cctggcaggg aggttcaggg 153180 tgtgtttgaa gaaatggcag ttccctttgc ccaaccacac gcatcttcat tgggaaaatc 153240 tggctccgca cctcatctga atgcacggcc ctgtgcagcc gacagcaggg ctgctctgcg 153300 acccgggagt ttccagctgc ctggggatgg acttggcgtc agagcccagc gctgttcttt 153360 gagtcctgct cccatttgga aatgaggggc cccggaatcc tgggcttcct accagaggcc 153420 tgtgatcgtg ggggaggcgc tctgcacatg agggtgggtg ggtgggttta gtcagagggt 153480 ggttattact gtttttgcct ttgaatttgt gcatctgcag tggccgaggc ggggagccgg 153540 caggagcttg ctctcttgtg ggggacatgc agtcgcccgg cctcaggtgg gtgggaactc 153600 atgtctttag ttacccatgc tagcgtttct aaacctcata tctgtggtat agggtagtgg 153660 tatagggtat tggttggtaa cctttctctg taaagagccg tatggtaaat acttttggct 153720 ttttgagcca cgggctctgt cacaggaaag cagccgtaag ccatatgtca atgaatggga 153780 gtggctttgt tccaggaaaa ctttccttac aaccataggt ggtgggctgt ttgctgagca 153840 gcagtgcaga gaaagccccc agcctcgagg ctggcccacc cgcctgctgc ctgcctgttg 153900 gccatgtggc cccttggggc ttctgtcctg tgcattaggc gagcaggcag ccagcgctga 153960 cagggttgac ggacgcacgg atggtctcct tctctctgac ctcgggagac ggtagatgtg 154020 tccaggacac ctgctgtgcc tctctgcgtc actccaggca ccggattatc ttctgtggct 154080 tctctttttt ctccaagtca gagctggagg gcatggggcg gttgtttagt agagcctggg 154140 gaggtgactt gcccccttgt ctctgcagtt ctcatttcct aatctccagc agcctggggc 154200 ggaagtgaat ttatggtctc cctgcggccg tgcttgccgg ggctccccac ccagcatttg 154260 gaggagccct gcccaggcga ttacaggttg gtagctgatc agctaaactg gattattcat 154320 tatggttggg agtgaattga aattgcaaag ggcaattttc cttctcacat ttcaaggtca 154380 gatgagagta tttgccgtgt ggcctctgtt tatctgggaa tgcaaattga atttggtgat 154440 tccagttgac gagatgttgg gaacagagcg ttcatcagag gcagagtcgg ggagaagtga 154500 ccgggaggcc aggctgcagc ttcagagcct gctcccctgg ccgttccttt gattggtaat 154560 tatttcagcc tttggtcttc tcattctctg gttttgtttc cgctgtttgg atttttattt 154620 ttttcagaaa aatgtgtatt gacacttgga ggcatttaag attgggatta gatagagtaa 154680 ataacaacag ctgcgtgcca cgctgagcct gatgtcctgg ggcacctgcc ctctcggagt 154740 cccagcccct tccgagtctg aacctgcccc ccagggagga gggcttgccc ctctctttca 154800 cctgcaagtg cccacctgtg ccactgagtg cggctgcccg gccccaacct catgacggtg 154860 tgggggctga gctggccacg tggacttgaa cccgagtctt cagcgaggca ttcaccccct 154920 cccaaccgct ggctcggcca agcccctgca cttgccctct tctgagagac acatggaacg 154980 tgtcacctgt gtggcagtgc tgttgcttgg cccgactggg gcatctcccc ccagccctat 155040 gggggtgccc aaggcacggc cctggagacc ctggaggtca gtacagtggt gtcctggggg 155100 acacggtggc ttctgagccc ctttgtcctt ggggatgtgg ggactggggc cggtgctgcc 155160 gctgtcctcc cagattctgg tggagatttg aacccaagtc ctcagcgagg catgccacct 155220 ctgagcccct tcctcctcag ggatgtgggg tgggggtggc gctgctgctt tcctcccaga 155280 ttctggtgca gactaaacga ggtcatgtac ccaggagcac cccctgcagc cgaaagctgc 155340 tcgggcgaga gtgggaaact gctcaggagg ctcggcctcc gagttcagac atggaggggc 155400 cctggccgcc agcctcctct gctttcttct tcagtcctgg gtagatgaga agcataaact 155460 ctgatctgaa tctccagcag ctcctgatca gggagcatct cctggctcag ccgcggaggc 155520 cccgtgagcg tggggcaggg gaggaactgg gacctcttga tgctctcgtg cttcacgacg 155580 gacgcacgcg tctgatccag tcctcccctg cccattcgca gcgaggggcc tggtggcctc 155640 agttccatcc aagaggaagg agaaggccag aggtggatgg agcgctcaga gcctccggat 155700 agtgggttga cgtgggggat cctgcaggta ggcgggaccc tctcaaccct gtaggtccca 155760 gggcagttgt ttccctgcct ctctgcagag gcagctattg attcccattc tcaggcggct 155820 cctcagatac acaaggagcc tgcgtctgtc gtgccggtct ccaggccgga gctgggggct 155880 tcgatggcag agacggctcc tctctgtggt gagtgggggc ccttccccgg tgttccctct 155940 tagcaaggag cgaatgtgga tgcctgaaca tgctcagtgt tgcttctgcc ctgtctggga 156000 accctggcct tccgggagag tatttctgaa accagttcgt gctccattta aaattttgcc 156060 tctagatcca ggctgctgcg aggctccccg acgggcgcct gtgaacacag ctctgtgtac 156120 agttcttgtg actggaggac gagcacgtgt ggtttgggag gttgttctgt ccagcgatat 156180 cctctttcag aacctgtggg tgcttccgga gcagagcagg gcaggctgtc cactggggct 156240 ggagcctgtc ctctgctccc tgctagcctc ctggatcctt gtctcctgct cccgcgcgcc 156300 tcctgcagaa cggcactgct ttttgtctcg tgtacctgct ccaggccacc agttagagtt 156360 cactgctccc cgctgggtcg cagccctccc aaccgctggc tcagccaagc ccgtgcactt 156420 gctctcttcc tgagagacac atggaacgtg tcacctgtgt ggcagtgctg ttgcttggcc 156480 cgactggggc gtctcccccc agccctatgg gggtgctcaa ggcatggccc tggagaccct 156540 ggaggtcagt acagtggtgt cctgggggac acggtggctt catgctcatg actcagtcgc 156600 tcaaggcttg aatttactca tctgtaaaat cgagatgatt aaaaatcata cttgtgggtg 156660 ggtcttgatc tatgttcctc agatagctaa gaataaaggt gcttttagag attttgccaa 156720 ggttcgaata caattttatt agtattttcc tagtttcatg ccagacgtca tcactgagga 156780 tcaccgtgca tgcggctgtg tttacatctt aacccttgag gccactggca ggctcaccgt 156840 gctgcgagct caccatgtcg taaccatctc gggctcacca tgccgcgggc tcaccaagtc 156900 gtaactctgt cttgggctca ccatgccgcg ggctcaccaa gtcgtaactc tgtctcgggc 156960 tcaccgtgcc gtgagctcac tgtgtcataa ccgtctcggg ctcaccatgc tgcgggctca 157020 ccgtgccgcg ggctcactgt gccataactg tctcgggctg accatgctgt gggctcacta 157080 tgtcgtaacc ctgtcttggg ctcaccgtgc cacaggctca ccatgttgta accgtctcag 157140 gctgaccgtg ctgcgggctc atcgtgtcgt aaccatctca ggctcactgt gccgtgagct 157200 caccatgtcg taaccgtctt gggctcacca tgttgcgggc tcaccaagtc gtaaccctgt 157260 ctcagggtca ccatgccatg tgctcgctgt gtcatacctg tgtctcgggc tcactgtgct 157320 gcaggctaac tgtgctgtgg gctcactgtg tcataactgt gttggggcag tcatcagccc 157380 ggaagcctcg gtgtgacccc atgcccatgt gtgaacagtg tgtctgggcg ttatgggtta 157440 ggagaccgtc tgtgttcggg ctcacttaac aaagtaccat agtcggggat ctgaacagac 157500 gtccgtttct cacagctgtg gagctgagga gtgcaggatg gcagtgccgg gtctgaggag 157560 ggctctcttc ctggtttgca gatgaccagc ccctgtcctc acagggcaga gggagaggac 157620 tcgagctttg tgctgcttac aacttgcgca tcccattggg agcactccgc cctcaggacc 157680 gaatgccctc tcaggggccc ccgtttggtc accatcacat tggggatctg ggttttcaca 157740 ggtgaacttg ggacgacaca ggcattctgt gcactgccca aaacgtgctg gttttgccct 157800 gggcccgggc gtggctgtgg aggcgtcttc ataccctgtg gatccacact ccaggcacca 157860 ctcagccttg tgactggggc gggaacagcc gcctcatacc atcccaaggg tcggatcagg 157920 tcccgggagc acacaactgc ttcgccttag accccagcac cacctgtcct ggcctctctc 157980 agagcctgtc tcccgcggtg gccacgccgt gggctcctgt gctccagagc cccatggttt 158040 ctggggagag tccagtgatg cctgtttgtg cgatgcctgc ccttgccttg gcgggtgctc 158100 acagtgggct gggacttggg agaaggtaga caaagagtgt gtgggaggaa tgggtcgtgc 158160 gtggaagagc tggctcagca gtgtcttgag gaaggtcgtt aaaatgtctc ctgccacttt 158220 gggatacatt gtgtcctttc gttgttcctt gaaagtcggt attcttaggc cgggagtttc 158280 tgatgaagat cacattaaag tggccggcag tggctggtca cagcgcagat ggatgctcag 158340 aagctcagag cttgttcttt gagtagaggc tggctcagag agccattgat tgataaacat 158400 gcctggcttc tccttgagga actaagaact tcattctgaa ctcccagagg ctcacggaaa 158460 tgccagtgac ctcagagttc agtccaagca tggaactaga ggcttaattt tttgagtttt 158520 ctcttctgta cctcagaaga aaggccggga ttgaacagag agaacatccc caacagggga 158580 gagcccgccg tcgctggtgc cgctgtggct cagcgtgctg ggtcccggtg ccctgcaggg 158640 cctgaggggt gggaggcaga ggccatcttg ccggagcgcc tctacctgca cgcctgggtg 158700 ggcagcacca cttgttggcg gtgtctgaaa cgctagatgg ggggccttta ggctgcactc 158760 tggggccgtc cactttgtgc cggcccttcc tgcacctcca gggcttggct cctaattgcc 158820 acttcctcgg gtcttcagga cagggctgcc tctgctggac cttcccctcc tctcgagacg 158880 ccggcacctc atggacacat gccagcctgc tccttgcctt cctgcccctc tggctcagcc 158940 cgctctccac gtcccgtgca gaggccgttc ctggtttgct cgtcctcttg tgaccttgcc 159000 cattgctccc ggttggccca acctcgggcc cactgggctg accacgaatg agcacgccag 159060 ctgcccattg gaagcgtccc cggctctgac accgcctgtc tctgacacca caggctgtcc 159120 cgccacccct ccccgagggc ccccccagcc tccggtttcc cctccagtgt caggaggcac 159180 ctgcttgctg gtttgctgat ggcctgtctt ctgcccattg tggttactga gttgttgcct 159240 cgcagctcca cactcccttc tctgagccct actttgcggt gccagggctg cagcccacac 159300 ctgcgcttcg ccagggagtg cctgtcctgg gggcgctgga gagggcccgg ggtcagcctg 159360 caggcaagtg gggcagctct ttagccgctg gccttgcccc ctcccagcag cctgccagcc 159420 tgcagattcc gtagcgccta gaggtgccag ctccatgggc tgctgccctg ttctcagagg 159480 cctgggtcca ggccctccag ggtccccatg cagacaccag catggcctcc ctcagcagcc 159540 tcagttcctg ttccatgggg cccatctctg agtgtctaca ttttaatgat gtcagcctct 159600 gccccgtgtt cccacagccc aagggctggg agctgcttcc tgaagtcact gcgtccttgg 159660 cgcctgaggg tcttccttct gctctcggtg acctcagtac ctgcacccgc cgtgagattc 159720 tctgctcatg ccacacgcgt ggcttctttg cttgagattc ccaccccagt agaatggagg 159780 cccagcgagc ccaggctggc tgcggtgttc cgtgctgcca tctctgctgc ctggaacggc 159840 atgtggccgt cctcacccac atcccgtgtg ctgaacagac tgggtagact cgcctgccag 159900 tcaggtgtga gtggcaaaca tcccggacat ggttcttggc gagcattcca cagtgtcgtc 159960 tccttgtcac gtcttggtgt tggattttta cagtctagtt ctgttgttca gaagatttca 160020 gtgtcagcca tcaggccttg gggatgtggc cctgatgacg cgggcccgag tgcttgcacc 160080 tggacggtcc tggagtgggt gtctctctgc tgcccacgcc gtccctcagc cgggaatgtg 160140 tgttgctctg gttcacttct cccatctccg ttcatgatgt ggatttcact gccaggaagg 160200 agaggtttgc ttcacaacct ggcggatgag cttttccagc ctgtgctcag ccccacgccc 160260 ctatgcctct gtctaccctc tggggtgctg cagaacacac gcttcacgct acatcctgca 160320 gccactgcat ttcctcagac cgggtctgta aggaagccca ggttcagctg ctcgatgctt 160380 gacagccaga cacgagaggc gagagtggcg gaggaagagc aggcgtattc ggggagccag 160440 cggatcgggg agatggtgac ctacagtcac aaagaccatc tgaagtcagt acagatccca 160500 ggctctagtt atgctaaggg taggggcaag aggagggggt tgggtccaag aggtgactga 160560 cgatcgtaga gatctgggtg ccagcaaggg tccgaggggt cgggaactgc tctgtccttg 160620 gccaggccac agcactcctg cagatcttta acaaagccta gttagctgtt tccacacttc 160680 ccctttgatc ccagagtgag tttttgcatt attactcttt gctatttttg cattattatc 160740 tcagtactct aaaagctagg agtaggtaaa gaccctttaa gcagtggcgg agggatatgc 160800 tagttctgct gagccactgt tacaggccga gggccgggct tggggcgcct cggtgcctgc 160860 cgtcctgcct caccgaggcg gcctaggctg cagagagtgg gatgtgggcc tgagggaagc 160920 agctcaggcc acatccagtt cctgggaccc agtcttggcc cctggctcta ttgcactgag 160980 ccctggtcct caagtgccgg gagcctgggc tctgaagcaa gacagccact gtcctgtggg 161040 tgtgcgttac tcacatctgc tctgcgtggc ggggggactc cagccccaca tgtgccccca 161100 cacagatgtg agcgcaccct cactcaggat gcagggtgtg ggtttgctgg gcccccttca 161160 aggctgccca gccatcctgt gctgagctga gggtgcttcc cagcgcagcc ccttaccctt 161220 ctctctggcc agatgcctgt gctgtgcctg tcacctgaaa gacagcacct gtcacattct 161280 tgcctttgca cattctggct ttgaagcaga gtacagggaa tggtggcgtt cttctagtta 161340 aatgaccaca cggagccgtg atttaaagca cttgtgaacg ttcccacctg aattcagtga 161400 ttcaagagta gattttacag cccttgagta ttaaattggc ccatgagtag tttaaaattg 161460 aactgggtcc caaagtagcc tcataatatg tgtttcccat gagctttgtg cctgcttttt 161520 attttgtctt gcgtttttgg ttatggagcg cctggagggg gcaggggggc cgctggccag 161580 tgctgcacct ggggccagtg tcagtgtagg gctttccgag gcggctgatg ggataggaaa 161640 gactcagaac ggtttcctct gctctcacgt cgcagcagtc aacacagaag actctgacca 161700 gatgtggggt gtttccccac ccaccaagca agcagttggt tctgcctggg acaccagccg 161760 ttcagctcag tctcactcag ttctgttctg acactgtcta cctggaggtg ctgtcagacc 161820 ctgggtgagg gctcagtccc caccttctgg tgctggtcgc gagccgcagg tgtgcttctg 161880 accggccagc tgtaaactgg ggttcctacc acccagttgg gattcccctt gggtttgata 161940 aatttgctgg agtgtctcac agaactcaag gaaacgtatg ttcaccagtt tattatgaag 162000 cttactgcga aggatgcaga tgaatggatg cgcagggcga gatgtggggg aagggtgcag 162060 agcgtccgtg ccctccccac cctccaggaa cagtgggagc tctcccagtt cccgtgagaa 162120 gcctttgggt tttgatggag gccgccaccc tccgggaaga gtggaagctc tcctagctct 162180 ggtggaaaac ctttgggttt tgatggaggc caccaccctc caggaacagt gaaagcgctc 162240 cctgctccgg tgagaaacct ttgggttttg atggaggcct tgtcaggcgg acataattga 162300 ctccgcccct gctcattggt gaaccactca gccttcagcc cctctccttc cccagcttag 162360 gggtggggct gaagtcccga gcctctagtc cggcctcgat cttcctggtg tcccgcccca 162420 tcctgcagct gcccaggggc tgcagccacc gtcagtcatt ggcacatgga aggcctcagt 162480 cgggaaagcc cgagggtttt aggagctgtg ttctggtaga tgggttgacg atcagttaca 162540 tatttcacaa gatcacacgc ggctgaaatg agacgcccgc gtcctggacg ccagtacatt 162600 ggccccagtc tgtgggcttg tgtggcttct gctggggccg gctgagggtg gccaggttgg 162660 ggttcccgcc atgcttggct gggtcaggac cgccaccaag tcccttctga cgttctgtga 162720 gtgttggatt cacattcact ttcaacttat cctttatttc aagacttcta ctaagttaca 162780 gttaaaaacc ccgtattcac ttcactcaaa catgagtcca gtggagacca ccgcccaaga 162840 aagtgccatc cccccagccc cgggatgaag ctttcccttc cccaaaccac cgcccaagaa 162900 agcaccatcc accagccctg ggatgaagct ttcccttccc caaaccacct cccaagaaag 162960 cgccatccac cagccctggg atgaagcttt cccttcccca aaccactgcc caagaaagca 163020 ccatccacca gccccaggat gaagctttcc cttccccaaa ccactgccca agaaagcgcc 163080 atctgtcagt ccagggatga aacttttcct caagtcatgc aactaaggcc gagcagaagc 163140 aatcaatggc tgggaaggtg tgaacgtgag ggtggaggtc atggccccat cccacattcc 163200 tgtttccaag cagcctcctg gctctccctg atggttgcct cacagggctg tggtccctgt 163260 tagcttttct ctatcccagt gctgtgtttt atttccttga gatttagtta agatttcctt 163320 tggaaagaag tttgtggtac tcaatagagt cgtgtgcagc tcccgtgttc cagcgccgtt 163380 ccgctctgcg cctgcctggg ctgtctgagt agggatgggc cctccctccg cggactcgca 163440 ccctccccgg tgtggcctct cttctttcct ggctgtgtcc tttcctggga gagctctcgt 163500 acctcactgt ggagtcctga ctctcctcct ctcgggcggc ctctcatctc tcctggctgt 163560 gtcccttcct gggagcacct gtgtgcccgg ctgtcccatg tgggaggtgg agtcctgact 163620 caccctctcc ctgggacagc ctctcctctc tgcgcctcac tgtgcccttc ctgggagccc 163680 ctcccgtgag gaggtggagt cctggggttc ccggaatcac agaaagccgt tgcatcatgg 163740 gtgggttctg cagtcagggt cagtggacgc tgtcatttgt ccggtcccaa gtcagctcct 163800 gaaggacaga gagagagggg caagatccaa acccctgagg cccgctactg ccaggccacg 163860 aactcggaag ctcaccaaga gtggttggga gccaccaaag gcttaaaaat cgcatgaccc 163920 agcccctctc tgctgtctga ggagacagct tggtgcccag tggcagaggg gtctagtgag 163980 agccgttggg aggctattgt ggtaacgtag gtgacaggca acgagcacag ggactgaggc 164040 agtggctgtg gggaccatgc agggaaaagg gaggtttcaa aagcagaatt gaaaggaacc 164100 atcagccacc cgaaggggcg gacagggaga ggcctcttgg gcagcctgga gttggccctg 164160 cctctggcgt cggcccacag gaggcctctc gggttcccag tgcttagcgc caggctgggc 164220 tttcaacctc acagaatgtt tttagaacag gccccccaac caggcgcctg gcgcttgctt 164280 ccccgcacca cgctgcacat ctgcggtgat tcagagggga agcgctggct ctgcaatctc 164340 gctcattcag aagtcccgtc tcctgaaggg ctgcgtcgcc gacaattttt cccattgtgt 164400 gtggagttga gctcccttcc ccctccctgc cgtgttctgg gatcaccctg ggagtctatt 164460 tgaaatccag aaactcctga aaggccttaa gtagctattc agcagtgcgg aaatggcagt 164520 gagggggttg cacgtgcagc tctattttag gatgtcctgg tgggctcgtt cctggggtgg 164580 ggcggggctt ggtggggtgg tcaccccagg cttcattgct ttgccctctt gtctctccca 164640 tgcagcgccc gggggctgga gaaggccagg cagcagctgc aggaggagct ccggcaggtc 164700 agcggccagc tgttggagga gaggaagaag cgcgagaccc acgaggcgct ggcccggagg 164760 ctccagaaac gggtcctgct gctcaccaag gtgatgtatg cccttacatc ttgatcagag 164820 tcgcagggag ctgcgggtca gtgcacacct ggttagctgg atctcactgt ggaggcagga 164880 gtgctgcagc cgggtcaggg ttggcacttt ggccctgggt tgccaggagg gttctgggaa 164940 tgccagagag tgctcagccc cggtgctccc tgtgggactc tctgggcctg ctgcgtgccc 165000 cacccttttc agttcctcca gcatctcagt gtccacccct ggcctggtgc tgagctctgg 165060 agagggttcc ctgtcactgc ggaccccctg caggctccca cgtgccttgc agtcagcacc 165120 ctcatgcttt cccatccagt gatgccattt acactgtgtg ggtcttggcc tgggcttggg 165180 atgaaggctg tcacctgctt ccaggtgtgc cccacctgtg ggtggctcca tggcccgact 165240 ctaagcctca gtgcctgcgg gggttctgat gcctggcacc gtgagcagag gtcgctggag 165300 catgaaagac ggtttttgtg agttctgttt aaaatgttcc ttgggcactg aaatttcaga 165360 agacaaggcg ggaaagaagt caatctgtcc ccagatgctc tctgggccag ggcgggtgtc 165420 cagtttgctg ggcggagact ccccctgcct gcctccagct agtgctgagt gggcggaggg 165480 ctgtgccacc ctggcccagg atgcatgctg cacctgtcaa gtactgggag ttgtgcctca 165540 tggatgttta cctgttcttg atcgtttttg atgaaaacca agcctctttg ctgctgggac 165600 ctcttggttg tggagctttt agaaaatgag taacatttcc gttccaaaga tgctgtttta 165660 cagcttctcc agctcgctct gggcggctcc atgctgtctc ctaaaggaaa agttcacatg 165720 ggcctaggtc cctcgggcac tgactgtgtg ggcacccgga acacaggctg agctggcccc 165780 tgcgcatagc tcagatgctg accccaaagc cctggctttg caggtgcacc ccagacaggg 165840 gacactccaa aatgttctca catggctttt cagccggagc tgtctgctgc ctctggcaga 165900 ggggacaccc agccctgctg catggtcagg cacggtacgt ttctgtggag caagctctcg 165960 accttcctct gtgttccctt ctcttccaca ccgtgtctgc tagtgtgtga gcttctaagc 166020 aagatgcgtg aggtgcacgt ggcgtggatg tgtgggcaca gcccttggag gattcgctct 166080 tctagcgggg ccaggcagtg gcaccagacc agcacctgcc acgcacctca acagaggtgg 166140 acgccgtggt ggtgccgcag aagggctttt ctcaggaggt ggcattcctg tggggaccca 166200 agaatttccc ctttgcgaaa gtgtgtgtgg agaaccacgg cggagggaga gaaggcaggt 166260 catcacaaag cgctgctgca gtcacctcga ggcctggagc gggaggagac agcggcttgg 166320 gcccacaggc cacagcacgc gggctgacca ctgcggtggt tcgggctgac cactgcgggg 166380 gtttgggctg accactgcgg gggttcaggc aagtgcagcc cgaccctgcc gccgaggaga 166440 ggcccgggaa gcagaggggg cgacactgtg ttctttcaga gtggcgggac accttagctc 166500 ggtgatcttt gggtgcgtga tgacgtgctg tggtcccgtg atgctggaag ctcagagctt 166560 cctgggggag gaagagtggg agggctgggc tgggagctgg gcctttctct gggatctcag 166620 atgtccctca ttctctctgg gtctcagttc tcctttctgc taaactttgg gctcaggcct 166680 gatgaccccg ggtgcctgcg aacgtggcct gatgaccccg ggtgcctgcg aacgtggcct 166740 gatgaccccg ggtgcctgcg aacatggcct gatgaccccg ggtgcctgcg aacgtggcct 166800 gatgaccccg ggtgcctgcg aacgtgctgt gttcgggtgg cacccccttg agtgcacctt 166860 gttgttgggc ccagtccccg attctgggtc ggggctgggg agtgacatcg gcccacaccg 166920 gccaggcggg cagcactttg ggttggtcct ccatgcgtgg cctgggtctt ggcctgggct 166980 acaagtgtgg cccccacagg agggcagccc cgcccggcct cagctgaggc tcatcccttg 167040 ggaacctcct ggtttcttaa gtgaggccag cggttggaag ctgatgggca gagttccctt 167100 gacaggtcac gtgtgggcct gagtgttctt gtgtgctggg tctggcctgc agcctgtgac 167160 ccacgcgaca ctggtgctgc tgcccacacc ctcttagtgc cagggctccc ggccgtgatg 167220 aggagttaca tgcagtcact ggatgtctgg tgtggttttc atccctgtgg ggctccctca 167280 tggtctagtg gagccccgca gccttctggg aagtctgtgc ccggcttcct tcctgccgtt 167340 gctctttgat ggccaccccg gcccgctcag ggcaggaagt ttctgttctt ctctgctctg 167400 ctttgcaggt ggagagcctc tggcactttc tggcccgcgc cagcctcacc ccgaccctgc 167460 tgtgctcgcg ggcctgctct gtgttagcaa gaaggtgggt attgatcgcc gggcatggac 167520 tggttgttta tcctgacgaa ggattgatcc cagtcgcccg tgtagcccca ggccagggat 167580 gcaggatccg tccagccagc cgtgatgaag ctgttcactc agccatctgg agggagcggc 167640 gtgcctgctg ctctgggtct gtgtgccttg gtgtcggcca gtgcccacct cagctctgca 167700 tggcagcccg cccagctggg gtggtcgagg agcgccttct ctcaaggcgc acccaggagg 167760 gctgcgagcc tccggctggt gggggctctg ggcctctgct tcccattgga ggctctcctt 167820 gtgtgcttga cattttagta cacggtgctt ggagtgtgtg gttttatttc gagaccttta 167880 ttaaacggct ctagtctaag gatttaattg ttactgatag ctaagagtat aattaccttg 167940 gtaaaatatc atgactattt taagcagttg aaaattggct tctggaactg ggtgaacaca 168000 aaccattttc ctgtttgaaa tgagccgttt ctccagtgcc ccaagcttcc gcagtatggc 168060 tgcagagtct tgtttctgga atatcagtga tacaagctaa cttttagcaa gaaacttttc 168120 aaatgacaga aaagcctccg cttcccaccc cttgttgtct gcactccacc ctcccgccct 168180 gtctcacagc agatcagtta ctggaggccc caggcttggg gggagcagtt gacgctgggt 168240 gtccagcggc gtcggactca cgtcgtggct gctgagcaca gactgtggtt gtcatggtga 168300 caccctgccc tgggaacccg cacactggga aagacagatt tgtgtcttct ggagttgttg 168360 agggtctgag tttcgagctc tgggctgggg tgttgggtct gggctggctg aatgagcacg 168420 ttcctcggcc acctcctccg aagctggggt tggtgacgac acacattccc ctctcccacg 168480 tcctcgctgc ctggggcatc agatctgccc actgccataa agttcctttt gtcaatcaaa 168540 aaaccgtcca caaacattcc tgatgatcca cggtctcaaa accaacgtgg ctgggcctgc 168600 tgtgggattg ggagcggatg agctttaaca ggagggctgg gaccctggac acggctgcca 168660 ccctcagtga tgggagagtg tggagagctg gtgtctgtat tcgctgggtg cagtttaggc 168720 cagatccatc caggagacag ctgaaggcag atggagactg ggcccaagaa ggcgggggct 168780 gctgctgttt aagaaacagt taaatagggg gcagaatgca ggaagtacaa ggggggaccc 168840 ctcagaagag ttccatgttc ttcctgcctc acatccagaa gagagtccta gaagaagcct 168900 ctgtcctccc ttgagaatct gctgtcctcc tgaaagaagc ctctgctctc ccatgagcag 168960 ccgctgtcct cctatgatca gccactgtcc tcctggaaga agccaccatc ctcccgggag 169020 aagcctctgt cctcccttga caacctgctg tcctcctgga agaagcctct gtcctcccat 169080 gagcagccac cgtcctccct ggagaagccg ccatcctttg ggagaagaca ctgtcctcct 169140 aggagaagcc gctgtcctgg gagaagccgc tgtcctggga gaagcctccg tcctgggaga 169200 agccgccata ttcctaggag aagctgccat cctcatcctc ccaggagaat ctggtatcct 169260 ctgggagaag ccgctgtcct cctgggagaa gctgccatat tcctgggaga agccactgtc 169320 ctcctaggag aagcctctgt cctcccagga gaagcctctg tcctcctggg agaagctgcc 169380 acattcccgg gagaagccac tgtcctccta ggagaatcct ctgtcctccg gggagaagcc 169440 tctgtcctct tcggagaagc tgctctcttc ctgctatgtt cctggcccag aggcagctct 169500 tgtgagcctg agccatccca gcctcttaca ggggccagag ccgcttcctg aggcctcctc 169560 tccatgctat ggtgccttcc cgagggaatc tggggcaggg gagccaggct tagctcaggg 169620 acccctgcgc gttctcagtt gactctgcca gggcctcctc tcttcttggg ggtcgtttct 169680 gtgcccagga tgctgtgctg gagtctccca tgccctttct ggtggagggc ccgcctggat 169740 attggtgttg attgttttga agacatgttg ctcttcgtgt cctgtgtatt cactcggctg 169800 cctgaggctg ggctcctgtg tgctccctcg ccagggggtt gctgggctgc atccccagcc 169860 tccttggatt cagtgtctcg gcagggttag ccgcgaggcc aggcccagaa caggacatgc 169920 gtgttccttg ctgaagctca gtgtcatctg tggagccggc ctgctacggg agaggctcca 169980 ggcccccttc tggtccatcc taggaaggca gtgcagtcct cgctgggatt ctcccaggcc 170040 tggggtttga ggaggcccct ccatttcctt ctgactgtgt ctcttctcct ctgcaggatt 170100 gtgtgtgctg agggcagagc gagggaggct ggctgccccg agggagctga ggccacaggt 170160 gctcagggtc agagtggccc gtggatcatg aaggagtgtg ttctggtggc cgcaccctgg 170220 ccatgacaaa ggcgggtgtg gtgcccacgg gaagagggca gggcctcgct ggcaccgtgc 170280 ccaggctgcg cagcgattta gaaatgggcc cacgttgctg gagtgttttt atttttgaac 170340 aggttatttt catctctcct ggaatagcac ggtggagaca cacctgatgc atgtttttgc 170400 tcccatagga cgtgtgggtg gaagggacat ggagcagagg caagcgctgt tgtttatttt 170460 gtgttcatac agcttgggca gcttccactt tggagaccac cccaacaagg ttaatgtagc 170520 tcatgcctgt cccagccaca gacaaggccg ctgttcctcc agctgagtgc cacttcaagt 170580 cactggcttg cctttatttc aaagccctga tcttccctga tggtgtctgt ttaagtcctg 170640 ggatccggca cagcctggag tgaggacgcg gagccaggga ctcccagggg cccaggactc 170700 tgcccactct tggatcagag agcaagattt tggcgcagtg aggtcccacc caccccacgt 170760 ccagtctttc ttttcactgt tctcgtgaaa cacattgcgt gtgcaaagat catatagaac 170820 atatacatac agctcaaaga atacagcaag ttcccgtgtc tcagtcccag tgtaagaaac 170880 agaacagcct ccgctgtcag acggagccgt gctctaaacg tagagcagtc ccttccctca 170940 tttttctttc tagtttaatt gtgtgtatat ctttaaacat tgctccgctt ttcccatttt 171000 tatgttttct gtacatagag ccacgcttct gtggcttctc tttgttttta tcttagcgtt 171060 atccttttga ccttcgtccc tgggaatgca gcgtgttcct ttttgctgct gttgtgatgc 171120 tgtgtgcagg gagtgggtca cggtttagtg acctgacgtg tgaggtgttc cagttttgcc 171180 ttcctgcggt gggtgctgca cagtgggtgt ggctcagccc cacctcggga ggcttgttct 171240 cagtagtctc cgtgttgaag tttagtgtgc acaaattaca gacccaggac agactctaga 171300 agagcaggta gttagcaacc ccagcaagac cctcgtgcct ggttccagcc gctccctcag 171360 ctccagggca agcgcctcct gacttcactt ccctgttttt tttttgtttg agacagagtc 171420 tctctttgtt gcccaggctg gagtgcagtc gcgtgatctc ggctcactgc agcctccgcc 171480 tcccaggttc aagcaattct gttgcctcag cctctcgagt agctgggatt ataggtgtgc 171540 gtcaccacac cgggctaatt tttgtatttt tagtaaagac agggtttcac catgttggcc 171600 aggttggtct cgaactcctg acctcgtgat ccccctactt cggcctccca atcccaaagt 171660 gctgggatta caggcgtgag ccactgtgtc cggccttcaa ttccctgttt tttttttttt 171720 ttttttgtcg ttgctgtttt ttgaaatgga gtctcgctct gtcacccagg ctggagtgca 171780 gtggcgcgat ctcagctcac tgcaacctcc gtctcttggg ttcaagccat tctctcgcct 171840 cagcctcccg aggagctggg atttcaggtg cctgtcacta tacccagcta atttttttgt 171900 atttttgtag agacggggtt tcaccatgtt ggccaggctg gtcctgaact cctgacctca 171960 ggtgatctgc ctgcctcggc ctcccaaagt gctgggatta caggcgtgag ccactgcgcc 172020 tggcccactt ccctgttttt aagcgtcaca tattggaatc acatacctgt actctttagt 172080 ccctggcttc cattacacgt tatctttgtg agagtcatgt gtgttgtgta tagctgagat 172140 ttgttgattt ttcttaatta ctctgttaag ttttccattg tataaaaata ccacttttta 172200 aaatacactt ggctgtaccc gacatcggat ggtttccagc atgggggtgt tgactcttgc 172260 tgacgtggac gttttaacac gtgtatgacg tttggtgatc ccctgggtgc ccttgcgctg 172320 ggcatgccca ggtgtggcat agggtcagtt cccggggctg ccacccccgc cagagttact 172380 gtgccaggtg gcactcctgt tggggtgtgg atggtgctgg tccctccggg tcctcacctc 172440 ctgcctttgg ttttctccct ggtgggggcc tgtactcgaa agctgttgtt cttactttcc 172500 tgaggcttgg tgaagctgag ctgcttttta catgctcact ggccggttag acaccgactc 172560 ctgggggcac ctggacaggc tttctgttcc tacccctttg ggcttttatt tttattttat 172620 tttattttaa ttttattatt attttttgag acggagtctc actctgttgc ccaggctgga 172680 gtgcaatggc tcaatcttgg ctcactgcca cctccgcctc ccgggttcaa gcaattctcc 172740 tgcctcagcc tcatgagtag ctgggactac aggcacgcgc cagcacgccc agctaagttt 172800 tgtattttta gtagagatgg ggtctcacca tgttggttag gctggtctcg aactcctgac 172860 ctcgtgatct gcctgcctca gccttccaaa gtgttgagat tacaggcgtg agccactgta 172920 tccgtcctgg gcctttaaat gattgtttgc cttgttctta ctgagttgta gttctttact 172980 ctggatgtga aagtcttttg ttgaaacgta tttagttatc ttctcgtagc ctgtggtttg 173040 ctttttcact ctcggaattt ctctgttgat gttcatgcag ccagctcacc gacgtttgct 173100 gatgctggtg cttttgagtc atgattaaac agtctttgcc tgccaaagtt gtgaagatac 173160 tcagtggttt tcttctaaac actttattgt ttacctttta tatgttgctg cttttgttct 173220 gtgaaacatg ctgttgatct ggcagcctct attgcaaggc cgccttctcc ccacgcgtgg 173280 cgctgccatg gccgtggccc ggggacccct cgtggccgtc cacttcaggg ctttctggtg 173340 tgttccatgg gctctttttt tatttgttta cgattccatg ctgtcgtcgt tgcctcctcc 173400 ttccagtgtt tccctgtgtc caggtgaagc acagcattag cttatcttgg cattagcgta 173460 tctcgacatt agcgttatct cggtctcggc attatctcga tattggcata tctcgacatc 173520 agcgttatct cggcatcggc gttatctcag catcggcgta tctcagcatc agtgtatctc 173580 agcatcagcg tatcttgaca tctcggcatc ggtgtatctt ggcatcagca tatctcgaca 173640 tcttggcatt ggcgtatctc agcatcggcg tatctcggga tcggcgtatc tcgggatcgg 173700 cgtatctcgg catcggcgta tctcggcatc ggcgtatctc ggcatcggcg tatctcggca 173760 tcggcgtaac ttggcatctg cgtatcttgg catcggtgta tctcggcatc ggcgtatctc 173820 ggcttcggcg tatcttggca tctgcgtatc tcgacatctc ggcatcttgg cttcggcgta 173880 tctcggcatc agcgtatctt ggcatcagcg tatcttgata cctcggcatc ggtgtatctc 173940 ggcatcggcg tatcttgtga accatgaatg ccacatgttc caccatttac cttgatggcc 174000 tttaatttct ctcagcaagt ttgatggatt ttagggtaga ttcttacatg tcattagact 174060 ttctgccctg cgtatttgaa cattcgacgc agttttcatg ttgtcttctt ggactttgat 174120 cttctatgta tgtgttcctg gcctgtggat gtaccattgg gtcctgcaca ttgaccctgc 174180 acatgacaac cttgctctga tgctggtgtt tgacgtgcac actcatactc tctgagagat 174240 gctggccatg cttccccacc aaccccatgc ctctcttctc ccctggctac gcttccctgc 174300 cagccccaca cctctcctgt cccctggcca tgctccctct ccagccccgc gcctctcctc 174360 tcccctggcc acgcttcccc accagccccg tgcctctcct ctcccctccc ctggccatgc 174420 ttccccgcca gccccttgcc tctcctctcc cctggccatg ctccctttcc agccccgcac 174480 ctttcctctc ctctggccac aatccctctc cagccccacg cctcttctct cctctggcca 174540 cgctgcctct ccaaccccgt gcctctcctc tggccacatt ccctctccag ccctgcttct 174600 ctcttctggc cacactccct ctccagcccc atgcctctcc tctcctctgg ccacactccc 174660 actccagccc tgcttctctc ttctggccac actccctctc cagccctgct tctctcctgg 174720 ccacactccc tctccagccc tgcttctctc ctggccacac tccctctcca gccctgcttc 174780 tctcctctgg ccacactccc tctccagccc cacgcctctc ttctcctctg gccacactcc 174840 ctctccagcc ctgcttctct cgtctggcca cactccctct ccagccctgc ttctctcctg 174900 gccacactcc ctctccagcc ctgcttctct cctctggcca cactccctct ccagccctgc 174960 ttctctcctc tggccacact ccctctccag ccctgcgcct ctcccctggc cacactccca 175020 ctctagcccc gcgcctctcc tctcctctgg ccacactccc tctccagccc tgcgcctctc 175080 ccctggccac actcccactc tagccccgcg cctctcctct cctctggcca cactccctct 175140 ccagccctgc ttctctcctc tggccacact cccactccag ccccgcgcct ctcctcttct 175200 ctggccacac tccctctcca gccctgcttc tctcctctag ccacactccc tctccagccc 175260 tgcgcctctc ctctcccctg gccacactcc ctctccagcc tcaagcctct cctctcctct 175320 ggccacactc cctctccagc cctgcgcctc tcccctggcc acactcccac tctagccccg 175380 cgcctctcct ctcctctggc cacactccct ctccagccct gcttctctcc tctggccaca 175440 ctccctctcc agccctgcgc ctctcctctc ctctggccac actccctctc cagccctgct 175500 tctctcctct ggccacactc cctctccagc ctcgcgcctc tcctctcctc tggccacact 175560 ccctctccag ccccgcccct ctcctctcct ctggccacac tccctctcca gccccgcgcc 175620 tctcctctcc tctggccaca ctccctctcc agccccgcgc ctctcctctc ctctggccac 175680 actccctctc cagccccgcg cctctcctct cctctggcca cactccctct ccagccccgc 175740 gcctctcctc tcctctggcc acactccctc tccagccccg cgcctctcct ctcctctggc 175800 cacactccct ctccagccct gcttctctcc tctagccaca ctccctctcc agccccgcgc 175860 ctctcctctc ctctggccac actccctctc cagccccgcg cctctcctct cctctggcca 175920 cactccctct ccagccccgc gcctctcctc tcctctcctc tggccacact ccctctccag 175980 ccccgcgcct ctcctctcct ctggccacac tccctctccg gccctgcttc tctccatgcc 176040 cctttcctcc aggtgcagtg tcatggagga atgatgacag taggcacctt gtctccttca 176100 ggctgtgacg ggcgctttgg taatccatca gtaagcgtgg tgtgtgctag atgttctgtg 176160 tgatactctt tactgaatta atgaaatcct ctccaacttg tgcttttcta agagtctttg 176220 tcacgaaggc ctaccccata aattttgatg cgggttgttt ttgttactgt tgagttcaaa 176280 acattttctg atattctctg tggatttaga aagtctggcc ttccagcagg atttaacgca 176340 tacaaagcat ataatacagg tggactggcc agctgaaaag ggattgagaa ggagaaaccc 176400 agactcagtt cactcactcg atcattaatg tttcattccc caacttcttc tttttggggg 176460 ggcggtgggg ggaatggagt cttgttctga tgtccaggct ggagtgcagt ggtgcaatct 176520 tggctcactg caacctctgc ctcccgggtt caagcagttc tcccctcagc ctctgagtag 176580 ctgggactac aggtgcacac caccatgccc ggtgaattct ttgtattttt agtagggatg 176640 gattttgcca cgttggccag gaacttctca cgtcaagtga tctgcccacc ttggcttccc 176700 gacgtgctgg gattacaggc atgaggcacc gcgctcggtc attccccaga ttcttactgt 176760 gcgtctcctg tgagcctggc acatttaggt gctgtggaaa acagcaggga gctgcacagc 176820 agactcggag ctcaagggcc cctctctagg tggggctggg gcaggtgtca gtcgcgttga 176880 ggcggtgatg gctgctgtga agaaagggag gcgctttagg gctcgtgtgt cagggagggt 176940 gtgggaagcc ggtgaacagg cgcccttgct gagcccagaa ggtcactgcg gggagagctg 177000 tgtccatctg ccgtgctaga ccgtggtggg gcttggtttg tggtaatgat agctgcacgg 177060 gtacttggga aggttgtggg gcgaggtgcc acgtctcccc ggcttccccg tggcaatgcc 177120 gtaggtggtc gtggtgcagt gggaagacca ggggctttgg cgttagcaca gcctgtgttc 177180 ctctccgcga tcggccgctt gtgtaggttt ctgtggcccc acaacagtcc ccctgggctg 177240 cctcttggag ccacaccaac tccttgtcct ggttctagtg ttgagtagga cttgtccttc 177300 acccctctgt gataatgggc gctgggtggg agcccgtggg agctctgtgg tgggccttgg 177360 ttcgaggtga gcaccgccct cgctcacgtg ggtatctcct gggtcgcttt gcagatgggt 177420 cgtggagcca gtcttgtact tccttccacg tctttcctgg atagccattc tgtggtttct 177480 tcctctgccc cagtgggagc ctaaatctgg ctgtgtgctc ctccctcccc tgagggtgtg 177540 agatctagcc ctctttccct agagcagagc agagcagagc agagcagagg gcctccatcc 177600 ctcccacaga agagcctgcg cgagccccat gctgcttctg atcgccgtct cttctgctcc 177660 acacccctct ttaggtctga ggcttcatga tcggcacgat ttctcttgct ctttcttttt 177720 taatactgaa aatttttggt cttaggtagc actgaaggga gtatttataa cacccagtac 177780 ctgctgtgtc atctggaaag catcatcctc tgtgaccctc caggggtttg tgtcagacag 177840 tcatcatgtt ccctgtggcg cccgctgagg cgtcgggggg tcagctctgt ggccccgttt 177900 tagcccagca agtcgaggct taagagtggc atagagactg cccaggccat gcggccagcc 177960 ttgatgctag atttgtgttt tttatttatt tatttattta tttttgagat ggagtcttgc 178020 cctgtcactc aggctggagt gcagtggcat gatctcagct cactgcaacc tctgcctcct 178080 gggttcaagc gattctccag cctcagcctc ccgagtagct gggattacag gcgcctgcca 178140 ccatgtccag ctaatttatg tatttgtagt agagacgggg ttttgccata ttggtcaggc 178200 tggtctcgaa ctcctgacct caagtgatcc acccacctca gcctcccaaa gtgctgggat 178260 tacagctgtg agccactgtg cctggtccta gatttttttt tttttttttt ttttgagaca 178320 gggtctctct gtgtcaccca ggctggagta cagtagtgtg gtctcggctc actgcagcct 178380 cgacatcgca ggctccggtg attctcctgc ctcagcctcc cgagtagctg ggacttcagg 178440 tgccaccacc gtgcccatct aattcttttg tgtttttgta gagatcgtgg aaatctgagt 178500 gtgacttggt agctctgggg tgcagcctgc ggtccccatg tctcaccggt tccctggtgg 178560 cgctcctgtg ctgctccggg ccagttctgt caggggtggc agaggcctgg atcgtgccct 178620 acgatgcggg ccacaggggc cgggtcacac agctgatgtg gatgctgctg actggcccta 178680 ggcctggctc acccccagct ccctctgaag accactgcct acctgctgtc ctcactgtct 178740 gcctccgaga ggacacacgt cctggcgtgt gctcattcac tccctgcttt ctgtcagggt 178800 ttgtggcgtg cctctgcctg gtgctgtcgt ggcacgcacc gcctcgctgt gctgcctgcc 178860 tagtgcctgg agggaggctt ggccccgctt cctctgtctc tgctgccccc gccctttgtg 178920 acaagctctg cactgtgtac gtgaacacag gacagatgga gttcgggccc tgccgtcgtc 178980 cctgagtccc ggccccaccg ctcggctcct cctgctactg tgacccatgc aacccatctt 179040 gtctcctggg ctttagcctc tggggatgtc caaggagcag ccctgagtac cgcatgtgtt 179100 ccccgctctc ccatcactgc gagggcacgg cccagccgag cgcagctcaa gttcagcttc 179160 agaccttgct ttgttcatac ttaaagcaca tccctccacg tacacctgga tcggtgcaaa 179220 gcctgcagga ggggccctga gacgctggcc agcccggctt ccagggtcgt gtttgctctg 179280 ctcagtgaga gggcctcttc cctccacaga taagcagggt tctctcggct ttggaattta 179340 atttccaggt gttaatatat cgccctttcc cattaccttt ctagactgac atttctatta 179400 catccattca ggaaagaatg tccactttgt tatgggacaa agccatttgc acagttatta 179460 gaaagccaac cttgtcacag acactgctgc actctccctc cgagagggag ctggacctgg 179520 ctgtggcaga aaaaaattcc agggagaaaa gcaattttag gaaatacggt gaaatcaaaa 179580 caatgcattt tacccgtctc cagtgtgaag atgatgaagg ttgggttgtg ggagcgtgga 179640 ccgcctccac cagcccgagc cctccacgtg cgcccgaccg ccgtctctgc ctcaggtgcg 179700 tggagtttgg aggctgcgtt acactggatt caggtcaccc atctttactc ttggctcttt 179760 gaaaagacca cagtcctgtc cccacccgcc catgggtggg actttctgga cagttccagg 179820 tgaggctgtg gaactcctgg ccctttcagg gagatttgag gagatggcca cagcactgtg 179880 ttgggggagg tgggctggga gcagcagtgc tcgtgggctc tggccctggt gggagtgccc 179940 tgtctgcggg cacccgggtg cagccctgac ccctcccgcc ctgcctccct ctgcagaagg 180000 gtgctggtgg caggtgtgtc atcagaaacc ccgatgaggg catttctgga tggtgctgct 180060 gagataaggc tgtctcctcg ggtctccgtg ttgagggtgg ctagaatcgg gtgcccctgg 180120 agcactgtgg aagccaggtc tactttcttt tttgaggagt catggcctgc gtccacttaa 180180 tggtggcaaa tcacacttgg agagctcggt cacaggagcc tactgaaacc tgcagcccag 180240 aatgcagggc ctgggtcaca ggctccctgg cttcacccag gggctgtccc tggccctgta 180300 ccctgttggc ctggggcacc cccataaccc gtgtccccag gccctggctg gaacgtgctg 180360 tgcggggaag atgggcccca cctctgcagc ctcctctgct tccccgttgc tttcctgccg 180420 cccgccaggg ccttggggcc ttcacacagc ttctctactt cccggaaccc agatcatccc 180480 cggcgtccgg ctcatagcat tgaggcaggc ccttttctcc cttgttcacc ggcggctggc 180540 acagttcctt gcatacagca ggctctgagt aaatgcctgg tgaatattgg actccttcac 180600 ctacaggagg tgctgaggcc tttggagtgg ccagggagca gctctcctgc ctctgcctca 180660 cctgccctgt gctctgcccc cgcccggagg actcttggtc ccagcctcac cgtctgcatg 180720 ggcctccgcg gcccccaaac tcaccggttt tcaggaaggg cctgctacca ggtagcagat 180780 cccgaggctt ctgcttctga tgcctgagct aatgtcagca atgtggaaga gggtgttact 180840 tgctttcaac tttcccaaca accaaagtcg caagacgtgt agctgtcagt ggcagagcag 180900 gagggtaggc agtggctggg agcaggtgcc agggcaggga cggctcggcc ttcagatgca 180960 ggcactggag gcggcaccca cccgttccct cctcaggctg gtggaggagc ctccgctgtc 181020 ccgggacttg gggcagctct cccttctgga tttcctcctc ccacatgtcc tgctggggac 181080 acatggcttc ctatctcccc atggccccgg aggtccagcg cctccctccc ccatgctcca 181140 ggctggggcc ccagctccct cccggttcct ctgtctgttc cgggcagcag tctgtggcgc 181200 cagggccatg cccatgccag ctgccgtagc tgtgtcccag ctgtttgctc caggtttatt 181260 ttgatggtgt acccctttat aaaaactgtg gaatttgcac actgatacgt gcatatttgt 181320 ttaaaaagga taggtatgac ctgcggccaa taatgaacac acccatttat ttgtaagata 181380 taaggactta taaacgtaag tagggtttcc actgtatacc taggccccag ggagctgtca 181440 ggtgccctcc ctgggcaccg tgcccgggcc ccagtgagtg tccagccccc tccctgcctg 181500 ctgtgcctgg gccctagtga gctgtccggc gccctccctg cctgctgtgc ctgggcccta 181560 gtgagctgtc cggcgccctc ctgggtgctg ttgcttgctg tctgttgggc attctgtctg 181620 tgtggtcttc ctgaggctgt taccaactgt ggtggcggca ggcctggggc tcctactacg 181680 ccgctgcctg tgctctgttg ctcacatgaa ggggccaggg aagcctgttg gcatatggag 181740 tcatgccatg gctggctgtg gcggagctgt ggctgtgcgc gtggcgagga cgatagggtt 181800 ctgcccttgt ccgtggtcac cctgctcctg ctctcgcttc tctgaggcca gcccctcctc 181860 tctgatgtgt gcggagcgtg ggtcttggcc tgccgggggc tccttcgtgg aatgcagggg 181920 gtgcacaggt gttgactctg catgaatggt tgtctttccg cctggctgtt tccctgcctg 181980 acgcccctgt aaacatccat tcccaacacg cttcccagag gacgcttgcc cttggagtac 182040 tcctaacaaa agacttccca gtgaaatcag tttctggcac cccatgtggt atagcctgac 182100 acggcacctg ctgctcagct tgtccatggc tctgaggagc cctcaggggc cccaggcagc 182160 tggtggggga tggggttggg gggtggacag caaggtgacc tggcgggcgc agggcagctg 182220 gtgggggtgg tggggggtgg aaagcaaggt gacccagtag gcacagcgca gctggtgggg 182280 ggttggggga ggtaggggac agcgaggtga cccggcaggc gcagggcagc tggtgggggg 182340 gtgggggagg tgggggacag caaggtgacc cggcggatgc agggaaggcc cagtcttcat 182400 gtgcggtttc aatgtctcgt tcctgggctt ttctgcatta agtgtgagtt tctaacatac 182460 cacgttgaaa cgtcttggat cttgcctgct gagccacgtg gctcttcctg aaggacaagg 182520 tcagcgcccc cctcgccacc acttcatcca gatcccagga gccccttctg tcctgtaggc 182580 caaggctcca cagcaccacg tgggttatgg acgagaaacc tggagtgtcc tgctaggaga 182640 gaggctgtgg aattcnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 182700 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 182760 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 182820 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 182880 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 182940 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 183000 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 183060 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 183120 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 183180 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 183240 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 183300 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 183360 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 183420 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 183480 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 183540 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 183600 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 183660 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 183720 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 183780 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 183840 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 183900 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 183960 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 184020 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 184080 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 184140 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 184200 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 184260 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 184320 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 184380 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 184440 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 184500 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 184560 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 184620 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 184680 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 184740 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 184800 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 184860 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 184920 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 184980 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 185040 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 185100 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 185160 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 185220 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 185280 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 185340 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 185400 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 185460 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 185520 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 185580 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 185640 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 185700 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 185760 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 185820 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 185880 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 185940 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 186000 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 186060 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 186120 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 186180 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 186240 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 186300 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 186360 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 186420 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 186480 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 186540 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 186600 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 186660 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 186720 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 186780 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 186840 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 186900 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 186960 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 187020 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 187080 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 187140 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 187200 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 187260 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 187320 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 187380 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 187440 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 187500 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 187560 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 187620 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 187680 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 187740 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 187800 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 187860 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 187920 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 187980 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 188040 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 188100 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 188160 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 188220 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 188280 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 188340 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 188400 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 188460 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 188520 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 188580 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 188640 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 188700 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 188760 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 188820 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 188880 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 188940 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 189000 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 189060 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 189120 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 189180 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 189240 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 189300 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 189360 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 189420 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 189480 nnnnnnnnnn 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nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 191160 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 191220 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 191280 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 191340 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 191400 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 191460 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 191520 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 191580 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 191640 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 191700 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 191760 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 191820 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 191880 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 191940 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 192000 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 192060 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 192120 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 192180 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 192240 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 192300 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 192360 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 192420 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 192480 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 192540 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 192600 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnngaatt 192660 cccagtcccc ctcagctttg gaggtttata ccagagagac cgaggcttag agaggagccc 192720 agggaggctc ctccagtgcc caggccaggc atcatccagc tggcacaggt ggctttagcc 192780 cagcctcggg gggacacaag cagggcctgc agggtgtctg ggaagggctg gagggaccag 192840 gcccggaacc ttgtcctgcc tacccaggct ttggcctgac attgtccttg tttgtgcttt 192900 aaaatcccct atcctgtttg gtagagaaac atgctctctt taaactcagt ttcgaagaaa 192960 tccaaatctt tgaataacct tgatcttgaa aggaaaggaa gttagctgca ggtgaaaatt 193020 gatggtcatg ctcaaaggca tggttccctg ccaaggaagc ctcttgagtc tttctactaa 193080 aaatagctgc agcatcctgg tggtggtgtc tgaaccctct ctaggcccct cctggagaca 193140 ttcagagatg ttaaaggtga cagccagcct cacctggccg ttccgcacag gtgtgtttgc 193200 tcctggcctg tgaggcacag gtgggtgggc ctgctgagga ctgagccgcc ctcgggggta 193260 ctgggctgct ccctccgcag cctctgcccc ttcagttgtc cttggtgtca cggcacaccc 193320 aagagccttg taagttccct gcaccacagt ctgggtgggt gcctgggtcc ctgtgtccat 193380 ggtcctggga gaggtccctg gcctcagtca gaaggtgtga agtgtctgga ctttctccag 193440 gccggtgata ggccactgtt ggcttgtggt ctccatggtt ctgtgggtgc ttcaacggag 193500 ctgccagaaa ggtcaagcca cagcctgaca ccagccagag tggaggcggc ccaggaaccc 193560 cctggctcac caccctcagc ctggtgcttc cgtctgcccg tgtgggtgtg gacatgggtc 193620 tgaggcactg gctaggggat tccctgcttc cagcaggcgc gtgaggttcc atcctggtct 193680 ctggtttctg gtctggcctc atacctggct tagctctcgt aggagtgcaa caggtggaag 193740 gggcggtgat gcccgcagat gctgggtgag gtgccccgtg aacgtgtggt ctggtgcccg 193800 cagacgctgg gtgaggtgcc ccgtgaacgt gtggtctggt gcccgcagac gctgggtgag 193860 gtgccccatg aacgtgtggt ctggtgcccg cagacgctgg gtgaggtgcc ccgtgaacgt 193920 gtggtctggt gcccgcagac gctgggtgag gtgccccgtg aacgtgtggt ctggtgtccg 193980 cagacgctgg gtgaggtgcc ctgtgaacgt gtggtctggt gcccgcagac gttgggtgag 194040 gttccttgtg aacgtgtggt ctggtgtccg cagatgttgg gtgaggtgcc ctgtgaacgt 194100 gtggtctggt gcctgcagac gttgggtgag gtgccctgtg aacgtgtggt ctggtgcccg 194160 cagatggtgc cagcagatgt tggatgaggt gccctgtgaa cctgtggtct ggtgcctgca 194220 gacattggat gaggtgccct gggaattaca gtgctcgata gtcctcctgg acactggtgc 194280 tgatgaagcg agtctggcca cccacgccag gcagtgccca gtgccccttg ggtggctcct 194340 gccctccagc aagacatggg gatgctgctg gacccaggtg tctgtgaggt ccaggcacag 194400 atcttgcttc tgcaggaggc ccctgggcgg actaggtgag tccttcctcc taccgcctct 194460 ttgaaaatct gtgtgtgttt aaactaaatt tcttgagtgc catcagaagg cccgtgagct 194520 ggtgagctgc ccccgagcct tttgccaccc atggtgggca tgagccacct actgagtcgg 194580 ctccgagtca gcagaggcca tggagtgggg gcccccactg tgcagggaga gggtctgacc 194640 ctgggcgggg caccgggaag ggaggtggag gcctgaggcc agccctgctg gaattcctct 194700 cttctagggg gaggaagcct aggagctgga atcagaaaac ctgttagaac ctgagctctg 194760 tcactctctc acttgtgcct ggcgccagct ccctttccct ctctttgcct ttgcttcctc 194820 tctggaagaa tgaagcatgc acgcctcacc ccatctgcac ggggagccga ttcacagatt 194880 acatgaggga atgctttgaa aatattttta aattgtaatg ttcaaatata tgtgtgaggt 194940 agttcatcat caactcactc aacaaacata tggttagttc tattctaagg tgatgtgtgt 195000 tcctaaaagt caccctgcta cacaaaatca cattaaaaat aagatgggac cctgatgaaa 195060 atggcagcat ggttgacgcg gtcagtggct ggacacaggc aagtgtgaca atcggcacag 195120 ctcttcgcct cgagaaggcc tggcgctggc ttggggaagt gggagtggtg gcttgtgagt 195180 cactgtggag tggggagagc acctgaagct ggaggggtgt ggcacagggg gctcagccag 195240 gctcgggagg ctcccatcac agctccgttc agctgagtgc ggttttctgc attcgtcttg 195300 gaggaggttc ttcacagagg ggcggagggg gactttttgg ccatcactca acatcctatg 195360 ggacagcccc ttcctggctg acccacctgc ctgccctgtg ccaggcctta tgcagtgtgg 195420 ttgatgctta ttaccattca tcaaatttat ttcctgacaa atcctatgtt aaatacctgg 195480 catgggacct gcagtgagtg ggcattcgat gtatagcggt cactgctggc attcgtcaga 195540 gtaacttctc atttcattaa catccctcta atcatctcac ttaaaactca cttggagaat 195600 tctgagctca gatttggaaa tcccgtgttt gtgcaacagg aatttgtcgt tggatgagat 195660 gaaggaactt gcctgggtga acaggcagga ttcgcagccc aggtagctgc tcattctccg 195720 agtccctcta cacctacccc gctgcccgac tagggtgctg gagcatggtg tctgagagca 195780 cgcgtgtgcg tcagtgtgca catgcgtgca cccgggtgtt catgaacaca cccgtgtcgg 195840 tgctcagtgt gcatgcatgc acacatgagc attactgtgt gcgtgtctgt gctgcatgag 195900 ctctgtgtag gagacgtgtg tgcatatctg tgttgagtgc tgtgtatgtg tgtgtccata 195960 cgtgtgtact tgtgtgcgca tgtatgttgt gctgtgtgag ttctgtgtgc acatgtgatc 196020 atgtgagtgt gcacgtgtgc tttgtgagct gtgcatgcac atctgtgtga actgtgcatt 196080 gagcatgagt gtgcatgtat ctgtactggt gagctgtgtg cacgtgagtg cacgtgtgtg 196140 attgtgcatg tgtctgtgga gtcagctctc tgcatatgtg agtgcacgtg tgtgagtgtg 196200 catgtgtctg cagaggcagc tctctgtatg catgtgagtg tgcatgtctg tgctgtgtga 196260 gctctgtgtg tgcatgtgtc tgagcatgca catgtgtgag tgctgtgtgc gcacatgtgt 196320 gtgcatctgt gcttaccatt ctggaacact ggttctttta tgcattttgg cttcttttcc 196380 cacgagaccc tcatggaaca ttaagcccag cagacaaggc cagccccaac cattgtgata 196440 gttattaaac agcaataaag caggatctgt atttacagac ccagagtgtg ctcagactgg 196500 gaggtattaa acatcatcca tcatcaaatg gaaaacagtc agatgcaggg agtgtagaat 196560 ggagttaata ttcttttggt taacttcacc cataaagagc taaactgccc ccaataaaac 196620 accaagggga ggaagggagg ttcttccaga cggaagcaat catcggcacg gtctgcagac 196680 aggcccccag ggtttcctcg tgccggtggg ttttctgcag cttgttacgc agctgcggct 196740 cagagcaagc ggtgtctcag ggtccctttc cacagttctc attgcctgct ttgccttagg 196800 tcagctcatc agcagccctg gggagctggg gtgaacggag gaaagacact gacttgtaga 196860 acctgagaat ctgggaaggg agggccttag ccgaagactg tttgcccagg agggtggcac 196920 gcagtaaaca gttcaaccca ggagttcaac ccgggagctg gcattggggc atggatgtgc 196980 gcgctggtgg ccattcatta ctgatcctcc agtttccttt gtcgtctgtg agtgggtgcg 197040 ctcagcccag ggggtgttgt gtgcgcagcg tgtggtgcag aggtagcacc tgggacaggg 197100 ggccgggcac tgtgcgtgtg ggcacaggga gcgctgctcc tcctccttag acctgaggct 197160 cctgtctggg caaggtctag ccctccacct aggagcttac ggaatcttca gtggggacag 197220 atggtctgga aaggactcac ctcttttccc acccttggtt gaatgtggcc ccttgggcac 197280 aggcgggcag cgctcacccc tttcctacac taagacgtcc tcacggctta gtgtagggca 197340 ggcgggtgag gcggggtttg tgtcgcttct gatctggaag gggtttagca gctgaggaga 197400 tgatcgccac gcagagttcc gtctccagaa aaataagagg atttgcacag ttcttgaact 197460 tcacccttcc aaagttttca cctcttgtag actagaagtt ttaagtgagc ttctgtgtgt 197520 cgaaatcatt tcatgggcag tgccccagcc ggagcctgtc tggaggggag ggttgggtgg 197580 gcacgggcgc cgggcctggg aggaggagga caacatgggt ttcctagctc gctggacggc 197640 cctgaggttg tgggggcctt tggtggctga aaggggtctt gtatttctgt gcacattgaa 197700 aggcgatctt atttgcctgc gctgccgtcc agctgaggac agggacatag ggtgcctgtg 197760 agtgcaggcc tggaaaggga tgggactccc ctctgtaggg agggcggggc ttcagtccac 197820 ctggggcgtg gggcctgcgc caccacccgc atcccaggag aggcactgat tgcagggctc 197880 ggcctggggc ttacatggga ccctccttga ctccctagag gcagccgagg tggccactgc 197940 agcactcagc tggtcttccc caggaagtcc ttcccttaca gggcctccac tgccgcctct 198000 gtcatgggca ggccctcagg gagcagggct gtggcggcct gtggtgcagg ggacgtgtgc 198060 catgtctcct aaagatgatg gctcagctcc atggggggcc ctcggcagaa cgtttggatt 198120 taaggactac ttggggctca ccatgtgctc cgaggcttag ggaaggcctg ggacgggccc 198180 tgaagtgctg tctggctgag gctgggctcc tcaggtgaga aattggctcc catgtcccgc 198240 tcccctcccc caccccactc tccttccttc aaggaatcct gttagacttt tcactttgct 198300 ccacggcctc caaatcccac taagcgactg tcgcttttcc agggcatcgt caggtgctgt 198360 actaagcttt aataaagggc tttatccaca gcttcagaaa agtctctaaa taaattagat 198420 ccactggtta gcctccaacg gtgattttta ttaacctcca gttaaagaaa tattgctggt 198480 tacagaagca caatttattt ctgtgtaagc caggctggtg tgaccctgcg ggctcccgag 198540 agggatagtg ctatgtacac gcagagtgct gggctggcca tgagaggcac ctgagagggc 198600 acccggcagc ctgagggctg ggagtcactc tcacagggac acagagactc tcacagggac 198660 atgggggact ctcataggga cgtggggtat ctcacgggga cacagggata cgaggactct 198720 cacagggata cgggggctct cacagggata caggggactc ttacagggat tcacagccac 198780 tgagacacgg gctggtgctc ctggcctgga gcagagaggg gtgtggaggc cgggtgggag 198840 gccggagcct ttcatgtcct ttctggcccc tggtggcagc agctcccttg ctgaatggct 198900 tcaccctggg aggtgatcag aggccggggc ttgccgtcag ggcgccctgg ctcagatcgt 198960 gcctctgcgg ccgtgtggct tgggcgtgtg gcccctgtca gagcctctgc ttcctctgtg 199020 aagtgcggag aatggttgct gctgctcatc agagtgggga ggtgacaggc ctggcccggg 199080 gctcgggttt tgttcatgct gttgcctccc ctgggctccc ctgtctacac cactggcaca 199140 ggagctgaga gggtgtccac gccccggggg actacgccat actgatggcc tccatttctt 199200 ggggtctgtc tcactgagct gggactccag ttccagttct tgtcatcctc actgaatctc 199260 acaaagctga gcgggaaaca cgtgggctgt gctgagtcgc cctcgctgta caggaagaga 199320 aaccgaggct ggagcagtgg agaggcttgt gtggtcgatc gcctggggac ttcatgtgta 199380 ctcaggaccc agacctcccg gccgcacccc cgtgctggtt ctgtgccctg ctgaaccatt 199440 tgggaaattg tgttatcatc tcacacatgc tgcgggctcc tctgggattc actgctgctg 199500 tttctaaagc actgttccca gtgtgttcac agcgtcccca ccttcttcca cgtgcgccgg 199560 gcagcttctc tttggcctct cacacctgag gtgctttgtg gcaggagcgt cctctcagga 199620 gcctgggtgc gtgagttcaa atcctggtcc caggtgctgg ctgtgtggaa cccagccgaa 199680 gtcattcgtc tgtgtctcag tttcgttgct ggagagagcg gagattgtcc cagcgtgtcc 199740 tcacagtgtt gttggcggac tgaacaagtt gggaggaatg agcaagagtg acccttggat 199800 caggacctgt agtagctgcc tctgtcctgt gagcattcgc tatgattttt attccagacc 199860 gttggctgct ccccttcctg cggcgcattg tggccgccag ctctaggcag ctcgtcctcc 199920 catgctgctg tctcccctcc tctctccatc aggcctttgc tgtggttgct ggagcattgc 199980 tgccgccgtc cattgcgtgt gctctcttga cgggacgggc acccatctgt gcttgagtca 200040 cgtccgagcc cgcggccgcc acccacaccc tgttcctgca cggtgaggtc tgccacgttc 200100 caggggcagg ctttgcccgg ccctccctgg ccctgttcag tagccctggg cccagcttat 200160 gtctatgttg ggcagtgcgg ggtgttggga ggagagaatg ggcagaggcc cctgcctcag 200220 ggctccctgg ggcctggcag gaggcctggg gtggtgctgc ccccactctc gagaaaaagg 200280 ctggcactcc gcagggctgt ttgtggtggg aaacaggcgc tcagccagtc tggatcccca 200340 gcccccccag gccctccgcg tgcctccact ctgcagggca cccgtagcct ccagagaaca 200400 gtcatgaccc agcgtccttg taggcacggt acccgggcat cacgttccca agcccgccca 200460 ttccggccac ctccagccca caggatgtgc caggtcgtgc cgagggcctc ctaaggagcg 200520 tgggattgtc agaacagatt gcagcatgga tttttggagg attaaagtta attaaagagc 200580 tcttccttgc tttcacgtcc ttgtgtctgc cagctattta catgctaatg ctgccctgac 200640 accgaggatg aggggtgtct gccgcactgc actgcgctgt caggagggga accacaggag 200700 aaggagggga gcgcagtgct atgtattacc ctgtgcccct ccgatgggac aggggcgtgg 200760 atgcagacac attcgaaagt cagtggcagg gtcgttttct tgtatttcct gaagtgtctt 200820 cgtggctgac ttggatgttc tccattcagg ccccccctta cactgcataa ttgaatgcat 200880 tctgcgtgga aatatcttcg cataagcaat tttataaata aagagattgt ggagagtagg 200940 gtctgaagtt tctaagtgca gggctgtgtt ttccagaagc ccatccttct tggcgaaggt 201000 gactttcagc ttcacggggt cggcctgtgg cagcgtcctc tggccctcag cagcactgcc 201060 ttgatgtgga cgtggacgtg gatgtggacg tggacgtgga cgtggacatg tgtgtgcgtg 201120 aaggctcctc aggtgtatta gtccgttctt gtgtctctat aaaggaatcc ctgaggctgg 201180 gtcattctgc ggactgtaca ggaagcacag cgccggcatc tgcttctgct gaggtaccag 201240 gaagcttctg atcatggcag aaggcaagga gcaggcacgt cacatggcaa gagcaggagc 201300 aagagagaca cttgaggttc cagaatcttt ccaacaacac tcctcactcg ggatggctct 201360 gggccattcg tgagggatcc gccctcataa tccaacacct cccaccaggc cccacctcca 201420 cctttgggaa acatttttca acctgagatt tggagggagc agacatccaa accatatcgc 201480 caagtatttg ttgaatgaat aaatgaacgt tgataccatc attgggtgta ttttagctgc 201540 agattctaaa cgccagggtt ctggggtggc tggagtgtga aaaggtcggt ggtggcagtt 201600 aggaatgccg tgtgcatgcc cttgtgcctg tgtgcccatg tgtgtgtctg tgcgtgtgtc 201660 cgtgtgcctg tgtgtctgtg cacatctgcg tgtgtctgtg tccatgtgcg cgtgtgtgtg 201720 catgtgcgta tgtgtgtctg tgtacgtgtg cgcatgcgct tgtgtgtgca cgtctgtgtg 201780 cgtgtctgtg tccatgtgcg tgtgtgtgtg catgtgtatg tgtgtacata tgtgtgtgca 201840 tgtctgcatg tccgtgtgca tgtgtgtctg cgtgtgtgtg tgcacatgtg cgtgtgtgga 201900 tgtgtgtgta catatgtgtg tacgtgcatc tgtgtgtctg tgtgcatgtc cgtgtgcgtg 201960 tgtgtgtcta agtctttctt ggatggtccc ttgctgcttt cccagggagc tagttctctc 202020 tggccttggc tgggtaggat gcaggctctg ctcgcctctc tggaacagag caggaggtgc 202080 tgcggggagc tgggtgcagc gtggccaggc caaagcaggc acctgagtga gttttgtgtt 202140 cagtatccct cccccctgtg ggctgccatg gtgagagttg acatttttgc agcgtggaag 202200 tgagactgtc ttgtggagtt ttctactcct ctcgggcaaa gagagggtta gtgacctgac 202260 acctgatggt atgccttcaa agctcttcct catctggttt cattcaactc atgtcaagcg 202320 tcagtcgtga cccatgtcaa aggtatatgc agctggatgt aagttaaagt ggagaaaaca 202380 gattttattc agtcgctgct gacagcaggg gacagagctg agctcctttc aggtttgtgc 202440 agatgtgact gggcatttta aagggagtgt ggggaacagg tgcccaaatg gagtcaggga 202500 agtgaaaaat tacagaaagc agcaagaggg ttgggtagca tgaatgtgat gagctgactc 202560 tgctacgagc tggcaggttg gggctggcag ggatgggctc ctgctcccct tccccagccc 202620 cagactagga gacaggcctg ttttcctgat gattacgttc caaagggttg gctctcggtc 202680 cttgagaagg acatcccaga gctgtaggag gtgcgggcat gtgtgtctcc aagggactga 202740 ggaaggattc acagttgtca gctcggattt tctgaagtaa ctgtgctagg aaggggaggc 202800 agggcagggg cctgttgtca ggtgtggtag aaccaagggc aaatcctcct gacagccttg 202860 agctttttcc gacaggaact ctgggggtgc tgtagctcag gcttcaggaa gtcctgctgt 202920 ggtgggcggt gtctcagtgc agggggtagg atggagccct tgtgtgctga gagctcttct 202980 gtggttctca gcagccaaca gtgagagaca cacgtgattg tgaagccagg cttctcaggg 203040 cagcccctat gacggcacac atcacgtaga aggtttaaat cagcattggc tgaatgagcg 203100 attccaaaga gcagccaaca cctctgtttg caggaagatg gagttgacgc attttctttg 203160 atccttctgt taagtataat gaagagtcct ggacattatc tatggaatga gcatagtgag 203220 cctctgcggg atggaggcca ggggccttgg gcctcggaac agcctggcgg ggagctgccc 203280 aggtttcctc gtctgcctct ttcatcccag acttggagct aaggaagcac atccccaaaa 203340 tgccgacgct ccccagcaaa ggactaggta aatagcagct gggaagacag aaaatgtagt 203400 taatgcctag caataatgga aagaaaaact taatggatat aaggtcagca gcagaatgga 203460 ggcgacagga gcgcgttcgt gaactcagag atggaccgat aggaactgcc catctgccca 203520 ttctgaacag cagagagaat acgatggaat aaaatgagca aagttcccga caccgatgag 203580 acctgggaat acgatggaat aaaaggaaca aagtccccgg tgccggtggg gccacaacac 203640 aagatccagc attccagttg tggggatctg ggagggtccg gaggagctga gatggagccg 203700 cagaggcagc aggcagcgtc ttcaaaacta atccagtgtc tttgctgttc tgtgggtcta 203760 ctcaggttgt ctgtgtttct cttgagtcag ttttggtagc ttttgtcttt tcaggagttt 203820 gttcatttca cctccgttat taattttcgg catgcagctg ttcgtagtat tcctttacag 203880 cctttatctc tggaaggtca gctagtgtct ctttcactcc caactgcagt gatctgcacc 203940 ctctttcttg tttccttggt tggcccagct aaaagtttct gtcaattctg ttgctattct 204000 cacagaacca actttaggct tgaccgattt cttttattgt ttttgtgttc tttatttcac 204060 ttatttttgc tctaatattt attatttcgt tccttctgct tgggtcaact gaagttggac 204120 tccatcaaga ttaaaatttt tgccccgtga aagttcctgt gaagagatga aaagacaagg 204180 tagagataaa gaggaactat ttgcaagctt catatctgac aaagacgatt tgttatctgt 204240 aatagatgag aaaactctca aaactcagta atagaaaaac aaaacagaca cacctaatta 204300 gcaaacaagc aaaagatata gacagacctt tttaccaaat aacatataca gatgacagtt 204360 aagcccgtgg aaagatgttc aacatcatta gtcatgaggg aaatgcaagt taaaaccaca 204420 gtgaggtgtc actgcacacc tgtcaaagtt cagaaacgga caccatcaga tgccagtcag 204480 tgtgtagaga aactccatct ctggtgcctt gctgatggga gagtgacagg gtgcagccac 204540 cctggaacca gctcgagggt ttcttaaaaa ctgcactgca gctcccatat gaccagcagt 204600 cgcattcctg ggtgtcgatt ccagtgaaat aaaaccgagg ttcggacaaa acccgacaga 204660 ggactcttcc tagcagcttt tgcataatgg ccaaaaactg gaaagaattc tgatgtcctt 204720 cggtggtgat ggttaaacaa cggtagtgcc tccgtcacac agagtaatac tcaggactaa 204780 gaaggaattc actgtggata aacatacttg aatagatctc cagggagttt agcggagcga 204840 agagcccagt ccctgaaggt cgtgtgctgc atgatcccat ttgcatgacg ttattaaaag 204900 gctgaagtga tagacagcct gtggatggct gccgtgagtt acggagacgc acaggaggaa 204960 tcgtggctgt gaacggacaa cccgaggggt ttttgtggtg atgaaatgtg ctgtatcttg 205020 actgtatcat tgtcggcata cgggttgtga tactgtgctg tagttgtgcc agatgttgct 205080 attgggagga actggatgaa tgctacttgt gatctctgta ttatttttta tagctccaag 205140 tgaatctgta attggatcaa aataaaaagc ttagatcagg cacagtagct gatgcatgga 205200 atcccagcac tttgagaggt cgaggtgggc ggatcacttg aggtcagcag gagttcgaga 205260 ccatcctggc cagcatggtg aaaccctgtc tctactaaaa atacaaaaaa ttagtgaggc 205320 gtggtggcac acacttgtaa tcccggctac ttgggaggct gaggcaggag aattgcttga 205380 acccagaagg cggaggttgc agtgagccaa gattgtgcca ccgtgctcca gcctgggtga 205440 cagaatgagt gagactgtgt ctcaaaaaaa aaaaaaaaaa aaaaaaaaaa agtcatcagc 205500 ttcattatct cctaacagca tcagcttgtc ctctgaaact ttgaaggcag ggatcgactt 205560 ctcctctgta actgtaaaag ccctagacgg catcttccag cagaaggctg ttttatgtgc 205620 actgcaaatc tggtgtttag tgtggccacc ttcattggtg ctcttagctg gatcttctgg 205680 agaacttgct gcagcttctc cgtcagcact tgcggcttca ccttgtactt ttatgtgatg 205740 gggactgcct cttaatgtaa acctcatgaa cccacctctg ctagcttcag acttgaattc 205800 tgcagctttc ccacctctct cagcctcgtg gaacttgctc tgacttaagg gaatgttggg 205860 gctggtttga tctatccaga ccactcagac ttctccgtat cagcaataag acagtttcac 205920 tttcttatcg ttggtgtgtt cagtggagca gcacttttaa tttcctccaa gaactttccc 205980 tttgcattca caacttggcg agctgtttgg cacgagaggc ctggctttcg gcttatcttt 206040 gcttttggca cgccttcctc actaagctta atcctttcta gcttttggtt taaaggagag 206100 acatgcgact cttcctttct cttgaatgct tagaggctgt tgtagggtta ttaattggcc 206160 tgattttaat actgttgtgt cgcccaggga atagagaggc ccaaggagag ggagggaggg 206220 agatggctgg tcagtgaagc agccagacac aagcagcgtt ggtcggtgaa gcttttgccg 206280 tctgaggagc atagtgtgtg gcgtcccaga atcaatgaca gcagtaagat cggagaccgc 206340 cgatcacaga ccacaacaga cataacagtg atgcaatgtc ggaagtacag tcaggacgtg 206400 gcgccccaga atcaatgaca gtagtaagat cagagaccac ccattacaga ccacaacaga 206460 tataatagtg atacaatgtc tgaaacgcca tgaggattac cagatgtgac agagccgtgt 206520 agggagcaca tgctgttggg aacatggtgc ctcgccgaag gcaggacggc cacaagcctt 206580 ccatttgtaa gaagcacagt atctgtgtag tccaggagag caaggcgtgc ctgggtccat 206640 gctggctcct tattgtggcc agcacactgt gctcgtgtaa gatgttaaca gtggggcacc 206700 tgggtgtgga atatgtgaaa agtctctacc atcttctcca ttcttctaaa tctaaacccg 206760 ttctaaaaaa aaaaaaaaaa aagaagagtc tattaagaag acaaagaagg agccgaaatt 206820 tccacgtggc agaaggcact ggaaccggtg agatctgatg tgtacctggg cctgatccac 206880 gtttgctgca tggctggaca ccttcgtggg cgcgtggaag ctcatgctgt ggggggagct 206940 gtgggaggag catgcggcag gtggaggtct tctgcgcgtg ggtgggcacg cggaagctcg 207000 tgctgtgggg ggagctgtgg gaggagtgct ggaggagccc tgggaggagt gttcaggagg 207060 cggagcgtgc ctcgtgcgcg ttggtgggta tgagtggcgt tggtgggatc tagctgacca 207120 cctcccacct ggttggtctg catctgtaga cagcttagtt cttaggattc taggtaccca 207180 gtgtcatttc cgacacctgc ttgggctccc tgtactgcca gggctgttga gtctttacag 207240 cacctctgat caggagccct ggccttgggg aggtgggaca ggcacacgtc tgggttgctg 207300 ggttgccttt aggggtaagc tcttcctttt gtcttctgtt caaaagaggg cccacagtgg 207360 attcaggcct ctgatttacc actgcctgga gcttggggaa tgctctccag tgacaacctg 207420 ggcttccgtg ggatttaatt ttgatatatt ggcctttgtg tgtaggaaga gtccaaactc 207480 acgaccggat ggattgtcct cctcagacta gacacttcat ccagagagga ctctgagcca 207540 accctaaggg attcaggctg gagctctggt tccccgcacg gaggtggcgc aggaatgcat 207600 cgtcctcccc tgtcctgact tgtcagcgct cctgcgctca tgcctgggag cctggacccc 207660 agctctgtcc cgacttgtca gtgctcccgc gctcatgcct gggagcctgg accccagctc 207720 tgtcccgact tgtcagtgct cccgcgctca tgcctgggag cctggacccc agctctgtcc 207780 cgacttgtca gtgctcccgc gctcatgcct gggagcctgg accccagctc tgtccccact 207840 tgtcagtgct cccgcgctca tgcctgggag cctggacccc agctctgtcc caacttgtca 207900 gtgctcccgc gctcatgcct gggagcctgg accccagctc tgtcccgact tgtcagtgct 207960 cccgcgctca tgcctgggag cctggacccc agctctgtcc cgacttgtca gtgctcccgc 208020 gctcatgcct gggagcctgg accccagctc tgtcccgact tgtcagtgct cccgcgctca 208080 tgcctgggag cctggacccc agctctgtcc cgacttgtca gtgctcccgc gctcatgcct 208140 gggagcctgg accccagctc tgtcccgact tgtcagtgct cccgcgctca tgcctgggag 208200 cctggacccc agctctgtcc cgacttgtca gtgctcccgc gctcatgcct gggagcctgg 208260 accccagctc tgtcccgact tgtcagtgct cccgcgctca tgcctgggag cctggacccc 208320 agctctgtcc ccacttgtca gtgctcccgc gctcatgcct gggagcctgg accccagctc 208380 tgtcccgact tgtcagtgct cccgcgctca tgcctgggag cctggacccc agctctgtcc 208440 cgacttgtca gtgctcccgc gctcatgcct gggagcctgg accccagctc tgtcccgact 208500 tgtcagtgct cccgcgctca tgcctgggag cctggacccc agctctgtcc cgacttgtca 208560 gtgctcccgc gctcatgcct gggagcctgg accccagctc tgtcccgact tgtcagtgct 208620 cccgcgctca tgcctgggag cctggacccc agctctgtcc cgacttgtca gtgctcctgc 208680 gctcatgcct gggagcctgg accccagctc tgtcccgact tgtcagcgct cccgcgctca 208740 tgcctgggag cctggactcc ggtttacatt tctcagcgtg tccttgggct gtgtgtggtc 208800 tgcgtgtccc tggggttgtc tgtggggtca tgtggcccct ctgggctgcc tggtttcctt 208860 ttctcccaca tcgtgtctgg catttcttta ttcagaaatg aggcatctgt tgttggcttc 208920 cctgtggagt ttgtgtccct ccctgagctc ccgcctctgt ggggccagcc ccagtgtgga 208980 cttgtggccc cctgtgctgc tgggcctcag gtttgggtct gcggagtaca tgggtgtgag 209040 tgctctgacc actggactct taaaacatgc agccctcttt gactgtgaca ctggacatgt 209100 gcaaagcttg gggactgatc aaaaagtata aagaggccat tgaaaaagac cttgactcct 209160 gcacccagag gtagcaccaa gaacatggca tgcatttcat ctccacgtct cccttctctc 209220 ctttcctccc ctgttcattc attcagccaa tctatcagcc aaccagtaag cactcacgga 209280 cacccacgtg cgcaggtgcc atggaggcag ccgagtgtgg ggactgctgt ggcagagctg 209340 gcagccttgt gtgcttcctg cacttgtgac attttattgc agccagtgcc tgtgccatta 209400 agcattcctt gaaaataaaa tcttttttgg ctgtacgatg tttcttcgtg tagacatacc 209460 aaaagtaaac tcttggccgg ctgcggtggc tcatgcctgt aatcctagca ctttgggagg 209520 ctgagacggg tggattgcct gagctcagga gttcggacca gcctgggcaa cacggtgaaa 209580 ccccgtctct actaaaatac aaaaaattag ctgggcgtgg tggtgtgtgc ctgtagtccc 209640 acctactcag gaggctgagg caggagaatc gcttgaaccc gggagacaaa ggttgctgtg 209700 agcctagatc acaccattgc actccagcct gggcgacagc gagactccgt ctccaaaaaa 209760 aaaaaaaagg agactcttta ttggaaattt agctttgttt ttaatttttt catgattatt 209820 gctaatgtgt gcaacatcct tggactcagt gctttcccca tatctgattc atttgttatt 209880 tatttatttg tttagacaca gggtcttgct ctgtcgccca ggctgcaatg tggtggcgcc 209940 atcttggctc actgcagtct tgaactccag ggctcaatat atcctcctgc ctgagcctcc 210000 ccagtagctg ggactatagg tgcatgccgc cccgcctggc taattaaaaa aaaatttttt 210060 ttgtagagat ggggtctcac tatgttgccc aggctggtct caggtgattc tcctgcctcg 210120 gcctctcaca gtgctgggat tgcaggtgtg agccaccgca gtctgattac tttttaggca 210180 attgttactg agtggaaggg tgtgaacacc ttcaggaccc ttggccagtt ttgctgactc 210240 gttttccaga agcgcccgtg actgctgtcc cagcaggtgt agcgtgcagc cctcatggcc 210300 tcactcgtgc tgagtgttag cattttactt cttgccactc caggtgagga acgggtctta 210360 atgaattttg tgtttgtcag ttacgtttct tctgttgatt gttgattttt cccagttttc 210420 tattaccgtg ttagtgattt tcctattgat ttgtaaaagg ttttcatgta tttgtggcac 210480 gttttcccca gtttgtcttt taccttttgt gtttttaagt ggcgttttgg gacccacgga 210540 ggtgttggtg tggcgaagcg tgctggtctt tctctgtcat tccttccact gcttcggggc 210600 ccacagcctt tcagggcctt gctccatgga gtatccatct tgtttccttt agttctagtg 210660 cagtgaagca ggcgagggca ggggtgaccg ggtcatctgg gctggttcaa actggggctc 210720 cgcacccagg tgttctgtgc ccccggggtg cgttactcac acctgcagca cccgggctgt 210780 ctctgtgaga atgggatgat cgaagggccc acctcctggc cagcacaggg cctggcacgt 210840 ggtgcctggc tggcgagtgt atgagtgggg tgctgggctg ggagcgtgag ctctcggagt 210900 tctgcgtctg tttatcatgg ccagtcagtg gcagcgtcag ctgggtgtcc tcagcccacg 210960 ctgctgtacc ccaagaaggc agtagacacg tgataccagt gggctggggg catcttctca 211020 gctggtgccc tctccacgtc cttctgcggg ggcgccttgc ccccctgccc catgcacact 211080 ctccctgtgt gcagagtggg tcttccttcc tggtgtgggg ctccctgagt gccctgcctg 211140 tcctcgcctg ttcttacagt gctcacgtct gcctccctct ccaggctgag ttctgggaga 211200 gcaggccggc gccacccccc tcaccacttg ctaggagctg gcctgaccct ggtgggagcc 211260 cacagccctg ggcgcgaatt caaaatgcca gaagcagcac agggtccctc gagcctggtg 211320 ggaggtactt cccatgggcg agtcatcttg ttttgaattc tcctcatgct gatttctggc 211380 cccactcagc ccagcacagc tctgaaggag acgaaggcaa ggccagctct ccccagctga 211440 gatgagcttt cagttgagga aggaccctga tgtcagagct gtttgggtaa tggcctgccc 211500 ctggccatgg atgtgcacca aatcttttca ggactcgtgg ggtcactgct gcccgggggc 211560 tttaggtagc tattagagcc cagggctggg caagcgcttt cccacctgcc cgttagcatg 211620 atggccaaga gcccaggctc ggcttcacgg aggctggaga cctggggcgc gcgccttccc 211680 ctggagcctt gtcctcatct gaaagggagg actccagcct gcctcaggag gtggttccga 211740 ggactgattg gctgatggtt tcactcgttc attttttaat tgaacacaca gttcctgagc 211800 acctgttctg ttccaggcac tggacaggga ctggggccgg gcgtcccgca tgaatgaggg 211860 gtcagggagc tgatgcatgg aaactccttg gcacaaggcc cggagtgtgc ctggcaccct 211920 gggcactggc tgcctgcctg ttacccgtcg gtggagaaag ccacctagac tttgcagcac 211980 tgtaagattt ttgaactgta gaagaccaag tccatctaat tccctgtttt gctgatagga 212040 acgctggagg cctagagagg aaaggaaccc gtctgactgc tcaggctgag tagtggcccc 212100 agagccgtga ctccactgtg ctgtctgttt cccacgttgc cctgctctcc tttctccctg 212160 tcctgtcaaa taaactgcac tcaaaataga gccatgcggc acagggcctg tctcaggccc 212220 atggccccat atccgcgtgg gtcaggcatg ctggcgagac cttgcgaggg tcacgtcctc 212280 ctccctggtg aggggccgtc tgcagccact gtggcttggg tatggcttcc tgtcaggatg 212340 gtcccagtgc cctcccagat gtgcacggca cccacgtcgt catagcgcag gtgtgagcag 212400 ctgctgtaac aaggctggtg ctggttcagg tggatgctgg ggaatgcatt tatacagcga 212460 acacaaatga agtggaattt gtcatagagc agtgtgaaat gtaagtaaaa ttgcctcggg 212520 aaatcataat tgattccact ccttcctaca ataggtgttg tagagctttt tatcagaggt 212580 tgaaattgta aaaaccaggc ttgctggtgg ggagcccaga acagcccctt ttccccctcc 212640 cccacagcta cacgtgggtg gtggaggcca gtggggaggg tgtgacggca ggaagccaga 212700 ggaggagctg gctgagggta accccaagac agctgtgggg cagggaaggg agcgtgctct 212760 gtgtgcctgg tgcagctgca ggcagagggg tgagtagtgg gagaggaccc cgtgcttcct 212820 ctctgagcgg cctggtgttc agcctcctgc tgccttcagg agagctcgcg taggtgcagt 212880 tcatggagaa tgcacagctg gctgctggag ggaggatgct gctgaaggct ggggaccgtt 212940 ttttctcctg ggggctcctc cgaatccagt cgcccagcag aaatagagct ttgtcaacag 213000 taaaccgggt ttattggtca gataagataa ccttgtaatg agacttgtgg aacttgaggc 213060 aaaaatgagg aagaacagag aggatggaat gggaacaagg gagagacatg gtatcatcaa 213120 gctctgagca aggttggccg agagcaccag gcgcaggttg ggggctgagg aggacagaaa 213180 cgcgtctgac agcagggcgc ctcccacggg gccccggaaa ccctcgctga cccacagtat 213240 tgcccttcaa aacctggtca ttggtgccca ttacagagaa ccctttcatc gggaaaagag 213300 accgtttctc ctcattctca gtttcctctg ccggggcggc gtctggtttg ttttggaggc 213360 attttcgtca agcgcagatg ggcaggttcc actcctgcgg ggtccggcca cctgtcactg 213420 gcgccctggc ttacccaggg gcctctgcac atcaaggctg ttcaggggcc cgcgtgtaac 213480 aggctctaat tagcgtaagc aagtgaatta gccttatctg ttcatgaaag aagtgaagca 213540 agaaatgcat ttggtgacac tttgtcagtg ctttgttcga gctgctatac ggaaattatt 213600 aatagtagaa ttgcattctg ttacaatcgc cctctaattc agtcaccatc cattgaactg 213660 gactttttac ccagttagca aggtaatgag tttggatgac tctgaaaact ttgtgacctc 213720 caccccgggc gtcactgtgg gctgggggaa cctcctcagg ctgtgtgtgg accttccgtg 213780 gagcgcgggg cggggcgtag cggacatgca cctgtacaca gctctgggtt ccgcgtttct 213840 ggggcactct ctgccagcca ggggtgccct gcagaaatga ggctaggatt acacggggag 213900 cagcttgggc caaagactcg atttccatct gctccctgaa tgtggtgagc ccggtgtcca 213960 caggactgtg taggagggga cagccagcat ctgccctttc cagagacctt tctcctggca 214020 ctcgtgtctg ggcgctaggg atgatcttgt ttctgttcct tggattttta cttctcttca 214080 gctccatctg aagcttttcc cctctctcat ttcattgtaa tcataactcg cacatcaacc 214140 tcaaattacc ctctatcaat cactctcttg cctagaaact tgctgggctc ctcctcttct 214200 gctgccctgg gtgtgtcatg cagagtgccc tgcgcctgcc accaactccc accgcccttg 214260 ctctcccact gccagaaagt taggcctcca ggcctctgga gtccgagttg ggctcacggt 214320 tccatctgag tgtgtttgcc ctgagctgtt tgtaaatggg acttacaacc acagccaagc 214380 tcttcaaatt atggagttcc gtttaaaaaa aaaaattact gccttttaat ctttttatta 214440 gagcataaca gacatacaga aagtgctttg tcctgagagt acatcttaga gggctatgat 214500 gaaatcagtc catccatgtc tcagctccac ggtcgggaac acggtgtcac cagggctccc 214560 aagttcacct gccggctcct ccacctcccc caaagccctg ccttcccgat tctcacacgc 214620 cagttctgcc catttaaaaa tgttgtgaaa tggagccatg cagcgtgtaa tctttcgtgt 214680 ttggtttctg ttgctgtgtt atttcatttc tatcttatgg gtatatcacg tcataatttt 214740 taaaattttc tgtgaatggg cgtttgaatt tctttatttc ttggctactg tgactaacac 214800 tacagaatgg gagattatat catcttttgt taggtatttg tatttcaaat gtctcctctc 214860 attctgtagc agcttttcac actctaaaca gaaattctta atttgaatga aatctaattt 214920 atcaatcttt acctcccttt gtggttgtga tttgtgtgtg tcctgtttaa gaaagcttcg 214980 ccaccctcca ggttgttcca gggtttcact cctgtcttct tggtggcttt gcttcttcac 215040 actgaccgtg gcactgcgca gccttgttgc cctgcgcagc cttgttgcac tgtgtgaagc 215100 cttatttttt ttttcatttt tcttgtcaac gtgggtatcc agtggactca gcactcctta 215160 ctgcaaagct gctccttccg cctgtgccac agtgctggtt acaccttcac gtgaggtggc 215220 tctgtctgta ttggctgttt ctggaatctg tattgtttcg ttggtgtgtt catctctttt 215280 tggcaaaacc acaagtttca attcctgaga atgttagagt ctcgttacct gatagggtgg 215340 ccctctctgc ttgtctgcat cagggctgcc ctggctctac ctggccatcc gcctcttcac 215400 gtagatttta cagctcaacc tgtcagtctc accagtggac ttgctagagt ttttattgag 215460 aatgcattga ttaaatgaca tctgcacaat attgaatctt ctaatccatg gacgtactat 215520 atgctaacat gtgtttaggt catacttttt tttttttttt tttttgagat ggagtcttgc 215580 tctgtcgccc aggctggagt gcaatggcat gatctcggct cactgcaagc tctgcctcct 215640 gggttcgcgc cattctcttg cctcagcctc ccgagtagct gggactacag gcgcccacca 215700 ccacgcccgg ctaatttttt gtatttttag tggagacggg gtttcgccgt gttagccagg 215760 atggtctcga tctcctgacc tcgtaatccg cctgcctcgg cctcccaaag tgctgggatt 215820 acaggcgtga gtcaccgcgc ccggccttag gtcatactta ttttctctcg aaattgtttc 215880 ataatgtttt ctgggtggac atatcatggg ttttgttgtt ttgaataata atgtttgtgc 215940 tttgaataat aatgtagaaa tctaattgga ctttgattat taactttggt cctgcagcat 216000 tgctaaatct acttatttta ataatttatt tgtagattat attgactttt ctatgttcat 216060 aattgagtga tttaataata gctttcattg tcttcttgat cttcgtacct ttcatgcctc 216120 ttcttatctg tggcttagca tagccagtgc tgctttggac agacatgctg atagctggtg 216180 tttgttttgc atcatcagaa gaaaagcttt caacatttca ctgttaaaga tcgtgctgac 216240 gactttagta aggaaatcct tttcagatta aagttctccc tattcctcat ttgccaagag 216300 ggttttgctt ttgttttgtt tcatagtttt tatcgtgaat agatgttgaa ttttaatcaa 216360 atgccttttc tgcaaatatt gagatgatca tttgattttc ttctatattt tgttaatgcg 216420 cattaaatta attgattttc aaatgttaaa ccaaacttac attccaggaa taaatgagca 216480 tggcctatgg gttatgctct gtgtgtaatg ctttatttgg tttgccagta cgttaattag 216540 ggattttgca tctgcattta ttggggagaa aggtcattac ttttcatttc tcagaatgtc 216600 gttttcaggt tgtgatgtta tggcttttct ggccttagaa aatattagca agttgtcttc 216660 tgttgttttc tgtaatcgtt ttataaggtt ggtgatattt cttctttaac cgcttggtgg 216720 agtgtaccag tgaaagcatc tgggcctagg ggtttcttgt ttacaagatt ttaaatttgg 216780 gcttgattta ttttaatagc tttgaaacat cagattttct ttttttttct ttattcagtt 216840 gtggtaaaag ttagttttta acttttaaaa cttcatttta tcaaaacttt aaaattcatt 216900 tgtgtaaagt tgtttattgt catgttttta atatttttgt gatctctagt tatgtctttt 216960 tcaatattgt tatttgctta ttctttgtaa tctgtctcat caagagttta tcaattttat 217020 tagtcatttg gaggaaccat cttttggctt tattgatttt ttcccatatg tattttattt 217080 cattaatttg ttactttctt tgagtctaat ttgatgttat tctaactttt gagttgtata 217140 tgtagataat tgatatttat cctttcttgt gttacagtat atgcatttaa ggttgtcaat 217200 ttagttgcat accgtacgtt ttgatgtgtt gtattttcct tatcattggg ctcaagtcat 217260 ttatcaattt ccattgtgat ttttattttg accaatgggc tattcagaaa caaatttctc 217320 aaattcccaa catctggtga ttttcaggta tcttcttatt gatttctagc attatctccc 217380 tgtgctcaga gactatcctc tgaatgaccc cagtcccata aaacttacca agaaatgctc 217440 tatggcccca tcggaagtca gttttgtaaa tggcccatac acacttgaaa atagtatgta 217500 ttctgcaatt gttgagtgca gtgttttgta aatagctaca tatcatttgt taatcttatt 217560 cttcacattt ctttaatgat gttttttctc agctcctgca agagttgtgt tgaaatttcc 217620 cattatgatt gtgagttttg tctatttctt cttttaattt tgtcaattat tgcagtatgt 217680 ctttggatgc tgttttatta ggcacatata aattgtgaat tatcttcctg gtgaattttg 217740 ccttttgtta ttatgagaca ttctttatct ctgcggattg ttttgatttt taaatctcct 217800 ttctgggata ttaatacggg tatgtcagct tccagtgttt aatagcattg gcacctttta 217860 ctttttcact tttcattttg agcattgtta aattgtttca ttataaatgt agtatactat 217920 aaatatataa gtatttatat tcagcgtaaa aatcatttct tagtcgaaat atttaatcta 217980 attgtaactg atgtaattaa tgatacattt gcattgaaat taaccatctt aatagttgcc 218040 tttagttttt attcgttttt tatgaaaaca tcttaatcgt agaataaatt tttttatgat 218100 cgttatcttg ttatgtgtgc ttttatgtaa ttttagtggc tatgttggtg attataagat 218160 agactattat tatatactta acaaagtcta ataaaattaa tacttctttt ccttctagac 218220 aatccaaggg tcttaaaatc ctttcttctg tttacatttt gctccattcg taggctattg 218280 ctataaagta ctttattcat acacttacgt gtttgaaaag atactgtttt tgtatattca 218340 tttatatgta cacatttcta acccttttta ttcccctgtg ttgcaacctg tatctctgag 218400 catccatctg caatcgtttt tcttctgtct gcaaaatacc ccttgtttcc tttgatacag 218460 atttaatgct gaggaattat ctaattttct tggggtccgg aacatattta attcactttt 218520 atttttgaag aacagttttg ctgggtataa aatcataggt tatcaatgcc tgtcctatcc 218580 accagcctac aaccctttga acctatcatt ccactgtctt ttgactccca ttggttctgc 218640 tcggaaacaa gctgtcagtc tcactgttgc ttcttttaag ttaatctgtc ttcctctcct 218700 cttccctagc tcttttgatt gttctctttt tggcaggaga agtgttgttg aaatgttcct 218760 ctagatctat aattttttaa ttaataaagt ttgttttcgg gagagtttaa ggtttacaga 218820 aaaactaaga agacagcata gagctctcat atgattcttt ccacagcaca gttttgtctg 218880 ttactaaagt cttacattac tgtggtatat ttgttacagt tcatgaacca gtactgacac 218940 attattttta accaaagccc atagtttaca ttaaagttta ctctttgtgt ggtgtctttc 219000 tatggatttt gataagttca taatatcatg tttccctcat tacagtgtca tacagaatag 219060 tttgcttcta ttctctggaa gagattttgg agaattggta tcatttctca ctgaagtagt 219120 tggtagaatt catcagtgaa gccatctagg tctggtgctt tcctttttgg gaggttatta 219180 gtgatcaact taatttcttt catagataca gcctgttttt tttctggctg aacccagggc 219240 tggggtcgtc gccaaagtga ctgtaggaag tgcccacaag ggatagccac aaacccgcct 219300 gagatggggc tggctgggat tccaaagaga gaagcactaa accctgagtg atcatttgaa 219360 gcgtttatta ggggaacttg cctacagagg gggcagcagc ttccttgtga ccacagcaag 219420 acctgagtat gtctacaggg aggggtctca ttgtggagtt tctatgggag ttgaaggaaa 219480 ttggctcacc gccaatttct atgtgacagc aacatgctga tctttctgtt tcaggcagta 219540 atggaatgct caagcccaca ggggaagtat gcagctgcct ggctcacatg gtggtgaagg 219600 ccctctgtgt gtctcagtca ggaaagagaa agggagctgg gggtgggcag gccactagaa 219660 agaccgattc atgtgatctc ttcctcctca tgtgagtttt ggtggttcgt gtctttcaag 219720 gaattggtcc atttcatcta agttatcaaa tttctgggcg tagagttgct cataatgttt 219780 ctttattacc ctttagatgc ctataggatt agtagtgatg gctcctcttt cacttctgat 219840 gttagtaatt tgtgtcttcc ttttttttat tttttttttt taatgttggt taacctggct 219900 acagatttat gaattttaag gaaccagctt ttggttttgt tggtttttct ctatggagtt 219960 cctgttttca gcttcactgt tttttattgt aatttttatt atttattttg ttttatttta 220020 tttttattta tttatttttt tgagatggag tcttgctctg tctcccaggc tgaagtgcag 220080 tggcgtgatc tcggctcact gcaacttccg cctcccaggt tcaagcgatt ctcctgcctc 220140 ggtcttccaa gtagctggga ttacaggtac ctgccaccac gcctggctaa tttttgtatt 220200 tttagtagag atggggtttc accatgttgg ccaggctggt cttgaactcc caacctcagg 220260 tgatccaccc accttggcct cccaaagtgc tgggataaca ggcgtgagcc actgtacctg 220320 gccaattttt attatttctt gctttaggct tacattgttc ttcttttttt agtttcctaa 220380 tgggaagctt agttgattga ttttagatcc ttcttttttt ctaacattta cattcaatgc 220440 tataaatttt cctctaagca tggcttttgt ttcatcctac aattttgata ggttgtattt 220500 tcattttctt gttcaaacta ttcttaaact tctcttgaga cttctttgac ccatgcgtta 220560 tttacaagtg gattgtttag tctccaaata tcttgggatt tttcagttat ctttctgtta 220620 ctgatttcca gtttaatttt agtgtggtct gagagcttac tttatatact ttatattctt 220680 tttaatttct ttaggtgtgt tttatggccc aaatgtggtc tgtctaggta aattttccat 220740 atgagtttga gaggaatata tattctgctg ttgatgcagt gttctgtcat tgtcatttag 220800 acccagttga ttgatggggc tattgaattc tgctgtgtcc tcactgattt tctgcctgcg 220860 ggatctgtcc gtttctgata agagggtgtt gaagcctcca actgtaacag tgaattgagc 220920 catttctcct tgtagttctt tcaggttttc ctcgcatatt ttgagacact gttgttaagt 220980 agatgcatgt taagggcggt catgtcttct tggagaaatg acctttttat cggaatggag 221040 tgccattttt cattcctgat cgtttccttg ttctgcctga gattgatcaa gctgctccac 221100 cgttctttta tttgggctta gtgtggtcta gctttcttcc tttcctttca aagtgtgttt 221160 atattttaag tgggttcctt ataaacagca tataattggg tcttgttttt ttaatccatc 221220 ctgaccgtct tttaattggt gtgtttagat cattcacatt cgaaatgatc gttgatactg 221280 ttaatacctg ccatgtttgt tactcttttc tattgggaca cttgttcttt gtttttttta 221340 aatcttcttt tctttatctg ctttgtttgg ttttaactga gcatgttata tgatttaatt 221400 ttttaattct gttagcacag aatttttttt ttcttttgga gacagagttt tgctcttgtc 221460 gcccaggctg gggtacagtg gcgtgatctt gccaccatgc ccggctaatt tttgtatttt 221520 tagtagagac agggtttcgc catgttggcc aggctggtct tgaactcctg acctcgggtg 221580 atccacctgc ctcagcctcc caaagtgctg ggattacagg catgagccaa gcacagaatt 221640 atcctagagt ttgcagcata catttagcat gaatctaagc ccatggtcag atggcctttg 221700 accaggtcac aggcagggtg ggcgcctccc gcagaacacg cccattcccc ttgcctcccg 221760 tgccacctgc tgcttcattt cacccatccc tgcaccatcg tcaccccaca cattgctgct 221820 cctatacttc aaacaatcgt ccattagatg aacgagacta aggaaagtaa gctaggctca 221880 gcggctcaca gctgcagtcc cagcgacttg ggaggctgag gtgggaggat cacttgagcc 221940 ccagaggtag aggttgcagt gagctatgat cacaccactg cactccagcc tgggcaacag 222000 agtgagactc tgtctcgaaa aaaacagatg aataaagtag attttatttt tccttatttg 222060 ttacttctct gctctgtctt tccacataga tctgagtttc tgacctctca tgggattctc 222120 tggagaatcc acctcacact gcttacaggg gccagggctg ccaatgacca atctccccca 222180 gttttcgttt gtctaagaga gtgttttttg tttgtttgtt tgtttgagac agagtctcac 222240 tctgttgccc aggctggagt gcagtggtgc gatcttggct cactatagcc tccacttcct 222300 gggttcaagc gattctcctg cctcagcctc ccgagtagct gggattacag gcgcctatta 222360 ccatgcccag ctaacttttc tactttcagt agagacgagg tttcgccgca ttgtccagga 222420 tggtctcaaa ctcctctgac accagaccat ctgcctgcct tggctcccca aagtgctgag 222480 attacaagtg tgagccagtg tgccccgctg agagtttttc tttctgcttt tcttacagaa 222540 gatcatcttg ctggatgcag aattccaggc tggtgctgtt ttgtttcagt acttggatac 222600 ctccctcccc tctctgctgc ctgagtggct tcggtcagga ggtctgatgc atttctcact 222660 ctcttggttg ataatgaagg gctctccctt ctcaggctgt cttattttcc acagttgaat 222720 atgatatggc taagtgtgga gtttttggta tttttcctgc ttgatgttct ctgagcttcc 222780 tggatctggg gtttagattt gacaaatctc ggccattatc acggcagata cttactgtgt 222840 tcgctcctcg cctccttctc cttctggttt tcctgtcatg agtaggttcc accttcacgg 222900 tcatcccact gttcttaggt cgcctcttct tttgttttca ttgctttttc ctcagtgcat 222960 tttagtacgg gaagtttctg tggacctgtt tttacatttg ctcatttatg ctctcatctt 223020 tatttttatt cctatacttt ctgcatatgt tgttttgttt tttttcattt tttatgttgg 223080 ttagttagct tgctactttc agttttagcc tttctactct aaccattaaa ttaatacatt 223140 ttcttctaag ttattcattc ttgagattgt gccactgcac cgtagcctag acgacagagc 223200 aagaccttgt cttaaaaaaa aaaaaaagta ttctttttgc ttaggccgct gtcgtctcag 223260 atgaagtttc tcctgtcttg tgtgtgtttt taactagtgc ctgaagtccg tccgatgttt 223320 tccttcgtct ctgcccacag ccaccgggtc agcctccctc ccaggaggcc cctagactcc 223380 gggtaccagg gcagcccggg caggtgagag aggacccagg gagctggctt tgctctcaca 223440 gaggcggggt cctcatggtg ttctgctcta gcttgttccc atgatgtcag ggccgggcgt 223500 ccccctgcgg ctcggtctca cagctgccgt gtgcccatgg cgttccgtcc tctgaaggct 223560 gctgggaact gcagggtcag agccgcagga aggcaagggt gggggccgca tggtgccggg 223620 gccgggtgca cgccttgatg ggaatgctgg ggtcacgctg gggctgtgga tagcaatctc 223680 gggcctcgtg agttcctcct tccggcagcc cagagcgggg gttagtgccc cccccgatca 223740 tggagagcca cttccagtgg tctcaccagt gaggctgtcc atggcactgc ctccccgggc 223800 tgggcgctga ccccgggact gtagggccgc agcctgggcg gctcctctgt ttgcagcacc 223860 agccggggct ctgcccctcc gtggtctgag cgacagggca gccacaacag ctcgcagctg 223920 ctgagtcctc ttccctcagc cctgtgcctg cctggcggtt ctgaagatca aatgaggtaa 223980 cgtgtgctta agtcatatgt agcattagca tgctgtgctg atgtcaccaa ttaaaatctg 224040 cctgagtgaa tcatacttga aaacagtcag ttgtcaaaaa aaaaaacctc gtttaggggc 224100 agcaggccca ggaaagagaa gcgagggaca gacaggaggc gaagcgttct gtagttggtt 224160 gtgggggcca gggcatccgg cccaggagca ggcgtgggcc gagcacaggg acgccgcctc 224220 atgtgcactc agcactgtgg cgtggcgagg cgtggccttg cgttgggggt ggtgaggcgt 224280 ggccttgcgt gggtggaggg tggcgaggcg tggccttgtg tggggggtgg ctggggctgg 224340 gccgggcagc ccgaccccca cccccaaccc ctgtggccgt aagtggccct ccttgctgcc 224400 ctttccattg acgggtgctg tctccatgta cttattaatc ctggtgcacc ttttaagcac 224460 tctttggggc attcgtgccc ccgttttgca caaggagggt gggttcagag acgttaggtc 224520 ccttgcccaa gggtgcacag ctggtctgtg tcagattgga gcgcaggact gtctgacccg 224580 cgtgggtcct ccgaggcgct tattactgcc gctttcgcct gtcatcatgt tctcgatggg 224640 ccccacggat gccagagtcc tgctcatttg ggaaacgacc agctgggatg agggttccag 224700 agagaggcct cctgcctctc ccagcctctg tcccagcagg gccttctcct gtctggggcg 224760 atcttgctgc tggggtcaca gcagacctgt ccaggctggt gactgggggt ctggggaaag 224820 agtgggcaga ggactctggg gaggcgggtg gcagcgagga gatggtgccg gcgtcagtgg 224880 gcagagccgt gtctgcagcc ccacgttccc gcctgaatct attcagtttc ttgtggtggc 224940 tccatgcgtc gggagaggta attagaacag ggcttttcag ctatttatga ccatacattt 225000 ccttttctaa aaaaaggaga agttgtggag tgactcagag ttgggtggag gtggctgagc 225060 tgaggtggga tgggcttggg aagaggccct gcagagaatg tcgcatgtgc agaacagcct 225120 tggagccctt gcagagtggg cctcggcctt gggctggagg gggcggaggg agggaggcag 225180 gctccacagc actggtggca gaggccgggc gggagtgggt ggcggaggct gggtgaggga 225240 ggaagatggg tgaggggctg ctgcttcatt ggagggggca cgcggtactc agcttacttc 225300 tgggcttctc tggaaagtgg gggttggtgc tggggctcta aggaggggcc tctgcatatg 225360 gagctgcctg cctgcctcac acagcccctt caggctgcca ctgactccca ggagggaagc 225420 cctctgtgtc catggtgtgg acttagggag tgctgggcgc ctgcctcacc aggcgtggcc 225480 atggccagag gctgtcccca tcgtgcggga cgcgcctgcc ccacctgcct gctctcctgg 225540 ccatctttca cgagcagctg tagtcatagt ggaagaacca ggcagacagc agcgaggaca 225600 gaagtgacca ccgtggctgc cgtgcattca tcgcctgtgt atgcgggttc cgtgtgcctg 225660 gttttctgtg ccatgctgca tttgaacttc gcagtgaggc tgaggcgttc tctgccctct 225720 cctgtgtggt tgagtgtcct cacactcaga gaggctcttt gtttttccca aggtcacaca 225780 tctagttacg gtccaggcag gatgtgggct tcgttgggtg tgtgtgttgg gtctgacttg 225840 ggggctggcc tgggcatgca cacctcaagt gaccgctgct tgggggccac ggggccggtc 225900 tctgcccact gcggtgcctc cgtccatatc tcccctgcct gcagcacctc caacagggcc 225960 ggcgtcctgc agtctcccgc tcctgtgggt gctctcacca cccgcagccc tggtctctgt 226020 ctcggcttcc tggtctcgct gctctgatct cccctgccct tcccaagccc aggcccaagg 226080 gctgtgccct gggtttcttc ttccaagggc actgggccct attctgccca ctgtctcagc 226140 ccctgctgcc caggtgtcct gccccctgct atggcgttct cagcctcttt gggaatctgt 226200 ctctcattgc gtgggaatca tcggcatgct tggggcttat actcaaaagc tctgtggtaa 226260 ttagcgcgcc ggagcacctg ctgatgaggg aatgagcgtc attatctctc ttgctctttc 226320 gcaagggtcc tctgggcgcc tactcaacgc tgttccctct gattggagtg cccttcccca 226380 ccgctgcctc ccagggcgcc cagatccttc ctgcagcctc cctgggtgag cagcccctct 226440 gcccgactat cgcaggccag ggcagagccg ccctctactg ctgcccccgg cccccatcgg 226500 ccggtgtatc cagggcaccg aggccctgtc ctcagctgac ttcttccagg tgatgccgac 226560 tgctcacctt ctcttcacat ggccgttcgt tgcatgatga gcacattcta ttccttagaa 226620 ccgggacgtt tctgtaccta aggaggagca gccagtggac aatgtaactc tgctgggtgc 226680 ttcttaaagc gagtctggga cgcccccgtc agcactgcca gccgcctgtt tgttcagcag 226740 ttaatcaccg catttgctga ggtggaaatg aagtggactt gcccgcaggt ggagtcagct 226800 gttaaaaagt catagcaagt cacacccaca ccgtgcctgc tgtttcacta ccggtgacaa 226860 aacaggttct tgaaagggta caaacaacaa actttctaat gcttttcttc tgtgccagcc 226920 agtgctagcc tggagttagg ctgaagagag ccgtcacgaa gagaagctct cagagattta 226980 ctgatcaata aaagagacaa ttacagcttg tttaccaagg gaagtccccc gccccggcct 227040 tgcgcggcgt ccgcgcgttg gtactgacaa ctccggtaac tggcttgaaa cgataaaagt 227100 caatgggaag atataggatt tcaataagat tatgacacac gataaacctt cctgtgcaaa 227160 caaattttcc acagatacgt gacccgttct agttggattt gtaactttaa tttctcactt 227220 attgaatttt gaattttttg tcatcagcta attatgaagt ccacaccagg gtggcacctg 227280 tgtccctggc tcaagagaca gacggcagga gagccccaga cgtggcggcc tgagctccag 227340 ggtcttctga gagagcaggc cggggtttcc tgagcccctg cagcctcgcc ctcctcgcct 227400 gtgggggata gaccgagggc ctggcagggg ccaggcagtc atcagtgctg gggagcactg 227460 ggtcggtctc tcctaggagc caggcggggc ctgggcgggg gctcagcttg tgtacgtgca 227520 gactcaggag gccgcacgga agggaccctg gcagttttgt gcactccgct tctgggtggg 227580 ggtcttgctc cccaggctgc ctgagtgagc tggtctctat cagggccatg aatttgccct 227640 ttcagccagt actggtgggg gcggtcccca cagctctcct gccctcacct ggtggggagc 227700 acgctggcca caactcaatg aggtggtgca gggctgtgcc ggagcattgg ccccttgcgc 227760 agcatgtgtg ttgggaaggg gtgtgggcca gtggagaccg cttcccgggt ttgtgaggtc 227820 ctggctctcg cttcttgagc acctgttgtt tccagggcag ctggctggac agttcattcc 227880 tgacagcatc agtcttcatg gccaccccat ttcccatctt atcaacaaag gaactgagac 227940 ttggggaggg aggttgaata gctggcctca ggacagagct ggggcttgaa cctgcatctt 228000 atagataccc atccgcttct tcctgggctc tactacccca gcatcctcat cctccatctc 228060 tcaagaatgg ggcagagccc ctcagcagag gctgctgaga gcatcagtta gatgtccctg 228120 gggcacatgt tagaagggca gattcccagg cccaccctga atctacgtcc agggcatcca 228180 gatgcccgtg aagatctgga agctgccctc ccgcacacct gggtgggtgt ctggagggct 228240 ggctccctga tcatgtggtt cctgtgggct cacgcagggc ggacaggcag gagaaggtcg 228300 ccagcctgcg cctggaatct gctccatcca gactcagcgt ctgagaccag aagggtccgg 228360 gggctgtggt tcaggcccac acctggggca gggagtgcag gcaatgggag gccagaggga 228420 agaccacact tccccgcagc agcacgtcct ttttgggggc catcttggca gctcagttcc 228480 cgacccatgg gcacccgcag ggtctggagg cagcacacag ctcccggggc ccctgactgg 228540 ctggcaggac acaactgagc aggggtttct gcccggctct aggaatcagc cctgacactg 228600 tggtcagtgt catcccagga agctgagccc tgctgggcct ggctgctctg tagggatctg 228660 cgtgtggcct ccgacatcct gggagctctg tgggaagaca aggagctccc cagcccagag 228720 ctgaaaagcg gggactcagc cttcccgaga gccctgggcg gttggacgag cgatgggttt 228780 cctgtcccat tggaacgcag cagcttcctg gtgcacactg tcccctccct cgacaggtcc 228840 gggcagaggt cccaggaaga gggggactca cccagctctg ggcctgccca ctgtcgtttc 228900 cctgggccca gtgtgactgg gactcagagg agtcacgcag acccaataga acaggctggg 228960 gtggggaacc tgggcttctg cccactgtgc gccctcgcct tgtgtgtgct gtgtccacag 229020 gggcagaggc gtctgctccc agccgacccc atagccatac tgccggtacg aggtggagcc 229080 cacacccgct gtagtgaagg cctgacgtgg tcagagcggg tgccgaggca aagccagggc 229140 tgctggcatt tactgggtct ggggatgctg aactctgggg ccctcttcac tttggtgggc 229200 cctcaggggt gggctctgag tgctggcctg ggtcctcacg agggagcccc cgcgtgaccc 229260 agctctcgtg gggccttccc tgagccgtct ccatcattac ctcatccccc gtcccgggtc 229320 ctgatcagct gccctctgtg tccacaggag cgggacggta tgcgggccat cctggggtcc 229380 tacgacagcg agctgacccc ggccgagtac tcaccccagc tgacgcggcg catgcgggag 229440 gctgaggata tggtgcagaa ggtgcacagc cacagcgccg agatggaggt gaggggccgc 229500 gggcgtgggg ctcacgtcgc caggtggggc ttcttcccgg tgggccttgg cagagcctgc 229560 ggcggggagg tggaggtctg gaccccgcct ccccagttcc cggctggcag gtgtctgtca 229620 gggagggtgt ccacgggctg cttcctctgc atgtggatcc acgttaattc tcacgatggc 229680 acctgcagca tcctccgctg tcagggtgtc tcaggtggtc ccagcctgca agcggatgac 229740 agagggacag tgcccctttg actggttagg accgcctcat gatgcctgcc aaaggggcac 229800 tcaaggtcct tcccctgtga ggggcatctg ccaaggagac ctggtctccg ggtgctcaga 229860 gttgttgcca gggctctagt ccccgctgct ggggaggctc tgctggggcc tgacgggcag 229920 ggtgtgaggc ccagggcgcc cagctccctg tggaactggg agaggtgttc ctccttgttg 229980 cagcctccag gctgcatccc tctcctggct ccagggttct cccaggagag gtggcctcag 230040 ccttggcttc tgccttttcc ctgccccatg ggccaccgtg acgctccgtg cccttgtcta 230100 gctctgagca gctctcacct gtgcagtggg aagaaggagc tgggtatcgc agggcctggg 230160 cggaggccac gtccacactc cccatccaca cttctcatct acactggggc cgggggctcc 230220 tagcacaccg ttcccagcct ggagcttgaa aggcccgtgt tctcctctca ggatttgcac 230280 cacttctccg tgggcacagt gcagccccgc ctgggcgtgg tgggatacct gccagggtct 230340 tctggcctcg ctggcacacg ccgccgccgg gtgccttacc attctgctct gcctggccct 230400 ttacctgact gctcagtctc attgtcaccg tatcctatgg agtgggtgcc gttgtgatcc 230460 gaatttcgct cacgaggaaa cccaggcctg ggggcgtcaa gggacatgcc caggtcaccg 230520 agctggtgtg tgacaccgcc aggccacatc tcagagggcc tgggcctgtg gtgtctgcga 230580 gcacagctga acagccgagc tctgtgagct ctttggtctc aagggtcact gtgtctgggc 230640 tgggccttga tggtggagac tgcggtgaga tggagatgca gatgatggca tcggtgtggc 230700 ctgttgccct gttgtaggct gctgtgtcct ttcctcattc agccagtgac cagctggaag 230760 atgacctggg tcccccgatg gagagccagc ctcacaggcg tgaccacagc caccttccag 230820 ccgggctgct gagcacacac agcaggctgg gccgtgtgcc agggaaagtc tgacagagcc 230880 tctggcccct ggagccgagc tgctgggtag gggagacatt taatgaacaa acataattca 230940 tgtgggatgt taggaggagc tgaatttctg gagaaaggat tgtaatggag ggtctcaggg 231000 agctgcgctg catgggcgtc ccagcagctg ttcagggaag atgggagaag gaggtcgcca 231060 aactacatct agaaagctgc ttggcagatg gttcagtggt ttagaggggg cgtgggcaca 231120 gaggctcagg cactggggat ggcacttggc gagaatgaca ggtcccagcc caggaggccc 231180 caggcccagg gcccacatgc actcgctacc ccttgctcac atggaggcca cgccgaaggg 231240 ccctggaact atgccgtgtc cccacctatg ggtgagccct caaccaccac cacgcttgac 231300 aagagtgaac cctgggtgtg agaccaccct caggcactgg tactgccccc tggtgtgttc 231360 ttctgatgcc ctgccccctc tgtccatcct ccttcctccc gctcctggct ttcctttctg 231420 tgtctagcca tcccgtgcgt gcagggcctg ctgcggaggg ctgcacactg accttcagtc 231480 gtcacgggaa aggctagctc cggctgtacc tgggagctgt cgtaaaccta agtgcgttaa 231540 tagccatctc attgcaacac ccttggctcc ctgtgaagca ttaatgaaga gagatttgcg 231600 gggagggtct ctgacccctt ctgccgtccc tggcgttttc cacgttgagc gatttctcca 231660 gcctgtgctt gccctctgca ctgtgattgg ctcgtcacgg gcctggccgt gggcacatcc 231720 agagtcctgg gttctggtgt tttgtgtgtt aaggcgatca gggctgtcag ggacctcagg 231780 actcattgac cagatgctgg cactgtttgg gcaccgtgct tgcccccttg ccgggcagct 231840 tggagcctca gccctcaccc tgctagtggg atgtatgttg cggaccttgc ccctcccttc 231900 ccatggtggg gtgtgggggc aggttactcc ccttcctgtc tgtctcctgg ggtttcagga 231960 gaattaggca catagaagag ttgggcccag cagggctaga gcagggtcag actccaccag 232020 cactgactag tcctcactgt gggagttcac acggctggtc ctccctgagc cctcacagcc 232080 tcctctgccc atccccctgg gtaccctcca gaagcaggcc agcacctgca gtctcccccc 232140 aggaccccgc tgcactggcc tgtctgtgtt gatggagaca gccacggtat cggctgctgg 232200 cacagattcc agagaggtct tccaggcccc tggctgttcc ctgagcctgt gcaggtgcca 232260 ctgccctctg gggtctgtgg agcagccacc accacatcct gcatgacagc gtgacctgat 232320 gccttgcctc atcagagggg gcacctccgc gtcagctctt tcctcccagg agcctgggag 232380 aggtgtccct gcctttctgc ctcagcggga ccaggtcacc tgcggagcct gtgccctgcc 232440 tttccctgaa gtgacagtcg ggtgggaggc tgggggtgcc gccagctcct gggctgggtt 232500 cctgcctcag gggagcatct gctgggggct ccccacctcc tcatggatgt ggcgcaagtt 232560 cgggagaacg tggccccaac tctgggaact aagcatgttt gcaaggtgaa ggcgggggcc 232620 cagcaggagt gctatgctcc agggaaggtt ggggcgcggc tgcacatgaa gtgtggcaag 232680 ggtggctgca ccctctgtgc acagggagcc cctggggcag ggacgccagc ccaagccagg 232740 gatgcccccg tggagggcca aggggctgct ctggagaccc tgcacatgcc gcgtgtctct 232800 ggctgttggt ttctgtgaag ggcccgtctc ctcttctcct cacggtcggg gggtgggggg 232860 ccgccatcgc cccagccggg gagggctcct gaccccacag agcccaggtg ctccccccga 232920 accccctgcc tccctctctc cctgctacct ccacccggtt tttcttttct ttctgtttcc 232980 cgtctccttt tcccttcttg attttctttc tgtcctctgc acgcatgtct gatagttcct 233040 gtctccatct ttccctctcc cttggcctct gttcacccct ctgtccccca ctcacactcc 233100 tatgtcttct gacctcgggc ctcgcaagcc ttccctggaa gcttgcccgg ccctgcgcat 233160 gcccctgggg aaggcgcctc tcggggcagg tgaggatctg ctacctgacc gccaggtggg 233220 ctcggggtag tcgccagcgg gaggatgcag catcgctctg agagtggttc ccttccaccc 233280 acccgttagc taaaccagac accagtctgt tctcatctgg accatgtttt cattctagca 233340 gagacgttgc aggaaaacag tgttgagttg ggagaacccc agacccgtct ggtgaagttt 233400 tgccgtcttg cacggtgtta tttattccat ttaataaagc ggctgcggga gcccgtagca 233460 tgtgtcagga gtcctctgtg gatagagcta taaatacgca gtgcacgcca ccttgattca 233520 acacattggc ctgatttgtg tttccgattt atttaattaa aagcgattac tgcgctgctg 233580 gccgtgtgga ggtgtgtgga gaatccccgt ttcaggttgc agggactctg aaatagttcc 233640 taacgattta ggcagaagtg gccgtcacgg tgtttccgtc ttcccttcct ccccgtgacc 233700 tcccagaggc tcgggcagct ctgcgggtgc tgtcacttgg ctgccgtggg tggtttggct 233760 ccaggagggc tggggagagc ctgatcttca gggcctcggg ttgttcacca ggcccaatac 233820 ttgtgagtgt gttggtgatg tttccctcat tgaaagaact tgagatgact gtactgtacg 233880 aagcagagat aaagccaaaa aaaaaaaaaa aaaaaaaaac ctgttaaaaa tcatgcagtg 233940 aagaaaagtg ggccaagggg tttatggaaa ccaccctgga gtctgggctg tgggagcctc 234000 tgctgtgtgg ccacaggtcc tcagtgggaa tcgcgaggtg ctggctccat tcccagaacg 234060 gggcgtctgt gcagtacaga actgcgctga gccgggctcc ccgtgacacg ccggtgccac 234120 ccccggcagc acacacttag agcaccgctg cccagcacag gagctgacgt tgctgggcgt 234180 gaggaataag cccagggcag gctctgtcct ctccaccatg ggaggacctg ctgccaccct 234240 cagagcatcc cccagggcct gggcgtccac cccctagcct tccttgcatc aggggctgca 234300 gtggagcccc tgaccgtgca ctgactgcct gttgtgtgct ctgtggccag cgctgggctc 234360 acagtcatcc tcagacctcc acccacaggg agagcttctg tgtacagcct cacccagggg 234420 caggtgctgg ggctgtggcc tggttagccc tgtggggacc ctgtggtgtg ccgcctcctg 234480 cttcttcacg ttgtgtcaca agccacttgg agacctggcc aggaaggtgg aggcctgagc 234540 ttccgtccca tccttttcca cgtgaccgtg accatgacca ccggtggggc tgccttcccc 234600 tagctccagc ctttgtaccg tgtgtggggt ctgtgcctgg tgccctctgg tcctcctcag 234660 tccggctgtc ctgtggctgc tggggtctgt ggctgcctgt cctagccatt ttctgccatg 234720 tcctggctgg caggagtgtt ggatcacagg cagcaacttc tcacctcagg ataaaaatag 234780 cccggctgag gcctctgtgc agcacctcgg tggtgccaag ggcgccaggg cccggggctc 234840 gtgtctcagc acacgtagcc acccgggaca cgtggtccca cccggaaaga gctgtgtgtg 234900 acccttcagc tgcttgggtg gaggcagctc cctggtcact cggtgccagg gttgcggggc 234960 cggggcgtgg ctgcgctggg ggcctgctcg tactggtttt cccgccatgt gatgaaaccc 235020 tctccccaca gcctccgcac ccctcagtgc tccctggtgt gtgcccctga agcctggctc 235080 cgagtgggct tggcctctcc tggggaaccc gagcactgcg tcaggtcgtt tgggatggag 235140 ccgtgttcct tcccacctga gcttcctgcg tgtctgcgtc tgaggctgtt tgggatggag 235200 ccgtgttcct tccccccctg agcttcctgc gtgtctgcgt ctgaggctgt ttgggatgga 235260 gccgtgttcc ttcccacctg agcttcctgt gtgtctgcac ccagcccggg gtgggctgtg 235320 gaggaggggc tgaggctggg gaagtgcctg gcctgcctgc gagcaggctt ggcatctggt 235380 gttcccagcc gtcagcccag cccccacccc gggccttggg aagctctctc tccatcccac 235440 catctccgca tcagaacagg ctgcacccta cactgccttg cggagccaac ctgagcttgg 235500 ggagctcttg tctcagaggt gaggacgctg tggccagggc ctgggggctc cacccggtca 235560 cccagagagt gagaggtgtc tgtgtccccc gaaggtgact gggcagcccc acagtcagtg 235620 ctaaagtgca ctgtccaggg tgtttccaca gggggtgctc tgccgcccac ccactgcctc 235680 catcacagat gcggtttcct ggaggaaccc taccgagacc agcctggagt tgcgctgtct 235740 gaggccctgc gggagctgct ctccagtgca cacacgggct gtgccagctc ctcgcccttg 235800 tgagtgtggt tctccccgag ctctggggat tccatgtttt aaaggcagcc ttattgaaat 235860 atgatttata ctcagtaaaa tcccccagct ttatctgtat gatttgatcc atgttgaccg 235920 tcagtttcct gccacccctg gctcgtagag acaccggtct ggggcctgtg actgttgttt 235980 tgggctttct tggaacttca cgtaaacaga gtcctgcagt tgctgtgtct gtcatctctg 236040 actgagcaca gagcttttga gacccatcaa cgttgtatca gcagttcatt tacttttatt 236100 acaaaataat tctctatcct gagactctac caaaatggtc tcgtctgttc acccactgac 236160 caataccagg gtggtttccc attcttgcca gctgggacag agctgctgtg aatatctgcg 236220 tgccagactt cctgtgaatg caggttttca ttcctttggg ctctacatcc aggagtagga 236280 ttgtggggtt taactttttt tggcggggac agtgtgggga cagagtctcg ctcagtcgcc 236340 cgggctggaa tgtagtggcg tgatcttggc tcactgcagc ctccgcttgc cgggttcaag 236400 tgattctcct gccttggtat cctgagtagc tgggactaca ggcatgcacc accacaccca 236460 gctaattttt gtatttttag taatttcacc atgttggcca ggctggtctc aaactcctga 236520 cttcaggtga tccacccgcc tcggcctccc aaagtgctgg gattccaggc gtgagccacc 236580 gggccgggcc ctaacttctt aagacattgc caggctcttc ccagcggcca taccgtggca 236640 acacgcgggg tccagtgacg cgttactgca caggctgtcg gcaccagagc tgggagaacg 236700 ctccgctgtg gcactgtcgg ctttggtatc tggatccagc ggggcagcag cacatttagc 236760 cctggcttca atctgtgtgt ctccagtgac tgacgtgccc agcgtttccc gtgcttctcc 236820 acctcggcgc ctcttctctg gtggcgtctg ttcaggtccc ttccctctgt ctggtgctgg 236880 cctgccaggc ccagctgccc atctgtgcct cctggagttc ccattcctct ctcctcaccc 236940 agcaggcctg ctgggctctg tctgtggcac tgccccggcc tgcgtcctgg gggactcacc 237000 ccatcccctc ccgcggctct gagctctgag ctgcctgccc tccctcgcag gaatcccact 237060 gttccttgtg ttgtatctgg tgtctgggga ctgaggtggg gggtgtgtct gtgctggttc 237120 ctacagcttg tccagaagga gaagttctag cgcattttgg agcccatgag agcctgtccc 237180 ccaaagcttc ctggtgcccc atctgggagc ctcctctgcg cacacagaga gcgtcgtctt 237240 gggtctctcg ggaccccaat gtcctgcctc gcctctcctg tgctgggccg tgcgggttta 237300 gtgatgtcct gtctctcctg tgttgggctg tgtgggttta gtgatgtccc gtctctcctg 237360 tgttgggctg tgcgggttta atgatgtcct ctctcttctg tgctgggccg tgcgggttta 237420 gtgatgtccc gtctctcctg tgctgggccg tgcgggtttc ggtgttttct ttgtttttct 237480 tactttagct gtgttcttgg aacaataagg tgagggagga gtggacgttt gccaaatgct 237540 cctcggtgct gggactctgc tgtgagcttc tcacaccctc cctccacaga acctggggag 237600 gcccaggaca ggcacgcatt gtggctgaca ccccaggcca cagccacctt cgttctccca 237660 actccctcct gccctgtcca cacccgctcc catgtaaaac attctttttt gttacttgga 237720 aacttcatgt ctgaccactt accctgttgg agctgcagac agcagtgtgt gtccttgaat 237780 ggccacaggg cctgctcgtc tgtgttctct cggtgttcca tggctctgtt cttaggagca 237840 cccacacgtg tcttttcagg ttatgagtga gaggtggctg aggtgtcctg cacccacaaa 237900 ccttgtgctg tagaatgtct ataagccaga cctgagctcc ctcctgcctc cctgccgctc 237960 ccccatctcc atgcccatgg agcgtgctct ccatttcaca ctcctggaat tccggcccct 238020 ctgcgtgctg agcttctgtc tggtggctgc tctgctgaga accctccgcc tggagtcacc 238080 tctgactcag ggttgtgcag tgtcccattt ggccatccat ttgggaagat gcagccggtt 238140 acaaacgaac tttttttgtt ttgttttaca tcttcgtttt tgtttttttg acacagggtc 238200 tcactctgtt gcccaggctg aagtgcagtg gcccagtcat ggctcactgc agcctcaacc 238260 tcttggtctc aagagatcct cctgcctcag ctccctgagt agctgggacc acagttgtgt 238320 gctaccacac ccagctgatt tttaaatttt ttatagaaac aggatctctg tatgttgtcc 238380 aggctggtct cgaactccta acctcaagca gttgtcctgc cttggcctcc ctaaatgctg 238440 gtgtcacagg catgagcacg gtgcctggat gaaaccattt ctctttatgg taacagaacc 238500 gtccttcttt tcctccctaa ttcgtccccc agggtgctag agtatatgtt ttaatggaaa 238560 tataacacaa tacaccaaag tgcacagatt gtaagttttc agcctgtcgg acgacagagc 238620 gagtgtgtgt gtaacccccc taatgcaggc gaagacacag aacttcctgg gtcacacagg 238680 accccgtgga tgtctctttg cagtctgagt gacacctgtg tgttcagtct tcagtgaaag 238740 gtggctctca ctgtctgtaa gccgtctgtc ttcatggctg gatggctcct gtgatgccct 238800 ctgctgtcct ggtcgcctcc tggggagcac tcagctcgtc gatgtctgcc ttcttgaacc 238860 cagggccctg cgtgtgagcc gagccatagc tgctcctgct gacgtgcggt cgtcctcctg 238920 gccgcatccc ggggctgcac tctcacggga gctgctccaa gcaggccctg cccaggtacc 238980 cgagaccagt gcgcgagtct gagttcaggg ctccttggct ccgagtcacc tttcgccagc 239040 gactgtggct ttgaggatgt atcagaaatc tcactggtgt ctgtgtttcc aggccctggg 239100 tcatgtgagg atttcagatg catgcgttct gttttttcca gccatcgatg gaagtgctag 239160 gctgaatggg gctggtacgg aggtggacgc ctcggcctca ggctgatgag ccgcttgtga 239220 atgaacttgt cttcagacac acatcactca gtgctgtcct cacagaaacc tgatgaagcc 239280 ttcggaaaat gcctgcagcc tgcccgcgtg gcgccggagg ctgtgaaggc tgaggctgct 239340 gtggcctgcc tggcctcggc aggaccctgg gctggccacc gtggtcacgg ctccaccctg 239400 cagtgattct gtgtcgggag gcacaggaga gcgtggttgg tccgggcctc gcgcacagct 239460 ctcagccctg ctgcttccgg acgaccctgc ctcttctaag ctgctcctgt aaagtgcctt 239520 tgaccttgca aggttgccat gtgaactgat gtaaatgggg atgacgatgt gcctcacctg 239580 tagctgtcac ctgaggccgg tgcccatcgt gccagccgcc tgtgtgccca ggacagtgtg 239640 ccgggtgtgg cggacatgga cgggctgcca ggggtgtggg tggctctaac gggtgcatct 239700 cgctgcccag gccagctcag agctttgcca ggggtgcggg cagctctcat gggtgcgtct 239760 cactgcccag gccacctcag agccttgttg tcgtcccccc tgtttgggct gctctctggc 239820 ctggtggcct gtgggtgctg gtagacctgg gcggggtgta gggctgcgtg aggagagcct 239880 gagtgtggac tgcagctgcc tcccatgtgc tgaggctctg cccaggggca tggggtgccc 239940 tggatgcccc gacccggctc cctgtgcccc cgggagtgcc cagggctgca gctcggtgaa 240000 gtgcgttgtg tctaggccca gtttggggga tgtccctctt ccatctgccg ttcccagtcc 240060 cagctgctgg tgaccccagc agtggccgga ttatccaggg ttcagctggc tgtgaggagg 240120 gcagtgtgct gctcctaggc ctcgaggcac caagctttcc agtgtggggt ccacacagcc 240180 cagcgtggcc acggccacct gcctcctgat gacagtggct aggctggctc cagggcctcc 240240 cccagggcag tgtgagggca gcaggcgggg ctggtcatgg gcagagctca aggccttccc 240300 ctcatccaca ggcgttgcac aggggtgttg ggcaatgggg gtccctccgg tggccccact 240360 gagtgaggcc ccacaccaga ggcttgggag gctcaggtgc tcacacctgc agcctccacg 240420 ggagcacctg gagcctgggt ttgactctgc tgtggcgtcc agaaccagca ggcaccagga 240480 tagcccgtgg gaagtccaga gcctggctct ggctgggcct gtaggggagc ttgggggccc 240540 atggtctgca gagcggacag gttgaggact gtgggctgtt gcctcagcca ctttccccag 240600 gctgtgtccc caggggctgt agtgccttgt tttctgtgtc tccaaacata cttcccccat 240660 ccccaccaca tgtgcacatg ccacacacag gtgtgcatat acatacccac acttgtgtac 240720 acgcacatac acacgcctcc ccgcctctct cccgtttctc ctggtgactt gcctggtggt 240780 ttccagttgc cgctgggcca ggcatctgcc tgcctctcga tttctccctc accctcaggc 240840 ctgctgggcc tccaccccgc agatcccaca ccccaccaca gccacctgcc tcactcctgg 240900 gctggccctc catctccttc ccggactttc ctgtgtgctg tggcctgggg gggtctcaca 240960 aggccccctg cctcgccctt cctcccaggt tctaggacag agccgcaatg tgtttaggtg 241020 gtgggggcag tggggagcca agcggggtcg tgggaaggag tcaggaaggg gcagagggag 241080 aggatgtggg ggaaggtagg aaccgcaggg gcagaggccc agggcggggg tctccgaggt 241140 cctgagcccc atgcaccgtg caggtcatgg gtgcagggtc actgtcccca gcagggagct 241200 ggactgctga catcctggcc ccacaaccag acccagcctt gctgctccat gaggcctgtt 241260 aggaggaggc ggctggcttt tcattgctgg cttttctacc cttagtgtgg ggtcaagcct 241320 ggtgcccttt ggggagtgtg tcggggcagg agacccttcc tgcctgggtc ggggtcctgc 241380 ttgggggtgg ccgtggtgga ggagatgctc tgaggtgggg cctctgcctg gaaggtcacc 241440 tgattctgtt ctttaagcac gagcctgcca gggagagtga attgatttcc tctgactgaa 241500 agtcccatgc tgaacctttc cctccgtctc tccccagttc cacagtccct cttgggccca 241560 cccctgtcca ccccattcac agtcagtttc ctgaggcagg ttttaggaat ggaccttggt 241620 tctgtgaagc ctcccgcagc ccactcggtc ttcgtctcca tcagttgtct ccatcactgg 241680 gctctcggcc tcgcggggca gccacactgg cccctgccca ccctctggct gcccacttcc 241740 cagctcctgg gtcccgttgc tccccagaga gtggaggctg cggggtggtg ggggttgtgt 241800 tccctgcagt cctagaaatg gggcctggcc caccacagtc tcaggccgaa tcctgtcttg 241860 tcttgcaggc tcagctgtcg caggccctgg aggagctggg aggccagaaa caaagagcag 241920 acatggtgag tcagacgcgg gagtggctgg gattcagggc acctggaccc tgggtctggg 241980 cagggacgcc tgtccccata agcctttagg ctgcaggcgc cagtgcatgg ctgcctcttc 242040 tgtcgtcgga agctgcgttg agcggggaag ggtgtgtgag gagcctgagt cccatctcta 242100 ctagtgacag gtggcatgcg ccggcgggga gcacagcccc tcgggcccca ccaccgtgtt 242160 tgtggcaggg ggccagtgac atgtttgccg catgaggcca cggtgtcggg gcaaagcagg 242220 tgtgagagcc tacgaggggt ctgtccagca gcgaactgga catcagtgct gtggcttcat 242280 ggacccctgt cccgaccaca caggacccga gtccccagtg ggacagtgcc tcagccgggg 242340 cttgggcgcc actcagcatg ggtcctgacc aggagaggga cgtctctagt gagtgcttat 242400 ctgccctctg tgaatgcagc aggcgtgctt ttaagctgtt ttctcctcag cccacatggg 242460 ccccactctc ctggctgcct ccgagcctgg gtggggggcc cgcagtgtgg gcccgtgggg 242520 gaccaggcag gctctcctgg tttctggacc tccagtgtca aaagcttccc actgttttag 242580 ggaacaaatg ggctttgctt ttgaagcgtt ttggcctaaa caaagtgtag gttccctcca 242640 tgctgccctg gccttggcca tgtctgtgaa ggacaaggac ggccctgggg catgcgtgcg 242700 tgcgtgtgtc tgcatgttct gccctgggcc atgcgtcagg ctggcctggg tcacaggcag 242760 agctgctgtc ggcgttgtac ggaccccagg gcctgcagcc caggtcgagg ctcccgtcgg 242820 gcatccttgc ttgccagctc gtgactgtga gccggtgtcc tggctctcag ggcctcaggg 242880 ccttcctctc cacccggcag gggtgtgctg agggttcatt gcttgacagg ctctggggct 242940 ggcagcacag cctgtggcgg ttgtgggtgc ggccatggtt acaggccctt ctcatgggac 243000 agggttggat ggggttggaa atcaccgtct tgagaggtac gggcaccagg gcctaggctg 243060 ggaatgggcg agggctgtct gcagaccctg gaagaagctg cccagcggcg cagagaggca 243120 acagcagggc accgcgcggg tctgggcaga gctggcatct gcaggaccaa ggccaggtgg 243180 gctggcaaca gctgtcctga gcctctggaa tggtcgctgt tcactcagca gctgcttaag 243240 gacattcttc ttggtgctgg ggacgcggca gccagcaaca caggctcctg ccctcctgga 243300 ggcacactgt tgccaagtga gtagtcagtg gcccatagga gagtgaaaga cagaacttcc 243360 ggtggtggcg aatggaggag ccgcattctc ccggggccgc tctgcagagc gtcctgagcc 243420 aagcctgggg gacccgactg ttggtggtgg aaatggtggg gcaggcaggt cccggaccca 243480 acagtgaggt taggggtgac agaagcgggg tccgcggtgg ttggtagtcc aaccttgtgg 243540 gccctgtgtg gtcacggcag ggctgtggtt tcatgggtgg aggaggtggt gacacaacct 243600 ggtgtccatt cgtaaaggat gcctggctgc tctgtgcagg gccgcaatgg gtgggaagtg 243660 gcaggccggg gtgggagacg caggtgccct gggctaggac tgcaatggcg tgcggaggcg 243720 tggtccgagt ccgctgcgtt gaagggagat gcaggtgagg tagagagcgt gagggctggg 243780 aatcaaggac ggcttcggca ttccgccccg ggtgggctca tggtatgggg tggggagatt 243840 gagggtgaag tgtgggagtc tcacgcctgc cacacgttgg atgcacaggg ctggaggctt 243900 tgagtcggtg ccctggggtc agaggtgccc atctgctctg catggtgttt ctgttgttgg 243960 gaatgagtag gtagcagaga agtcagaact ggaggctcaa gcctctttgg ggcattccag 244020 catcctggca tctagtcttg gggagcagcc atgagttggg gtactccgtg gagggcaggt 244080 gcagtcacag agccctggag aaggaagtgt tttcagggga cagtcagact gcagagaaga 244140 cccggaaggg gagcagagga ttgccctggg ccctgcggcc ggcgtttcat tgatgagagg 244200 agaggcccag aagggcctgg tcaggggctg ggcctggagc cgggagggaa gattcgcttt 244260 accgatgggc agtgggagag cggtttatgc tgaagggagc cttactgtag tgacgggcat 244320 gatgtagggc tggggcagtg gaggggcatc gaaaggggct ggggccagca ggttgctgga 244380 gcttcctgtc tcctcctgaa gtgggcatga ggcgcactgg cctgtgaggg tccccgcagt 244440 cccgctgagg tttgtggtgt aaacttggag ccaggttggg cgtcaggctt ctgtctgcca 244500 cgctcaggtg cttcccagca gacacagtca tggggaatgg ggtttaccag ggcgggtttg 244560 ccaggggagc gcagtggagg gagggaggcg gagatgtgac gctttgctca gcggagggaa 244620 aatcaggctg ttgggggctc caggacaggc ctttctcagg tctgggtttt aaaattggag 244680 aaattggagt atcaaccatg tttttcttta ggctgtagaa atactggggg gtggggttgt 244740 tgttttgttt attttcctct ctgtgttctg ctgtgacctt tcattgctga tgtagtttgc 244800 aggggaaccc attgtaactg tattgtttaa tggcaggtct gagactcggt ttccattcct 244860 ctgccctcat ctgagatggc tcagggcagg cctgaaagat gctcctgctt cagtgagcgg 244920 gttagtgggg actctgtgga gtgtggggtc tggtgtccag cagtgtgtgg ggttaggggg 244980 ctctgtggac tgtggggtct gtggactgtg gggtctggtg tccagcagtg agtggggtta 245040 ggggactctg tggactgtgg ggtctgtgga ctgtggggtc tggtgtccag cagtgagtgg 245100 ggttagggga ctctgtggac tgtggggtct ggtgtccagc agtgagtggg gttagggggt 245160 ctgtggactg tggggtctgg ttcccctgag tgcaggtgtt caggaaggat gccagggtcc 245220 tcttctgcct gtgtgggggc ttggcggggg gttggcaggg ggttggtggg ggacacaccc 245280 agagccttcc tagttcccag ccctgagggc tgtcggtgct tccttctcag tgactgagct 245340 ttctggaccc ttcagtgagg acccttttcc tgttgcctct ggaacagcct ggggtgggtg 245400 gagggatgct cccatctgaa gatgccctgt ggagaccctg gtgttctgtg tgtcaacacg 245460 ctggctgcct cactgttggc ctgaattgaa acgtgcctgg gggccatgct tctgcatgtg 245520 caggaggcca ggagggttag aaatggagtt gtctgagcac aggccaagcc ctcggcatta 245580 tggctgagcc acctgcccgg cacctgcagc tgccctggag catggactcc ccatgtccaa 245640 cagaggcacg gacgcctcgg agctggcatc ttgacccggg catcggccct tgtctggctg 245700 caggtggttt tggaggagct gctcactcca gtcctctttt gtggggagag agacagaaac 245760 tggtcttggg ccctcaggtg gggtgggtgt ggccgcccct ggagtgctgg cttctccaga 245820 tatctggttc tggtcagggg gctgtgaggt gcgcttggtg cagcgctggg ctggaggttt 245880 ggctgctttt caacctgtgt tttttctctt ttttagccca tataatttct gttccttatt 245940 catcgtacgc agcaccgttt aagcgctaat gcctgggccc caagctgcag catttgactt 246000 cgaatttggt gggaggattg cccccaagca gaatcatgat tttacccctc cctgggttga 246060 gctcctgttc ctggccccgt cctttgtttg gagccgcagg gctcccgagg gacgagagga 246120 ggggtctcgc tggctgtgtg cccctcttgc catgcaaagc ccttcagagg aggtcctggg 246180 gagagcagtg ccaggcaagg gggctacaga caccgtggtt ggggctggcc cctgccaggc 246240 atgcctgaag gccagtggcc tccctcccct gccccccgcc accgcactgg gctgtgcagc 246300 cctgggctcc aggttgcccc ttctctgtgt gacccagagc cctcagtgtc atggcttctt 246360 cccgggggtt acaggtgcat gttcctgtct gaagggggtc tctgggctgc gggacagcct 246420 gactcccttt tcattttatg gtggaggaac ctgagcggga gctcgccctg agctgggatg 246480 gctggagtca cccaggtctg gctctgaggc ccctcccacc cagttccctg tgactggctc 246540 ggcagtgggt gctgtctggg gaaggggctc ccttgtccct ggaaaggctg gggcctaggt 246600 ggtctgcacc ctcagggctt gtgtggagaa gccacattct aggcagggct gactgtgtca 246660 ctcacgcctt ctgtccacag tggtctggga catggcccta gtgcccgtcc cgtctcccag 246720 cctgcagctc ctttacctgc tattttccaa cccaaagtca ttttgttatt taggaaatga 246780 gaaaagagag aaaaaagaaa aatttaaatc tttagttaat tgccaatgac aagacaaagg 246840 cactctgact ttcttattat taattagcaa acccgtacta attagtaagc ataagtacaa 246900 ttcatgtttt tttctttaaa tgcaattaat atcgcaagga gagatttcct gggccatcgt 246960 cgtatcatta gcgaaccccc ctaattagct aggcccgcag tggctggaga tgggagtctt 247020 ttgattacag ctctaaaata tcctctaata ttttatagac tttggggagt gaggagtgaa 247080 gctttatttt ccgattcaga gggaattacg ccgctctcag ctctaaaata tcctctaata 247140 ttttatagac tttggggagt gaggagtgaa gctttatttt ccgattcaga gggaattacg 247200 ccgctctcag ctctgattaa gcagcatctt ccttgattgc tgatttccct ttgtggcccc 247260 tctgtgcctg ctccttgctc ccaggggcac cctgtgccaa gtctgcctca ccaagggccg 247320 tggctacagc agcactgagg cccggacagg ctgcttcccg tcccccaccc ttctttgtcc 247380 atctctgaaa tgggaagggt gtcgaggccc actctgagtc gggcctagcg gcaggtgctt 247440 tacagacaga ttctgaaatc tggcgaccgt gagcagggca ggtcccgtgg gcccatgaag 247500 aagctctagg ctctctgggg tctcctgtgc aggagcctgt ggtccgtgtg gctctcagag 247560 cctctggctt ctcatgggag gctgaggaca ccggcggagc ttccctgaag agactcccag 247620 tgaggcatgt gtagacccgg gggaccctgc ccgcccagca gccgtgtgta gacccggggg 247680 gaccctgccc gcccagcagc cgtgtgtaga cccgggggga ccctgcccgc ccaggagccg 247740 tgtgtagacc cggggggacc ctgcccgccc aggagccgtg tgtagacccg gggggaccct 247800 gcccgcccag cagccgtgtg tagacccggg ggaccctgca tgcccaggag ctgtgtgtag 247860 accggcaggg cccggcacac acgggaggcg tggctggtgc ctctatcttc actggtgctg 247920 ctactgaaga tggaccaggc agctgtgagc ccctcgtcag tgctggtcct catggctgtg 247980 cccagcccgg aatctgtctg gtcacatcca gcagcatggc cagtgcctgc agatgaatga 248040 tcatgagagc ctcctggtgt ggtaactgac agtacctcat ttcaccttcc ggacccatcc 248100 tgctccacga cgaagtgcta cttctgactg gagtgcttcg tgcttggcat gctggagggg 248160 cttgctgctg gcaccggggt tctgtatggc tggtggcacc ggggttctgt atggctgctg 248220 gcagcctcct ggtccctgga aacctgttca gttcacgctg caccagcatg tatgtccccg 248280 cgcgcgctgg tgtgcaggtg tcctgagctt ggagaggctc tttggggcca gggatgtgtc 248340 tggggcaggt ctggggaatg gctcaaagtc tgagactgtg tccttagctc actctcctcc 248400 tctccagccc tggaggcggc ctctcctggg ccccccgcct ggggctcctg cgcccgccct 248460 tccatcccac acaactggtc ccttccctca gccacacctg tcacctctct tgctgtgtgg 248520 ccacaggcag gtgcttcact gcctggtcct cagggtggag agaggaagcg gggagcctcc 248580 ctggagtctc acaaagctaa gtgagttcgt gtgctgggaa gatccaggct gttctgggaa 248640 gtgattctgg gtgagaacag gggcctgatc ttcctcagca gccccggggc tggttccagg 248700 ctcgctgccc gttcaccagc tcaggtttcc ctgcgtccag cctcatcctc agtgcgtgcc 248760 ccgaggtgcc ccccgaggct tctccacaga gtggaaggaa tcgtgctggc cacagcaggt 248820 gtcacatgga gcaacctttg ctttaaatgc ctcttgcatt ggagggaagt tgtctaattc 248880 agcaagcatt tgttgagtgc ctcttctagg ctgttgtctg agggaacaga gaccctgtgg 248940 ctgcgcatct gtctattcag ctgccctaac aggaacaccg cagactgggc tgcttaaagt 249000 agcagatgtt ggccgggcgt ggtggcttac gcctgtaatc ccagcacttt gggaagctgg 249060 ggtgggtgga aatcttgagc ccaggagttc gagactggcc tgggcaacag agtgagacct 249120 cgtctctgtt taaaaaaata aaataaaaca aaacccttgc agacatttgt tgctcacggt 249180 tctgcaggct ggaagtccag gatcaggaac tggccggtct ggtgtttgct gaggcttcct 249240 ggttccagat ggcgccctct cactgtgtcc tcacacggtg ggaggggcga gggagctctg 249300 gggtcccttt tatgagggtg ctaatccccc ccccgaggct ccgcccggtg gcctcctcac 249360 ctccccgggc tccctcctag gatttcagca tgagagcggg agcacacagt ccatggcatg 249420 ggcccacctc cttcctgctg tgtgagaccc ggtgggcgct cactgccctg cccagtcctc 249480 ctactggggg gtctctgcct ggtccctcag tgcccgatgg gcctgccctg cctacggtga 249540 tgtccccacc ctctgagcac atcttctcac gcccttccaa gcaatccctg tgctgctccc 249600 cctctgagga tgtcttttca gttcagcgga gcctcaggcc ccctgggaat tgagctggac 249660 ccgtgctgct gcccctgcat cgcagacacg ctcttccctc cctgccttca cggggcctgc 249720 accttcacca tcaccgccac catcgtccct gtgctgccct gggtgtggcg gtggcacgtg 249780 caaagccagt gtgtgctgtt gctcaccatg tcatgagtac acacttgttg tttacacaga 249840 ttatccccct gtgatcctgg cagcaaaccc acaagctggt tgtggcccca gatactcaga 249900 cgaggaacag gggcagccag gattagtgac ctgcccgtgt tggcaccggc agtggtggag 249960 agtgctccag ggttcacacc caggcaggct gaccccagac cctgtggcca gggcagttgc 250020 aggggcttcc tcatatcagg ctgtctgtga aatccaccag gacaggaccc agggctttct 250080 ggggctccag cgttagccca gggccaggca ttcagctggg gagtttaaag catctgccga 250140 gtgctgagtg gggacaggtg ggaggaggat gcttcatctt ccctctgtcc cctttcccag 250200 tgtgaggacc cagccttttc agtttttacc agtttgcaaa gatcttatga gaagatgctg 250260 gtgatttaat gtcgttacct tgtaaggatc atctgcattt tagaaaaagt agctgagaag 250320 atggtttctt cgcccagaaa atagatttct caggcataat gtctgagcct tggttgtaga 250380 ggatttggat ccctgcttct cctccaaaaa acagaagaaa atctcagtgc agagggaagg 250440 cgtaagcttg ttttctatct gggccagtgc cacagtgtgt gagctagcag agcctcagag 250500 tgtgtctgat acgtcgtgac ctttgtgtta ttttctcttt cagaatgatc ttagatattc 250560 tccaatgttt tttccggtaa actttagagg gagcttgcca aggttcctgc cagtcctctt 250620 gcattgcctt ggtctgcgga ctgacatggg aaggcaagct ggttgcattg tggctccccc 250680 agaagccctg tgccctccct gcactgtggg tcctgcccac tgcttactag ggttattcct 250740 gggtggttta gaatctcagt cacctgcatg tcactgctgt ctgcacactt gccatatgac 250800 ccatgggggc atcttttggg cgttgggggc ggggatgagg agaaggtggg cacttcagac 250860 tcagagcagt gaagtccccc gtgcattcca ctccacgaaa cttagatcga gtctataata 250920 accacgagaa aggaaatcgg ttcatttatc ttgaaaaatt atgggagtaa ttctgtatag 250980 gggaaatata gtaccctcat cctaagtacg aagcattttc ctgtgattta aacttgtcgt 251040 gtctctgcag tggccctttc tggcttaagc tttttctcag ctacgtgtat cttccataag 251100 ctgatcccgt tctggcccca ggcccacaat ggtgtcacct gcccctgccc ctgcccctgc 251160 cgcctgcctc cctgacgtag agcccatgcc atcctcacat ccacctgtcc tggagacact 251220 gggactttcc cttggactgg gccgcctggg ggcttgtttt tgcctgtgat tcagccagca 251280 gccctggcag acagccttcc ccaagctccc ccagcagagt taacttccac agtgagaggc 251340 ttcacaggga caggaggtgg cctcagatgt cctaaaaagg cagatgtagg attggagctg 251400 ataggaggga gggaggccct ttctgtaggg agaactttca aattcaggct tgtttctaag 251460 caggggctct ttatccagca tcccagggca ggtgctcagt tctccacaaa gcgcttgagg 251520 ctgcatacac atttccgtta cttgcacacg tttttctcca gagagcagtt gccatcttca 251580 aaaggtttct gacacctgtt ccccttcccc agcgttaaca actgctccta ttgaggaggc 251640 agcctcattg atcccagtga aggttctgga gcccttggaa gccacataga gagacaccac 251700 ccatctggct tcccaacgct cctccgtgag tgtaaatggg gctgggtatc cagcgtggaa 251760 gtcagagcag tggcgctctg gtggggcagg tgctcaggca cccagcggtg ctcatgaggc 251820 cagcagtggc gctctggtgg ggcaggtgct caggcaccca gcggtgctcg tgaggccagc 251880 agtggcgctc tggtggggca ggtgctcagg cacccagcgg cgctcgtgag gccagcagtg 251940 gcgctctggt ggggcaggtg ctcaggcacc cagcggcgct cgtgaggcca gcagtggcgc 252000 tctggtgggg caggtgctca ggcacccagc ggcgctcgtg aggccagcag tggcgctctg 252060 gtggggcagg tgctcaggca cccagcggcg ctcgtgaggc cagcagtggc gctctggtgg 252120 ggcaggtgct caggcaccca gcggcgctcg tgaggccagc agtggcgctc tggtggggca 252180 ggtgctcagg cacccagcgg cgctcgtgag gccagcagtg gcgctctggt ggggcaggtg 252240 ctcaggcacc cagcggcgct cgtgaggcca gcagtggcgc tctggtgggg caggtgctca 252300 ggcacccagc ggcgctcgtg aggccagcag tggcgctctg gtggggcagg tgctcaggca 252360 cccagcggcg ctcgtgaggc cagcagtggc gctctggtgg ggcaggtgct caggcaccca 252420 gcggcgctcg tgaggccagc agtggcgctc tggtggggca ggtgctcagg cacccagcgg 252480 cgctcgtgag gccagcagtg gcgctctggt ggggcgggtg ctcaggcacc cagcggcgct 252540 cgtgaggcca gcagtggcgc tctggtgggg cgggtgctca ggcacccagc ggcgctcgtg 252600 aggccagcag tggcgctctg gtggggcggg tgctcaggca cccagcggtg ctcgtgaggc 252660 cagcagtggc gctctggtgg ggcgggtgct caggcaccca gcggtgctcg tgaggccagc 252720 agtggcgctc tggtggggca ggtgctcagg cacccagcgg tgctcgtgag gccagcagtg 252780 gcgctctggt ggggcaggtg ctcaggcacc cagcggtgct cgtgaggcca gcagtggcgc 252840 tctggtgggg caggtgctca ggcacccagc ggtgctcgtg aggccagcag tggcgctctg 252900 gtggggcagg tgctcaggca cccagcggtg ctcgtgaggc cagcagtggc gctctggtgg 252960 ggcaggtgct caggcaccca gcggtgctcg tgaggccagc agtggcgctc tggtggggca 253020 ggtgctcagg cacccagcgg tgctcgtgag gccagcagtg gcgctctggt ggggcaggtg 253080 ctcaggcacc cagcggtgct cgtgaggcca gcagtggcgc tctggtgggg caggtgctca 253140 ggcacccagc ggtgctcgtg aggccagcag tggcgctctg gtggggcagg tgctcaggca 253200 cccagcggtg ctcgtgaggc cagcagtggc gctctggtgg ggcaggtgct caggcaccca 253260 gcggtgctcg tgaggccagc agtggcggcc ctgggcacgc tgcagccctg gtggtgaggc 253320 cccggttcct ccaagcacag ctgctctggt tctgcagcgg cctcatccca ggggcggtgc 253380 atcaggcgaa cattcggccg ggacatgccc tccggctggg ctgttttttt ctgaggagaa 253440 agcatttccc agctcaggcg cacatctgtg ctcacgagga aatgtctggg tgagccaagg 253500 gggctgtcca tggcccacag cgcctgtgtc tcctccaggc tggaaaggaa gctggagagt 253560 ggactccacc taagatcccc ccgaggcctc cttaggaagc cacagccact ccagaagcct 253620 tcctggtgcc agagggtgca gagttgagcg gaaaggtggc ctctggccag gatgcccagc 253680 tgtgacctca gcaccctctc atctcttgga gacctggagc ctctgcccca gtcagcccca 253740 gggagccctg ggatgtgagc cctcaccttg cagccagggt tctgtgaggc tctgggcctc 253800 agcctcacca cctcccgggc acaggttgca gctgagactc agcgatgcca cgtgagttgg 253860 cgatgaggcg gcgggtgcac gcgcatgtgg acgccctcac tctggcactc agcggcagcc 253920 tcgttaatta gaattgcggt ggggggagtt acccagctcc tcctcttgtt attagtttgt 253980 ggcattaggg aaggcccctg ggagcacacc ctgcatcttc ccaaattaaa ccgaatgcaa 254040 ggtctctatt taaaggttat gctgcgctag tgagtttgcc acaaggacca ttagcatgaa 254100 tgtttcatga aggttggggc tatgagtgga tctggtaggc caggcctgta ctccaggagg 254160 gagggacctt gtaggcagag gaacatgggg ccagccggcc tacactgagg ctgggccatg 254220 ccgaagccgg gccacgctgg ggctgatcca tgctgaagcc aacctgtgct gaggctgatc 254280 catgctgagg ctggtccacg ctgaggctgg tccacgctgg ggctggtcca cgctggggct 254340 ggtccacgct gaggctggag cgctgccggg acgtctgtgc tcgcgctcag gctgctctcc 254400 cagggtcccc acacctgttc cagtttgggt ctgggcagcg cacatgctgc tgtgcgagct 254460 ccgtcttcca gggtgaggcg gctcccgccg ccgagggctc ccagcccgtg cctggctttc 254520 tgctcccctc tccctgtcgg ccccaccgga gatcaacagg ttgcttcatc tcagtcaaac 254580 atacagttga gttccgtaaa tgagaccaaa atctgtttct gtgagataaa attgataaac 254640 ctctagccag actaatcgta actaagagga cacaaatgaa cgctcctggg cgtgagagaa 254700 gtgacagtgg tgccgccatt ttccacgttt cgttagagcc gtcctggcgg gtgtgaaatt 254760 ttccacgttt cgttagagcc gtcctggcgg gtgtggagtg gctcccgtgg ctttgtttgc 254820 gttaccctga ggccagtggt cctgaacttc accctgtgct tatcagccac gcatctgtct 254880 tctctggaga agtgtctgcc ccatccattg cccactttgt aaatgggttg ttttgttggt 254940 tagtggtaag tcttcatgtg ttctagacac tagacccttc tcaggtatgt gatataaggg 255000 gctcctgtga ggcagcccag gaagggctct cagtcttgct gggcatcagg gccttgtcag 255060 ggaggagatg gccatctgtg ggccttggga aggggcatgg aggggccagg cacacgtggc 255120 cctgcctcct gcagcctggt gcgggcacag ggtttggcca gagagaatga tttccacagg 255180 ataggctcag tgctaggact gcccggagca cacgcagggc ccctggaagg cagccctggc 255240 cgccgggaat cctgtcctcc aggcttttgc cgtgggatca cggcccttcc caagaagtct 255300 gcctgtggcg ctgccctccc cagccacgct gtgcgcctgg gccaccctgg agcgcggccg 255360 ggtcctccag agagtccgtc agggactgtg ctgctgcttc acagccaccg tgacacaggc 255420 atgagggagt aaacacagaa aacgaagttt taggtactga gtgctctgtg cctgggccag 255480 gcccagagca gtgtcttgtc cccaggcctg gctttggagg gcttccctgc cctgtcactg 255540 cattggtggg gccctgatct gtctgcgctg aagtcttgta ggctgggcgc tccacaaagt 255600 gcctgggcct caggtccctg tggtggggat ggctgggctg ctgtgtgcca cctgaacggg 255660 ggacggccgg gctgctgtgt gcgctgcctg atgcagcggc agagttgccc ctgggaggtg 255720 tgggaggtga gtcttgctct gtgaccattg gatgaataat gaatgggccc tccgccatgt 255780 caggaagcgt tcagcagggc cctctccttg tccccagcgc cctcttcctg gatcccacct 255840 tcccacccgt gcttccgcac gctgctccat ctacctgcta ctccttttct tctgggtctc 255900 ccctccctca cgggcctcct gccgctcctc gcctctcatg ggcctgcccc gggtgtgagt 255960 aggtgttcta caggtcctcg gtgaggatgc ctcctagggg cctgcctgac ttcctgccag 256020 ctcagcctcc tccctaggct gtaggctgcc ccagagatcg gagcttcaga catggtcccg 256080 tgcctgggag cccgggtttc ccacccaggg acaggtggtg gtatccccgt cgtcacggtg 256140 agggctggag gcacaggtgc ctgtgagtta cctctgagaa cgctgctgcc ccgggcctgt 256200 gccctgccag cgagtcccac aggtcctcac aaggagccct ctgcaccctc cactctcggc 256260 tgccgagccc gcaggagaaa agacgtggag ccggggctgc cgggcggccg tggccctgcc 256320 gtgcgggccc ggcggctggg cgagggcact gcagttggtg ccgagagcac cccgggacca 256380 tcctcgcatt tgctcttccc ccacctgcct ctccccccct ccccgatggc tttccttccc 256440 ttaaatactg atatgtctac acggcttctc aaattggcgg acagcagagc agactccggg 256500 gcttgtgtgc tcagcatggg cggctctctt cgcttcatcc gggatactta gacccgcccc 256560 agtacctccc cgttccgagc tcggccgcac acacgctgga cgtgcctggg aagtggccat 256620 tgccgcgtct gtgcccacca tctgcccacc cgtgtgcccg tccaagcacc gactgtgtgc 256680 caggttctgt gctggcaatg gggccctaca tggttaccac gtctcctcca gggaacgtcc 256740 catccagtgg ggaggagagt cacgtgccca gtcaccatgt ggtgtggtgg agtagagggt 256800 gcggtcacag aggagtgggg gtgggcactt ccagctggca ggggaggggt gagggagctg 256860 ccaggacaga ttgtggggaa ggcggcattt ccactggatc taaatggtgg atgggagcgg 256920 ggggtgtagg tggaaggtgg cccacagaca tggatcatgg gtctggccct ctgtggctac 256980 tgtcctgtgc catgggcctg gagggggatg taggggtgag agctggcctg gcggggaggt 257040 gcagggtggg tggaggacct gcagcatggc tgggggtgtc gggcacaggc tcaagggggc 257100 aggcattggc tactctgaga atacagttgg gagcttactt atgagtctaa ggttacacat 257160 taaaataaaa gggcttgatt ttttgctctg aacattgtgg cacacgtcag catttccccc 257220 ttgtttcctg gaaatcatct acaaataaca agaagcgtga aaaccaaaat ggcacttaaa 257280 ttttgacaaa acagaaatgc agctgcaaac caagccccag gcagaggcag gaagcccgtg 257340 gtgcaggaga gtgcagtgag cagacgcagt gagcagacac atccccgggg aagcctggag 257400 cagtgcgggt ggaggcagct ccatgaggga gccgcggagt agaaccccct tgccggcgcg 257460 agggagccgc ggagtagaac ccccttgccg gcgcgaggga gccgcggagt agaactccct 257520 tgccggcgtg agcccttgcg agaggcggcc cctgaccctg gctccgcagt gcgggggccg 257580 gcggcagctg gaacgggggt ccctggactg gcgtgtggtt ccaagctgga ctggcgtgtg 257640 gttccaagct ggactggcgt gtggttccaa gctgcagcag aggttggtgc tgagctgagg 257700 ggtcacacag gtgcatcaca cgtacttgaa gccgcatctg tggcagacag aacatttgct 257760 cttaggaaaa ctcacggtgt cctttctctc ctgccggagg gagctactgg gggctgattg 257820 gactcgcagc aaaactgtca ctggatttca gataaaagga agcaggcctg tccttcccca 257880 ctgtgaacct gtgcacggag ccggattcaa taaaactcat cttcagcagt gagcagtaaa 257940 ggttactcca tgcatttgtg ttagagcaaa ggagaaaaag aacaaaaaca agtggcagaa 258000 aaagtttcac agaaaaacgg tggacattga gcagatgaaa attctatcca gacattttgc 258060 caagaaacaa aagttaacga ggcggtagag tctgtgaggc ttgggcggaa cgcacacgct 258120 ccaagaagag acggtgaggc cgggggttgc atgagacagg acccggaggg tctcagagca 258180 ggagaggggg cagtaggggg cagtacagga aggaaggtga ccggatgcac ggggaggcga 258240 atcacgggga aaactaccta aagaacccgc agcaagagtt ccatctcctg aattggaaga 258300 tgaagtgaat gtggaagcct ggaaatgtaa gtgctacatg tcatgtattc aaaaagaagt 258360 gtcaggatgg cagagggagg agagaacatg aggatggcgg cttcgctgtt gagagccgaa 258420 gacacagaca caccatctaa aggtagtatc aggtggggag agcagatcga gctgcatgtt 258480 aggctcccta gagcaccagg tgcggtagac tggtctatcc cgagagagtg actgtgaggc 258540 cctcgctctt ggccatggag ccaggatccc gtggtctgca tctgtgcaca gcagacctgg 258600 aagagcctgt gctgtgccca gtccgctctg caggcctgag aaccagcgga gcctgtggtg 258660 aaagccccag tcctgggcgg aaaacgggag ctgccccgct caggccacca ggcaggcaag 258720 ggaggaacgg tcgcctcctc cagttttcat ttcattccgg cctcaagggg ttggaggagg 258780 cctacccatg ctgcccgggg ccgtctgctg agtccccgat tcaaatgctg atctcatcca 258840 caaaccctcc cagacacacc cagaaagtgt tttgatctga gtaccccagg tcctgtccag 258900 tggacacatg gaatgaaccg tcacagacta taaagttcaa cagggaggat gatgtatctg 258960 actagttagg cacccaacat aggagataca gtaggtactg tctagtagga aagtatcggt 259020 gtgaaacaaa gctgagttat aaaagcaacc agggtaaaac atgcacactt ttctaagcct 259080 cgagagaatt acacgcaaaa aagtaaacta gattaaaaag gccacagaat gagatagatg 259140 taaaagctac aaaatcgaaa gcataacaac ataatacaac agaaatagac acaaatccag 259200 ttatagttgg actaaactct cctattaaaa ggaaaggact tcctgattgg attgcaaagc 259260 aaaaccaaac atgttggaaa gtacgggaag caaaggcatc ctggtgaagt gaacctggaa 259320 agcaggagct atgatctcca tgcagtgtga gttcaagcca gaagccgctc agaaacaaag 259380 gtgggcgctt ttcacagtga ggttcagatg ggttagccaa ataacacatc accgctgttg 259440 ggaaaagcag aaatgaggaa agattcaagg cgaaattgtc aaagatgcca gtagcaggat 259500 ttatgtccta atctgcgata tagcaagtgg gcaaagaata atggaaaaca gaaaaataca 259560 tatgtgcgta aaacccatat cccccaaatt agagaatata ctcatgttaa aaggagtgca 259620 tagaaaacat tcacaaagat taattgtgta ttcggtaata gagaaagcct ttataaatta 259680 aaataagtag aactaataca acttcttgtg attgcagtgt gatgtgaaat caagaacaaa 259740 atcagggaaa aaaaagctcc taacacttgg aatttaaaaa acaaaaccca aacagaacaa 259800 aacactgtgt cttaaacaat tcttggttca aagaagtacg attcaaaagt gcataagatg 259860 tagaaaataa ttgtcatgaa aacacttctc atcagagcct gtgggaacca cctaaattca 259920 caagtttaaa tatttatatc attgaacaag aaagcatgta aatatatgga ttaaaccttc 259980 aacccaagaa gtcagagaac aaaaggaaag taaaccttag tgaaacaaaa aggtaggaat 260040 ttgtaaagat caaagcagaa gttaatagga aagtgaaaaa tggtagaaat aataaataag 260100 tccaaatacc tgttatttga aataaaacca ataaaacata tgaattattc acagttctaa 260160 taaaaaattg atagaaagta tcaccatcca aaataggaaa caagactaat tacctggagc 260220 tattgactga gcaggagcat gcgagagctt tcaggcgtgc tgagaattct gtgtcctgat 260280 ctggacggtg gatacgtagg tgaagacatg tataaaaagc catcaggctg tgcacataag 260340 attgagaagt ttactgcgtg taaattatgt atacctcgat gggaaagaaa agcaaaaatt 260400 aaaaaattga gaattatgag ttttgtctga tttctataaa aagaattatg aattatatct 260460 cagttccatt ttaataaact taaaaatctg tgggaaatga atgacgtttt agggaaatgt 260520 tacctatcaa tcccaactcc agaagagaga gaaattttaa acagatcaat tactgtagaa 260580 aaacgttgtc ccaaaattgc catggctgct ctcccccacc acaagaggaa agaaacagaa 260640 gatgcatcag gccaagccag tttcatggga aaattctacc agatcttcaa agcgcagata 260700 ctttgagcac tgtgtaaacc agttcagact gtgggaaaag gaggggaagg cattctggaa 260760 gtgttgtatt gacaccaaca actgcaaagg ccttacaagc ctgtgtgtgt gtgtgtgtgt 260820 gtgtgtgtgt gtgtgcgcgc gcgcgcgcgc gcgcgcgtct gtgggtgtgt gtgcgtgtgt 260880 gcacgtgtgt gtgtgtgcat gcacgcgcat acgtgtatca gtgtcattgt taacatgtca 260940 cgagtgaaat tcaacagcag gttgaaatac atcatatgca gtaagattta ttccaggacc 261000 agcctgtcag cttgatttta ggatatcaat ttatagaata ccctcttcat gggggcgttt 261060 gacaaaatcc aacactcagc cttgattaaa aactcttaat aaaataggaa tatatgggta 261120 atttctcact gtgatagaaa atacctattt gaaaaaaaag gtcatgtgct gtaaataaga 261180 aagtattggc ttcagctcca gtgaagccac aggccaccta aggatgtcca gtatcacaac 261240 tgtgatttcg tattattctg gagatactag tcatccaaag tagacaaggg aaagaaaccc 261300 aaggtatcaa tattgggaag gaggaggaaa attggaaaat cgtccctctt tgctgctgat 261360 aagattatgt gccaagagaa tcaactgaga actgctgctg tcggtcggaa tttagtgaag 261420 ggggcgggaa acaaaaattt aaaatcacgt atacaaagat aagttagaaa gaagaagaaa 261480 aggctgggcg cggcggctca cgcctgtaat cccagcactc tgggaggctg aggcaggtgg 261540 atcacttgag gtcaggagat cgggaccagc ctcaccaaca tggtgaaacc ccgtctctac 261600 taaaaataca aaaattagct gggcttgatg gcgtgcacct gtaatcccag caacttggga 261660 ggctgaggca ggagaatcgc ttgaacctgg gagctgcagt gagctgagat gacaccactg 261720 cactcgagcc tgggtgacac agcgagactc tgtctcagaa tatatatgta tatttatgta 261780 tatattttta tattttatat atatagtgaa aaaaagcaag gtaccaaatg atgtgtagga 261840 catcttacca tttttgttaa ataaaatgaa gtgtggtggg aggaagaaca tagacatgtt 261900 gctggcatgc gcaccagcag cctccggaag gaacatatgc tcaaacctca gaacgttggc 261960 tggctgagag tcgggggcct ggggcgctgg ggttggaagt tggggacagg ctgctcaggg 262020 catgggcatc cgtgtttgtt gtctgaactg tggatctttc tttttaatgg acccatgata 262080 attgtatata tttatggggt acatagtgat gtttcagtac atgtaacata tggtgattag 262140 atcagggtaa ttagcatatc ctgccctgtt gcacactgtg caccccctgc cccagtgcct 262200 tttttcccag gctcctgctg gcccccagcc cagggggtgt tgtccccctc acatcattcc 262260 accctgggtg tctggcaggc tttgcagctt cactgctggg ggcctccggc tgccgtggta 262320 cctgctggca cctgtccttc cctccctgag gccacactgc ccttcctcct cccttcgtga 262380 cggagtgagc tgggctttgg agtgggtcag gactggtggg aacaaggttc tgacttgggc 262440 caggggcagg atttacctcc ctaaacccat cggatcctgt ccatgagaca ccccaggagt 262500 ggtgaggggc gtctctgggt gggccttcct tagcaccccc gggccctgga gctggtgcct 262560 acgtagcccc tcagcctgcg ccagcctgcc tgaccaggcc cccgtctgtg ccctgctctt 262620 ccttgagccc gcagtccgtt ctggctcctg gcctccccac cgtctgctgc ccctgatgcc 262680 tcccacccta ggtgtgtagg ggcgagttag aatccacact cctggccggg cacaccggct 262740 cacgcttgtc atcccagcac tttgggaggc ggaggcgggt gaatcacccg aggtcaggag 262800 ttcgagacca gcctggagaa cacagtgaaa ccccatctct actaaaatac aaaaaattaa 262860 ccaggcgtgg cagcacgcgc ctgtagtccc agctactcag gaggctgagg cagaagaatc 262920 acttgaacct gcgaggtgga ggttgcagtg agccgagatt gtgccactgc actccagcct 262980 gggtgacaga gcgagactcc atctcagaaa agaaaaacag aatccaggct ccctcccggg 263040 cggtgcagca tctcacgctg ttctgtagag gaattggaag tagcggaata aacgacggct 263100 tgtggctgtt aaaccaaacc gacggcagcg ttggagcgtg ctctctcccc agctgcgtgt 263160 ccactctcca gagactctca catgcacccc acacacctca ccgtgagcct gtgcatctgt 263220 tgctattcag gagatggaag tgacaaaaaa atgagagaac ttgagtttgc aaagttagag 263280 tgctgtctgg cctggcagct tcaggcttcc aggagagagg tctctcccgc agctcccagc 263340 ccagggcggg ggtgctgcca ggggtggtct caggggcctg ggctggggtt ccccacacac 263400 ctgggtgcgc tcgtgtctgc tgaccctcta tcctttgctt tctcctagct ggagatggag 263460 ctgaagatgc tgaagtctca gtccagctct gccgaacaga gcttcctgtt ctccagggag 263520 gaggcggaca cgctcaggta cgtcccccag agaggaggcg gacacgccca ggtgtgtccc 263580 ccagagagga ggcggatacg cccaggtgtg tcctgcgggg gaggaggcag atacgcccag 263640 gtgtgtcctg tgggggagga ggcggatacg cccaggtgtg tcccacggag gaagaggcgg 263700 acgtgctcag gtgtgtcctg tggggtgggg ggaggtgggc acgctcatgc gtgtccccca 263760 ggaaggaagt ggacatgctc aggcgtgtcc cccagcgggg aggtgcgcac gctcaggtgt 263820 gccctttcca gaggagggga gtgcgggaga cacgtccacc ggcagcctcc tgtccccctc 263880 tccaggccgt gaccttctct gtgtgctccc ccgtgggtgg ctggagtaaa gtcttgctcc 263940 tctgctgcct tcctggaagg gcttttcttt gtaagtccca tcccatccac ctaggttcct 264000 ctctgcaggg acactcgtct ctgctggtgt ggccctttct tcagcagcac ttctccagcc 264060 agcactgaca gcaggggtct ctcagtgtcc ctgacgctca gaagggagca ggtcctccat 264120 cagggggcgg cgctggagcc gggtctgcag ccgcaggggc tgcatggcag tgctgtgccg 264180 agatggctgc acgggagtgt ggctcagagc agagcccagg cagtgcagca gccaggcgtg 264240 tccagcagcc cttgggctcc gcttcagaca tgctgccagc tctctgccac tgcactgtcc 264300 taggccaccc tcaccccagc tcctgcttgc acacggcgcc cctagagcag ggtctgcagg 264360 ccgggctgct tttctagagc tctctgcctc tcccccgcct tgtggaccca tcagggtcct 264420 caggcaagag gtttccaggc agatgcaggt ggagctccgg gctccgcttt ggtgcctgtg 264480 ttggcgctgc cccatccagt gcggattgaa agtggctgtg gggcaacccg agtatcctgc 264540 cagaatccaa tgtgggaggc ggtggctgtg ggcacagggt ggggtggcag gaggcccatg 264600 gctttcctgc attggccact cctctgctct gagtgtctgc agcaggccag gccctgggca 264660 tccagggttt ctcctggtca tcagaggaac tgagaacagg ggactgagac agctccaggg 264720 gacatcaaat ggccctgcag tgagatgggg gtggcagtgg ggagagagca cccttcctag 264780 gccacacagc tttggtgtgt gggcccctgg accccccgcg gcagcagcct ctgcttcgtc 264840 cgtcacaccc actccctggg gttccagttt tcacctgtgg atggcccctc tttctcaggg 264900 ttgccgagag taaagcagga aaagggctgc ctttagtgtg gccccggccc aggaagtgct 264960 ctgcacatgg cagctatgat gccttctaga ttcgatgttc ctccagcgtc tctgaagcat 265020 tcctcatgca tgggctgtgc cttacacatc gccctctctg ggatctgccg gagtctgagc 265080 ggtttcattt acatctgctc agccgttcaa gtgttcagat actgagtgtg tgccgtggcg 265140 tccttagggc cgagcatgga ggctgatgga gtggtgagtg ggccccgacg cgctctccgt 265200 cttcatctgc gtctccatgt ctcggggacc tgggggccat tcttcaccta gaggctctgt 265260 cgttacagcc tgtgaggtgc acgtggtcct gtgacagtgg atgtctcccc ctggaagtgc 265320 gtctgcgtgt ggtcttcggg ttgatggggt tgggggctgt gtgtgagtgt gggtgtgggg 265380 tgggggaagc tggagaccgg gcaggtgcca tggtgagcat gcagtctctt tcctagcagc 265440 agtgggaggc actagaggct ttaaagtgga agaatgtgac tggagaaagc actggctgcc 265500 aggcctgggg aggggaagga gagtggcaga ggggccgtcc ccaccacctg ctcaccaagc 265560 attggtgctg ggagcccctc cgaagccgga gttggctttt cctttgcaga gatgagcaaa 265620 atatgcctcc cacacacacc ctgacttgca agagcagccc cacctgggga gaaagaccct 265680 tgccacacag agcagcgggc ctggaggcct cggagagggg gtagtgtgta gtgagacaga 265740 aggaatggcc cagaagggca gcccaggcag gtcaggagct caccaaggcc aaggctggat 265800 gacgtgccag acaggcttca atgtgtgtct gcagtgagag ggggagctgg gaccagcagc 265860 agaggccaca ccttgtcatc atggagaaag ggcctctgga ggcacgcggg cgcaggggga 265920 gaggccgtgc acagcagcgc atcgggaagg tctgggctgg tgtggctggt gcctgaccct 265980 gcaaggtcct gaatgccacg cgaggcaggg tggtctccac cgttgtcctc cagtccccag 266040 gagccacgtg ggaggtggtg gagtaggttc ttaaatctgg ggagttgcag ctgtggcttc 266100 cagcatctgt gaaggtttca ggaaggtcag cgtgtcccgg cccgtggctg cccacgcagg 266160 agcctgcgtc acgctgcacg gctccccgct ctctgagatg gcactctgct ttctgctggg 266220 ccttttggca cctagaacct ctcgttctgc agttgatggg agcatggcca ggcgtgtgtc 266280 agatttgtgt gggctggcat gcttggggtt tattcatttt tacaatttaa gaaaaggcct 266340 ttatcattga tatcttttac atcaaggtca aagcttctcg tccccaccat tttgtttgga 266400 gcccttcagc ctgccactgc actgtgggag cccctctctg ggctggccga ggccggagcc 266460 ggctccctct gcttgcgggg aggtgtggag ggagaggcgc aggcaggaac tggggttgcg 266520 tgcgtggtgc tcacaggcca gtgcgagttc tgggtgggcg tgggcttggc gggccccaca 266580 ctccgagcag ctggccagcg ttgccggccc cgggcagtga ggggcttagc acctgggcca 266640 gcagctgcgg agggtgcact gggtccccca gcactgctgg cccatctgcg ctgcagtcga 266700 attctcactg ggcctcagcc gcctccccgt ggggcagcgc ttgggacctg cagcccgcca 266760 tgcctgagcc cacacccacc cccagccgtg ggctcccacg cagcccagcc tccccgacgg 266820 cgcggccccc tgctctgcgg cgcctggtcc tattgaccac ccaagggctg aggagtgcag 266880 gcgtgtgacg tgggactggc aggcagctct gcccccagcc cggcgtggga tccactgtcg 266940 gaagccagct gggctcctga gtccggtggg gacttggaga aattttatgt ctagatagag 267000 gattgtaaat gcaccaatca gcaatctgtg tctagctaaa ggtttgtaaa cgcaccagtc 267060 agtgctctgt gtctaggtaa tctggtgggg acttggagag cttttatgtc tagctaaagg 267120 attgtaaata caccaatcag caccctgtgt ctagctcaag gttcgtaaat tcaccagtca 267180 gcactctgtg tctacctcaa ggtttgtaaa tgcaccaatc agcactctgt gtctagctaa 267240 aggtttgtaa acgcaccagt cagcaccgtg tcaaaacaga ccaatcagct ttctgtaaaa 267300 tgggccaatc agcaggagtg ggtggagcca gataagggaa taaaagcagg ctgccagagc 267360 tagcagcggc aacccgctgg ggtccccttc cacgctgtgg gagctttgtt ctttcactct 267420 tcgcagtaaa tcttgctgct gctcactctt tgggtccgca ctgctttatg agatgtagca 267480 ctcaccacga aggtctgcag cttcactcct gaggccggca agaccacgaa cccactggga 267540 ggaacgaaca actccagacg tgctgcctta agagctgtaa cactcaccat gaaggtctgc 267600 agcttcactc ctgaagccag caagaccacg aacccaccag aagaaagaaa ctccgaacat 267660 gtccgaacat cggaaggaac aaactccaga cacaccatct ttaagaactg taacactcac 267720 catgagggtc cacggtttca ttcttgaagt cagtgagacc aagaacccac caatctcgga 267780 cacaggagga ccagggatgg tcctcacaca cacatgcaca gccacacatg tgtgcctgct 267840 cttgcccaga tgcacactca cattttcaca tccatttatt tgttgtatgt gaatgacatg 267900 tatcacatag catcgttttt caacactgaa gctagagaga gcgtcggtgg ggatttttaa 267960 gaggcagcag ctgaggagcc ctttcagcca gaacaaatct gagcccgtcc tctctgctgt 268020 caaatagcag ctctagcaaa tcctaaatgt tgcctgtaga ttcagcaact ggttagacgc 268080 ttgctaattc cagaggcttg cctatctgtg ccagtgcctg ctagtcacac tcggaccctc 268140 gcttcccggc cgtgtgatgt cttctgggtc ccgggaggtg ctgggggccc tggagacgcc 268200 ggcctgcctc aggggacgag aggtgaccca tgaccccact cacccgaggt ccccactctt 268260 caggacactc tgtgatctcc actcacaccc cagggaccca gtgcccaggc ccacgtcctt 268320 tccagagggc caggtgctag acttttaatg ttcttttgta gaaattatca tctttcatcc 268380 aacaaatctc cattaaacac cgctgctcta agtcccctca tgaaactaca tagaggtaac 268440 tggaaagaca gtccctgcct gccaagcttc tagggcagtg ggttgatctt tgagctcacc 268500 gtgcccagcc caggccgcca gggagagttc agcctgggaa agtggaactg gttttccctg 268560 gttctgtcct gttctgcagc cgctcctgct gcccaccgtg gagaacctgc tggctgggcc 268620 gggtctggag tacaagtgat tggtcccatt ggaagggcag ctgtggctgg aaagaggtca 268680 ccctcagatg ctatggtccc aggtgggaag gcgtggcccc gagggggcct ggtgatggac 268740 tgcccagccc atctggggat caggagccca gggcaggacc tggggagcct ttgtggcctc 268800 attctccctc ccccgagcag cttcaggagc aggctgaggc agccaggtca acagggtgaa 268860 ggctggtgag ctgcctccac ctggctgggc agcactgtca gcaggcccgt gaccaccaga 268920 gctgtcccca gcccactgcc tggctgccgg tagcgacagc ggcccctgcg cctgggctct 268980 gcaggtggtg ccggtgacca cagccagtga aggcaggtgc gctccccagg tccggcctgc 269040 agcttgggtc ctcagggccc tgcctgcctg ggtcctgtac cccggacctg cttctttctc 269100 tccgaaagcc tgcccacctc ccctggtccc ctggtcccca gcatcctcag gttacccgaa 269160 cactctggcc ggggcctgct ctgtgcgctg cattgggcac tccaggcctt tccttctggc 269220 gtctcacgcc cttccgctct tgagagcttt cctggctctg ttcactgatc atttcctctc 269280 ctctgttttc tgtgtcttct ttctgaaact gttacttgga tgttggattt tcgaatagtt 269340 ttctctctct taaatctttt tgatcctatt ttccttattt ttgtcctacc ttctgtattt 269400 tctcagcttt gttaacctgt tcttatttta tttgttgcta tactcttcgt ttcctgagag 269460 tctgtttctg ttctctgagg attcttttat gtataaagca tcctgtcagt gttcatgagt 269520 gcagtggggt cactgtgtct ttgatgttaa taatagtgct ttttggagtt ttcttctcct 269580 agtgaaccct gttctctgtt gctctaagtt gctgtttttc tgccagtgtt ggaccttact 269640 cttttctttc tggatgattt ccttaagcgt ttggtggtcc cagctgcctg tgccagggtg 269700 ggtttgccct gtgcttctcc gaggaatccg gctgggtctt ccactgggga gcccttggga 269760 ggggcctctg atctttcctc tccagcctgg gtgactctgg cgtgggggcc tgtgctgcca 269820 gctcctgggg gctgagcagg gaagtgtgtc gccaatgcag gactcctctt gcggtggggc 269880 accctgtccg tgccttacct aagggcctgt ctcagcccgg agatcttatg caggatgtgc 269940 agagtgacat gcaggctcct gcccttcact cccagaagca gaagccagca gagtgccctg 270000 tccccgccca gcagcatcag cgtggcccct cggggagcgc gtctcctgcc ccagccttca 270060 gcagccggca ctgctcctgt gtctgtgctg ggcagggtca gcagggctga tggcagggac 270120 cttggtgcca ttcagcagag gcaggcccag ctctggctct ctggtccagt agtgttgcca 270180 tgcccaacag ggatcggagc ctacacctca cccagcaccg aggcagagca ggatgtggag 270240 gggggtcttc aacccccagg accccatgtc agaggctcag cagggccttc cccacaccct 270300 gcagcaggga ggctgccgct gcccttcatg cctcctgtcc gtggtggtgg cgagacaggc 270360 aggggcccag ctcgcacccc cctgtctgtg gtcctcgtgt gtggggtaca cattcccgct 270420 ctaggggctg agctcgtacc cagctgtctg cggccctcgt gagcaggtac acattcccca 270480 ctgtaggggc ccagctcgca tccacccttc cgtggccctc gtgagtgggg tacgcatccc 270540 cactctaggg gcccagttca cacctgcctg tctgtcgccc ttgtgagcag gtgcacgtcc 270600 gcactccgcg tgtaccagga tggtgtccgc caggtctgtg cggtggcaga actcccactc 270660 tgcccccagg tctggcactc ctagatgtac acaagccaaa taacagttag aaaacccagg 270720 acgcagaagt gtctgggatg aacagagaat cgggcagatc tacatttaca gttgagaact 270780 cacacctcag cctccacgac tgacggaact gagtgtcctc atcagcccgc aggacctaat 270840 cagtgtctgt ggaacaccct gtccgagagc agaggactct tgcctctgca ttcacctggg 270900 acagtcacaa cagatcacat cacgggtcat caaagagacc ccagtaaatt cgaaagaatc 270960 gaattcactc agactgtgtg ctctgagtgt aatgaaccca aactagatgt cagtaacaga 271020 agaacaacag ggaagtctct aagcattagg agattagcaa cacatgtctg cattgcccgt 271080 gtgggggagg aggtctcccg gtacaaataa gtacactggg caataatgga aatacacaca 271140 tctaagtaag tggggtccag ctagaccggt gctgagaagg aagtacgtca tgctcagtgt 271200 tcacgttgag aaagaggaat ggtctcttaa tttatgttcc tatctcaata acctggagaa 271260 aggagagtgg aatagcccag agcaagcatg gatgaaggaa ataacatgag caaaaagcaa 271320 tgaaattaaa aaaaaaatag agaaaattat taaaacaata agttctggct tttttggaaa 271380 aaaaattcaa taaaattgac aaatctctag caaatttgac aaaaataaaa agacaccacc 271440 aaaatcatca atatcagcaa tgaaataggg gccatcacta caggccctgt agccattaag 271500 cagagggtgt tatgccacaa acaacttgaa gcagcggact cactcctcag aacccacaag 271560 ccaccagact cgaccaagat gaaataggtt atctgaataa tcttgtaaac tattttttta 271620 aaaaaaattg aagtcataaa gatgcgaagg atatccctag gcccaaatgg tttccctaga 271680 gaaatctacc aaacagttaa taattaagat caatttgaca cagaaaattg aagagattgc 271740 tagggtttag gcacgggggt gcatgtgtgt acaaaaggac agcggggcga gccttccggt 271800 gtcaggacag gcctgtgtct ggatggcagt tgtgggcgca cacatccaca catatgacag 271860 atcacgtggg agtagacatg gagggaagtg tctgtgagct ggcggcaggc gagcagtctc 271920 tggattgtac ccatgttagt tgtcccgttt ttgatattgc tgtttaagtt gttaccatcg 271980 agggagattg ggtaaagagg acacggacct ccttgtacgt ttcccacaaa ttgctgtgaa 272040 tctgtgatga ggtcttcatt ctgttttaaa ggtctccagc cagccctgca gttccagcgc 272100 tccctcctcc ctgcttccgg aaattgttgc tggggtgggt atccctgaac ctggggagct 272160 tgtggtgtca aagcttcttg gctgttccat tgctggcgtg ggattcagct tttctggggt 272220 cgtttgccac tcatctgtct ggaagctttc cagcttccat tttaaaggct atttgatgct 272280 gtgccttctt ttctttgtct tcaggtaaat gcctcaaaaa aagtaagcaa aacctttacc 272340 cttgttttac cgggattttg agagagatta cacttaagtg cacgtgttca agctaccgtc 272400 tttaactgaa gtctttgatg atttttccgt ttatataata tatattttaa gtgaaacaca 272460 catcatttgc atcctgtttc tccactatat attataacat aaacacttcc ccatgttttt 272520 ataggttttt gtaagtctta atgtatagtt gattaacccc ttttggagct tgagtggttt 272580 cgcgttttca cctagtgaga atgaaggtga actgttggcc atgttttgac ttctgtgcga 272640 gagaattctg tgtgtctgga aagaccaact gtagcctgta ggagcctggc tgcactgaga 272700 aatcccatcg cttgtgtttc ttactggtga cggcaacagc ccccagcagc agcggtggcc 272760 atgattgcag tgagaggcaa gtgatgtttg tgcggggctc actgtgggcc ccgcatggca 272820 ctgcgtgcat ctccacgttg atcgagttct aactgcgggc ctgagacggg gtttaaggat 272880 attcactgta ttgaggtgga actcgcacac cgaagggctg gctgtgggcc ccgggtggca 272940 ctgcatgcat ctccacacta ctgaattcta actgcaggcc tgagaaggag tttaaggata 273000 tctactgtat tagcgcaact cgcacacaat ggaagggatt catttaaacc tgagttcatg 273060 gtcggcgagt accaagggcg ggcggtggta cccttatccg gggagcaggt catagaggct 273120 acattatctt cagagtttta aaacaataag taaataaaag tggatgcact tcttaccacc 273180 acatgcctgc agttctaaag aatgccagca atgatctaca attctaccac cattccccca 273240 ccagatgcca ccgtcacgtc tcaatagatg tatgcacaag catgcagcca ccacagtaag 273300 atataggaca cagcccagca ggtgtttaaa ttttttactt ttaaaattat ataataggct 273360 gggcatggtg gctcacgcct tttatctcag cactttgaaa gaccaaggcc ggcagatcac 273420 ctgaggtcag gagattgaga ccagcctggc caacatagcg aaaccccgtc tctactaaaa 273480 atggaaaact tagctgggcg tggtggcgcg tgcctgtaat tccagctact tgggaggttg 273540 agacacgagg atcacttgaa cctgggaggt ggaggttgca gtgagccgag atcgtgccac 273600 tgcactccaa cctgggtaac agagtgagac tgtctcaaaa aaaaaaaaaa aaaaaaaagt 273660 aaaaattaaa attatatagt aaaattaact tttttcttat aggatacagc tctatgaact 273720 ctaatcaccc tgtaatcaga gtgcaaaata acatcaaccc ttcaggaatc ctccatggtc 273780 cccctttcca ttcacccagc cacacaggga cctcccggca gctgcacatg tctgctcaac 273840 tctgcggctc ggctttttcc agcccagtcc tacaacatgc agtcttttga gactggctcc 273900 tttcattcag cacaacgccc tcgagcgaga tccatccagg ttgtttgtgt ataaaagtca 273960 gttccttttt cacttaggta gctttctcat aaattttgag gtcaggagct atgagtctcc 274020 ctggtggtgg ttctttttca gggggtttga ctccgctgac gggtaaacag tgggcagtct 274080 tcttctccct gacacagatg gctttacatt tacttaggtt ttcttccatt tcttttagca 274140 atgtttggca gtttttaggg tacaaatctt atgcctcctt gggtaaatgt attgcagagt 274200 gttttgttct ttttgatgct gttatgaatg gaattgtttt cttgatttcc ttgtcagatt 274260 gcttgttcct aatacaggga aatacaactg atcttttgtg tgttgacttt gtattttgca 274320 actttgctga ttttgtttat tgactagaac aggttatttg cagcttcttt agggttttct 274380 gtagcctggc atctgcaaag agagagaagt agtttcactt tttcttttcc aatttggata 274440 caatttattt ctttttcttg actaattgtt ctggctatgt tgaatagaag cagcaaaagc 274500 agacattctt gtcttgttcc tgatttaggg gaaaagcttt tagcctttca ccattgagat 274560 tgacataagc tataggtttt ttgttttatt tatttattta ttatttttga ggtggagttt 274620 cgctctgtca cccaggctgg agtgtagtgg caccatcttg gctcactgca acctctgcct 274680 cccgggttca agtgaatcct gcctcagcct cccgagtagc tgtgattaca atcatgtgcc 274740 accatgcctg gctaattttt gtatttttaa tacagatggg gtttcatcac gttggccagg 274800 ctggtcttaa actgctgacc tcaggtgatc cactcacctc ggcctcccaa agtgctggga 274860 ttacaggcgg gagccaccac acctggccaa cagtcgattt tttgaaaaga tggaattgcc 274920 acactgttta ccagattcaa taggcaagtt gcggaaattg gacggagagt tctcataccc 274980 tcttcacccg gtttctctcg ctgttgacat ctcacgctgc catggtgctc gtcaccggcg 275040 tgtgactctg ggcctgtctc cagcccttgt ttggatccac caggctttcc tgcatgttgc 275100 agccagggca ccgtgttgat tttagtcgtc acatctcttc tgccgctggt cggtgacagt 275160 tttgtctttc ctcgcttctc ctgacctcag tatgtttagg agtccctaga acgcccccga 275220 agcgagcttg tgtgatgtgt ttcattgtta acctgagatg gtggtttttg gaaggaagat 275280 cacagacgac aagtcctttc tcaccacgtc ccatcaggga gcccctgaca tccacgcaac 275340 agcaggtgga cctgaccgct ggactgaggc gttgacagcg gacctgactg ccggactgag 275400 gcgtggacag tggacctgac cgctggactg aggcgttgat ggtggacatg accgctggca 275460 ttgacggtgg acctgaccgc cggactgagg catggacagt ggacctgacc gctggactga 275520 ggcattgatg gtggacatga ctgctggcgt tgacggtgga cctgatcgcc ggactgaggc 275580 atggacagtg gacctgaccg ctggactgag gcattgacag tggacctgac cactggactg 275640 aggtgtggac ggttgacctg accaccagac tgaggcgttg acagtggacc tgaccgctgg 275700 actgaggcgt tgatgtggac aagaccgctg gtgttgacgg tggacctgac cgccggactg 275760 aggcgtcgac ggtggacctg accgccggat tgaggcgtgc tctgccgggt gcctcgtccg 275820 cgaagctgtt tgcactttct ccagtctctt ccttggaagc gaatccctca gggcacaggc 275880 gacgctcccc ctctggaggg atgagttcta catgtatgat gtggagttct gtgagggagg 275940 tgtctcctct tccccattta ttcacttctt catttattac cagcagtgtg gactggaggg 276000 agtttgccac gtgctctgtg ttctgatctg gtgcacgcac caggacttgt ttattaccag 276060 cagtgtggac tggagggagt ttcccgcgtg ctctgtgttc tgatctggtg cacgcaccgg 276120 aacttgttta ttgccagcag tgtggactgg agggtgtttg ccgtgtgctc tgtgttctga 276180 tccggtgcat gcagcgggac ttgtttcgct gcgtgatctc cccgcggccg gccgcgccct 276240 gctgtgcccc gtcattgggt tttctgagcc cttcctcact ctctggcacc acagggtgct 276300 ccagactcac ctcgtgtcct ctgccccagc tttccaatca tccgttcctc cagggagccc 276360 ggagccttct cttggcagca cagtcctgag cagcccaggt cagggtctgg gtatgcctgt 276420 ggctcctggg acggcactgc ttctacaccc tcccgccagc tgcctttacc gtagtgtttg 276480 cgtgctgtaa atatttctgt ccttttactt gcagcgtacc tgtacccgtt ctttgagttt 276540 ctgtatacat gatgtcatcg ggtcagtttc taaaccatca tggcaatctc tgtcttttca 276600 ttgctaccat tttattattt gtttgtgtgt ctcctccatt tttgtttttc cttttcatgc 276660 ttcctgcttt ctgttgagtt acttgaatgg tttttagtat ttcattttaa tttagcagat 276720 gggcatctga ctatttctca gtctgatgtt ttgagtgttt gctctgggaa ttagagtact 276780 tatcactgcc tactgagaat cagcctcatc ccacttgaag tcacacctgg aagcccctcc 276840 cggcaggtcc cttgccctct cccttcctgc tgtccctcta cctacatgga aatgccacag 276900 gttttgtttt cagtcataca gtgttttgaa aagggcagta agagacccgg gtattatctg 276960 taagcccaga tagctgccat ctgttcctcc ttcattgtcg atgctccagg tatccttcat 277020 gtcctctttc cttctgaagg atttccggca gcctctcctg gagagcaggt ggctacgatt 277080 cctcacggtt tccctcgggt gggtccgtct ttattcctct cgtgttcctg aaggagctct 277140 gccctgcgca cgcagcgcgg cccgcggccc tcgcctccca gcacgccacg attgcggcgt 277200 tcctcctcct caccgcggtt cctgcctggg gagagatttg cagacgctcg aatcgctgtt 277260 ccctttgagg tcacacagtt tttttctgtt ttcaccattt tttttgcctt cagttttcag 277320 cagtttcgtt tggatgtgtc tgggtgtgga tttctttggg tttattctgt ttggagtttg 277380 ctcagcttct tgaatctcta gggatttttt ttgttttttt tttttttttg ccaagtttgg 277440 gatatttcag ccatttattt ccttaaatac tttttcagca attcactttt ctgtgaattt 277500 gctgagacct ttgggtttcc gtgtgctgtg agagcgtgca cactcgtctg catgggccgt 277560 cttgtggccc ctctccgccg cacttcccag ataacccagc cccatctcct cagccccagc 277620 agctggaact gcctctctcc aggctgactt gaaatctctg tggttcttca tgtgccgagt 277680 aatttggggt tatgtcctga gcattgtgag aagaggtttt gtgtttaagt cctgtgagaa 277740 atgagagtgt tttagtttag cagtgagccg acctgggtgg tttctagccc aggtcccagc 277800 gaccttctgt ggggcgcggt tcccatccca gttcaggttg tgaagccttg gcagcgctcc 277860 tggccttggc ctgggacatt ggcagtgcct gtcagcttag ctatcatcag cttcagaggc 277920 cagtgtggat gggacccagg cacaggccaa cccagggacg ccctcagctc tcaccggctt 277980 cagatgccag tgtggatggg acccaggcat gggccgaccc agggatgccc cccaactctc 278040 caggactacg cttttcagtc cttccattct gtgatcttcg ggtcctttca cgtttctggg 278100 tctccccttt gtggtcctcc agggacgtgg ggctctcttc gcaccgtctg ttgcactttg 278160 ctggtgtcat ggaggttggg cccacgcccg gccctgcagg agggaggaca gggaggaaaa 278220 cgcagctaga gtttgtcctg cccatctgga acgacagcag cttcagacag agagcacggc 278280 tcctgcctca ggctccctgc cgccactgca gccctgtggg ctgagcccgt ggtagtgtgc 278340 gaagagcaga ggcaggggcc acgggggccg gggagtccat actccgagca gggagggtcc 278400 cacgctcctg aagctcagtg gctttctttt ccggccccca ggtgagtgct ggaggacttc 278460 gccttgagct cctggtacag cagcctcacc actgcctgga tggtggcacg aggttgaggt 278520 caggggatgc gagagaagag ccacgatgtt ccctacccac cagtgcggtg ggccttccag 278580 agccgggcac gtgtccaggc attgtagccc tgtctgtggg agaggaaggg caggcgtggg 278640 cacccgtcac actgccatgt ctgcgcggct ttgtcacgtg ctctctttat gacaaacaag 278700 cctggagggg cgaggtgctc cgtgtcagga cacgcagcga gtgttgggtt aagctgggcc 278760 ccacccaccc ttgtgtgacc atctccaggg ctgggggtcc tacgtacccc actcgccagc 278820 ctctctggtg gggttcccac acccgttgtt caagggaaat ggtcatcaat gcctgctgtg 278880 agccagacac catgatcagg gctggaaacg tggagctagc catttgatga aggggacaga 278940 gaagtaaaat gtgaagtgtg gtggtcaagg cccactgggg aggggctggc gggcagtgca 279000 ggggtctggg acccgtggga ggctggcctg ggtgaggggc ttcctggact ggatgctgtc 279060 tgcccgttgg gcctcgggtc tccctactgt cccctctcca ggccccagga gcctcacctg 279120 cggcacccag gcctcccgcc cccattatgc atcttttagt tcagcaaaaa caactaatca 279180 tttttcttgc aaaagtttcc cccgtgtgtg atgggtttgt tataagcaag atcccggcta 279240 ccctccacct gctttccacg cacacgctcg gagacaggca cctgctttga ttggcgtcat 279300 cttctcgagg aaagatctag gctggcagct aatttatgta gcgctcctcg tgtttaaaaa 279360 agttgcagta agtcaatttc aagaagctta tgccagaact gattgctttg agccatttga 279420 aggcaaacca gaattctgag cttttgagca ccatcccccc aacttgttta ttcgtttgtt 279480 ctctttctcg ctctctgtgc ggtagcagtt tgtctgaaag gagggcagca gaagaaagcg 279540 caccccttcg gtgcacaaat gagcccgcat gtgggcttgc tgtctggcgg cgagggtggg 279600 tcacgcaggt cattctgtta acatggctgc agctacacgc gtgcgctcat tccaattcag 279660 cccttgaaag cattttgctc ccaagccttc agaatccata atatcatttt aaaaggggcc 279720 ttttcatcca gcgtctccct aagtcaagaa gcccctgcag aaggcagctt ctcggagatg 279780 gccttggagg cccccaccat gtcgtcactc atcaccttgg gcaggttcac tcccctatga 279840 agccctggga ggcgagggtc aggaacaccc accctgggcc ctcggccagg ccccttacca 279900 gctctgtgat caggggcctc tcagatggct ttctgagcct cagtctcccc tttactcagg 279960 caccaggact tccctgctag attgatgtga agactgaggg ggttgtttgt aaagccacag 280020 cacttgcggg gctcccaaaa cctctccagg aggcatcagc tggtgccgga ggtgtgtgct 280080 aggtctcaca ctgcacggcc accctgccga gagacggtga cactgggctg tgctcagatg 280140 tctcccctgc cggcgctccc tgcctcaaga ggagcgaagc attgttgctg cagaagtacc 280200 ttctaggccc atgctcagga tgttggtgtg agtgggagtg ccccagacac ccagggaggg 280260 cagcgcacgg cgtctgctgg gatgacagag acacttgccc ctggccagca gcctcgcctc 280320 cggaagcatg tcctgcaggt gcgccgtaca agcaggaagc agatgtcaga ggtcattcac 280380 tacagtatgg tttttacagc tttcctgagg tataactggt gtgcagtaag ctgcgcgatg 280440 tcaagtgcag tgtggtgaat ttgcatgtac acacacatac acccatggag ccgttaccac 280500 attcatattc aagaccccca gacatgtgct cttgtttgac aggaatccct cctccctgcc 280560 tcctctcccc accccaaacc cgccgacgtg ctttccatca ctgtagattg gcgggcggct 280620 gtcgagtctt ctgggcatgg cgttggtcct ggagcatgtg gtctccctct ttttgcttct 280680 tccacgcagc atggctggtt gggggagaga tcactgtgca cacagctgtg ttgtcttcac 280740 tgctgagttg tgttctgtcg tatggagaca ccagtttata cgttcccttg cgatggacat 280800 ttggagtttt tctggttttt ggctattctg aaactgctgg atattataaa taaagtccca 280860 tgtagaaatc gacttcgttt tctttcaggt aaacgcctag tgtggagtgg ctggcggtca 280920 cgtgtgtaac gtgttccgag gttgcccgtc ttccagagta gttggtgtgc agcttctcct 280980 caccagcatg cagcacagtc tttttcctta gtccctcttt tattttttta aatgtttctt 281040 ttacagacag ggtcttgctc tgttgcccag gctggagtgc agtggtggga tcatagctgc 281100 ctgcagcctc tgactcctgg gctcaagtga tcctcccacc ccagcctcct gagtagctgg 281160 gactacaggt gtgcaccacc acacccggct agttttttaa aggttttcat ttaggctttc 281220 taataggttg gcagtcatgt ctcactgtgg ccttttattt tttatttcac aaatgactaa 281280 tgatgttgaa catcttttca ttcagctcac ttgtcatctg tagatcttct ttggtaaagc 281340 acctgttttt ttgtccattt taaaatttga ttatttttct tactgttgag tttgggagag 281400 ctctttatat gttctggata caaggccttt atcagattat ttgctttcca aatattttct 281460 cccagtctgt gtcttgtctt ttcgttcttt catcaggtat tttgaagaga agttttttta 281520 tgataaagtc caatttttca atgttttctg ttatatatga tcctttggat attagtccat 281580 tttcatgctg ctgataaaga catacccgga ctgagtaatt tataaagaaa aagagattga 281640 atggactcac agttctacat ggctggggag gcctcacaat catggcagca ggcaaaaggc 281700 acatcttaca tggtggcaga caagagagaa tgagagccaa gccaaagggg aaacccctta 281760 taaaatcaga tcttgtgaga cttattcacg accacgagaa tggtatgtgg gaaaccatcc 281820 ctgtgattca ttatctccca ccgtgtcctt cccacaatag atgagaatgg tatgggggaa 281880 accgccctat gattcattat ctcccaccac atcactccca caacacgtga gaacggtatg 281940 ggggaaaccg ccctgtgatt cattatctcc caccacaggc ctcccacaac acacgagaat 282000 ggtatggggg aaaccaccct gtgattcatt atctcccacc acgtccctgc cacaacacac 282060 gagaatggta tgggggaaac cgccctgtga ttcattatct cccaccatgt ccctcccaca 282120 acacacgaga atggtatggg ggaaaccgcc ctgtgattca ttatatccca ccatgtccct 282180 cccacaacac acgagaatgg tatgggggaa actgccctct gattcattat ctcccaccat 282240 atccctcccg caacacatgg ggattatggg agctacaatt caagatgaga tttgggtggg 282300 gacacagcca aaccctatca ggtatcatag ctaagaaatc tttggctgtc ccaaatttac 282360 aagattttct cctgtatttt cttttaataa ctttgtaact tttggttcag gattgagcag 282420 gattttcatt tattgtacaa gattttaatt ctttatttcc cccaagaaca cccagttgtt 282480 ccagaaccat ttgttgaaga gtttgtcctt tctacgctga attgccttca tatatttttc 282540 aaaaattggt tgtgtttgtg ctcctatttc tggactctgt tttgtttgat cggtctgtct 282600 gtcttgcaga ccagtactgc actgttgtga ttactacggc tttaacgtag ttggtgaaat 282660 taggtagccc ctcctttttc attgtcaatg ttgttttctc tattctaggt ccattacatc 282720 tccatatgaa ttttagaatc agcttgccaa tttgtacaaa gaagcctgtg ggattttgac 282780 tgaggttgct gattctgtgg attaatttgg gggagaagtg cgttcccaac acccagagtc 282840 tcccagcctg tggacaaggc ctctctctct ccctgtgtgg aggttgccct ggagctctct 282900 tcacagtgct cggagcttgt cacgtgcagg tttttcttgg cctgttccgt tccatctctg 282960 tgtatttcat ggtgttggat gcttttgtca gtagtatttt ccagatgact ttctggtgct 283020 gattgctagt ttaattccat gatggtccta taacatagtt agaattatga aattcctaaa 283080 tagactgagc cttcttttat ggtttagcat gaggtcttct tggtacatag ttcaagtgct 283140 cctgaaaaga ctgggtctcc tgctcttaag agtcgaagca tttatccagg tgaaataggt 283200 caagttggct gatcatgtgg tccttgtcct cctgattttt tgcccgttgt tctatcagct 283260 attgagagag ggatactgaa gtctcagatt gtcattgagg acccgtctat ttctccctgc 283320 atttctggct ggttttgctt catttgtttt gcagctcttt tattagcaca cacatgttta 283380 ggattattat tttcctttga ttaatcaatc tctttattat tataagttac cttcttggta 283440 ataatatgtg ctctgaaatt tactatttct ggtattagta gcgtctctgg ctttctcttg 283500 ctggttttct tagtgatggc atgttatgtc tttttgcatc tttgtattta aagtgcatta 283560 ttgtcagcgg tgtctgattg ggtgttgctt tttaatccag tttgagtgtc tgccttttaa 283620 ttgtggtagt taggctactt acatctaatt tgtttatgat ataattagtt ttgatcttgt 283680 catttgactg ttttctactc atctgtctct tcttcatttc tgtttccttt tttttttttc 283740 tttttacctt ttttcaatcc actttggtat ttttctgatt ttgttttatt tccttttttg 283800 gcatcttagc tataagtctt tgttatttta gggcttgctg tagggtatat agtatacatc 283860 tttaacttac cacagcctac cttcaagtga tattacgtct tctcacacac agtataatca 283920 ccttacagcc acagtgttgg tttttctcct ccagccttta tactgttgtc atacatttta 283980 tttattctat atattaaatc cccaatatat tttcattagt tttgtttaat ctattaatca 284040 ctttaaaaag ttaataattt aaattttttt aagagacctg aatgtaagaa agatcctccc 284100 taaatgcagc tgctgttcca gccctcctgg ttctccgtgc agatctgggt gtatttgccc 284160 cgccccgccc tcgtcctccc tcacctgcag gccttacctg acatttctgt agagcaggtc 284220 ggctgatgat gaattcttta agctttcgtg tctgatctga aggcatcttt atttgcttct 284280 gttttgggag atgttttcac cgttaaggtg gcggttttta tttctttcgt tatttcagaa 284340 atttctccct cctcttttct ccgttgcact gtttctcatg agaaccccgc cttgtgcctc 284400 tgtaggtacc acctctgcct ttaagatggt tttccgtgcc gtggtcctga gcaggcttgt 284460 cctgatgtgc tctggggctg ccagcgtctt ctttcctggg cctgtgttcc ttgcgctgcc 284520 tcgtgtctgt tgagctttct acatctgtgg ctttatcctt tccattgaaa gtggaacttt 284580 cttatagtat ttgtcccgtc gcttcctctg ccttctttct tttggggact ctcgttcatg 284640 aattttatgc ctcatgaagc tgtcccacag ctcagtgatt ctcttttcat ttttcaggaa 284700 tcttttcctc tctgtgtttg tttgcttatt tatttgtttt tgagacaggg cctcgctctg 284760 tcagtgctgg agtgcactgg ggtgatcttg gctcactgca gcctccaccc cctgggttca 284820 agcgattctt atgcctcagc ctcctgagga gctgggacta caggggtgta ccacgacgcc 284880 cggctaattt ttttattttt agtagagaag gggttacgcc atgttggcca ggctggtttt 284940 gaactcctgg cctcaagcga tccagctgcc ttggcctccc aaagtgctgg gattacaggc 285000 gtgagccacc gtgcctggcc tctgtgtttt gtttttgata gtttctattg ctgtgccctc 285060 gaggacatta aacttttctc ttacggattc taatctgtca ttaatcccat ccagcatgtt 285120 tatctgacag gtagtttcca cttctacctg tgtctcttcc gagtctgaac tgttgcattt 285180 ttccagtagt tttaacaact gtctaaatgt ccctgtttgc cagtgttgcc gtctgtgcaa 285240 tgctgcgtct tggtaggtat tcgttgtttg gttaatctct tcattatagg ccgtgtcttc 285300 ctgctgcttt aaatgtctgg taatctttga ctggatggca ggcattgtga attttagctt 285360 gttgtgttct agatgttttt gcatttgtat caatcttctt gatctttttt cagagatgca 285420 gttaggtttc ttggaaagag ttgggtttcc tcgggtcttg ctgttgtggt gtgctgggac 285480 gccctggagc agttctcagg ctggaatagc tgtccctgct cctgtccctg tgcggtgtcg 285540 agtaatcttt ccatcactac aggccttgac agactttttt tatttttaaa ccacatgaat 285600 atgttttcca ttcaaaatat tagatctaga aatgaagaca aaactagaca gctttttaca 285660 gtgaactaaa actggcccca ttccggttgc ggccatggag gtttgttttg tattctattc 285720 ccactgtgga gaagggaact caccatgggt cgcctggaag cgtgcttttg tttctcatct 285780 gaattgtgcc tctgtggtcc cctgtcatca gcttcttcca caccccgcag tagaagtcct 285840 ttcctgtctt ttcctcattt ctgaagatgt cccgaggttg ctttcctgtc cctcagtgtc 285900 ccctgcactc cgccatcaca tcaccctctg ggagtggctg acggacacgg acacactgac 285960 tcccaggcgt cctgcctcgg gctggttccc tctgtgcttc cagccaaggt gtggtcgaca 286020 gagactttct ccgcacaggc tcctccagct gagcaggggc cgccacggac tcccccatcc 286080 tgtacttgtg tcgttttcca attttctctt gatgttatcg ctggactctg agagcttcac 286140 agatatgtat ttagaaataa agctgtatag ctgggtctcc taacctttca cctccttatc 286200 acccagaggg tgggacttcc ccagcatggc tggcctcgga cacctggtca ccgtcttgct 286260 gtccttgcag gttgaaggtc gaggagctgg aaggcgagcg gagtcggctg gaggaggaaa 286320 agaggatgct ggaggcacag ctggagcggc gagctctgca ggtgagggcg gggcagcctc 286380 tgggtgaggc actgcctggg cctctcattt ctttgggcgt cgtgaacgac cgtggttcct 286440 gctgccacag aacacccgtt ttctggctcg tctgtctgaa ctctcctccc tcccatgtgc 286500 acccccttgc ctggcaggga ggccatgccg ctgacaggcc tgcactggct gcctctggag 286560 tcctctgcgg cccgcaccac ccacacgcct ggtgtcggtg gagtgggctc tgggcagatt 286620 tgcactatgc ccacccggga tctgctgtgg cgaggctgga ctgctgtttg tgttctttta 286680 attgtacttt ctctttggtt ttcatcctcc tgagttgctg catggcagga agccctcagg 286740 ttcgaggtta ccgggttttt ggacaggcca ttgattttat cttggcacct gttagaggca 286800 gatcaaatct attttttatg accagtttct gacgatggga ggagtgacat ctgtggtgat 286860 gggcggctcc gagccgcgct ggcctgtcct cagcctagga cctgtcatct tgttttaact 286920 gggccgtggt gtacagggag cggtcacggg gctgctgccc gcccaccaga ggctctgcgt 286980 cagagctgct gaacgtcttt ctgggtgttg ggctgagcag agcctgaacc ctgctccttg 287040 gtgcccacgt tgcttgctga ctgggggcca ggcatccctg caggcaccac ttacggcttc 287100 cctgctccag cttccagccc tttccccaag gtgtcctcag tggccggccc ttggagcttg 287160 ttgaggcttg aatgaggtga ggggtgtggg tgagtgcggt gccagcactg gtgaacacct 287220 gatggggcct ggccaccatc cctgttctgc gcagacggcg tgtgctcggg agctcactag 287280 cggagcactc ctctgtggga gatgccaagg gctgtcaggt accgtggggt tggcatgagg 287340 agtggctggc agtgtcacct gtgaccctct cctgagctct gccagggcct tggaggggtg 287400 ggggctctgc ccctaggcat gtcctgaagc tgctcagagc tgaggcgtgg tgctgcagtg 287460 tggccagtgt ggccatttgg ggagaggaca gggctgggcc tggtggtcct ggggaagcag 287520 atgtttatgc cgtgatatgg tgacctcgag cctagcccag gattcaggag ctgttcctcc 287580 ctgggtcagg gcaacaggga caactgtgcc cggatggcgt gggagaagca agtgcagagc 287640 agtgaagcgg ggaggccact ggggttcggc ctgtggagtg ttggaaactt ccagacagcc 287700 ctccagctgc caccacttct gacaccccct gcgattacac ccttagtggg gggacgtcca 287760 gggtggccct ggggaaggtg aggcctcaca ggccctgtgg tggctcaggc tgcccctggc 287820 tctggatgcc cagggctgtg ccattgaagg aaatactgta aataggggtc catttccaag 287880 ataaagtgcc ttgaaccggc ttaggtcacc aaactacaga agaaacagga tatactaggc 287940 ccctgcttgg atcaccaatg cctgcttgtc ggcctcccgc tcccccctgc caccccaccc 288000 ccccacccac cttacttgcc ctcatccaaa ccaaagaagt ttagtctaag atggaagtta 288060 tactactctg caaaatagtt cgtttcatct gttcttatca gcctgcccag ctacttaggt 288120 cacaagtcaa ataactgaag agcccctgag ctgacgagga ttgcagtgca ttgtgggctg 288180 caacaaaatg caacaggaca accctaaaaa cacacctata gcccctgccc aacaaccagt 288240 aggcaacatc caggaagact gtgaccccag agtactcagc ctgtgaggaa ccgggggagg 288300 ggcctgcgca ctaggggata aatggcttgt tgtcaccgtg ctgggtgtgc ctgcccacca 288360 gacacctaat cttgcaagac cattgaaaat ctctcttttg gctgggcatg gtggctcacg 288420 cctgtaatcc cagtactttg ggaggctgag gcgggtggat tgcctgaggt caggagctca 288480 aggccagcct ggccaacatg gtgaaaccct gcctctacta aaaatacaaa aattcgctgg 288540 gcatggtggt gggcacctgt agtctcagct actcaggagg ctgaggcagg agaatcgctt 288600 gaacccagga ggcagagatt gcagtgagcc gagatcacgc cactgcactc cagcctgggt 288660 gacagagcga ggccccagga gccggctgcc gcccctgcac ccactatgcg atgccctctc 288720 ctctccctgc tcccgctccc tctggagaag ccttcaagtt gggccgcttc aaggaagatt 288780 gattaaaatc agctgcagtc tgacttaatt gggaacatat gcttggagag gggcttgact 288840 agttagaact ttttgtaatt agttcacagc tggttggcga ggaaagagaa tttcagttac 288900 cccttagagc tgggcgcgag tgccgctgcc ctcccgcggt gctgaggcca ggagaccagg 288960 cctgggaggt cttcgtgctg ccttcctggg agggccgtca ctgggccctg ctgtggcact 289020 ggcctttctg ggtctcccta agagcccaga gctgtccaca cactcattag ggccgactgg 289080 gtgcaccctt gtgtcgctga aggggctgga agtgggtggg cggggctcct ggactgcaag 289140 ccctcccatc ccgtggtggg ggtgggagag ctcggggcac ccacggacgg tggctggccg 289200 ggcttctggc gccccctctc tagatgggga aagtgaggcc cacagggagc ctgcgtgtga 289260 aggaggaagg agctcagact ctccatgtta ggaggcagaa tgagtcttga acgtgttgca 289320 gtgttctgaa gtgaagacag aaatcgggcg gaccccgtgg aactccagat ctggcggcag 289380 agggaccccc atggctattg gtgcagccgc aggagtcagg tcaggtgggc ggcacagtcc 289440 ctgaccccac ctgcagccac ggcctcctgc cccacccctg tccccacctc ctgagtgtgc 289500 cctgtgctct tccccaggcc tagaactgag gagctggggc cccagcgctt tgttctcttc 289560 tggctcccgg ctgccctctg atgcgccacc tcatagctgg gacactgggc cttgtcagct 289620 tggaccccac agcctggggt gggccacagc tctgtctccc actggctgca gcctggcctt 289680 agtgtgctcc caaggatgtg gagggcacgg gcctttcccg caggctgtct ttggagatct 289740 ccggtgatgg ctcctggggg gccctgcaca tacctggtga accaggcctg catggtggcc 289800 attcctgttg tctgtcataa taccgtcgtc cttacctcca agacacttgg acgttttcca 289860 cgtctgtggt tctgatgggc cacatgcggg gatggagggc accgagctgg ggcaggaccc 289920 acagtgaggc tggtcggggc tcacaggcta cggggcagga cacacagtga ggctagtcgg 289980 ggctcacagg ccgccctggg tagagagggg cacgtccagt ggaggccgca ctgggcagga 290040 cactgacctt ctggctgggc gggcgcatcc ccacctgaca gtcccaccca ggagcctcca 290100 gcttgtgtgt gtgaagtgtg cagcctgggc cggcacctgt gccccgtggg gcccccgtgt 290160 cacccagcag tgatgggagc agcattcaga ctcaaccctg ttgggttttt tcagcatttg 290220 atgatgaaca tttaaagata cgttgtgaag ttgagggaag tttgcagcga gcgcctggtc 290280 acccgccacc aaggctccac cacggatgtt ccgccgcggg gcttcctgac atctctttat 290340 ccctcgccca gccgccgcgc cactttattc ttctgacgcg ctttaagtaa attgcagaca 290400 tctgcacgct tcctctaaat gcctcagtgt gcgtgtaatt aagtagaatt catctttggg 290460 ttctgaagcc cgtgctccag ccgttcctcg atgtggcctc atcatggtgc ttgtttgggc 290520 aggttggtgg tcagggctgg tggagccccc cagtgcggct ccctccccgc cccacctgcc 290580 tgctcctccc tggcgggggc ctgggtgggg tttgtggccg gggccaacct caatgtccca 290640 agtgctgttc aggaaagaga ccagacaaga gccctgtgac gtttaaataa gtgcatctgt 290700 tttgggaagg agtgggtaga agattgccgg gttccctgtg agcagaagct ggaagcacac 290760 ggagaccgtt ctgctcccgt ctgcaccagc aggcaggtgg tgcggtacct cacatccctg 290820 gtccgtgtcc ctgggaccag ggtggggcgg gcccgtcacc tctcctcaga cctcctcacc 290880 ccctccctga gatgccatcc ctgtggcccc cagatccctg gaattctgaa gccaccaacg 290940 ctgcagctgc cctgggagag ggccgcgttc cctcctggag ccacagctgc cccctttgtg 291000 ctggcgtcca tgcccaggtg tggtgggctg gggtcgtgtc cctgtaccgg ggcctcccgg 291060 cgggtgctct gagccaacct cctcaggtct ggcctctccc gctcgctgga ctcttagtaa 291120 cgcatgtggc tcatcagtgg gaccttcatt ctgtgttcgg ctctttctcc tgaaccttct 291180 accatgttgg acagagtgtg gcctctggac cgggacgatg ggcctggtgt tacctggtgg 291240 cctcgggaag tgctcctctc tgtgccctga gggcctcctt tgtgaggcaa gggggttgga 291300 cttttcctgg gaggcaggat cacgggaggg cagctctgca gggcccatgg gactccatgc 291360 tcaccagccc agccctcccc tcccatgcgt gagccacctt cacgcacctc tgtgccaggc 291420 gctgctctaa gccagggcac agcgggggcc aaggagccac agcccggatg ttctgggccc 291480 ctgttctgtg ggagtcatac agcgagctga tggttcagac ggatgaggtg cttcccgtcc 291540 gtgaaaggaa gcaggtcatt ggcacggggc cccagggacc cacgttaggt cctggcggga 291600 ccaagggctc ctggtttcct cccgtggctc gtggaaggac aggagaagcg cccactccgg 291660 accgggccgc cggggaggct gagtcggccg cagtcctcgg agcagcatcg tgttttctat 291720 gatggtgctc gttttctttc catgagatct cactgctcca cagattcccg gcagccgatg 291780 ctgtgtgtgg gaaaccagga atgttctgcc cacaagggct gaaggtgctg gtgaagttgg 291840 gcgtctgttt taatcggagc ttcctggcag cctagggaga aaggaaagtg tgatcactta 291900 ggtaattcct gccatgggag tttgcagact aagcctgaga ttctagaaga aatgtcaccg 291960 atgggggctt ggccatggtg ctgccactga tggaagagtg gctttgtttc accacactga 292020 ccagcaagtc caccgctgcg tacatgccca gaagaaccaa aagcagggac tcatggatac 292080 gggcacccac gttcacagca gcctcgctca cggtagccca gaggtgagcg caccccagcg 292140 tctgtggaca gatgcatgga tggacacagt gtggtccttc catacggtgg agcatgatag 292200 atacagcctc aaggaggagg cgcgtcccga cacctgccgc agcatggatg gacctgagga 292260 cgctgagctg ggtgaaaccg gccagtccca gaaggacaca ggctatgtga ttccacctac 292320 acgaggcccc tagagtcatc agatccatag acaggaggtg gagaggccgg tgccaggggc 292380 tggggctggg gcaggggaat ggagagtgag tgttgatgga tgtgggcttt agcctggaga 292440 gatgaggaag ctctgggaat gggctgtggt ggtggccgca cagcactgag agtgtgctga 292500 atgccaggga gctgtgcact tagaatggtt atggcggtca gcttcctgtc acgtgcgttt 292560 caccacagtg agacccagca ggcagcttgt taggagtgag ccacaccccg gacgggaggg 292620 gcagggcgct tgaggtgact actccaaccc tgccctcaca cggcctctgt ccttcggtca 292680 ctcctgcctt cctcaggccc ttcatccacc agctggtcct gcacctgctg cctgagcccc 292740 tgaggcctcc tgccagctct ggctgagcct caggcaggat ggtttaggcg ctggctgttg 292800 tttgtgccct gtagtgggga gactgggata gcagaggctg tccagggctc ctgctcatcc 292860 gccagtctgg cagggaccca gttcacttcc tcggcaggcc aggggagcag cctcccgggt 292920 gaagcccacg tgtctgggaa ggaggaggag gacctgtggt tgcagcggga ccaggacagt 292980 gctggtcccc cgcctcctcc tcccaggaag catgggcttc gtgcccaggg tgggtggcca 293040 gtgggtgccc tgtgcactga ccacactgcc gtggtgggag ctcaggtaga tgcctcgtct 293100 gcagatgggg caggcgatgt gctgtgagct gaacgaggag cacgggtggc agagccagga 293160 cccaccgcgg tgctcactgg gctctgcccg ctcatccccc acttgcccac gtgtgctgct 293220 ccccccatgc tgagctttgc caacggcccc actagagcac cctccccctg tgggcctgca 293280 gctgctcaca gaggcagcag agggtggcga agggcctggg tgcaggggag gaggtgagag 293340 ctgcagctgg gggcagacat tgaggggctc ccgtgtgggg tcgactggcg ctcagagcca 293400 ggcctcagcc caagtcactg ttgtccaacc cttctgacga ttggggtttt tatcttctcc 293460 ctccaaattg tttacaagtc gccctccgca gattaccttc tgaaggactc gggtggaagt 293520 cagcgggtga ttaccagcac cgggtaattg gctgtgctga gagtccttca tctgctgatg 293580 aggcctgagg tcaggggagc tttcatgagg gcttgcgggc ctcgaggtgg cgcgggacgt 293640 gcaggagggc ggcagagcca ctggacggac ggacagacgg atggtgtgag tgtgcccgag 293700 ttctcacttc cctatcacat ggtgaccatt ctcgccgctg ggtgacatga gactgaggtc 293760 agggtgctgg ggactggccc agagtcacac agttgtggct ggtggaactg ggacccagct 293820 cgggctctgc cagacccctg cgtctgctgc ctgggcaggc atgggcatgc acgcctggcc 293880 cacgagccct tgtcctttgt ctagagatcg tctagtagtc tctgctgtcc cctcaagtag 293940 agatgtgccc agggacccac tgctgagcac ctcgatctcc cccagcctgt ccctgctgct 294000 gccacttgga ctgaagccat gtcttgcact tggggtagaa aaccaaactc aaaggcggga 294060 cctggggggt ccgggctcct caaagctgat atccctgagc atgtctgcag cctcttggag 294120 gcccggggcc tcctctggga agcaagggcc gtggccctgt ctgcaagtgc cccgcacggg 294180 gtgccagtcc ccgcggctct tggacatggc acgatggagg tctccccaag cagccgctgc 294240 tgcaggcact gcgtccaagg gaccgatgtc ctttggttcc tgggcgtatc tgcagagaaa 294300 cggatgagag cagcttttta gaggagaagg gaagcacagg gccctgccgg tgcctgtggg 294360 gtttcagggg aggtggaaag tggctgcggc tctcctgggg gccaggaaga ggcccctccc 294420 cgccgcctcc acttggcagg actctgggga aggggaagca ctttgcttct ctcatgagga 294480 actgggtttg gacctggagc ctgcccatgg cctggtttgc cagatgcccc tcggttctca 294540 aggacgtctt gagtcctcag acagggatgg agttcaagag ggactcagag ccgggcgcat 294600 gtggcagagg gaggagatcc acgtctttgg tttcactgcg cgggtccccc cgggcgatgc 294660 ttgcgtgccc ggcagagctc cttagagcct gagaccatgt gcacgtccgt taacccgccc 294720 gacctttcca tggacttggt aggtcaccat agccaccact ctacagacag cagatcgagg 294780 ctcagagagc aagctagtgc gtgtgcacac actctggacc gcagagtgtc agctctaggg 294840 gccgtgcccc gggcccctcc taggagagcc accctggagc ctcaaggagc agggcccggg 294900 cagcgttgcc ccagctgggc ttttcctttg ctgacaggtc cagggaagcc ccacatggcg 294960 tcctggggca gcagctgtgt gtccttcctc ctggatcctg tgtgtgtgtc gggcccagcc 295020 cctcctgtgt tgtacgagtg tctggcctgg gtctccctcc agagctatgc atctcgtctc 295080 tgttcaggga ctgctccagg caggtggggc agatgtcagc cttgctgggt gccatcagga 295140 ccatctcctc ctcaccacag gcacagcccc tggagcccag gagttcagcc cagggtgatc 295200 tggtctcagc cttggccaga ttaggaaggg gatgctgtcc ccgccccgct gaccagtgga 295260 gactctcaca tgccgtcttc cctggccacg gcaggccgcc cgccctttct ctgctatgga 295320 accacagagg ctgttatcag gggtgtcatg ggaggagccc ctgacccttg ctggaaccag 295380 gacaggcatg acccctccca gctccctcct cccctggcct ttcacgtgga gctgcccagc 295440 agggtctcag gccgggaagg ccagctccgg agctgtgcgg tggcctcagc gccgtctcct 295500 gggtgccagt gtcccggctc cactggtttg gcagacgtgc tggctcacag ggcgtgtcct 295560 gctggggaaa gctgcggccc ctccctcagg ccctggtgaa ccctcgctta gcctctgggc 295620 agggccctga gcggaggcta tacagcacac ggtcactggg gggtggaggg ggttcatggg 295680 gggcgtttgc tggggcccat ggcgcaggtg ggtgggctca ctcgcaggct ggctttgccg 295740 tggacgcctt ggctgtgggg agtttccact tctggtgaag cctggccatg gtgcgtgtgc 295800 tggaggggcc tccaggggct ccgccctgtg accccgggcc actccctcgc cccctgcagg 295860 tgccccagat gaggcccggg acactcactc cccatggtgg agcactcagc tctgcagaaa 295920 gggagctctc ggggttctgt cctaccccca tccagttctc atcctcccac cgctcccggg 295980 cactggtcac ggacagcagc atggcctctg tccctccttg ggcctcagtt tctctgtctg 296040 cttcaggctg ccctctccca tccatgtgcc tctacctgct tgggagctgc tttcctggaa 296100 taggtgggac acggccccgc aggcccctcg gcgacaggtg tgtataggtg catccagccc 296160 ttcagccctc ctgctggccc tgagtaagtt gcccaaggtc aggccgctgc tgagggcagg 296220 gctgggaggt gtgaccctcg cctgggcttg ttacagaggc aggttccaca acccagccgt 296280 gtgcggcagg caaggccacg ggcaggagat gggaaggcca agcgggcaag gccacgggca 296340 ggagatggga aggccaagcg ggcaaggcca cgggcaggag atgggaaggc caagcaggca 296400 aggccacggg caggagatgg gaaggccggg cctctgcctg tgcctcttgg tgggcctggt 296460 tctgcaatgc cctggcccaa caggcacagc ccgagctgcc tcgctctcct ccgtgagcca 296520 tttccttcag ccaggagagg tattgattga attttgacgc cggacgatct ataaatatgc 296580 ataaggactg gtggttattt aactgtgttt tccattcccc tcttgtcgct gcttccttcc 296640 agcgctttct ctgctctcgg catgcgcgtc aggcacacgg ggacaggcgc ctccctcccc 296700 aagtattgcc tgggccttgc tggaggcagc ctcctcccca gcagggacct tgaggatagg 296760 gcccctcaga agccatttcc tttgcccggg gcagccaagg gcccatggca cccagctcct 296820 gcacgcacca gggcgtgggc tcagggcttt cctgtcctct gctccgggtc ttatgagcat 296880 tttggccgga agggaggtcc ttaaggtgaa actcaccaca ctcaccctca cagatgggaa 296940 gccgaggccc agagaggacg gagacctacc agcgagttag gggcggaact cacagtggga 297000 acagagatgg agccaacgcc agcccccacc cagcctcctc ctccaggact tgggctgtag 297060 acagtcccct gaacacagag agaaacgggc cgtcgaggcc gaggcctcct ggaggcacag 297120 gtgtgggctt acaaggcagc ccgggagcac ccgcaccctc tctgggcctt gtctctccct 297180 gtgcagaccc ctccaagacc gctttgtctg aaggtggggc cctgtcatct ccagaaccct 297240 aggcccagcc tggaggggag cttggacaga cagtaggcct gcaagtggcc ggggacctgc 297300 cctgcccgtc ccagcattct cccgctgcac ccgccagccg gctcttccgc ttaaccgcgc 297360 tgggtagcag caccagagcg cctgctcgct ctgcaagtga aagatttctg ttgagtcaat 297420 gattgcacca tcgcatcaaa ggaaggctcc aaacttttcc ttttgagatt ctcgtcagcg 297480 tctcaacagt tttctcagct gtgaatcaaa caaggcaaca aattttagca gaagattata 297540 gccattttcc cctttcttcc tggaagctgt cagctaacag ccgattccag caaggttgct 297600 ccatctccca tctgcttgag ttgagtggtg ccagccccca acggtgctcc tgcttgctgg 297660 cacacacagt gctcagcgcc ctaggtgggt ggggtgcacg gggccggggc agcactggag 297720 gggcttctcc ccacgcctgg agcctcacac tgaccccctg ggcctgcagc tagaggtggg 297780 ttctgtgagc aggaggcgtc ctgccagaat gcacagaggg caggggtggc cctgagcgga 297840 tgggcagatg gggcctggga ggaagtgatc ttgcctcctg ggctgcagag cccaccccac 297900 atccgctgcc tcctggcccc agtgtacaac ccgctggccc ttcctctggg ctggggcttg 297960 gtgtgtccat tgcctcctgg ccccagtgca gaacccactg gcccttcctc tgggctggag 298020 gcttggtatg tccatggtgg gaagtgcttg ggtctttgcg taggaggatc ttgaggctgc 298080 actggcctgt gcctcatctg ggatgcccct ggaccacctc ctgccctggt ggtccctccc 298140 ccactgcctc cagacttctc aggccaccct ctgagtccct tggggccccc agccacagcc 298200 acgccatgca gagccctaac cccggtctgc ggcccagcgc cgccacctta cccgcacctc 298260 tgaggggtcg cgtgagtgct gcatgaccgt tctcctccag aaagcagcag aatacatgaa 298320 agagggctca cagagcactg gccgggcccg gcaccccatg gcgtctgcag atggccgctg 298380 ccctcaccct ccttcccttc atctccaggg tgggcccagc agcagcagca cctctcccac 298440 accctctgct tctcctgggt tgcggctgtg acccaggaag tgagagtggg actctccacg 298500 acttggagaa gggttccaag ccctttcgtg ggacctactt gctcttactt cctgcgttac 298560 tctaaccact ctagccacct ggtttaagcc ccaggagcac atccgagtgt agtaagtgtt 298620 catcatcatc atgcattcat tcagcaaaca catcttccac atggagcctg tgccgggata 298680 gtcctcggtg ctggggctgt ggtggtggac aggagtccct gtcaccgcgg agctggactt 298740 ctggcgtgga ggacgcctac tgagatgagt gtttaggctg atcggggtgt cccgctggca 298800 acagcagtca cccttggcag ccggcctctg ctgggcccct gctgagcggg cgccgaggca 298860 ccgtgctgct tccctgctct gcagagagag acggaggcct ggcccttcgc agcccccatc 298920 tagcgggagg gtctcggtgt ccactgtctc tcccagtggc cgacggccca ggtgaggggc 298980 tgcccgtacc cgtctccctc tgcttccggc tcccttggtg gccactgcac tgtgcacttg 299040 caggggctgc caagccacag aagccaggcc agccggtccc ctgcctgtca gctgctgact 299100 cacaggggtc tttgtcccca tcagctgcag aggtggcctg caggctccaa gaagccacca 299160 aggcagggcc ctgtgggcac accctgacgt cacctggtcc tgcagactgt ggtcactgca 299220 cttggtgtct gggcccagct ggcaggagtg ggagagggcc gacggggtgg ggggtgatgg 299280 tcaggccact gtgccctaga ggctcttccg gctgtggagg aggagggtct tgggggcagg 299340 gatccccttc agcctcacat ttcccagccc aagcaggata caagtaagga catttcctta 299400 cggagcccca gagtttctcc ttcaccctgg agctccctcc aggcagcccc tctcagccct 299460 tgtcctcccc gtggagagct gctcttgaag ttgaaatcgt ggtacatgca aaggaagagg 299520 ctggtttcag ccccgcaggc tctggcagct gcatccacgc ttcctgctgt ttctcactcc 299580 ccacccggcc cgccatttct aacagctcta ttgaaatgcg acgcacattc cacgtacctc 299640 gtccctttga agggggcagt tcagcgactt ttatgtccac ggctagtgca accaccgtca 299700 cccttcgcag aacgttttga tcccctctca aggaagcccg aaccctctag ttatccatca 299760 ccctgctgtc tcccgtgccc tcaaaccctc agccaccagt cggctactgc gtgcctctgt 299820 gggtctgtct gttgtgagca tttcctggaa agggagtccc gtggcctgtt ctgagcattt 299880 cctgggaggg agtcccgtgg cccattacca gcatttcctg ggaagggagt cctgtggcct 299940 ttgtgattgg cttttctcac ttcccttgtt caaggttcac ccatgtggtc ataggtgtcg 300000 gtggtgtatt ccttcttgtg gctgaaacac cccactgtgc acggccgcat cttatatatc 300060 cagtcatcaa ctggtggacc ttgtgttcct tcttgtggct gaaacacccc actgtctgca 300120 cggccacatc ttacatatcc agtcatcgcc tgatggacat ctggatggtt tccgctttgg 300180 ggctgttatg aacacagctg ccctgaacat tcacggacga gtctgtgtag atgtgtgtgc 300240 agttctctcg ggggtctgcc tgggactggg cctgctggat cacatggtaa ccgtttcacc 300300 attggaggaa ctgccagact gttctccagg gctgccgcac accagggttc cagtttatcc 300360 ccatcctcac caacgtgttg ttgcgtgact tcccagccgt cctgggggcg caaagtgata 300420 cctggctgtg atttcacttt ctgtctctgg atgccggatg atgccgagca gcttttcatg 300480 tgtctattga actcatagaa gtctgtcttc agatgccttg cccattgtga cactgggtcc 300540 tcataggagt ctgtctgcag acgccttgcc tattgtgaca ctgggtcgtt tgctgacagt 300600 gcttcatgtg ttgaggtgta agttcttcgg gtatagattt gcagacattt tctcccattc 300660 tgtggcttgt ttttgcctgt cactggcgtc ctttgaagca caagagttct tagtttggat 300720 gaagtctgat tacctgttat tttcttttgt tctttgtgct ttgggctaag aattctttgt 300780 taaatccaag gttaggaggg tttcctcctc tgttttcttc cacaggtttt acggttgggc 300840 tttgcgtggg tcttggatcc attgttactt agtttttgtt tatggtggga ggtggggccc 300900 agcttcattc tttggcatgc gccagcccat tgtcccagca gcatttgttg aaaagactat 300960 ttttccctat cgaaaggtct taacaccttt ctcagaatca cttaacatga acgtgtggtt 301020 ggttcctgga ctctccactg tgttgttggt ctgtacgtcg gtcctcatgc ccacaccaca 301080 ccatcctgat tgcagtggct ttgtagtaag ttttgaaatc aggagactga gtcttcctcc 301140 cgtgttcccc ctttgcaagc ctgtggtggc tcttctgagc ccctgcagtt ccgtgtgagt 301200 ttcagaatca gcttatcagt tcttcaggga ggccggctga gtcctgggat tgtacagaat 301260 gtgcagatca gccctgggag tctctggtcc cgacagcgcc gggtcttctg atccgagaca 301320 tgggatgttt cctaatcacc tagatcccgc ctagtttcct cccatgctgt tttgctgcct 301380 gtgtgtttga aatggctcct cttggtgggg tgggtgcagg agtggtgctg tttgtatagg 301440 acatagggcc gtcctcccat cccgacactc ggctgccctg gagacgggcc tcagcacagg 301500 gctcccatta cccctgcact tccagcacct gctgaaatgt gtggcgcgcg ggctccgagg 301560 catggaatgg tgtgcctgac tctgcgctgc ccaggctgtg gtcacagcag caggctggaa 301620 gtttggctgt cgcccccagc caccttgggg cacggtcctg tctcacctgg agcagaggtc 301680 ctgggccccc aggggctcag gcgtggcctc cttctggagg ggccgggaat gtcccctcca 301740 cttgctgagt gttggcccag gaggctcctc tgtgggatgc cagctgctcc caccatgagt 301800 ggcagctcca cccctgtatt cacagctgtg ctgagggcat ccagggcctg gaaatcatgt 301860 cagatggaca gacaggtgtg cgggtggatg gactaaggga agaaaggaag gatggcagga 301920 acgaacgcgt ggaggtcaag agcctggccc agaatcacgg tggggacgtg agcgggtggg 301980 tggtgcccag tctgcccctc ccgtgctgcc tctaggggct ctgccttctc caggcgttag 302040 gcagggaaag tcccctgaac ttacagaaag acgactaggt gcctggaatg ttgccatctg 302100 cacagagccc tagcgcctgt cctcccactt ccctcgccct cctgggaggt gggttctcca 302160 cgccaccagt tatggagccc aggcttgttc tcagccctgg tcagcggtgc catcgcaggt 302220 cgctccagcc ccagccgcag gtgcccagtg aatgctctcc gtgacccagg gcctcctgct 302280 gcaggtggaa gccgggccac gggaacctgc gccgaccttg gcctcacact gtggctccgg 302340 gagagcagga cctggtggtg catgcgtagc ggctgaggag gacaagcctg ggggctggtc 302400 ccagcccgga cacggtggct ttgcacacac caagccttcg cccccagcgg ggccagcagt 302460 gcagggcgct gcactgttgg gggccagagg gtgacaggat tggtgtttaa gaagaacttc 302520 tcagttttat cttttctctg ttttgatttg gtttccttca tctctactgg cttgggcttt 302580 tggtccttaa atcctctaat atacagaatt gtttcctgga cctcaagccc cccatcaggg 302640 gggaaacctc atcccaggat gatgggccgg tcgtggggca ccctggctgg gggctggggg 302700 ctggggctgt gctctggctc tcgttcctgc ccgtggaacg ttgaacgttg ccaggacatc 302760 caccccgggg aacttgacgt cctcaggcac tgctgggtcc aacgccagcg ctgggcgcac 302820 caccgctgac ccccgacccc tcctgcaagt ccccctatct gctaagtagg aggatgctgg 302880 ggccaggcga ggccttgctg ggcagcctct aggatggtca ctacctcctc ccacctggag 302940 gtcccttcag gaggtccgcg gtgttgaagc ctggggagga agaggaggct gaggcctggg 303000 agaggaagag gagggtgagg cctgcggggg gaggaagagg agggtgaggc ctgggggagg 303060 agggtctcac tgctctgggt cagaggaggg ctgagtacac gctgtgcggc ctggttcttg 303120 ccaggggtca gctgactaca gccccgcctt ctgtgcagcc cctcaactaa gaaccgttgt 303180 acatttttga agggttgaag aaaatcaaaa gaagaatatt ttgggacaca cgcgggttat 303240 ctgaaattca gattcgtgtt tccgtgcccg cagctccgtc agcggggccc atgctggcct 303300 tgtgtgccct gcggctttct gggtgcagtt gcagcgctac gtggttagga cgggggcagg 303360 gtgactgcac agccccgtga ctggctgctc tccgcaggag gcggccccac cctctgccca 303420 catcctccct ggctcctcga ggctccgtag gatggtgaag aggttgagat gctgtccagc 303480 ccacagaggc cccggaaagc cagtgccgcc cgtcagaggg gtctcctgag tgcgtgtggg 303540 tggctggatt ctgcatactg ggttatctta accccggctg tgaaaactgg atgaagtagc 303600 aatcctttca accccaagag tctgtgattc agccagagtt acaagatgtc tcttcatcct 303660 ctgaggttta caaggttctc agaaaacctg tgaagagctg cgcggatcct ctcctgcccc 303720 ggcccagcgg cagggctgcc gcctccctct cccctgggcc tgagtgggtg gatttcccct 303780 cccctcctcc ttcccaggag aagcacagag ggagcggcca agcgagccgt gtctgcaaac 303840 cccgcttccc tctgcggcgg cctctgccat cgtgccatgg ggccggaggt ccctggtcca 303900 ggtcagcatg tccatctcca ctggcctctt ccatgagggg ggtggcaggg ccagcagtta 303960 gcttgtgtga cgtgacgtca gggggatgtc ttagagtccg gggtggcacc aggaggggtg 304020 aggtctcttc ccttcttccc catcctctcc tctctccctg ttggaggcac attctgggct 304080 ctgggaccac gattgcccat ggctgatgag ctccagccca agtgaggtcc ccagggtaca 304140 gcccaagcca ggcctcgccg tccttcgggg acttggagag cagtggccca cagcagcctg 304200 agctcttggg aggctggagg cttactgcgc ccggtctctt caccccgtgg ggtgtgtcca 304260 caccggcctc tcctgagagc gtggggtgat ctgaacacag gatgtgtttc cctgttcccc 304320 tctgggagat aggagagtgc gtgggcagaa gccccaaggg tggcaggaac tcattgccaa 304380 aggggaggag gccattgcta tgcgtggtgc tggcctggct tgctgggtca tgtctgtgcc 304440 tgacatgacc catgtcatga ccatggtcat gtctgtgcct gacatgaccc atgtcatgac 304500 catggtcatg tctgtgcctg agggaccggg tgcccatcca gtctcactgc cccacagctc 304560 acagccacaa gctgcagaat ctcagcactt ggcgggagcc ctggcccgtg tgtgtgcgtg 304620 tgtgtgcgcc gctggctcca gccctggcct gtgtgtgtgt gtatgtgtgt gtgtatgtgt 304680 gtgcgtgcac cgctggcccc ggccctggcc catgtgtgcg cgcgcctctg gtcccggccc 304740 tggcccgtgt gtgtgtgcct ctggccctgg cccgtgtgtg tgtgtgtgtg tgtgagcgcc 304800 tctggtcctg gccctggccc gtatgtgtgt gtgcgcctct ggtcccggcc ctggcccgtg 304860 tgtgtgtgcg cgcctctggc cctggcccgt gtgtgtgtgc gcgcctctgg tcccggctct 304920 ggcccgtgtg tgtgtgtgtg tgcctctggc cccagccctg gcccatgtgt gtgtgtgtgt 304980 gtgtgtgtgc gtgtgtgtgc gcctctggtc ccggccctgg cccgtgtgtg tgcgcctctg 305040 gtcccggtcc tggcctgtat gtgtgtgtgt gtgtgtgtgt gtgtgcgcgc ctctggcccc 305100 ggccctggac tgtgtccgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgcc tctggccccg 305160 gccctggccc gtgtgtgtgt gtgcgcctct ggtcccagtc ctggtctctg tgtgcgtgcg 305220 tgtgtgtgtg tgtgtgtgtg tgcgtgcgcg cctctggccc cagccctggc ccatgtgtgt 305280 gcaccttttc atatgtttat cagctttttg ggtgtctttt tgggaagtgt ctgctcacat 305340 gttttgcaga tttttagagt gggttgtctg acatgccctt ggttatttct gacatgccct 305400 tggttatttc tgacatgccc ttggttattt ctgacttctt cgtatgttct ggatctgaac 305460 cctttctcag aaatgtgatt ttcaaacagc acctcctgct ctgtgggtgc ctttccactg 305520 tttcagtgga tgaagttctt aatttctata aggtcagttg tactcttttt tttttctttt 305580 acggccagca cttcctgaac cctgtttgag taacctgtgt ctactcccag gagacagaat 305640 gtggtggaat tgatgtttgt gtgtgatgtg aggtcggggt ctcaggtgtg cagtgaccct 305700 gcacctccct gccgtgggcg gctgttgttt gtgtgtggcg tgaggtcggg gtctcgggtg 305760 cgcagtaacc ctgcagctcc ctgccgtggg cggctgatgt ttgtgtgtgg cgtgaggtcg 305820 gggtctcggg tgcgcagtga ccctgcacct ccctgccgtg ggcggctgat gtttgtgtgt 305880 ggcgtgaggt cggggtctcg ggtgcgcagt gaccctgcac ctccctgccg tgggcggctg 305940 atgtttgtgt gtggcgtgag gtcggggtct cgggtgcgca gtgaccctgc acctccctgc 306000 tgtgggcggc tgatgtttgt gtgtggcgtg aggtcggggt ctcgggtgcg cagtgaccct 306060 gcacctccct gctgtgggcg gctgatgttt gtgtgtggcg tgaggtcggg gtctcgggtg 306120 cgcagtgacc ctgcacctcc ctgctgtggg cggctgatgt ttgtgtgtgg cgtgaggtcg 306180 gggtctcggg tgcgcagtga ccctgcacct ccctgctgtg ggcggctgat gtttgtgtgt 306240 ggcgtgaggt cggggtctcg ggtgcgcagt gaccctgcac ctccctgctg tgggcggctg 306300 atgtttgtgt gtggcgtgag gtcggggtct cgggtgcgca gtgaccctgc acctccctgc 306360 tgggggcggc tgtcccctgc tgtgggcggc tgttccctgc tgtgggcggc tgtcccctgc 306420 tgtggggggc tgtccctgct gcagggctgc atggtgcttg ttgctggggg tcggtcaccc 306480 accacaggtc agcaggctgg gcctccaggc gcactcctcc ctcaaggatg ccacacacat 306540 cccggccctg ggtttcgtgg gaacatcagg ttgcgaggcg cattcctgag ccacccacgc 306600 tgatgccagg ctcccttgcc ttccatctct gtgtggttga ccttgtttct cttgtggcac 306660 ggggcacctt ccaggctggt agggaagaga tgggaacatg gccacacggg ctcccagtct 306720 catcccagcc aggaacctca gaggagagga agcctccctc ccgggcactg agtgtggaat 306780 tctgggaagc accgcacttg gctgagcaaa ggccgcatgt cccctctcac cctgttcctg 306840 tggttaggca gaagggaccc agcaggtggc caggccttgt tcctgcacct gtccacaggg 306900 cacagggaag gagccactcc ttccaggaga gatggctgcc aggcaggctc aagaagacaa 306960 aagaactgag cactgtgctg tgtgtgaccc gtgctgtgtg tcttcctggg ccatggtgac 307020 ccatgctgtg tgtgacccgt gctgcgtgtg tgcctgggcc atggtgacct gtgctgtgtg 307080 tgttcctgca gggtgactat gaccagagca ggaccaaagt gctgcacatg agcctgaacc 307140 ccaccagtgt ggccaggcag cgcctgcgcg aggaccacag ccagctgcag gcggagtgcg 307200 agcgactgcg cgggctcctg cgcgccatgg agagaggagg caccgtccca gccgaccttg 307260 aggctgccgc cgcgagtctg ccatcgtcca aggaggtggc aggtaggcac cccccacccc 307320 cggtccctgc catcctcgac cttccgtggg taggtccatc cgtgcgcctt tggggcagcc 307380 tcaggcgccc ctgcctgtca tccccagagg gtttgtcctc ccctgtgggc agccgggtct 307440 ggtggttgct ggggcagagc accctggccc cgtgtcccca tggccccgtg gggttgtgca 307500 aacaggtgga gccatccgag tctgcaggca gctgtggaga agcaaggggc tgaaatttca 307560 ggcccttaaa ctaattcgta tcatttgtca gtttatatgt accccattaa tcacaagtaa 307620 atccagtcct ccacgaaaac aagtccatct ctcaccagct taagtgtgct tcatggcgtc 307680 cagagagccc tttgaggcca aggcctgtgg cgtcccaggg aagaatgagg cctccatgag 307740 ggccagcagg gcctgcccac accctccagg tctacatgag gcccacggcc tttggaacgc 307800 cagcctatcc cctgatgtgg ggaggtggtg ctggggtctg cccacgccaa gcctcggagg 307860 gtgctgccgg ggctgtgtcg actctgcagg gtgcccctga aggagcaggg ctgggagtcc 307920 agagtcactg tgcagtctgc acccccagcg aggctgtggg gctcaggaga cccctgcccc 307980 ctgtgttgct ctctgctgtt ggagggagct gggcactgcc ccacgctcct ggttctgggg 308040 ggacctgggg gagggttccc tgtccagccc ttagcagcag cctggagcgt ggcccggcgt 308100 ccccttgctc ctgtgttaga gccacccggc tgccagcccc ctcccttggg ggtgtctgca 308160 ggctcatctg tggtggggcc tggaggctgc tgctttctgg cctttggcat ctcgaggtga 308220 tttcagactc agctttcatc cgatgatacc ttcttctgtt tcttcccacc tacttgccat 308280 cgcgccctgt actgtgggag agcattccct gtgagcatgc aggtgcagag gttgtgtggc 308340 ggtgacttgt ccgcttccca cagcccagca cccaggctga tgtatcagga gtgattgtcc 308400 tctgccccgc tcctttgtgg ggagggtctt aggtggggtc ttccctccct cttgtgcccc 308460 acccccataa gccaagactg ccctgagtct gggcgcaccc tgccggcagg taggggctta 308520 gtggctggct agcgggtggt gtgccctcct ggagtagtat ggtggggttg gaggacaaaa 308580 gccagaaggg ggggcctgtg ttgccagatt gaggggcgag ctgatggcag tcgggggctc 308640 ctttccagct ccccacctgc acaagggctg ctcccggtct ccactgtggc tgtgagggcc 308700 tgagccccca tgtccccagc cccctttctg gtccagccgt ggctccctct ccgccctgca 308760 ttctgcaggt gttattggca agtttcggag ctgaggatgc agacttggag ccatattttt 308820 aggtggctct gcaccctggg agaggatttg ggaaggggcc ttccatcccc tgctgtcacg 308880 ggcctgtgcc ttggctgtgc acccattcgc ttgtctgttt gttcccctgt tgtctgggtc 308940 tctgcccgtc tcgggtttgc ccgtctgttc gttcccttgt tgtctgggtc tctgcccgtc 309000 tcgggtttgc ccatctgttc gttcccttgt tgtctgggtc tctgcccgtc tcgggttcac 309060 ccgtctgttt gtccccctgt tgtctgggtc tctgcccgtc tcgggttcgc ccgtctgttc 309120 gttcacctgt tgtctgggtc tctgcctgtc tcgggtttgc ccatctgttt gttcccctgt 309180 tgtctgggtg tctgcctgtc tcgggttcgc tcgtgtgttc gttcacctgt tgtctgggtc 309240 tctgcgcatc tcgggttcgc ccgtctgttc cttccctttt tgtctgggtc tctgcctgtc 309300 tcgggttcgc ccatctgttc gttcccctgt tgtctgggtg tctgcctgtc tcgggttcgc 309360 ccgtctgttc gttcccctgt tgtctgggtc tctgcctgtc tcgggttcgc tcgtgtgttt 309420 gttcccctgt tgtctgggtc tctgcgcatc tcgggttcac ctgtctgttc ctttccttgt 309480 tgtctgggtc tctgcctgtc tagggttcgc tcgtgtgttt gttcacctgt tatctgggtc 309540 tctgcgcatc ttgggttctc ccgtctgttc cttcccttgt tgtctgggtc tctgcctgtc 309600 tcgggttcgc ccgtctgttc gttaacctct tgtctgggtc tctgcgcgtc tcaggcacgc 309660 gggtggtcgg catctggctg tgacaggtgc ccgggccatg gctgattggg agtggggggt 309720 gcgaagaggc gtgtctgagc tgaccatgga gaagtcaggg ccagcgtggt ctggaagcag 309780 gaaggggagg atgagcagag gcctgggata gtgggggccg cgccacatgg cgccaccagg 309840 aggtgagggt gggtcgggcg tccaggcccc agtggctgat gcagcgcgtg tctgtgcccc 309900 caaaaatcac agtgttggtg gcctctgttt tatgtaaggc ctaaccccac agagggagag 309960 gatacagagg cagacttttg gagtctggaa ttggcgggtg agcagtgaaa ggactgagta 310020 gacttgggaa accggaatct aagccggcgg cgggtggagc tgagaacccg cctgagttac 310080 acctcaaaac tccaacgcag cccaggaact ggctgcaagt ggcgttaggg gagggatgcc 310140 actgactgaa gcacagtgga tctggaggct tgattgctga attaagagat gggtccccgg 310200 aaccatctgt ccatctgtgt gccctgggca gttgccgctc cccgggaaag atgaagactc 310260 caaaacaagc cagcagttta ttcttggagc agtgatactt aaagtgcagt acccaggtcg 310320 gccgctgcct ccctgggagc ctcttagaaa tgtggattct caggtctcat ctcagacttg 310380 ctcagccaga ggcctggggg cggccggcag tctgtgctag gcagccctac agaccacgcg 310440 gatgctcagc gcgtttgtgg accgctgctc tggagagggc tggcaaggtc cctggacaga 310500 cccaagtcag gacaacaggc ttgaactgag cccggattga tagatgcagg tgtgggcctg 310560 gatcgcacac ccccgccacg tgccctgcag aacacgggca gcaggtgtga ccctgtaggc 310620 tatggtggaa agacctccct gtgtatccga gcagcccaga aggacctggc gttggcagtt 310680 ccccagctcg acagctccca tggatcgctc cctggggaaa accgtggcag acggctccat 310740 gctcctaccc ggagtatccc tgggccccta gtgccctccc ctagtgagga gctgataccc 310800 agggattgtc agacagccca agggaaagga caggaaacga gcagggaaaa cagagcacag 310860 cgaaacgcag agaaacacag cgtcagcggg gagggaaccc actgtcccag caaagaaaat 310920 ctccaaaaac tgtctcctgg atctcctcag agagaagacg gggcttcagc aaccaaacaa 310980 cagggcagct taacacacac caagagaaag cagtgagcag ggggaaggca aaagtaggga 311040 acagtgaatg gaaatctaag aagatttgta aagtaacgtt gagaaagtct gaaagtaaag 311100 acaacgagat ggaaaacagg agaagagaag taagaacatt agaggtacag cccactgtct 311160 gaacaacagg aacatggaag gagggaacag ggaaaaagca gatgataaca gaagtgcctc 311220 aaggacgtct ccctgaagga aggacgcagc tccctgcctc ccgggagagg ctcagactgg 311280 gctgtctgtg gttggggata gacccgcaca gtgtgcggca gcatgaagat tcaggacaca 311340 ggacgaaagg aagaccctga gaacttcaga gaagaaacac agaggtcact tgtcaaagga 311400 tccgggatca gtcatctagc gtttcctagc agcagcacct ccgagtttct agcagagtga 311460 cctgcatctc gggatctcat agccccccag ccccacatca ggtctgaagg aagaagtacg 311520 ggcatctgca gggttcaagg ccttaaaaac ttgacggccc cgcaccgtct ctcaggaagc 311580 tggcagagga tgcactccca aaggatgagg gagtaaacca ggaaagagtg tggctgtggc 311640 acgcagagca gaccacaggg gcttctgccg cggaagcaga gaaggaggcc tcaggcctgg 311700 ggagcagccg gcaggggcca gaacaggcca gaggttctgg gatatagagc agagaaggaa 311760 gccttaggcc tggggagcag ctggcagggg ccagaacggg ccagagtttc tgggatatag 311820 agcagagaag gaagccccca gcctgggcag cctccagcgg gggctggaac ccaccagaga 311880 ttctaggaca gaacctggtg cgttgggtgt catgatgcgg accggagctt tccacacgtg 311940 tgtgccaggc gtgggctgcc atggacgttg gtccccaggt ccctgggtca ctctttggca 312000 gcctcctcct tccctgcgtg ccacacacat ttctcaggtt ttaggtttgc tgccccgcac 312060 aaaaagactg ggaagcacct gtgtagacag ctggcaaaga gggatggctg ccaagagcca 312120 tgagcaccta gaaggctgag tgcgtgggaa gcaggacgac cattggctct ggggacagca 312180 gagttgcatg agaagcagca gaagcagcag tgtcctgcat tctgagctgg ccctgagcag 312240 cctcacacag tcgtaaggga gctgaggcct gatctgaaca cagccctgag cctcatatta 312300 agaaagggga ccaggaggag ggagacgcgt gttgcagggt gggagggagg gagagctgaa 312360 gcctcgctgt ctctcgggaa gtcagcagga cgtccgagcg ctcaagtcca gaaggagcca 312420 cagaatgtgt attccagaga aatgcagtta ataccgacat gatcggctga gaggtgaaca 312480 tggtggactc tggagagaaa ggaaggaaat gagaagtgtg gagaccgctg ttccctgaca 312540 caccccacag aattcctggg ctcttaactc atgtgcatgt aaatctaaag ttaaaaagag 312600 aaaagtccag gtcacgccgc ttgctgccag agagggctgt cccctcccca ttctccagat 312660 gaggagcaag ggtgtgcccg cagtgtcagc agacccttga cgtggacccc acgacgcgcc 312720 ctcgctcctg tgaccgtgcg tggggtgagg agttgggggt gttcccgtgg tgtcagcaga 312780 cccttgacgt ggaccccacg acgcgccctc gctcctgtga ccgtgcgtgg ggtgaggagt 312840 tgggggtgtt cccacagcat cagcagaccc ttgacatgga ccccatgatg cgccctcgct 312900 cctgtgaccg tgggtggggt gaggagttgg gggtgttccc gtggtgtcag cagacccttg 312960 acgtggaccc cacgacgcgc cctcgctcct gtgaccgtgg gtaggctgcc tgcacagtcc 313020 ctgcaaaggg tgagatggca ggtgtgagcc tgagacagag acggatgctc ctccccggcc 313080 tggctggccc tgagcatggg ttaggggtgg gtctcctggg tcacgagaga gaccagggta 313140 agttgtgagg gcttcaggcc agcaggtctg cagatggcag gcctgtcact ggcttaaggg 313200 ggagccgcgt ggcctgagac agcgcccagt gtcccaccag gaagcaagtc ccaggggagt 313260 cccctcacac cctgatcacc cagcatctcg ggggtcagca gatgtctctt cctgctctgg 313320 ggaatcaggg cccccaagga acaaggtgaa ggggatgtga cggtgggacg aagcaagggg 313380 acacgtggca gtggggtggg cgaggggacg cagcggtgag gtggggtgag cggacacggt 313440 ggtgggatgg ggtgagggga cgtggcagtg gggacggggc gaggggacgt ggcagtgggg 313500 gatggggcga ggggacgtgg cagtggggga tggggcgagg ggacgtggca gtggggacgg 313560 ggcgagggga cgtggcagtg gggacggggc gaggggacgt ggcactgggg gatggggcga 313620 ggggacgtgg cactggggga tggggcgagg ggacctggca ctggggacgg ggcgagggga 313680 catggcattg ggggatgggg cgaggtgacg tggcatcggg gactgtgcga ggggacgtgg 313740 cagtggggac ggggcgaggg gacgtggcag tggggacggg gcgaggggac gtggcagtgt 313800 ggacgtggtg gtgggatgtg gcagtagggg acgggatgag gggttgtggc agtggggacg 313860 ggatgagggg acgtggcagt gggggcaggg cgaggggacg tggcagtggg gacggggcga 313920 ggggacgtgg cagtgtggac gtggtggtgg gatgtggcag taggggacgg gatgaggggt 313980 tgtggcagtg gggacgggat gaggggacgt ggcagtgggg acggggcgag gggacgtggc 314040 agtgggggac ggggcgaggg gacgtggcag tgtggacgtg gtggtgggat gtggcagtag 314100 gggacgggat gaggggttgt ggcagtgggg acgggatgag gggacgtggc agtggggacg 314160 gggcagggga cgtggcagtg gggacggggc gaggggacgt ggcagtgggg acggggcgag 314220 gggacgtggc agtggggacg gggcgagggg acgtggcagt gggggatggg cgaggggacg 314280 tggcagcggg gctgcagagt caagagctcc ctttcgtgtt tgccacggct tccccaaggg 314340 ctgtctctgg tgtgggcccc agacctccgg tcagagaaga cacagaaaca cataaagagg 314400 cccctgctct cggggatctg agtccctgct cggaagttca ggcaggaaca cccttgtgat 314460 tttcctggtg tctttgacaa ggcagtcact aaacaaccct tgccatcggc acgggccctt 314520 ggcggatagg agccccaaag cccggcctcc cgtgctggct ctgactcctc actcagcccc 314580 cctgccacgt ccaggctggg ccagggagat tgttaattgc agcttaatta gggaatgcat 314640 taatattaaa ataatcttag cagcacattg aaggtgatca aatttgtcac tgcctgtgtg 314700 ggcacagctg atcctagagg tgtctttggg gaggagggag gcagggggag gatggaggag 314760 cgaggaagag ggagaagaga taccagggag gagaagggag gaggtggaag aaaagagggg 314820 aggcccggga ggggaggagg gaggggaaga tggttggcca cagagttgct ctgcctggaa 314880 tccacctgct cggcctcagg gaggagggtg ccctcgaggg gaggcctggt ttggtgtccc 314940 tgcctgggct gaggacggga gcagtgactg cctttctgtt gcgtcctgtg cactgcttct 315000 gtctgtatcg gcgcgtgtcc tctgcagtct caggactcac acttttcctg cttggctggc 315060 gctggcccca caggtggcct cagtgaggtg ccctaatggc tgctccgtgg accaccagga 315120 caagcactgt ggagagctac ccattggcct ggcagtgcca agccagctgt gccctcccac 315180 ggccagaaat cagtgcccag ctctcacgtg gcacaggcct gtgtttacgt catgccccca 315240 ccccgtgcca cctgggcagg gccgccacct gcccacgcct ctgtttgctc agtacaaaca 315300 ccgtgcaatg ccgacagctg agcggttcaa atgggatggg ggtgcagggg ctccagccct 315360 gttcggcagt tagtgggagt tggagaagaa gggctggcgt ctgaagtgca ggaccatgcc 315420 tgtttggccc agtcctgtgc caagctgaga tcgtctgcct gggtcctgcc atctagggac 315480 ctgcaggtca tggggaacag tctcaggtgt ggcaggagtt ccgtcgtggg ctcctctagg 315540 gaccggtggg tcgtggggag cagtgtcaag tgtggcaatt ctgtcgtggg ctcctctagg 315600 gactggtggg tggtggggag cagtgtctgg cgtggcagga gttccgtcgt gggctcctct 315660 agggaccggc gggtcgtcgg gagcagtgtc aggtgtggca gttctgtcgt gggctcctct 315720 agggactggc gggtggtggg gagcagtgtc tggcgtggca ggagttccgt cgtgggctcc 315780 tttagggacc ggcgggtggt ggggaacagt ctcaggcgtg gcgggagttc cgtcatgggc 315840 tcctctaggg accggcgggt cgtggggagc agcagcaggt gtggcaggtg ttccgtcgtg 315900 ggctccgact gtagtgctgg agacagaagt gatgtgacgt cagccaaggc ctcgggcacg 315960 agctggtggc tctccactgt ctggagaagt agctgccccc cacgtgctgc ttggtgctgc 316020 ctatttttta attgaattgt tagtattgag tttggggtga atccaagttg agtatatagc 316080 tgataaatat cttctcccag cccgtgacga gcctcttcat tttctgaccc tgtgttcctc 316140 ggagcaaatg cttttcatct gggtgcatgc tgatgatcag gttttctttt ataggggtca 316200 gatccagaaa ctctctgcat aactccaggc caaacatatt ttttcttgtt ttctactaaa 316260 aggttttaag ttcacattta aatctgtgac ccattttgag ttagtttttg cccatggtgt 316320 gagcttgagt tcaagctact tttctttttt gtttttatat ggatgtccaa ttgtgccatt 316380 attattgaac tgactgtcct gccaccattg aattatgttt gcacctttgt ccaaaaccag 316440 ttggccatgc gttatggggg tctctttcta caccttctct tctgttccct tgatctaagc 316500 gtctgttcct ttgctgttaa taacacccca cggtattgat tactgtagct tcgtagtaag 316560 tctcgaaatc agcagcacaa tcccccactt tatggacaag atttacattc agcttgtctt 316620 tacctgcaaa acgcctgctc agatttttag aggaattact gcatctgtca gtcagtctgg 316680 ggagcatcta catcttggtt gcagtgagtc ttccgataca tgaacacaat gtagctctcc 316740 atttatttac gttcttctta ttttctttca tccacatttt gtggttttca ccgtacccac 316800 ccaccccttt tttgttagaa atacacatgg ttttgttggt tttattgtta gtgttggagc 316860 tatgtaatta tttgtaggct tgtttttatg ggtcccaggt gttcagtgcg tgtgtgtaga 316920 tgtatgacgg atgtttatgc tggctttgta acccatgacc ttgctgaact cacttcttac 316980 atctgggtta gttgctgttt tgattttgtt ttctaatcct ttgcagtcat agcacctgtg 317040 aatagggaca gttttgctta ttttgttaag atccatatgt cttctatttt gttttcttgc 317100 tgtgttgccc tgtctaggac cttagtatgg tgctgagtag gagatggggc aacagagatc 317160 ctggcctttc tcctcacctt gcagggagag cagtccatcc tcctccatga ggcgtgctgc 317220 tagctgcagt ttatttgtgg tttttcctta tcaagctgaa aacgctcttt ccattcttag 317280 tttgctgaga gtgtttatca tgtaggatgt tggcgtctgt cagatgcttt tcctgcatca 317340 attgatggga tcgtatgttt tttttccctt acaccgttag tgtgattgac agtgtgtcat 317400 tgtgattttt ttgggaagtt tccaacgttg agccaactct gcattcctgg aataaacccc 317460 ccccttggtt atggcatagt atttttacat gttgctgagt tcatcttgct gacatcgtca 317520 gtaatcttca cgtctgtgtt catattggtc tgtagctttc ttgtactgcc cttgtctggt 317580 tgtagtatac acgtaatgaa tgaagtgaat tggaagtatt ccccctttta tgtcctagag 317640 gagattatat agaattggtg ttacttcttt aaatgttttg tagaatttgc tggtgaaacc 317700 atctgggcct agggattgtg gttgtggcag gttctaatca ttacaggaat agtgagttct 317760 ttcatctcag ctgaatgttg gtagaatgta ggttttgggg ttttttttat tgtgaggaac 317820 tggttcatta tatctgtgat caaatgtatg agcagtgaat tgtctgtgct cttgcctcgc 317880 tgattttatc gtgcctgctg ggttcgtagc ggtactcctt ccttcctgat actggtcgtt 317940 tatgtctttt tttttctttt ttcttttttt gtctgttagc ctttctggag atgtataaat 318000 ttcactgatc tccttagaga cctagttttt ggtttcattg atattttgct gttgtagttt 318060 tgtgtttcct tccttctgcc tgctttagtt ttagtttgct ctcctttttt tctggcctct 318120 tcaggtggaa gattagattg catatttgag atcttttctg ctttccaacg taagcgttcc 318180 gtgttagaaa tttgcatctg agtgctgcat tagcagcatt tcacacattt tgataatgtt 318240 gtatttttat gtgtgttcag ttcaaaacat tttcaaattt ccattaagat gtaccatagt 318300 ttgaacgtgg cctccaaagt ccacgtgttg gaaacttcat cccagagtga tggtgttggg 318360 aggtggggcc tcctgggagg cgttgaggtc acgtgggctc caccttggtg agtggattcg 318420 tgctgttgta aaaggggctt ctgttagttg gctctctgta tctgccctcc tgccgtccac 318480 catgtgatgg cgcctcagga aagcccttgc cagaagctgg tgccttgatc tcggacttgc 318540 cagcctccag aactgtgagc ctataaactt cgggtcgtta taaattaatc tcaggtattc 318600 tgtgatagcg ccgccaatag actaggatgc ctgctgtgat ccatacagat ttagaaggat 318660 gctttttaat ttcaaagtgt ctctccctga ttttctgggt aatttctgtt caatttcatt 318720 atgttgaggg aacgcacttt ctacgattca ctttctttgc aatttaaagt ttatttggta 318780 gctgataatt tgataacctc aaaatgtccc atgtgcacct gataggtatg tgtgttctgc 318840 cgattaatag atgtgttttg gccatttata gttaatgtaa ttttttatgc atttggattt 318900 aggtacattt tatgattagt tttctgtttg tcctccattt tttattcccg ttttctcttt 318960 cctacctatt tcaggttatt tggccttttt tatactccat tttgatgtat ctatgtcttt 319020 attatatcta tttgtatact tttaaagtga tttttctgtg gtttacaatg tgcaagctta 319080 acatttcacg gtgcacttat aattcatatt ttatcatttc aggtggaaac gtcaggattt 319140 caccacgacg taggcttctc cctgcctccc tttatgttgt agtagtccta tgtacttact 319200 ctctatatgt ggaaaacccc accaagaaat attacaattc ttgctcttaa ctgtcatgcc 319260 tattttataa aacataagag gcaaaaagta gtttgtggtt ttgcctcttc cttctttcct 319320 ggcgttcctg ggttcccctg ggatcatttc tggtttggca ggacttcctt cggggcttct 319380 ttagagtagg ttctctcagc gtttgcttgc ccagcagtgt cctcacccca cctcgttact 319440 gaaggatacc attgctggat gtggggttct gggagagtgg ttcttgtctc ctagcacttt 319500 aaaaatcgac actgtttccc catcttctgg cttctgtggt ttctgatgag caacctgcag 319560 tcactcaaag aaatctcccc tttcccctcc gtgcagatga gagaggcttt cagacactcc 319620 aagtgtggtg gtgttttaag ttaaaggacg ggaaggaatt catgtgccca cattgtctgc 319680 tgggttccag cgtgtgtggg tgtaatgcct gccaccctgc cgcgagaagg actcctgtgg 319740 tgatgtgctt tctacaccaa gcttagtggc acggcatcat ctctaagata ctgtgaaaag 319800 ttaagtctgt gttttccaat cacttgcttc ttggagcgtc tttaaaatct cactcgataa 319860 ttccagcatc tccgtcatct tggcgcctgt tggtcgtgtt ttccctggca ggtttctgtt 319920 ttcccggttc ttttcatgct gcttaatttt agattgcatt ctggatgttt tgaatatccc 319980 gagattctag gtctttctta agttctctgg agaatgtaaa tttctgttgg tttcagcatt 320040 tcctgatggc acttccattt caggctcttt gccgagtttc ccaggccatt gaaccttgtg 320100 tcctccacag tcctggctgg gtcctggtgt ggtctagctc agagtccaac tctcacacct 320160 gtggggtgct gattagggtc agagccccat gcccagctta gagggcacct tccagagcca 320220 ctctgagcac ccagcacttc ccaggtgacc cagggttccc ttcactgcct tctggccaca 320280 gagccaggca aggcttgccc actgtgctgt gcagtcagtc ccacggccac agccgccttc 320340 acggccaacg ccagccacag cgttggaaca gggcaggaca tgccccacgc accctgtctg 320400 gagggagggg cccactcttg ggctctaggc gtctgtccag ctgtggctgt acctccgcag 320460 gattgcccgg gtgccggggc ggaagagcgc ggggttgccc ggctgccggg gcggaagagc 320520 gcgggggtgc cagggtgccg gggcggaaga gcgcaggatt gcctgggtgt cagggtagaa 320580 gaggatggag acagacagaa tttcccacac tgcctctcag gcttctcttg acaagctgtg 320640 tgcgtcttgt gctcactccc aggttttagg ggtccccaag tccagactgg gtagcaccag 320700 ggcaaacacc caaccagtga cagaaactcc agcaagcttc aaccacagac tgcagaactc 320760 acccagtatg aaatagatcg tctcattaat cctagaacca ttaaataact gaatccacaa 320820 tcaaaaagct tccaaaaaag gatatctcca ggcccagatg gttttctggt gaattctacc 320880 aaacacttaa agaaaactta gcaccaattt gccaaaactc tccaagaaaa cagaagaggg 320940 agcacttccc aactcactct gtgaagcaag catttacccc aacttcaaaa ccagtggcaa 321000 aactgaagaa cactgcgggg ctattttctg ttttctgaga gtgcaaggct gggttggtgt 321060 cgagcgtcag ctggtacaat ccatcgcgtc agctcgccaa aaggaaaaat tacatggcca 321120 aaccaacgga tgcacaaatg cagtcagcga ggcccaacac acgttcatgg ggaaactcgg 321180 caaaccagga gaagccgaga acccccaagt ttgccaaaga gcatctgcag aaaccgtgca 321240 gctcaccgca gacctggctg gtgagggact gggaaacgcc gactcaggca gaggccttcc 321300 ctctcaccgc cttggtccat gtcccagagc cccagatggg cagcagggtg aggaggtcga 321360 aggcacacgg actggaaagg caggaccgac ccttttcctc ttcacaggtg gcgtgattat 321420 gtcgaaaatc acaagataaa aacgagtcga gcgagttcac ccgggatttc tgtgtgtggc 321480 tcttgtatcc tgcaaccttg ctgagctcac tttatgagaa atatgtccgt gtgtctgtgt 321540 agttctgtaa atattacaca atagcagtgc acatgtggaa accgaaatta aaaacatgcc 321600 gtttctgttc actcttctga agatgaaatc tgcaggcatc actaacacca cagcacgccg 321660 acaacggcaa gctgctgagg cgaggcgtgg gaggtctgtg tgaatggaga ctctgccttc 321720 gtggctcgtg gggtgcagcg cagtaaagac gcggcgcggc caggtccagc tgcatgtctc 321780 tcgcagctgg aagcagggcg ctcgccgctg ggctggtgat gctagtggtt ctgggttccg 321840 acctcagccc gcctgcagcc tgtggctctc caggtctgta gtcggctgct ggctgcactc 321900 cctccatcgt cagagctgcc tcagggagag acagggctga ttggtttctt catctttccc 321960 agaacctgaa cccctcgtct tcaggttctc tcttatctgt taattccgtt gcttttaagc 322020 ttagtaagta ctttagtgat ttgataaata attctatttt cttctgggct ctttgagctt 322080 atttttatat ttaaagattt aatctacttg aaacttattt tggtgtatgg tatgaggtcg 322140 agatctaaat tgattttttt tccagatcac taaacaattg ccctagggcc atttatctca 322200 gaatccttcc ttccccgtag atttatacct tcatctttat taaaacttag gcaaaatcgg 322260 gtctgtattc agatcttttg ttttttttaa tttcatttat cctttttttt gacttaaagg 322320 ttttcttacc tgtttattat tctaagttaa ttttagaatt actttgtcac ggccaggcgc 322380 ggtggctcat gcctgtaatc ccagcactga ggctgaggcg ggtggatcac ctgaggtcgg 322440 gagttcaaga ccagcctggc caacaaggtg aaaccctgtc tctactaaaa acacaaaacg 322500 ccaggcgtgg cgggagggtg tctgtagtcc cagctacagg tactatagat gctgaggtgg 322560 gagaatcgcc tgaacctggg ggatggaggt tgcagtaagc caaaatcaca ccattgcact 322620 ccagcctggg caacagagat agaccctgtc tccaaaaaga aaaaaaaaaa aagaattagt 322680 caaattcaaa aaaaaggtat caaggtttta ttttttactg aaattacact gaagttatag 322740 gttaatctag tggaagaatc tttggctttc cagcgtctgt gtctgagcag ggaagggcgc 322800 ctcagggccg cctccctcac cgataccacg tctcagaccc gcagcgtgcc ggggttccct 322860 ttgcaggctc cggtccaggc aggagtgtgt catctgggct gccatctgct gggcaggggt 322920 cctgagtccc cactgctggc tccaggccgc ctctccgccc tcttcccacc tccccaccct 322980 ctctttgggt tgcctgtctc gtcgtctcca gggctcagag ccgagctttg caggaggagc 323040 agggaacatg aatctgcacc cttttctgtc tggaccggat gtcccgtgaa tcttttttat 323100 tcagtcaatg aagattaggg ttttttgctg tcggttttta aatggataca cagtgttcgt 323160 gcatcgttat ggggtgtagg tgatgttgtc ttgcatgccc agaatgggca gtggccacac 323220 aggggtattt ggggtatccg tcacctcatg gactggtcat ttctaagtgt tgggaagacc 323280 tcctgtcctc tcttctcact gttttaaagt agacagcaca tgtggctgac tgtagtccgc 323340 ccccactcgg ctgtggaacg tgaggtctta ctccttccat ctggctgtgc gtctgtaccc 323400 actgaccagc ctccgttcat ccccgcccac cccacacctg caccctcctt ctcccccaac 323460 tccatgcgat gggttccccc cgctcccgtg ggtgagagcg tgcagcgggt cttcctgttt 323520 taaccacttc ccttggtgcc tctgaggaat cgctgggtcc acaacacagt gtgaggctgc 323580 cacggcagcc gagtctcccc gactttctct gcccctgctc ctcccacaca ctgtcgctgc 323640 tccatctgca gacaacacag ccccgggcga gcttactggg cagggttctg ccgaaacaca 323700 gaactcgtag aatgtgtgta cacacgcaca tgcacacgca cgcacgcacg cacacggaga 323760 tgcttgttac agggagttgg ctcacgcaat gacaggcaag tcccgagagc tgcagggttg 323820 ggggcaagcc ggggacccag gagcactcat gtactgggga aggacaggga tgctgggccc 323880 acacagcccc ggcttctgac tctgggggtt gctgtctcct aacgctgctg cagccctgct 323940 gtgcgccctc ctggggacct ccgtgtcact ggggacctcc gtgtcactgg agctgttggc 324000 actggccctc tataagcgtt gggtggactg gaggaggggt gtgggtaagg ctgactccgc 324060 cctgccaccc ctgggcactt tgcaacttca gctccctccc cagagtcatc tgcagtttct 324120 ttttgttgat caaagttaaa tttcagttcc aaagcaaagt tgctcctgag ctgatggagg 324180 aggggttgcc acacactgtc agctgttttg gacttgggcc atggtcccag ctctgcacca 324240 gcagccatgt gaccttgggt tcagctctct cagctctgac atgtggctca ctccaatcac 324300 ggtcattgtg gagggtgtgt ttatagcaga ggcaccgctg gcccatgatg tgtgctcagc 324360 atgatggtga tggcgacgat ggcggctgtg gcctgagccc attggcctct gggcccgtgc 324420 aggagcccat ttggtagaag ctgagccagg ctggtgggta gagaaacaaa agtggctccc 324480 aatgagccca ttccccagtg cggtcctccc tttgtgtggt aggtccccag cgaggacggc 324540 aggcttggct ttacagttct gccttcagtg ccagccacct ggacctcctg caccaggtca 324600 gggagagaag gcagaggaga ccttgcaggc tgcaggtgtc cctggctcca acacaccgtg 324660 tgtccatctg aggccggggc agccgtgttg gacggcctgg gagcctgagg tcagaaggct 324720 tggatggagg tcctgctcca cgtcgtaaca gttgggggtc tgggtggacc cttttctctc 324780 tgcatctcag cttccccatt tgagaaacgg gaccaccggc ccaggtcctg gggcagttgt 324840 gagcgtctgt ccccgcacca agggtgagcg tgacaggcgg acgatctctg cagactcctg 324900 ggactgaacg ataggaggag gtccctgtcc ttgctgggga ggggccggat cacggcggca 324960 tgggccggag ggaactgccc tgctggcaag agccgccaga gcctggggtg acccagagac 325020 aggacgggtg ttggaaggat cagtgcccct gccctgccac gtgctctcac cctgtgcact 325080 cattgaggcg ccctgtagag aggggagggg aggggagggg ggctggggcc aggagtagcc 325140 acagcaccag tcgccctggg gccgggagct gtggtctcct caggtgggcc caagtgcagt 325200 ccaggtgggg cagtggcctc agagcacagt ggctttgctg aaggctggct ggcactccag 325260 ttaaacaccc taggcccttc tctccatgct gttctttggt gttggtgttg ggtaataaag 325320 gccagcacca ttaattaggt gtgtaattag agttgtaaag gaatcatggg atttaatcac 325380 agggtttgca ggtgagcggg gtagaggaag ggtaccaccc tctgtgctgg gcacacccgc 325440 ctggctgcct gcaaacagat cctccctgga ctgggcgccc cccatgccgt ggacccggcc 325500 tgggcctcgg agctcctggg cagtgcggag ggctgaagca ccgtccccag tggcgtgact 325560 gcggttgtgt gttgggaaca tgctcggggg ccccaagacg gagccgaggg aggatccaga 325620 cagacgctcc cagaaccagg ttctgcagca ccagtgagaa gtcagcagag gtgtggggag 325680 gggactgcgc tggggctgag gtcccagggc tgggacacag gtgggcctca ctgcagcagg 325740 gccagagacc aggctggggc ggtccccact gggccatcgt ggggcttctg ggctccatcc 325800 tgagggtcac acagagcctc ggaggcattc tgtcaatttg gaaggtggcc tggctgcaga 325860 gtggagcacg gtccggggca ggctgagccg ggcgctggcc gtggactggg cagaggtgct 325920 ggtctgcgag gtggggtgtg atatgtgggc ccacgattca ggttgtaggg atacagcgct 325980 gcctgggccc ctccccagcc ccacatctag tctgctgggc tctgggctga accacagggt 326040 ggggcctgat gcaacacagt cagggccgcc ctccgtcccc gctagccctt ctctttgctg 326100 ctctgggggc tttgtcttcc tggggaacca gagataggta agaatgttcc tggcacagcc 326160 aggtggcccc acccttcctg ctgtgtctgg cagaagtgcc caggatgact tctctgtcct 326220 ggctgtgcac ggccacacgc ccgggcagcg tgtgccagcc acagggactg ctgaggagcc 326280 ctcttgctct tgctacggtc cccagccgtg gcaagcagct ccgtcgccgc gacacccttc 326340 ttctctcctc tttctttctg gcacgtctgt aaactttgct tgtaactcaa gccaagtacc 326400 caattaggga tttcttcaca gttgcattta aacctgattg aagtgggagc tcttcagtgc 326460 ctgacacatc caacaggcgc ttcccctgag ccccggccag gcggtgctga gggcggagag 326520 gggcggcgct gctgggagct ctggctgtct ggaggggagg tgcgcccttc acccggggtg 326580 ggcacccagc cctgtctcgg cccccatgtc cttatctctg gtcaggggtg tggcccctca 326640 tgccccaggc tgtcatgagg ctcctgtgag cacagcgcac gtgtgcaggg ctgggtggtc 326700 tgcatgctag gtgggcagcc gagcgggagg cccatgtgct ggcagtgcag ggcgggtggc 326760 tccatgccgc ggctccctcg ctggacccca gcgccaagcc cacactgttc tgtccgtgtg 326820 tgttctgagc atcgcctgga cgctcggccc tggggcacat ggatggaggg aactgggtgc 326880 ctggtccagg gagggtaacc aacctcgagc tgtgggcatc cttgtcctgg aaaagcagga 326940 ggaaaactgc agtggggagt ggaggacatt cctgtcacaa gatgctgtga tgactggagg 327000 acactggaga agccgtgtcc tctgccagcc ccagcctcgg ttctcgttgg catgggagat 327060 gtgccagggt cgtgcctcgt aggtgaatgg gggtgccctg gtctcgcttc tcgctggctc 327120 gggagatgcg ccagggtcgt gcctggtagg caaatggggg tgcccgggct gttcatgcag 327180 tggagttcct gggagcccag cctggccccc accgtgggat cgggactact gtcatttcta 327240 ctcatgaggg aggggagctg cagggaggca acaagacacc cgcagcacag ggcatggaca 327300 cgaattcatc tccccgccag tgatcatccc ccaggcctgg cctgggcagc tgctgactcc 327360 cttgcagggc ctggagggta tgcgtagtcc gaggggctaa gtcgagtccc ttccttgagg 327420 gctcactgtc tgctgggcgt gtgtccccgc ctcccccgcc atgcctcatg ctctggcgtg 327480 tgacttgctc ctctctctat accgcccagc gtgctgtccc cgcctcgtgc catgacgtgt 327540 gttttgctcc tctttctgta ctgcccagcg tgctgcctag cacagacgga ccacaattca 327600 ctcatccagt cctcagctga gggacgtctg ggtggttcca ctttttggct gtcatgagtc 327660 atgctgtgga cgttgtggac gtttgggtac aagtctttgt gtggatacag ttttcgttcc 327720 tccagacggg aggggaattt ccacattcta gggaggagag gagctgcctt acggtttccg 327780 aggcggcttc acccgtttgc atgtcccacg tgaggctcca ggggccccac accctcccgg 327840 tgttggtggc atctctcttt ctgaccacag ccccactggt gggtgcggag tgtgtgggga 327900 tgcctgcact tcctcacagg tgaggatgat gggcaccgac gtggcttgtt agcctctcct 327960 aggtcatctt ctgcaaaata cctacttaaa tccctgccat tttcgactgg attgtgttct 328020 catcattttc tcaatgcttt cttttgataa gcagttttaa atctcgatga agtataacga 328080 atcacttttt cctgtggtag tgatggtggt agtgctttgt cccaagaatt ccctgctgac 328140 cccagtgttg aatcgacctt agactaagcc ccttatcccg ctggttctgt tcgtggcgtg 328200 aggggaggtc cacatctcac tgtctccgtg tggacattgg gtcgttttgg ccccgctggc 328260 ggaaaagact tttctttccc cgtggagttg ctttcacttg ctttttgaaa agcactcaac 328320 gctgaacatt tcgtcctggc tgtcttctgt gccggcgaca catttgcttg tacccgcagc 328380 agtcccacgc agccgaccat cggtccttcc ttgactgtga gacttggagg caggcagcgt 328440 gcgtcctcca gcccgccgtg gaacaccgct ccacgtacgt cccgcgtcgg cctcctgtgg 328500 cgttcctcgc tgcccctgac cgtcctcagc acctctgcct gcgccgtccc ctggccctgc 328560 agctttctgt cccgggaagc gcgtggcttt tcccctaagt ctgccccagg tctccttccc 328620 agccaggtgc tgccaggacg ccttttcgga ccgcagccct ccccctccca tctccccgtc 328680 cctcccggct gcggttctct gtagcacttc cgctccaagg tgctactgtt gcacttcgtt 328740 tattttttat ctgtttccct agttgaaaag caacatccat tagggcaggg ggttcatctc 328800 tccatacaca ctgtgtcctc agggcctggg gtgttaccag gcgcccagca cctctccaca 328860 catacctgct gggtgaatga atagctgagc agcgcttctg aggaccctgg caccagggtt 328920 gctcccagtg agaccccagt tcctgctgct ctgtggccca gcagggaggg ctcggctctg 328980 gaaaaccaga ggcccacact atccttagat gccaccgcat gaggctcctg ttgctgccat 329040 gacaaaccag cactgactga gttactcaac acagcagggc cggcgcggca ctcatgcctg 329100 tcatcccaac gctttgggag gcccaggtac aggggattgc cagaggctcg gttggagacc 329160 agcctgggca gcatagcaag accctattta taaaaataat aataataatt agccgggtgt 329220 ggtagcacct gcctgtaatc ccagctactc tggaggctga ggcaggacaa tggcttgggc 329280 ctgggaggtc aaggccacag tgagctgtga tcgcacccct gttcgctacc ctgggcaaca 329340 tagtgagacc tcgtctcaaa aaaacaaacc aaaaactcaa cacgatgtga tctcgggttc 329400 tggaagtcac acgtttccct gggctaaagg ccaggggtca tcagggccgg ttcgtttcag 329460 aggctctggg gagaatccac atccggcctt ttctggctcc cagaagcacc cacgtgcctt 329520 ggcacacggc ctttcctcca ccctcagagc cggagcgcac atcttcggat ctctagccga 329580 ctttcctgcc tccctttctg acgtgtgaag acccgcgtga ttgtagcggg ccaccaggat 329640 aatgcaggaa cgcccgtggt ctcaccatcc ctgccccgga cacatctgca gagtcccttc 329700 ccacgtgcgg tcctgggccc aggcatagcc accgcttgct gatgcctgtc tggtctcctg 329760 ccacccatca cagcgccatc tcctccttcc gactcccagg tcctgaggcc tccaggccag 329820 cactggccag gggagggggc tgggaagagc cagtgagggc gtgtggcaga gtggagagta 329880 tgtcccccat tgtggggtcg ggcctgggac ctggacgcgg tgcctgggct tgcaggagag 329940 gagaggtgga caggcgtgct ggggggggag acctgcccac gctgccctgg gagcttgtct 330000 accctctccc cccccagcat ggcgtccagc aggacatggg gcgttccctc cagcgtggcc 330060 acccaggact ccaagcaggg cccaggagga actgtgaggg ggcatgactg agtctgtggc 330120 gtttcctgca ggattcttcc cataggggtg aagtctgtat ggcggaggca gccagggagc 330180 ctcccctcca ctccccacgg aatccggacg gcctgcattg cagccccagt ggctctgctg 330240 tgtccccgac cagctgcttc cctctcagcc tcagctttgt cctgggggag aggccactgg 330300 gggctgctct ccctcccccc atagcagctg taaatcatga aatcctcatg gtgtcagccg 330360 agggctcccc ctccccgcca cttctagagc cagagcccct gcgaggtccc aggttgctga 330420 ccccacgcca acccccagga cgccagggcc atctccagga cctgggggag caaggggcct 330480 ggctgccgct acagctccca gaaggtaaag cctttggcct cagagagcct cccccgacgg 330540 ttcccttctc caggccgggc gtgcacgcgc ggattcctcc tcatgcagag cccgtctgcc 330600 ctgatggatc ccccacccca cgccacccca ggccgcttcc tccgggtgga gtgctcctca 330660 gcactcaggg gtcctccctg cacccacccc gcccagaacc ctgctccttg cccctctcct 330720 tccagagccc tgtgtctggc tgctccaatt actggagcag ttccgtgtcc tcttcccgag 330780 tctcctgcta tctgaagagt tcattacata ggaatccgag gcctcgctgc ctacattagc 330840 aggttttcat agactgccac atctccaaaa ggggaaaaga gacaggagat ttaaaactct 330900 cgtcttgccg aaagcagaca gattgactcg aaaatgaccc agtcaataaa agatgagctc 330960 tggaaaggct tccctcttct cagagggggc tcgcctgccg gggagctgag gttctgcaag 331020 cctcggtggg aaattaatca tgaacgcggc atgcaaagcg gccggagccc acacagcccc 331080 gcccccacgt ctcccaggac ctcgccgccg ccaccccagg cctctctcca cggaccagct 331140 gctgggcatg ttcctggagg gaagcttccg gaaacagatg aggtggccgt gttctgtggt 331200 cacgtcttga ctcggctgtg atatcgctgt ggggcactgc tccctctgga gtgtttctgg 331260 ctctgggagg tgcgtgcgcg gtgggctccc tgcctgcaca ggggccctgg ctgtgggcct 331320 gtgaggctgg gtctgcctgg agctggtggg atgagagggg agtgctctga ggaccgttcc 331380 cccactggtg cagggatggg gagcacaggg tcccggtggc tctgatgcat cggcggcagg 331440 gaccgcagcc ctgcctgtgc caggaggagc cgtgagagga tgggcacccc ttgccctctg 331500 tgggctggca tctccgtgca gggcctgcag tctctgcagt ggccacccat tcttatctct 331560 cctggtgccc acacctgccg cctgcctcac ctcacccaaa caggaggagt cacctctgac 331620 cccaactgct tccttttacc agagtttctc agctcatgtt ccccaaaagg ataggttaag 331680 ttttcctttt gagccacaca tgcccccatt tgctgtctgt ctctcagatg gccatccttc 331740 atccagtcga cagggctggc cttgcggttt ccactgctga cacacacgga gctggctggt 331800 tctggggtct gtacccgcac gcagggcccc tgccgccatc tggacccctg ccaccccagt 331860 ttcccccact tcaggatttt gggtcagaag gaaactatcc cgacagctat gtgtactcct 331920 gcagacttct gggtttggcc atggttcccg tcagccccca gacccccgac aagtgtctga 331980 ggggatgtgg aacccagccc actcccacca cttctgccct gcagctgcat ggagggcggg 332040 ttggacaggt gaggcccagc ccctgccttc aggcagctca cacagtgagg gaagcagccc 332100 tgcaaaggtg gccgcagctg gaaaggcgtg tgtgtgccgc agaggttcag acccagtcca 332160 ggggagaggg ataggatgcc caagaggggc ttcatctgga ggtgacgccg gactggagag 332220 ggttgggatg cccaagaggg gcctcatctg gaggtgacgc cagactggag acggttggga 332280 tgcccaagag gggcctgttc tggaggtgac gccggactgg agagggttgg gatgcccaag 332340 aggggcctca tctggaggtg acgccggagt ctggccttgc agaagttcgc tggtgaacat 332400 cgtcccctgg cagaaggcaa atgtgcccgc cacattgtgg cagcagaaat gagcaccatg 332460 cgttctgagt gtgcctgggg tgtctgggag gactgtggac ttgtagcggc agaggacaga 332520 acacctgggc tgcacacgag tgactgtgct gggcaatggc gcttcccttc cgaagctggg 332580 ctctgactct gcaagtgact gcgccggggg cagtgctccc cttccgaagc tgggctctgc 332640 gtcaaaagaa agacccctgg ggcctgagga ggagggagag gagggtgaca ggaagtagaa 332700 tttggactct agtaaagaaa gaccccgagc agaggtggtg ccagggaggg ttggtgagga 332760 cagagcgttg aaacctggtg tccagcgggt gttgagtgct gaatccagga aggccgaagg 332820 caactcaagt tgtctggctc aaggggtgcg ggggatggag ggagaggcgg ccgcccagga 332880 gcgggaactg tgggagtagc acttagacat gaggcacgcc tgcagttatg aatcctcacg 332940 gctaatcagg gctgtgggca caggcagctg aggccacttg aaaggactga tgcgcccaga 333000 ccaggccccg ccagggcctc cggtcacggg atgggtgcag ggttgggggt caggagagag 333060 acactgtggc cccacatcgc catgctggag cccatgtccc gcctgactgg cgtcacaggg 333120 agccctctcc ctgctttctc atcgtcggtt tccccatcca gaaggtgggg acaaacgtag 333180 ccatgctccc cagggcgggg cccggctggg atgggtgcag cgaggctgcg tgttcctgcc 333240 ccggacaggc acctactcaa agcccgagca ggctctcacc tgacgaacgt gttccaggtg 333300 gaagagaggc caggacacgg gcaaacacgc gatctcagat gctcgtgagc tctagggaga 333360 aagcaaatgt ggggtgccca gaagaccact ggtgggggtg gcccagggag gcttttctga 333420 actgaagcct gaatgaccaa tggagacagc tgctcagccc ccagggcagt gcccagcgtg 333480 ggctccagct ttggctccgc ggcgggtgtt caaggggtcc cctcaacagt gctggcatcg 333540 cagaggtggc cctgtgctga cgcgtcggac ggctgctgcg accagccctc cctgtagtcc 333600 tgttgctggc cagagaccgt ggagctggat tctggcctcc tgcaggcatc tttctgtcca 333660 ttcagcaggt gccacgtccc cccacatatg cagggtgtcc ggaggatcac tgacacgggg 333720 gccaatgtcc ctccttccgc caaggttccg ctgggcctct gctgccgaag gaccccatgg 333780 gggctgtgga gcctggtgcc gggggagggg gctgtccctt ggggttcagc tgctgtgttc 333840 tcggtgctgg gggaggattc ttctccaaat atgatatccg cgcccgcctg tcaccccagg 333900 actctcccac cccgtaatct ggtggctgta attgctggtg tcttttcata tcagttttgt 333960 gcaaggtgac aagctgcttg ctggagtaag tcgttaatca cacaagaggt gccctgtttg 334020 aaagctgcac agagctcacc cagccagcgc ctgccaggtg gtgggccagg gagcggctcc 334080 tccgtgtgta attccagggc gagtgtcttc tcactggagc agagtgtgca gtttctgccc 334140 agcaggggaa ctcatggctc atcatggagg ccgtgtctca agggccgtct ggtaccagca 334200 gagttgaagc gaccatcttc ttggggcagc agcaggccct ggctggcagg tggtggcgtc 334260 ccatcctcct gttgccaaag ccagttcctg gggaccatga tgcctgccag cccctcgggc 334320 tggtctccgg gaatttggat ttggggccgg cagcccctgg gatgagccag gtggggcgct 334380 gtggggcatg ctggggtacg gttctcacgg gtgacatccc ggggggtccc ggccagccta 334440 caggtgcgtc cccacctcct acagtctctt gcagagccag ccaggacccg gatacaaatc 334500 gcacagccat aaccactgca atgccccatg cccatggctg ctaataaaat tgcatcaata 334560 tttgatgcct aattattaaa tatttaaaaa tgtaaaactg aaatagttta gaagcttgca 334620 aaacatgaat aattcagtcc cgggaagcct ggctcggcat tgggcctggg caggaccggg 334680 gctgccagtg cctgccaggg cccagagtac tctctgcagg gacactcggg cggctccccc 334740 agccctgggc ctccactggc ttcctgtgtc cgcagcgtgc aggggatcct tggtcgtctc 334800 tcgtcgaggt cagacctcgg cctgatgtgg aggcctctgc gtcacctact agtacaccac 334860 gccggtgtcg ggctccttca gaggctggtc ccgctgctcc gagtctgggc acgttccctc 334920 ctgccctgtg ttcccactgg cactgagcat ctgagagtca tctctgaccc atcagaccca 334980 tcctagaggg aagatctgga gatgccaatg ctggcagcct cccagaaaca gtccagcagg 335040 accccctggg gccgctgctc atgccaggcg cccagccgcc gccagggaga catctaacga 335100 gaggtgggaa atagacactt gggggagcca ggccgtgtgg tgggggtcat gagagaaatg 335160 catgctgggg gagtttcata atgttgagaa cagagacacg gctctgctac ttccggggag 335220 tgagaaccag tcacttgtag aagaccagaa gtcagaacgg attcaggctt ctccacagca 335280 gtgctgagca cttgagacct gagggcgatg ccttcagcac tgaaagagag gccgggtgcg 335340 gggctcacac ccgtcatccc aacactgtgg gaggcacaca tgaggcccgc aggtcaacaa 335400 cagcctgggc aacatagaaa gaccctaaaa atatatatat tagcccagtg tggtggtgtg 335460 ctccctgtgg tcccagctac ttgggaagct gaggtgggag gattgcttga gccccggagt 335520 tcgaggctac agtgagccac gatcgcgcca ctgcactcca gcctgggtga cagagtgaga 335580 ccctgtctca aaaaacaaaa caaacacaac tgaaggagga gtgtatacag cctggaattc 335640 tgcatctggc caaattaccc atcagctctg atggtgaggt agagatgtct tcagccatgc 335700 agggttccag acattgttcc ctgtctcacg tcatcaggga cctgctgaag ggtatgatcg 335760 cgagagttgc ggggcagctg cagccctgag ccaggtggtc cccagttcca gctgcagcag 335820 cctggacaga cttgctgggc ctgtcatgct ggaatcccaa cctttgagct gggaaaggtg 335880 ctgtgcccag gctgtgctac atcgttggga ccgtgtgtgg gcaaacgtac tgtctggtca 335940 cccatgtctg ctaagagcct tcatctcacc cttgcagggt ggccctggcc ggactcctga 336000 gctctggggt cacgggccgc tgtctcctga gggggccgca cactgcaggg gccagggcgg 336060 tcaccctgtc tctccggacc atgctcaggt gatcttttgg gtgtccttgc ggcccagacc 336120 gcactgcccc ctcactccac acctggactc aggcccgcca ctcagatccc gcgccgagca 336180 cccgtgatgt ccgtagacag ccaagtggtt gttgacgaca cagggatgtg ttttattaag 336240 aggaacacgt tattgccgag agggttttcg cctccactgt ctcactgacc cgggggcagg 336300 tgatgtttcc cccactcctg ccacacccag ggaggaaagg gggcttagag agatgaggtg 336360 acttgtccgt gaacgcacag gcagtgtatg gagcctggaa tcactccctt cctcctggcc 336420 ccgtggcggc gtcatcagtg gggccgggcc tacgccgagt aggattgtcc tcctggcttg 336480 gcctgggcct caggggctgc cttgtttaat ggtgaaatat tagtcccttt ttgtgggttt 336540 tttaaagcct gaaaatccca acattggtta actgtatttg attcattgtt tagaaagaaa 336600 aatggctgtg ccgtgagtcc ctgaaggaaa agttccgaag ctgcctccag tccctaaatc 336660 gagagttgct gcagagtctg gggcttgggg tcctcggtgg cagctgtgca gggcccagac 336720 ccaggccagc tcctcactgg ggcaccggtc caggtcgggc aggagctggg ggaccgtggg 336780 acaggggcaa ggcggtggca gtggggagat agtggggatg ggggcgtggc aagggctgag 336840 cagctgggag ctgctctgag gccatgggtg ccctcaccgc ccctcgcagg ctgaagcccc 336900 tggaggcccc tggctctcac agtgaccctg ttagccacag cagggatggg gttgggggct 336960 tgggggcggg gcagtggcat ggcctctctt cggcctgcct tgattttaag ggcttttcat 337020 ctgaggccat gggaaggctg tatgttcagg gatgaacacg ggtgttcagg gacagacgca 337080 cacgtgttcg gggataaacg gacgttcagc agtaggcgtg tgtgtcccgt ccgctgtgtg 337140 tgtgcttgct tgtggttaag ctgactgtgt agcttgcgca ggggcaggag ctcaggtctg 337200 taggggatgg tggcttcgct cacctgcgtg ttcaacacgc acccgtcgcg cacttccatg 337260 ttccgggttc tcaggtgcag ggcaggtgtg acagtgcgca caggcctggc ccagcccacc 337320 tgagctcagg gtgcgccgca gggaaacagc atgaggccca gttgcactgc agggaaagag 337380 cgtgaggccc aggcatctca aacagctctg tggacgccac aatctgtgcc ctgcaggaaa 337440 agagcatgcg gagaacagga gccagagact ggagcgatgg agaagcaggg tgcaggagag 337500 gcagctggaa agggagggcg gctcagggcc ctggggcggg gctgggacca ggtcaggcta 337560 gggccagatg cagctgcagt ggcagccagg ccggggcacc cagcagggca tgaatatccc 337620 aggagagagc cctgcctcag cccaagtctt gctgtgggag catggagatc tgtctgcatg 337680 gccggggtta tcctggacgg ggtagcagga gcggtgttgg catacacaac cgaggccagc 337740 ctgggaagag gctgcttggg gttcggggac cctacagaag caccagggct ggcgtctctt 337800 cctcctgtgg ggtcttccca cgtgggccag ctgcctcagc tgtgcagggg ctggtctcct 337860 cagggcagtg ctgcctggtg cctgcgggtg cttggtaaac atctaggccc cggctctttt 337920 tttttttttt ttttttgaga tggagtctta ctgtgtcacc cagcgtggag tgcagtggcg 337980 caatctcggc tcactgcagc ctctgcttac tgggctcaag caattctcct gcctcagcct 338040 cccgagtagc tgggattaca gatgtgcgcc accacgtccg gctaattttt gtatttttgg 338100 tagagacagg gtttcaccat gttggccagg atggtcttga actcctgacc tcagataatc 338160 tgcctgcttt ggcctcccag agtgctggga ttacaggtgt gagccactgt gcccagcccc 338220 aggttcctct taaaatcatc ccaggacaca gatgggggtc aggccggcct cactcacggg 338280 agaggtccca gagggaggtc acagagccca ggcccacaga gctattccaa gcacctggaa 338340 cagtgcttca ccaatcatga attccacaag agcatcttcc ataggctact gcgtcctcgc 338400 tgcctggaac agtgcttcat caatcatgag ttccacaaga gcgtcttcca taggccactg 338460 tgtcctcgct gcctggaaca gtgcttcatc aatcatgagt tccgcaagag cgtcttccat 338520 aggccactgc gtgcttgctg cctggaacag tgcttcatca atcatgagtt ccacaagagc 338580 gtcttccgta ggccactgca tcctcgctgc ctggaacagt gctttatcaa tcatgagttc 338640 cacaagaacg tcttccatag gccactgcat ccttgctgcc tggaacagtg ctttatcaat 338700 catgagttcc gcaagagcgt cttccgtagg ccactgcgtc ctcgctgcct ggaacagtgc 338760 ttcatcaatc atgaattccg caagagcgtc ttccgtaggc cactgcgtcc tcactgcctg 338820 gaacagtgct tcatcaatca tgaattccgc gagagcgtct tccgtaggcc actgcgtcct 338880 cgctgcctgg aacagtgctt catcaatcat gagttccaca agaacgtctt ccataggcca 338940 ctgcatcctt gctgcctgga acagtgcttt atcaatcatg agttcctcaa gagcgtcttc 339000 cgtaggccac tgtgtccttg ctgcctggaa tagtgcttca tcaatcatga gttccacaag 339060 aacgtcttcc ataggcgact gcatccttgc tgcctggaac agtgcttcat caatcatgag 339120 ttctgcaaga gcgtcttcca taggccactg cgtcctcgct tgcctggaac agtgcttgat 339180 caatcatgag ttccgcagga gcgtcttcaa taggccactg cgtgcttgct gcctggaaca 339240 gtgattgatc aatcatgagt tccgcaagag cgtcttccat aggccactgc gtcctcgctg 339300 cctggaacag tgcttcatta atcatgaatt ccgcaagagc gtcttccata ggccactgca 339360 tcctcgctgc ctggaacaat gcttcattaa tcatgaattc tgcaagagcg tcttccgtag 339420 gccactgcgt cctcgctgcc tggaacagtg cttgatcaat catgagttcc gcaagagcat 339480 cttccatagg ccactgcgtc ctcgctgcct ggaacagtgc ttgatcaatt atgagttccg 339540 caagagcatc tttcataggc cactgtgtcc tcactgcctg gaacagtgct tcatcaatca 339600 tgaattctgc aagagcgtct tccataggcc actgcatcct tgctgcctgg agcagtgctt 339660 catcaatcat gagttccgca agagcgtctt ccataggcca ctgcgtcctc actgcctgga 339720 acagtgcttc atcaatcatg agttccgcaa gagcttcttc aataggccac tgcgtgctcg 339780 ctgcctggaa cagtgcttca ttaatcatga attctgcaag agcgtcttcc ataggccact 339840 gcgtcctcgc tgcctggaac agtgcttgat caatcttgag ttccgcaaga gcgtcttcag 339900 taggccactg catcctcgct gcctggaaca gtgcttcatc aatcatgagt tccacaagaa 339960 cgtcttccat aggccactgc gtcctcgctg cctggaacag tgcttcatca atcatgagtt 340020 ccgcaagagt gtcttccgta ggccactgcg tcctcgctgc ctggaacagt gcttgatcaa 340080 tcatgagttc cgcaagagca tcttccatag gccactgcgt cctcgctgcc tggaacagtg 340140 cttgatcaat tatgagttct gcaagagcat ctttcatagg ccactgtgtc ctcactgcct 340200 ggaacagtgc ttcatcaatc atgaattctg caagagcgtc ttccataggc cactgcatcc 340260 ttgctgcctg gagcagtgct tcatcaatca tgagttccgc aagagcgtct tccataggcc 340320 actgcgtcct cactgcctgg aacagtgctt catcaatcat gagttctgca agagcttctt 340380 caataggcca ctgcgtgctc gctgcctgga acagtgcttc atcaatcatg aattctgcaa 340440 gagcgtcttc cataggccac tgcgtcctcg ctgcctggaa cagtgcttga tcaatcttga 340500 gttccgcaag agcgtcttca gtagcccact gcatcctcgc tgcctggaac agtgcttcat 340560 caatcatgag ttccgcaaga acgtcttcca taggccactg tgtcctcgct gcctggaaca 340620 gtgcttcatc aatcatgagt tccgcaagag tgtcttccgt aggccactgc gtcctcgctg 340680 cctggaacag tgcttcatca atcatgaatt ccgcaagagt gtcttccgta ggccactgcg 340740 tcctcactgc ctggaacagt gcttcatcaa tcatgagttc cgcaggagcg tcttcaatag 340800 gccaccgtgt gcttgctgcc tggaacagtg ctggatcaat catgagttcc gcaagagcgt 340860 cttccatagg ccactgcgtc ctcgctgcct ggaacagtgc ttcattaatc atgaattcca 340920 caagagtgtc ttccataggc cactgcattc tcgctgcctg gaacagtgct tcatcaatca 340980 tgagttccgc aagagcgtct tctgtaggcc actgggtcct cgcttgcctg gaacagtgct 341040 tcatcaatca tgagttccac aagaacgtct tccataggcc actgcatcct cgctgcctgg 341100 aacagtgctt catcaatcat gagttccgca agagcgtctt ccataggcca ctgcatcctt 341160 gctgcctgga acagtgcttc atcaatcatg agttccgcaa gatcgtcttc cgtaggccac 341220 tgcgtccttg ctttctggaa cggtgcctgc tgctgggtcc tccttcccac tgcaggacgt 341280 acagcgaggc tggagcctga gacggttccc tgcaccctga ggctcacgta gcccggccga 341340 cctggttctg cgtgggtata gctcaggccc cggggaaggg cggaagtgga caggcagtgc 341400 cctggggctg cactcctaag atccgtcggt acctttaaaa ggttctctgc ttgctctcat 341460 ctgcgtgtgc cccgtaacac tcgaaggagt aaagaggatg tagagaaaag taccgcgttt 341520 tccttttccc tccttctgaa aggcctgggc cccggcatct ctgtccctat ccccgtgggt 341580 cacagctgtg tgctggctct ccctgccctg ccaaggtaga agcattttct gcgtttcagg 341640 ctgtgaactg ggcctcttga gataagtgct gtaaatgctc ctttatcctg acatcccggc 341700 cctcagtact gtaaagcctc tctttcctgc tagctagcct ttacctaatg gagcacaatt 341760 tatttttatt ctgtcctctt cacagctgcc tcctgtgatt ccaggaggag gcaggtgtgg 341820 ggctaaggtg gtgagggggt ggctgttcag gcaccagtgt cgtggatgcc ttcagccccc 341880 tggtacaccc cactgggccg ggccctgggc agccgccgct gcatcctctc tgactcccac 341940 ttgaacacct gctgttcttc ctcctctctt gcccctcacc gaggccttga gagcccatca 342000 gtaccaggcc tgtgtccctg catccctgca aggtggtagc aggtacctct aagagggccg 342060 gttctgccca aagcaggggt cccaggggtg tggaggaggg gcccgaggag ggccggtatc 342120 taggcagagg ggagttgctg cttcctaggc aggtgctcct ggtcagtgtg gccagagttc 342180 aacatccccg ggcagggaag gcaggagcca gggctgtggg tgggctgggc tcaaggcctc 342240 cctacggttt ggctctaagc ctggggtagc cctggaggtc agcggagagg gcctaaaagc 342300 cttggtgagg ccaccccaga gagcagggct gcagagctgg gctccctccc tgagcacccc 342360 tggcccagca ggccttgagc acacagcgag ccgggctggg caggggatgg gagcgctgaa 342420 ggctgcacca ctgtctcgcc tcagcccatg cactgctgtt gcaggtcggg cctgagaaca 342480 gcctgggcag tgcctatgtg gtcccagggc tggggtcggg cacagggctg tcgcctctca 342540 ccctgggggt ctctgccact ggcttctggg gtctctgaga ggagcctgcc caggatccag 342600 gcccatagaa cccagtccag aggaaccccg ggctcttggc tcacttggga ggagaccacg 342660 tgagagcaac cgacaagaaa gcaatgacat ttccaaggcg gaaaacccat cttttattta 342720 tttaatccaa accatcgtgt gaattattca ttcacgttga tgtaagccac tgaactacag 342780 ggataaaggg gggtcagaac gctggcttga tctgccccaa actgaaccga ctccgtcgag 342840 gcagccttgt ctggaggatg gacccttccc tacgtggaca ggagaccagg atcagggccc 342900 cctcacctcc gagggtctgt gtggcatgga ggatggaccc ttcccctcca gggccctggg 342960 tttgtctgtc agagggtgag agagtggccc caggagtgag tgcggcggcc catgctgctc 343020 ccagccgcat gggtggtggt ctcgcctctg agagggggcc ccacacactg ccttcctcgc 343080 cctgggacct cataccaacc tgctatgggt gggcaaacac agcctggagc cccggaactt 343140 ccagaggtct gtgagcggca caggcagctt tgaagtctat cggaaaacag ggctgtttcc 343200 ttctccaagg tcaggcttgc atttattacc aaaatctaat tcttcccctt tggacgcctg 343260 agatctatca aaggcagcac gggccatgtt agggtgaaat atggcctctg aaatgtggtc 343320 tctgcgttct tccttgtgca cgtggcaatt cctgctaccg atagccccat cttcgggagg 343380 atcagccgag ggacgcaggg aagagtcttg gggtcagagc tgccaattag ccttcagatt 343440 tcacagcctg attgctcgat tcatcaaggg ccccagcctc gtcctgctgg aggggctggg 343500 ccgtggaata acagtgtccc ccagggccgt ctttgccagc aacggaggga ggaggccagg 343560 ttggggcgag ggctgaatca gtgccaatgc tgccatccca caggtggatg ggcgccaggg 343620 cccctctgct gacaggcctg cggttgtaca ggccccatat cctcccagcc cctgacatct 343680 ggatgctgct aacgtggtcc ctgcaccgct gctccttcca gaacccatgg caggcagcgc 343740 ccttgctttt gcagctaagc agcgagtctc tgtgagcctg ggtgtcattg tgtgtggatt 343800 ggggatcgga tcgtgttcat agctgtcata gccaggcagt gagtgagctt gcactcggaa 343860 cgggctgctc gactgagctc acgccatcgg gggtgcccag cggccctgcg ctctcggcgg 343920 tggcctccgg cacgtgatct ggcctaacac ctctgaaggc agctgcctgc ctgtgtccgt 343980 gttgcaggca gaagtcctgg gagatggggt gaaggggtag gttcagagtc acaggtcagg 344040 gaggcagagc cgagctgaaa ccgcggcccc tcccgcgtcc tccatcttcc tctgcagact 344100 tgagggcttc tggtttgcac ctggctcccc tgtccctgct cacctccagg aagcaacctg 344160 gactgcatcg tccaccttaa actggcccat cagagcctct tcgggccgct gtgcacaaac 344220 tccccggcag cccctctctc actcactgtg acctggccag caggcactca cactgcacct 344280 ttcctcacac tcccctagag tggactgtgg gggaccccac accctttctg gggccttcag 344340 actcatctct aactcaggac cagcctcccc ccgggcgctg cctggagttg gaacccttgt 344400 tctctccaac catatggcca tggttgactt taacatcctc tttctcagcc tagccaggga 344460 gctgaccatc ccgtgcctgg ttgtgggcgc ctacagcagt cctgtgattc agtccctcgt 344520 catagtggag ggaggctagc agctggccca gctcccgtgg cctgcaggat agggtccagc 344580 aggctcccgt ccccgcctgg agcagtccca ggcccctgga gggctcccca ttgccagctc 344640 cagacagcac tgctgggaag cacccggcct aggggacggc tctgtgtgcg tctaagtgga 344700 gccagtcctg ataattaacg cggggataaa tcgaggttta actacttgga aggcctctcg 344760 ggtgagaaat tcatgataat cgctgttatc ctcctgatgg ctctgcagag cagttcctcc 344820 ccaagcagcc gtaaactctg acgggcaggg tgtggggctg taccctgaat agtcacttag 344880 agccatgtca ggggcagtgg gcctgggggt gccggctgtc gtctcacgat ggcctgacct 344940 cagaggtggc tggcaggtaa agccccgggg cagtaggatc cggaacgtcc cggtggcctc 345000 ctgcctgcct ccctgtttgt cggtgctggc tcctgtgggg taggcgtcca gcctcagaaa 345060 ggacccaggc ggcaacctgg gaatggatgg tcaggatcac tgggtggcgt ggcagcccag 345120 gccttcgctt tgggacccac atcctcagca ccggctcctc acgcggttct cgcctaaatc 345180 cccggagtgt tggggcaagc gaaccccgag tcacgcctga ccctgtggct tcctgaccct 345240 gtggcttcct ggcagtgact gtgctggctc caggggttgt cattctgcag gccgagggct 345300 gatccctgtg gaggggccct ggctgcttgt agtctggctc tcagagttac cgttcttaat 345360 gcagtaactt tattattgcc accaccagag ggtcagccgt tatcagctca cccctcactc 345420 ccgttccctc atgcatgccg atggaggctg gctggtgtga cacgggggct tgctgtgtcc 345480 ctgggcagcc gccactccca cctgtactcg gcttcctccc tgccctggcc gctcccgggt 345540 ccccacccct ccggcctggt gccgcactca ctgtctcctt ccgtccctcc cgcagagctg 345600 aagaagcagg tggagagtgc cgagctgaag aaccagcggc tcaaggaggt tttccagacc 345660 aagatccagg agttccgcaa ggcctgctac acgctcaccg gctaccagat cgacatcacc 345720 acggagaacc agtaccggct gacctcgctg tacgccgagc acccaggcga ctgcctcatc 345780 ttcaaggtgg gtcctgcgtg tgacggctct ccggctgtct cgctctctgt ctcctcctgt 345840 ggggagatcc gaccgtagcc ctcagcaaag gagcagcctc gcgtccaaag gggatggtgt 345900 ggagggctgg gcgggaagga ggtgcactgg cccgtcctcg tcaccccctg aggcttctca 345960 gccttgggcc aaccctatgt ggctttgcag ccctggacct cctgggtgca gaagacccta 346020 ggctgtcccc ctgactttct cagcctctgt ctgtcgcaac ttgggcttcg ttccatgagg 346080 gctgcggccg taggcgtgtg tgtcagtgtg tccagaggca gtggtgcctg gggaggactg 346140 aagtccgtgt ggggccgggg caggggacgc cttccaagat gccaggctgc gcagtgggac 346200 agcgcagtcc cagaagccag cacagggcaa ggtagacaga ctagaagagg aaaggagagc 346260 cagccgcatc tctacactcg cgtcctgcga gccagcaggc gctcttctgg tttgctggtg 346320 aagccagact gggtccaccg ttgtggacat gaagagtcct cgggcgagcg gggtccaaca 346380 gcagaaattg gggtgttatg tgttgaccct cagggtggag gtggccccac ttggacctcc 346440 agcagctgga gacccagggc aacaggggct tgttcatcac tgccccggtg agctaacctc 346500 cggtttgtga ggatggtgcc gtcggcctgg tgtggcattg tggccccggc atgacctcgt 346560 ggccccgtct tggcatgtgg ctgcttcagg aagggtggag ggggcggtgg ctgtgggaga 346620 tgaggacagg cagagacggg ccccacctgg gactgctgtg gtctggaacg ggcgtctaaa 346680 ctgcctgcag tctgcagcct ctgcgtgtct ttatggaacc gagaaccaac tttgatttgt 346740 ataaaagctg tacccagtgc ggcctacgca tgtccgtcag cgtctcacag cggtgagccg 346800 ctgcctgtct gattcagcct tagcccggct cttcctcctc cttctgcaca acccgcccgt 346860 cttcacagcc tgcgctgcac gggggcaccg tgccgggctt gctctgcgtt ccttgtggat 346920 ttcctgcttc tcagatcaca gtcatccatt tctacactct tgaaactctc aaacctttga 346980 ataataaaaa cacaccaagt c 347001 17 20 DNA Artificial Sequence Antisense Oligonucleotide 17 tgctttcgcg attacagaga 20 18 20 DNA Artificial Sequence Antisense Oligonucleotide 18 aggtcttcca tggttgcttt 20 19 20 DNA Artificial Sequence Antisense Oligonucleotide 19 cctccacacg ctgagagatg 20 20 20 DNA Artificial Sequence Antisense Oligonucleotide 20 tgcatctgca gagaacctgg 20 21 20 DNA Artificial Sequence Antisense Oligonucleotide 21 tgctggtact gcatctgcag 20 22 20 DNA Artificial Sequence Antisense Oligonucleotide 22 ctctttcctc cagctgcatg 20 23 20 DNA Artificial Sequence Antisense Oligonucleotide 23 ctctgctctt tcctccagct 20 24 20 DNA Artificial Sequence Antisense Oligonucleotide 24 atctgctctg ctctttcctc 20 25 20 DNA Artificial Sequence Antisense Oligonucleotide 25 tcagctccat ctgcattttc 20 26 20 DNA Artificial Sequence Antisense Oligonucleotide 26 ggctgctctc tccagctcca 20 27 20 DNA Artificial Sequence Antisense Oligonucleotide 27 gtgctggctg ctctctccag 20 28 20 DNA Artificial Sequence Antisense Oligonucleotide 28 gcctgttgcg ctccagctgc 20 29 20 DNA Artificial Sequence Antisense Oligonucleotide 29 tccgagatcc tccccttcag 20 30 20 DNA Artificial Sequence Antisense Oligonucleotide 30 tctcctggtc catcacgctc 20 31 20 DNA Artificial Sequence Antisense Oligonucleotide 31 tgcttctccg actccaggcg 20 32 20 DNA Artificial Sequence Antisense Oligonucleotide 32 ggattttctg attggcttcc 20 33 20 DNA Artificial Sequence Antisense Oligonucleotide 33 gggacagctt ctgctccaga 20 34 20 DNA Artificial Sequence Antisense Oligonucleotide 34 atcctgctct tgcagggaca 20 35 20 DNA Artificial Sequence Antisense Oligonucleotide 35 agcccgttgg tctctctcat 20 36 20 DNA Artificial Sequence Antisense Oligonucleotide 36 ggagcagccc gttggtctct 20 37 20 DNA Artificial Sequence Antisense Oligonucleotide 37 ctcgttctcc agctccaagc 20 38 20 DNA Artificial Sequence Antisense Oligonucleotide 38 cagcttggcc agcagcctct 20 39 20 DNA Artificial Sequence Antisense Oligonucleotide 39 gctttgcagc ttggccagca 20 40 20 DNA Artificial Sequence Antisense Oligonucleotide 40 agctcaacca cgaatctgga 20 41 20 DNA Artificial Sequence Antisense Oligonucleotide 41 agctccctct gctgcagctc 20 42 20 DNA Artificial Sequence Antisense Oligonucleotide 42 gctggccgct gacctgccgg 20 43 20 DNA Artificial Sequence Antisense Oligonucleotide 43 tctcctccaa cagctggccg 20 44 20 DNA Artificial Sequence Antisense Oligonucleotide 44 ttcttcctct cctccaacag 20 45 20 DNA Artificial Sequence Antisense Oligonucleotide 45 tctggagcct ccgggccagc 20 46 20 DNA Artificial Sequence Antisense Oligonucleotide 46 gacagctgag cctccatctc 20 47 20 DNA Artificial Sequence Antisense Oligonucleotide 47 cctccctgga gaacaggaag 20 48 20 DNA Artificial Sequence Antisense Oligonucleotide 48 ctgagcgtgt ccgcctcctc 20 49 20 DNA Artificial Sequence Antisense Oligonucleotide 49 gctcctcgac cttcaacctg 20 50 20 DNA Artificial Sequence Antisense Oligonucleotide 50 cgctccagct gtgcctccag 20 51 20 DNA Artificial Sequence Antisense Oligonucleotide 51 catagtcacc ctgcagagct 20 52 20 DNA Artificial Sequence Antisense Oligonucleotide 52 atgtgcagca ctttggtcct 20 53 20 DNA Artificial Sequence Antisense Oligonucleotide 53 cagctggctg tggtcctcgc 20 54 20 DNA Artificial Sequence Antisense Oligonucleotide 54 agctctgcca cctccttgga 20 55 20 DNA Artificial Sequence Antisense Oligonucleotide 55 agccgctggt tcttcagctc 20 56 20 DNA Artificial Sequence Antisense Oligonucleotide 56 ccttgagccg ctggttcttc 20 57 20 DNA Artificial Sequence Antisense Oligonucleotide 57 aacctccttg agccgctggt 20 58 20 DNA Artificial Sequence Antisense Oligonucleotide 58 tggaaaacct ccttgagccg 20 59 20 DNA Artificial Sequence Antisense Oligonucleotide 59 ttggtctgga aaacctcctt 20 60 20 DNA Artificial Sequence Antisense Oligonucleotide 60 ggatcttggt ctggaaaacc 20 61 20 DNA Artificial Sequence Antisense Oligonucleotide 61 ctcctggatc ttggtctgga 20 62 20 DNA Artificial Sequence Antisense Oligonucleotide 62 cggaactcct ggatcttggt 20 63 20 DNA Artificial Sequence Antisense Oligonucleotide 63 tgatgtcgat ctggtagccg 20 64 20 DNA Artificial Sequence Antisense Oligonucleotide 64 gatgagcagt cgcctgggtg 20 65 20 DNA Artificial Sequence Antisense Oligonucleotide 65 ggctggtggc cttgaagatg 20 66 20 DNA Artificial Sequence Antisense Oligonucleotide 66 aaggcaggga tgctgtcctg 20 67 20 DNA Artificial Sequence Antisense Oligonucleotide 67 ctgaggaagg cagggatgct 20 68 20 DNA Artificial Sequence Antisense Oligonucleotide 68 ccagcaggaa gcccgacgta 20 69 20 DNA Artificial Sequence Antisense Oligonucleotide 69 tggccgcccc agcaggaagc 20 70 20 DNA Artificial Sequence Antisense Oligonucleotide 70 gaacccaggc tggtggccga 20 71 20 DNA Artificial Sequence Antisense Oligonucleotide 71 gagaagattt tatttcacaa 20 72 20 DNA Artificial Sequence Antisense Oligonucleotide 72 gctcagccgc tcgcagccag 20 73 20 DNA Artificial Sequence Antisense Oligonucleotide 73 tggagtgctg ctcagccgct 20 74 20 DNA Artificial Sequence Antisense Oligonucleotide 74 ggagaggaag agcctcgtgc 20 75 20 DNA Artificial Sequence Antisense Oligonucleotide 75 tctcatctcc cgcaggtgcg 20 76 20 DNA Artificial Sequence Antisense Oligonucleotide 76 gctgtgcagc ttcctcgaga 20 77 20 DNA Artificial Sequence Antisense Oligonucleotide 77 caggctattc attctgcccc 20 78 20 DNA Artificial Sequence Antisense Oligonucleotide 78 cccccgggcg cagcagtgaa 20 79 20 DNA Artificial Sequence Antisense Oligonucleotide 79 tgatacgctt tggctgcgtc 20 80 20 DNA Artificial Sequence Antisense Oligonucleotide 80 gcgccggtgg ctgccatgag 20 81 20 DNA Artificial Sequence Antisense Oligonucleotide 81 tcttcaccat cctacggagc 20 82 20 DNA Artificial Sequence Antisense Oligonucleotide 82 ggcagccctg ccgctgggcc 20 83 20 DNA Artificial Sequence Antisense Oligonucleotide 83 catagtcacc ctggaccagg 20 84 20 DNA Artificial Sequence Antisense Oligonucleotide 84 cgacctcacg ctgttaagag 20 85 20 DNA Artificial Sequence Antisense Oligonucleotide 85 ccaggtctac ctgctggtga 20 86 20 DNA Artificial Sequence Antisense Oligonucleotide 86 gcgcctcacc cggtggctgc 20 87 20 DNA Artificial Sequence Antisense Oligonucleotide 87 agattctcac cagcagtgaa 20 88 20 DNA Artificial Sequence Antisense Oligonucleotide 88 atgctccagc gacctctgct 20 89 20 DNA Artificial Sequence Antisense Oligonucleotide 89 ctacagaaat gtcaggtaag 20 90 20 DNA Artificial Sequence Antisense Oligonucleotide 90 gccctcacct gcagagctcg 20 91 20 DNA Artificial Sequence Antisense Oligonucleotide 91 aaaccaaaga cgtggatctc 20 92 20 DNA Artificial Sequence Antisense Oligonucleotide 92 gtttgcagac acggctcgct 20 93 20 DNA Artificial Sequence Antisense Oligonucleotide 93 acatgctgac ctggaccagg 20 94 20 DNA Artificial Sequence Antisense Oligonucleotide 94 agagatgaac cccctgccct 20 95 20 DNA Homo sapiens 95 tctctgtaat cgcgaaagca 20 96 20 DNA Homo sapiens 96 aaagcaacca tggaagacct 20 97 20 DNA Homo sapiens 97 catctctcag cgtgtggagg 20 98 20 DNA Homo sapiens 98 catgcagctg gaggaaagag 20 99 20 DNA Homo sapiens 99 agctggagga aagagcagag 20 100 20 DNA Homo sapiens 100 gaggaaagag cagagcagat 20 101 20 DNA Homo sapiens 101 gaaaatgcag atggagctga 20 102 20 DNA Homo sapiens 102 tggagctgga gagagcagcc 20 103 20 DNA Homo sapiens 103 ctggagagag cagccagcac 20 104 20 DNA Homo sapiens 104 gcagctggag cgcaacaggc 20 105 20 DNA Homo sapiens 105 ctgaagggga ggatctcgga 20 106 20 DNA Homo sapiens 106 gagcgtgatg gaccaggaga 20 107 20 DNA Homo sapiens 107 cgcctggagt cggagaagca 20 108 20 DNA Homo sapiens 108 ggaagccaat cagaaaatcc 20 109 20 DNA Homo sapiens 109 tctggagcag aagctgtccc 20 110 20 DNA Homo sapiens 110 tgtccctgca agagcaggat 20 111 20 DNA Homo sapiens 111 atgagagaga ccaacgggct 20 112 20 DNA Homo sapiens 112 agagaccaac gggctgctcc 20 113 20 DNA Homo sapiens 113 gcttggagct ggagaacgag 20 114 20 DNA Homo sapiens 114 agaggctgct ggccaagctg 20 115 20 DNA Homo sapiens 115 tgctggccaa gctgcaaagc 20 116 20 DNA Homo sapiens 116 tccagattcg tggttgagct 20 117 20 DNA Homo sapiens 117 gagctgcagc agagggagct 20 118 20 DNA Homo sapiens 118 ccggcaggtc agcggccagc 20 119 20 DNA Homo sapiens 119 cggccagctg ttggaggaga 20 120 20 DNA Homo sapiens 120 ctgttggagg agaggaagaa 20 121 20 DNA Homo sapiens 121 gctggcccgg aggctccaga 20 122 20 DNA Homo sapiens 122 gagatggagg ctcagctgtc 20 123 20 DNA Homo sapiens 123 gaggaggcgg acacgctcag 20 124 20 DNA Homo sapiens 124 caggttgaag gtcgaggagc 20 125 20 DNA Homo sapiens 125 agctctgcag ggtgactatg 20 126 20 DNA Homo sapiens 126 aggaccaaag tgctgcacat 20 127 20 DNA Homo sapiens 127 gcgaggacca cagccagctg 20 128 20 DNA Homo sapiens 128 accagcggct caaggaggtt 20 129 20 DNA Homo sapiens 129 ggttttccag accaagatcc 20 130 20 DNA Homo sapiens 130 accaagatcc aggagttccg 20 131 20 DNA Homo sapiens 131 gcttcctgct ggggcggcca 20 132 20 DNA Homo sapiens 132 ctggctgcga gcggctgagc 20 133 20 DNA Homo sapiens 133 agcggctgag cagcactcca 20 134 20 DNA Homo sapiens 134 cgcacctgcg ggagatgaga 20 135 20 DNA Homo sapiens 135 ttcactgctg cgcccggggg 20 136 20 DNA Homo sapiens 136 ctcatggcag ccaccggcgc 20 137 20 DNA Homo sapiens 137 ggcccagcgg cagggctgcc 20 138 20 DNA Homo sapiens 138 ctcttaacag cgtgaggtcg 20 139 20 DNA Homo sapiens 139 ttcactgctg gtgagaatct 20 140 20 DNA Homo sapiens 140 agcagaggtc gctggagcat 20 

What is claimed is:
 1. A compound 8 to 80 nucleobases in length targeted to a nucleic acid molecule encoding MAD1-like 1, wherein said compound specifically hybridizes with said nucleic acid molecule encoding MAD1-like 1 (SEQ ID NO: 4) and inhibits the expression of MAD1-like
 1. 2. The compound of claim 1 comprising 12 to 50 nucleobases in length.
 3. The compound of claim 2 comprising 15 to 30 nucleobases in length.
 4. The compound of claim 1 comprising an oligonucleotide.
 5. The compound of claim 4 comprising an antisense oligonucleotide.
 6. The compound of claim 4 comprising a DNA oligonucleotide.
 7. The compound of claim 4 comprising an RNA oligonucleotide.
 8. The compound of claim 4 comprising a chimeric oligonucleotide.
 9. The compound of claim 4 wherein at least a portion of said compound hybridizes with RNA to form an oligonucleotide-RNA duplex.
 10. The compound of claim 1 having at least 70% complementarity with a nucleic acid molecule encoding MAD1-like 1 (SEQ ID NO: 4) said compound specifically hybridizing to and inhibiting the expression of MAD1-like
 1. 11. The compound of claim 1 having at least 80% complementarity with a nucleic acid molecule encoding MAD1-like 1 (SEQ ID NO: 4) said compound specifically hybridizing to and inhibiting the expression of MAD1-like
 1. 12. The compound of claim 1 having at least 90% complementarity with a nucleic acid molecule encoding MAD1-like 1 (SEQ ID NO: 4) said compound specifically hybridizing to and inhibiting the expression of MAD1-like
 1. 13. The compound of claim 1 having at least 95% complementarity with a nucleic acid molecule encoding MAD1-like 1 (SEQ ID NO: 4) said compound specifically hybridizing to and inhibiting the expression of MAD1-like
 1. 14. The compound of claim 1 having at least one modified internucleoside linkage, sugar moiety, or nucleobase.
 15. The compound of claim 1 having at least one 2′-O-methoxyethyl sugar moiety.
 16. The compound of claim 1 having at least one phosphorothioate internucleoside linkage.
 17. The compound of claim 1 having at least one 5-methylcytosine.
 18. A method of inhibiting the expression of MAD1-like 1 in cells or tissues comprising contacting said cells or tissues with the compound of claim 1 so that expression of MAD1-like 1 is inhibited.
 19. A method of screening for a modulator of MAD1-like 1, the method comprising the steps of: a. contacting a preferred target segment of a nucleic acid molecule encoding MAD1-like 1 with one or more candidate modulators of MAD1-like 1, and b. identifying one or more modulators of MAD1-like 1 expression which modulate the expression of MAD1-like
 1. 20. The method of claim 19 wherein the modulator of MAD1-like 1 expression comprises an oligonucleotide, an antisense oligonucleotide, a DNA oligonucleotide, an RNA oligonucleotide, an RNA oligonucleotide having at least a portion of said RNA oligonucleotide capable of hybridizing with RNA to form an oligonucleotide-RNA duplex, or a chimeric oligonucleotide.
 21. A diagnostic method for identifying a disease state comprising identifying the presence of MAD1-like 1 in a sample using at least one of the primers comprising SEQ ID NOs: 5 or 6, or the probe comprising SEQ ID NO:
 7. 22. A kit or assay device comprising the compound of claim
 1. 23. A method of treating an animal having a disease or condition associated with MAD1-like 1 comprising administering to said animal a therapeutically or prophylactically effective amount of the compound of claim 1 so that expression of MAD1-like 1 is inhibited.
 24. The method of claim 23 wherein the disease or condition is a hyperproliferative disorder. 